ATE289823T1 - Erhöhung der migration oder proliferation von keratinocyten - Google Patents
Erhöhung der migration oder proliferation von keratinocytenInfo
- Publication number
- ATE289823T1 ATE289823T1 AT97310407T AT97310407T ATE289823T1 AT E289823 T1 ATE289823 T1 AT E289823T1 AT 97310407 T AT97310407 T AT 97310407T AT 97310407 T AT97310407 T AT 97310407T AT E289823 T1 ATE289823 T1 AT E289823T1
- Authority
- AT
- Austria
- Prior art keywords
- collagenase
- keratinocytes
- proliferation
- migration
- increase
- Prior art date
Links
- 210000002510 keratinocyte Anatomy 0.000 title abstract 2
- 238000013508 migration Methods 0.000 title abstract 2
- 230000005012 migration Effects 0.000 title abstract 2
- 230000035755 proliferation Effects 0.000 title abstract 2
- 108010013295 Microbial collagenase Proteins 0.000 abstract 3
- 108060005980 Collagenase Proteins 0.000 abstract 2
- 102000029816 Collagenase Human genes 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 102000035195 Peptidases Human genes 0.000 abstract 2
- 229960002424 collagenase Drugs 0.000 abstract 2
- 239000003102 growth factor Substances 0.000 abstract 2
- 235000019833 protease Nutrition 0.000 abstract 2
- 210000003491 skin Anatomy 0.000 abstract 2
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/777,267 US5718897A (en) | 1995-06-07 | 1996-12-31 | Enhancing keratinocyte migration and proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE289823T1 true ATE289823T1 (de) | 2005-03-15 |
Family
ID=25109770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97310407T ATE289823T1 (de) | 1996-12-31 | 1997-12-22 | Erhöhung der migration oder proliferation von keratinocyten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5718897A (de) |
| EP (1) | EP0852144B1 (de) |
| JP (1) | JPH10212244A (de) |
| AT (1) | ATE289823T1 (de) |
| AU (1) | AU733240B2 (de) |
| CA (1) | CA2225898C (de) |
| DE (1) | DE69732616T2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5718897A (en) * | 1995-06-07 | 1998-02-17 | Trustees Of Tufts College | Enhancing keratinocyte migration and proliferation |
| JP4074043B2 (ja) * | 2000-03-27 | 2008-04-09 | 株式会社資生堂 | 皮膚基底膜形成促進剤、人工皮膚形成促進剤及び人工皮膚の製造方法 |
| US7176243B2 (en) | 2000-06-02 | 2007-02-13 | The General Hospital Corporation | CaR receptor as a mediator of migratory cell chemotaxis and/or chemokinesis |
| US7262174B2 (en) * | 2001-05-09 | 2007-08-28 | Geron Corporation | Treatment for wounds |
| ITPD20050207A1 (it) | 2005-07-07 | 2007-01-08 | Fidia Farmaceutici | Nuove composizioni farmaceutiche contenenti acido ialuronico e collagenas nel trattamento topico di ferite, ustioni ed ulcere |
| CA2711133A1 (en) * | 2008-01-08 | 2009-07-16 | Tufts University | Wound healing peptides and methods of use thereof |
| CA2743999A1 (en) | 2008-10-27 | 2010-06-03 | Trustees Of Tufts College | Nucleic acids encoding peptides for treating wounds, anti-angiogenic compounds, and uses thereof |
| WO2011003236A1 (zh) | 2009-07-08 | 2011-01-13 | 乔志亚生技股份有限公司 | 一种龙眼核萃取物的制备方法与应用 |
| KR20120117995A (ko) | 2009-12-08 | 2012-10-25 | 헬쓰포인트, 엘티디. | 강화된 효소 활성을 갖는 효소적 창상 괴사조직제거 조성물 |
| JP5946508B2 (ja) * | 2014-10-31 | 2016-07-06 | 喬本生医股▲ふん▼有限公司 | リュウガン種子抽出物の製造方法及びその応用 |
| WO2016094675A1 (en) | 2014-12-12 | 2016-06-16 | Smith & Nephew, Inc. | Use of clostridium histolyticum protease mixture in promoting wound healing |
| WO2025114817A1 (en) | 2023-11-30 | 2025-06-05 | Osiris Therapeutics, Inc. | Methods and compositions for enzymatic wound debridement |
| WO2025181654A1 (en) | 2024-02-26 | 2025-09-04 | Smith & Nephew, Inc. | Methods for measurement of endotoxin contaminants in enzymatic compositions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0625894A1 (de) * | 1991-10-09 | 1994-11-30 | LecTec Corporation | Wässriges gel enthaltender wundverband sowie verpackung |
| US5393792A (en) * | 1991-11-20 | 1995-02-28 | Advance Biofactures Of Curacao, N.V. | High dosage topical forms of collagenase |
| EP0637450A3 (de) * | 1993-08-04 | 1995-04-05 | Collagen Corp | Verfahren und Zusammensetzung zur Wiederbelebung von Nerbgewebe. |
| WO1996028543A1 (de) * | 1995-03-16 | 1996-09-19 | Knoll Aktiengesellschaft | Neue, definierte enzymmischungen zur zellgewinnung und für die wundbehandlung |
| US5718897A (en) * | 1995-06-07 | 1998-02-17 | Trustees Of Tufts College | Enhancing keratinocyte migration and proliferation |
-
1996
- 1996-12-31 US US08/777,267 patent/US5718897A/en not_active Expired - Lifetime
-
1997
- 1997-12-12 AU AU48364/97A patent/AU733240B2/en not_active Expired
- 1997-12-22 DE DE69732616T patent/DE69732616T2/de not_active Expired - Lifetime
- 1997-12-22 EP EP97310407A patent/EP0852144B1/de not_active Expired - Lifetime
- 1997-12-22 AT AT97310407T patent/ATE289823T1/de not_active IP Right Cessation
- 1997-12-24 CA CA2225898A patent/CA2225898C/en not_active Expired - Lifetime
- 1997-12-25 JP JP9369299A patent/JPH10212244A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU4836497A (en) | 1998-07-02 |
| AU733240B2 (en) | 2001-05-10 |
| DE69732616D1 (de) | 2005-04-07 |
| EP0852144B1 (de) | 2005-03-02 |
| EP0852144A2 (de) | 1998-07-08 |
| US5718897A (en) | 1998-02-17 |
| EP0852144A3 (de) | 1999-05-26 |
| DE69732616T2 (de) | 2006-04-13 |
| JPH10212244A (ja) | 1998-08-11 |
| CA2225898A1 (en) | 1998-06-30 |
| CA2225898C (en) | 2012-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |