ATE290364T1 - Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien - Google Patents

Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien

Info

Publication number
ATE290364T1
ATE290364T1 AT00954046T AT00954046T ATE290364T1 AT E290364 T1 ATE290364 T1 AT E290364T1 AT 00954046 T AT00954046 T AT 00954046T AT 00954046 T AT00954046 T AT 00954046T AT E290364 T1 ATE290364 T1 AT E290364T1
Authority
AT
Austria
Prior art keywords
thermally activated
dispenser device
chemical dispenser
reservoir cap
internal volume
Prior art date
Application number
AT00954046T
Other languages
English (en)
Inventor
John T Santini Jr
Michael J Cima
Scott A Uhland
Original Assignee
Microchips Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microchips Inc filed Critical Microchips Inc
Application granted granted Critical
Publication of ATE290364T1 publication Critical patent/ATE290364T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Rigid containers without fluid transport within
    • B01L3/5085Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • B01L3/50853Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates with covers or lids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0819Microarrays; Biochips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0677Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Micromachines (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Secondary Cells (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
AT00954046T 1999-08-18 2000-08-11 Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien ATE290364T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14949399P 1999-08-18 1999-08-18
PCT/US2000/022215 WO2001012157A1 (en) 1999-08-18 2000-08-11 Thermally-activated microchip chemical delivery devices

Publications (1)

Publication Number Publication Date
ATE290364T1 true ATE290364T1 (de) 2005-03-15

Family

ID=22530537

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00954046T ATE290364T1 (de) 1999-08-18 2000-08-11 Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien

Country Status (8)

Country Link
US (4) US6527762B1 (de)
EP (1) EP1210064B1 (de)
JP (2) JP4397558B2 (de)
AT (1) ATE290364T1 (de)
AU (1) AU6639400A (de)
CA (1) CA2381951A1 (de)
DE (1) DE60018582T2 (de)
WO (1) WO2001012157A1 (de)

Families Citing this family (239)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6783543B2 (en) * 2000-06-05 2004-08-31 Scimed Life Systems, Inc. Intravascular stent with increasing coating retaining capacity
US7070590B1 (en) * 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US7341598B2 (en) 1999-01-13 2008-03-11 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
EP1154691A4 (de) * 1999-01-05 2004-07-07 Massachusetts Eye & Ear Infirm Gezielte transsklerale gesteuerte wirkstoffabgabe an die retina und choroidae
ATE290364T1 (de) * 1999-08-18 2005-03-15 Microchips Inc Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien
EP2308522A3 (de) 1999-11-17 2012-02-29 Boston Scientific Limited Miniaturisierte Vorrichtungen zur Abgabe von Molekülen in einer Trägerflüssigkeit
US6982058B2 (en) * 1999-12-08 2006-01-03 Baxter International, Inc. Method for fabricating three dimensional structures
ATE323470T1 (de) * 1999-12-10 2006-05-15 Massachusetts Inst Technology Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren
DE60144142D1 (de) * 2000-03-02 2011-04-14 Microchips Inc Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
JP2003534870A (ja) * 2000-06-05 2003-11-25 シメッド ライフ システムズ インコーポレイテッド 増大された被膜保持容量を有する血管内ステント
AU2001283359A1 (en) * 2000-08-14 2002-02-25 Pharmacia Corporation Drug release (delivery system)
DE60116520T2 (de) * 2000-10-10 2006-08-31 Microchips, Inc., Bedford Microchip-reservoir-vorrichtungen mit drahtloser übertragung von energie und daten
FR2817969B1 (fr) * 2000-12-08 2003-02-28 Diagast Dispositif et procede d'analyse immunologique
TW554405B (en) * 2000-12-22 2003-09-21 Seiko Epson Corp Pattern generation method and apparatus
WO2002055058A2 (en) 2001-01-09 2002-07-18 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US6858220B2 (en) 2001-02-28 2005-02-22 Second Sight Medical Products, Inc. Implantable microfluidic delivery system using ultra-nanocrystalline diamond coating
US7232460B2 (en) * 2001-04-25 2007-06-19 Xillus, Inc. Nanodevices, microdevices and sensors on in-vivo structures and method for the same
EP1387671A1 (de) 2001-05-03 2004-02-11 MASSACHUSETTS EYE & EAR INFIRMARY Implantierbare arzneistoffverabreichungsvorrichtung und verwendung derselben
US6973718B2 (en) 2001-05-30 2005-12-13 Microchips, Inc. Methods for conformal coating and sealing microchip reservoir devices
WO2002099457A1 (en) * 2001-05-31 2002-12-12 Massachusetts Inst Technology Microchip devices with improved reservoir opening
US6827250B2 (en) 2001-06-28 2004-12-07 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
US6936183B2 (en) * 2001-10-17 2005-08-30 Applied Materials, Inc. Etch process for etching microstructures
US7097775B2 (en) * 2001-10-26 2006-08-29 Second Sight Medical Products, Inc. Coated microfluidic delivery system
US7354597B2 (en) * 2001-12-03 2008-04-08 Massachusetts Institute Of Technology Microscale lyophilization and drying methods for the stabilization of molecules
US20040073175A1 (en) * 2002-01-07 2004-04-15 Jacobson James D. Infusion system
WO2003092665A2 (en) * 2002-05-02 2003-11-13 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
US6953455B2 (en) * 2002-07-30 2005-10-11 Hospira, Inc. Medicine delivery system
AU2007200736B2 (en) * 2002-08-16 2008-09-18 Microchips, Inc. Controlled release device and method
DE60336727D1 (de) * 2002-08-16 2011-05-26 Microchips Inc Vorrichtung mit kontrollierter abgabe und verfahren
AU2003278766A1 (en) * 2002-09-04 2004-03-29 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
AU2003278881A1 (en) * 2002-09-23 2004-04-08 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
EP1551499A1 (de) * 2002-10-04 2005-07-13 Microchips, Inc. Medizinische vorrichtung zur nervenstimulation und kontrollierten verabreichung von medikamenten
AU2003279842A1 (en) * 2002-10-04 2004-05-04 Microchips, Inc. Medical device for controlled drug delivery and cardiac monitoring and/or stimulation
IL152629A (en) * 2002-11-04 2010-12-30 Innoventions Ltd Implantable medical device for controlled release of a substance
US20060167435A1 (en) * 2003-02-18 2006-07-27 Adamis Anthony P Transscleral drug delivery device and related methods
ES2359243T3 (es) * 2003-04-25 2011-05-19 Boston Scientific Scimed, Inc. Formulación de fármaco sólida y dispositivo para el almacenamiento y la administración controlada de la misma.
WO2005010240A2 (en) * 2003-07-17 2005-02-03 Microchips, Inc. Low temperature methods for hermetically sealing reservoir devices
US20050055014A1 (en) * 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
KR101556457B1 (ko) 2003-09-11 2015-10-01 테라노스, 인코포레이티드 피분석물의 모니터링 및 약물 전달을 위한 의료 기기
US20050107742A1 (en) * 2003-09-15 2005-05-19 The Regents Of The University Of Michigan Shatter-resistant microprobes
US8095197B2 (en) * 2003-11-03 2012-01-10 Microchips, Inc. Medical device for sensing glucose
DE602004028649D1 (de) * 2003-11-13 2010-09-23 Medtronic Minimed Inc Langzeit-analytensensor-anordnung
US8414489B2 (en) * 2003-11-13 2013-04-09 Medtronic Minimed, Inc. Fabrication of multi-sensor arrays
US7457667B2 (en) 2004-02-19 2008-11-25 Silverleaf Medical Products, Inc. Current producing surface for a wound dressing
US8019413B2 (en) 2007-03-19 2011-09-13 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US7850676B2 (en) * 2004-04-19 2010-12-14 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US8337482B2 (en) 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US7998060B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US8092549B2 (en) 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US8353896B2 (en) 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US9801527B2 (en) 2004-04-19 2017-10-31 Gearbox, Llc Lumen-traveling biological interface device
US8361013B2 (en) 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US7857767B2 (en) 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
AU2005245224A1 (en) * 2004-05-21 2005-12-01 Given Imaging Ltd. Device, system and method for in-vivo sampling
EP1765455A2 (de) * 2004-06-01 2007-03-28 Microchips, Inc. Vorrichtungen und verfahren zur messung und verstärkung des wirkstoff- oder analyttransports zu/von einem medizinischen implantat
WO2005122959A2 (en) 2004-06-08 2005-12-29 Advanced Stent Technologies, Inc. Stent with protruding branch portion for bifurcated vessels
US9267167B2 (en) * 2004-06-28 2016-02-23 Becton, Dickinson And Company Dissolvable films and methods including the same
US20070036835A1 (en) * 2004-07-19 2007-02-15 Microchips, Inc. Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US7026441B2 (en) * 2004-08-12 2006-04-11 Intel Corporation Thermoresponsive sensor comprising a polymer solution
JP5107041B2 (ja) * 2004-09-01 2012-12-26 マイクロチップス・インコーポレーテッド レザバ内容物の制御された放出または曝露のための、マルチキャップレザバデバイス
AU2005284908B2 (en) 2004-09-13 2011-12-08 Morningside Venture Investments Limited Biosynchronous transdermal drug delivery
GB2418144A (en) * 2004-09-17 2006-03-22 Psimedica Ltd Medical device for delivery of beneficial substance
CA2583911A1 (en) * 2004-10-28 2006-05-11 Microchips, Inc. Orthopedic and dental implant devices providing controlled drug delivery
CN104925744A (zh) * 2004-11-04 2015-09-23 微芯片生物技术公司 压入式冷焊密封方法和装置
US7413846B2 (en) * 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
US20080009801A1 (en) * 2004-12-02 2008-01-10 Nickel Janice H Method for dispensing material into a drug delivery device
EP1827399A1 (de) * 2004-12-17 2007-09-05 Alza Corporation Temperaturmodulation einer transdermalen arzneimittelabgabe
DE102004061732B4 (de) * 2004-12-17 2015-05-21 Technische Universität Dresden Steuerbare Einrichtung aus mehreren Einzelspeicherzellen auf Hydrogelbasis
US7827983B2 (en) * 2004-12-20 2010-11-09 Hewlett-Packard Development Company, L.P. Method for making a pharmaceutically active ingredient abuse-prevention device
WO2006081279A2 (en) * 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
KR101637140B1 (ko) * 2005-05-09 2016-07-06 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
US8309057B2 (en) * 2005-06-10 2012-11-13 The Invention Science Fund I, Llc Methods for elevating neurotrophic agents
WO2007001624A2 (en) * 2005-06-28 2007-01-04 Microchips, Inc. Medical and dental implant devices for controlled drug delivery
JP2009511153A (ja) * 2005-10-11 2009-03-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 埋設可能センサのための被個別稼動センサ
US20070088442A1 (en) * 2005-10-14 2007-04-19 Microchips, Inc. Passive wear-indicating sensor for implantable prosthetic device
US8273075B2 (en) 2005-12-13 2012-09-25 The Invention Science Fund I, Llc Osmotic pump with remotely controlled osmotic flow rate
US8083710B2 (en) 2006-03-09 2011-12-27 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US8992511B2 (en) 2005-11-09 2015-03-31 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US9067047B2 (en) * 2005-11-09 2015-06-30 The Invention Science Fund I, Llc Injectable controlled release fluid delivery system
US8273071B2 (en) 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US20070106271A1 (en) 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Remote control of substance delivery system
US9474712B2 (en) 2005-11-09 2016-10-25 Gearbox, Llc In situ reaction device
US8936590B2 (en) 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
US7540881B2 (en) 2005-12-22 2009-06-02 Boston Scientific Scimed, Inc. Bifurcation stent pattern
BRPI0620268B8 (pt) * 2005-12-22 2021-05-25 Oakwood Laboratories LLC composição eficaz como sistema de fornecimento para liberação controlada, seu uso, seu método de fabricação, e método para proteger um agente biologicamente ativo
SE531121C2 (sv) * 2005-12-30 2008-12-23 Nanospace Ab Engångsventil
US20080140057A1 (en) * 2006-03-09 2008-06-12 Searete Llc, A Limited Liability Corporation Of State Of The Delaware Injectable controlled release fluid delivery system
EP2319558B1 (de) * 2006-03-14 2014-05-21 University Of Southern California Mems-Vorrichtung zur Wirkstofffreisetzung
US8323570B2 (en) * 2006-03-21 2012-12-04 Koninklijke Philips Electronics N.V. Microelectronic sensor device with sensor array
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) * 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US7958906B2 (en) * 2006-04-11 2011-06-14 University Of South Florida Thermally induced single-use valves and method of use
US20080058788A1 (en) 2006-04-12 2008-03-06 Searete Llc., A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US9408530B2 (en) 2006-04-12 2016-08-09 Gearbox, Llc Parameter-based navigation by a lumen traveling device
US8642059B2 (en) 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US7846158B2 (en) 2006-05-05 2010-12-07 Covidien Ag Apparatus and method for electrode thermosurgery
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
JP2009538671A (ja) * 2006-06-02 2009-11-12 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 物質の制御放出のための装置
US7803148B2 (en) * 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
EP1867990A1 (de) * 2006-06-14 2007-12-19 Koninklijke Philips Electronics N.V. Sensitiver Test mittels Verstärkung eines Etikettsignals
US20080015494A1 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
WO2008012725A2 (en) * 2006-07-27 2008-01-31 Koninklijke Philips Electronics N.V. A drug delivery system with thermoswitchable membranes
WO2008017042A1 (en) * 2006-08-03 2008-02-07 Microchips, Inc. Cardiac biosensor devices and methods
US20130226267A9 (en) * 2006-08-21 2013-08-29 Marom Bikson Method to reduce heating at implantable medical devices including neuroprosthetic devices
WO2008029372A2 (en) * 2006-09-08 2008-03-13 Koninklijke Philips Electronics N.V. Device for the controlled release of a predefined quantity of a substance
US20080060995A1 (en) * 2006-09-12 2008-03-13 Sean Zhang Semi-Permeable Membrane
US7951191B2 (en) 2006-10-10 2011-05-31 Boston Scientific Scimed, Inc. Bifurcated stent with entire circumferential petal
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
US7842082B2 (en) 2006-11-16 2010-11-30 Boston Scientific Scimed, Inc. Bifurcated stent
EP2157907B1 (de) * 2007-06-07 2013-03-27 MicroCHIPS, Inc. Elektrochemische biosensoren und anordnungen
DE102007032688A1 (de) * 2007-07-13 2009-01-22 Biotronik Vi Patent Ag Implantat und System aus einem Implantat und einer Anregungsvorrichtung
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
US7959669B2 (en) 2007-09-12 2011-06-14 Boston Scientific Scimed, Inc. Bifurcated stent with open ended side branch support
US20090076591A1 (en) * 2007-09-19 2009-03-19 Boston Scientific Scimed, Inc. Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface
EP2052700A1 (de) 2007-09-26 2009-04-29 Microchips, Inc. Arzneimittelverabreichungsvorrichtung und Verfahren zur Verwendung mit Prothesenimplantaten.
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
WO2009069112A1 (en) * 2007-11-28 2009-06-04 Janisys Limited A delivery device for administering an active substance to a subject
US8170658B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
US8165669B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
US8160695B2 (en) 2007-12-05 2012-04-17 The Invention Science Fund I, Llc System for chemical modulation of neural activity
US8195287B2 (en) 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US8180446B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8233976B2 (en) 2007-12-05 2012-07-31 The Invention Science Fund I, Llc System for transdermal chemical modulation of neural activity
US8170659B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
JP5542691B2 (ja) 2007-12-20 2014-07-09 ユニバーシティ オブ サザン カリフォルニア 治療薬を送達するための装置および方法
US8277501B2 (en) 2007-12-21 2012-10-02 Boston Scientific Scimed, Inc. Bi-stable bifurcated stent petal geometry
US7869044B2 (en) * 2008-01-16 2011-01-11 Optotrace Technologies, Inc. Optical sensing system based on a micro-array structure
WO2009097468A2 (en) 2008-01-29 2009-08-06 Kliman Gilbert H Drug delivery devices, kits and methods therefor
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
EP2320989B1 (de) 2008-05-08 2015-03-11 MiniPumps, LLC Implantierbare pumpen und kanülen dafür
US8231608B2 (en) 2008-05-08 2012-07-31 Minipumps, Llc Drug-delivery pumps and methods of manufacture
DE102008024447A1 (de) 2008-05-20 2009-11-26 Biotronik Crm Patent Ag Implantierbare Schockelektrodenleitung und implantierbare Defibrillationsanordnung
US8932340B2 (en) 2008-05-29 2015-01-13 Boston Scientific Scimed, Inc. Bifurcated stent and delivery system
US20100061976A1 (en) * 2008-07-24 2010-03-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject
EP2320962A2 (de) * 2008-07-31 2011-05-18 Boston Scientific Scimed, Inc. Medizinische vorrichtungen zur abgabe von therapeutischen mitteln
JP5798918B2 (ja) * 2008-08-21 2015-10-21 ナインポイント メディカル, インコーポレイテッド 薬物評価および局所処置のためのデバイスおよび方法
US20100137246A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100136095A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136096A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136094A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100135983A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100137787A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Delivery devices for modulating inflammation
US20100136097A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US9474831B2 (en) 2008-12-04 2016-10-25 Gearbox, Llc Systems, devices, and methods including implantable devices with anti-microbial properties
US8285387B2 (en) 2008-12-12 2012-10-09 Microchips, Inc. Wireless communication with a medical implant
US7838715B2 (en) * 2009-01-21 2010-11-23 Palo Alto Research Center Incorporated Drug deactivation system and method of deactivating a drug using the same
US9480795B2 (en) 2009-01-21 2016-11-01 Palo Alto Research Center Incorporated Sensor system for drug delivery device, drug delivery device having the same and method of using the same
US8236238B2 (en) 2009-01-21 2012-08-07 Palo Alto Research Center Incorporated Drug deactivation system
US8246565B2 (en) 2009-02-25 2012-08-21 The Invention Science Fund I, Llc Device for passively removing a target component from blood or lymph of a vertebrate subject
US8317737B2 (en) 2009-02-25 2012-11-27 The Invention Science Fund I, Llc Device for actively removing a target component from blood or lymph of a vertebrate subject
US8003521B2 (en) * 2009-04-07 2011-08-23 Micron Technology, Inc. Semiconductor processing
JP5643488B2 (ja) * 2009-04-28 2014-12-17 信越化学工業株式会社 低応力膜を備えたsoiウェーハの製造方法
JP5758388B2 (ja) 2009-08-18 2015-08-05 ミニパンプス, エルエルシー 適応制御を有する電解質薬物送達ポンプ
US10092691B2 (en) 2009-09-02 2018-10-09 Becton, Dickinson And Company Flexible and conformal patch pump
US8604810B2 (en) 2009-10-16 2013-12-10 Microchips, Inc. Multi-channel potentiostat for biosensor arrays
EP3859746B1 (de) 2009-10-19 2024-10-16 Labrador Diagnostics LLC Integriertes system zur erfassung und analyse von gesundheitsdaten
US8911426B2 (en) 2010-02-08 2014-12-16 On Demand Therapeutics, Inc. Low-permeability, laser-activated drug delivery device
US8828246B2 (en) * 2010-02-18 2014-09-09 Anpac Bio-Medical Science Co., Ltd. Method of fabricating micro-devices
US20130065257A1 (en) * 2010-03-16 2013-03-14 Joseph Wang Enzyme-logic biosensing
WO2011156095A2 (en) 2010-06-10 2011-12-15 The Regents Of The University Of California Textile-based printable electrodes for electrochemical sensing
US8895597B2 (en) 2010-06-17 2014-11-25 Violette Renard Recinos Combination of local temozolomide with local BCNU
US9953138B2 (en) 2010-06-29 2018-04-24 Codman Neuro Sciences Sarl Drug component admixture library for a drug infusion delivery system
EP2436446B1 (de) 2010-10-04 2016-09-21 F. Hoffmann-La Roche AG Mehrkammerplatte und Verfahren zu ihrer Befüllung mit einer Probenflüssigkeit
EP2438860A1 (de) 2010-10-07 2012-04-11 BIOTRONIK SE & Co. KG Medizinisches Sensorsystem
US9687182B2 (en) 2010-10-07 2017-06-27 Biotronik Se & Co. Kg Medical sensor system for detecting a feature in a body
US8679093B2 (en) 2010-11-23 2014-03-25 Microchips, Inc. Multi-dose drug delivery device and method
BR112013027057A2 (pt) 2011-04-21 2020-08-11 Trustees Of Tufts College composições e métodos para a estabilização de agentes ativos
KR101356671B1 (ko) 2011-08-22 2014-02-03 서울대학교산학협력단 서방형 약물 전달용 마이크로칩
US10427153B2 (en) 2011-08-25 2019-10-01 Microchips Biotech, Inc. Systems and methods for sealing a plurality of reservoirs of a microchip element with a sealing grid
KR102109870B1 (ko) 2011-08-25 2020-05-28 마이크로칩스 바이오테크 인코포레이티드 공간 효율적 격납 장치들 및 그 제조 방법
AU2012362318B2 (en) 2011-12-30 2015-09-17 Kibur Medical, Inc. Implantable devices and methods for the evaluation of active agent
US20150005595A1 (en) 2011-12-30 2015-01-01 Kibur Medical, Inc. Implantable devices and methods for evaluation of active agents
US20130261372A1 (en) * 2012-03-30 2013-10-03 Elwha LLC, a limited liability company of the State of Delaware Device, System, and Method for Delivery of Sugar Glass Stabilized Compositions
JP6435272B2 (ja) * 2012-12-21 2018-12-05 マイクロチップス バイオテック,インコーポレイテッド 低侵襲挿入のための植え込み型医療デバイス
US10617300B2 (en) * 2013-02-13 2020-04-14 The Board Of Trustees Of The University Of Illinois Injectable and implantable cellular-scale electronic devices
SG11201506675PA (en) 2013-02-28 2015-09-29 Microchips Biotech Inc Implantable medical device for minimally-invasive insertion
US20140330256A1 (en) * 2013-05-02 2014-11-06 Elwha Llc Implantable Device for Manipulating Immune Cells
US20140330244A1 (en) * 2013-05-02 2014-11-06 Elwha Llc Implantable Device for Manipulating Immune Cells
WO2014179398A1 (en) * 2013-05-02 2014-11-06 Elwha Llc Implantable device for manipulating immune cells
WO2014190005A1 (en) 2013-05-22 2014-11-27 Transient Electronics, Inc. Controlled transformation of non-transient electronics
EP3030286B1 (de) 2013-08-05 2019-10-09 Cam Med LLC Anschmiegbare patch pumpe
PT3080589T (pt) * 2013-12-13 2019-06-25 Abionic Sa Sistema de evacuação de gás para biossensor nano fluídico
EP3134041A1 (de) * 2014-04-25 2017-03-01 Johnson & Johnson Vision Care Inc. Verfahren und ophthalmische vorrichtung mit wirkstofffreisetzungssystem
US10183154B2 (en) 2014-09-05 2019-01-22 Elwha Llc Systems, methods, and devices addressing the gastro-intestinal tract
US20160067466A1 (en) 2014-09-05 2016-03-10 Elwha LLC, a limited company of the State of Delaware Systems, methods, and devices addressing the gastro-intestinal tract
US9937124B2 (en) 2014-09-11 2018-04-10 International Business Machines Corporation Microchip substance delivery devices having low-power electromechanical release mechanisms
US9808608B2 (en) 2014-11-16 2017-11-07 International Business Machines Corporation Helical coil delivery device for active agent
AU2016211330A1 (en) 2015-01-28 2017-08-03 Chrono Therapeutics Inc. Drug delivery methods and systems
EP3256129A1 (de) 2015-02-11 2017-12-20 The Johns Hopkins University Lokale verabreichungsformen von acriflavin zur behandlung von tumoren
WO2017004576A1 (en) 2015-07-02 2017-01-05 The Board Of Trustees Of The University Of Illinois Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics
US10368788B2 (en) * 2015-07-23 2019-08-06 California Institute Of Technology System and methods for wireless drug delivery on command
US10881788B2 (en) 2015-10-30 2021-01-05 International Business Machines Corporation Delivery device including reactive material for programmable discrete delivery of a substance
US9867932B2 (en) 2015-10-30 2018-01-16 International Business Machines Corporation Drug delivery device having a cavity sealed by a pressurized membrane
CN120586220A (zh) * 2016-01-11 2025-09-05 Syqe医药有限公司 个人用蒸发装置
US11090404B2 (en) 2016-05-19 2021-08-17 The Procter & Gamble Company Systems for dispensing fluid materials
US10406336B2 (en) * 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
US11268927B2 (en) 2016-08-30 2022-03-08 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US10620151B2 (en) 2016-08-30 2020-04-14 Analog Devices Global Electrochemical sensor, and a method of forming an electrochemical sensor
US12188893B2 (en) 2016-08-30 2025-01-07 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US20190275136A1 (en) 2016-09-19 2019-09-12 Vaxess Technologies, Inc. Vaccine formulations with increased stability
WO2018089688A1 (en) 2016-11-09 2018-05-17 Jinjun Shi Restoration of tumor suppression using mrna-based delivery system
US20190374482A1 (en) * 2016-12-05 2019-12-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
CA3049529A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
US12109032B1 (en) 2017-03-11 2024-10-08 Biolinq Incorporated Methods for achieving an isolated electrical interface between an anterior surface of a microneedle structure and a posterior surface of a support structure
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
US10864358B2 (en) * 2017-05-02 2020-12-15 Bernard Fryshman Induction heating systems
CN108968976B (zh) 2017-05-31 2022-09-13 心脏起搏器股份公司 具有化学传感器的植入式医疗设备
US10737090B2 (en) 2017-07-11 2020-08-11 Medtronic, Inc. External defibrillation electrode conductive electrolyte dispersal pad
US10508755B2 (en) * 2017-07-21 2019-12-17 International Business Machines Corporation Fluid delivery device with hydrophobic surface
WO2019023093A1 (en) 2017-07-26 2019-01-31 Cardiac Pacemakers, Inc. SYSTEMS AND METHODS FOR POSTURE DISAMBIGULATION
US12599337B1 (en) 2017-08-08 2026-04-14 Biolinq Incorporated Method and system for confirmation of microneedle-based analyte-selective sensor insertion into viable tissue via electrical interrogation
CN109381195B (zh) 2017-08-10 2023-01-10 心脏起搏器股份公司 包括电解质传感器融合的系统和方法
CN109419515B (zh) 2017-08-23 2023-03-24 心脏起搏器股份公司 具有分级激活的可植入化学传感器
CN109864746B (zh) 2017-12-01 2023-09-29 心脏起搏器股份公司 用于医学装置的多模式分析物传感器
CN109864747B (zh) 2017-12-05 2023-08-25 心脏起搏器股份公司 多模式分析物传感器光电子接口
US11022579B2 (en) 2018-02-05 2021-06-01 Analog Devices International Unlimited Company Retaining cap
US12296129B2 (en) 2018-03-07 2025-05-13 Soovu Labs, Inc. Systems and methods for improved pain relief from stimulation of thermal fibers
US11318469B2 (en) 2018-04-25 2022-05-03 Hewlett-Packard Development Company, L.P. Selective release of material in thermally degradable capsule
US11596779B2 (en) 2018-05-29 2023-03-07 Morningside Venture Investments Limited Drug delivery methods and systems
US12397141B2 (en) 2018-11-16 2025-08-26 Morningside Venture Investments Limited Thermally regulated transdermal drug delivery system
US20220193384A1 (en) * 2019-04-08 2022-06-23 Universite De Lille Cutaneous device for storing and releasing molecules, and corresponding method
US12521343B2 (en) 2019-11-01 2026-01-13 Dare Mb Inc. Two stage microchip drug delivery device and methods
GB2631618B (en) 2020-07-29 2025-05-14 Biolinq Incorporated Continuous analyte monitoring system with microneedle array
US12551145B2 (en) 2020-10-29 2026-02-17 Cardiac Pacemakers, Inc. Integrated thermo-photonic chemical sensor
SE545874C2 (en) 2021-05-08 2024-02-27 Biolinq Incorporated Fault detection for microneedle array based continuous analyte monitoring device
KR102810271B1 (ko) * 2022-09-20 2025-05-21 주식회사 케이티앤지 에멀전을 방출하는 전자 장치 및 그의 동작 방법
KR102810283B1 (ko) * 2022-09-20 2025-05-21 주식회사 케이티앤지 에멀전을 방출하는 전자 장치 및 그의 동작 방법
KR102810277B1 (ko) * 2022-09-20 2025-05-21 주식회사 케이티앤지 에멀전을 방출하는 전자 장치 및 그의 동작 방법
KR102810288B1 (ko) * 2022-09-26 2025-05-21 주식회사 케이티앤지 에멀전을 방출하는 전자 장치 및 그의 동작 방법
KR102809029B1 (ko) * 2022-09-26 2025-05-20 주식회사 케이티앤지 에멀전을 방출하는 전자 장치 및 그의 동작 방법
CN120857905A (zh) 2023-02-02 2025-10-28 比奥林公司 用于改善基于微针的连续分析物监测系统的传感器灵敏度的方法
DE102023123792A1 (de) 2023-09-05 2025-03-06 Implandata Ophthalmic Products Gmbh Wirkstoffabgebendes Implantat

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692027A (en) 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US4003379A (en) 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US3952741A (en) 1975-01-09 1976-04-27 Bend Research Inc. Controlled release delivery system by an osmotic bursting mechanism
US4360019A (en) 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
JPS57163309A (en) 1981-04-01 1982-10-07 Olympus Optical Co Ltd Capsule apparatus for medical use
GB8422876D0 (en) 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4585652A (en) 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US5042975A (en) 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4731049A (en) 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
US5252294A (en) 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5170801A (en) 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
US5167625A (en) 1990-10-09 1992-12-01 Sarcos Group Multiple vesicle implantable drug delivery system
US5196002A (en) 1990-10-09 1993-03-23 University Of Utah Research Foundation Implantable drug delivery system with piston acutation
US5493177A (en) 1990-12-03 1996-02-20 The Regents Of The University Of California Sealed micromachined vacuum and gas filled devices
US5391164A (en) 1991-05-03 1995-02-21 Giampapa; Vincent C. Subcutaneous implantable multiple-agent delivery system
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
CA2122150A1 (en) 1991-08-26 1993-03-04 Yie W. Chien Iontotherapeutic device and process
US5429822A (en) 1992-03-13 1995-07-04 Cambridge Scientific, Inc. Biodegradable bursting release system
US5756117A (en) 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5380272A (en) 1993-01-28 1995-01-10 Scientific Innovations Ltd. Transcutaneous drug delivery applicator
US5368588A (en) 1993-02-26 1994-11-29 Bettinger; David S. Parenteral fluid medication reservoir pump
US5366454A (en) 1993-03-17 1994-11-22 La Corporation De L'ecole Polytechnique Implantable medication dispensing device
US5427585A (en) 1993-03-29 1995-06-27 Bettinger; David S. On-demand iontophoretic system
US5474527A (en) 1993-03-29 1995-12-12 Bettinger; David S. Positive displacement transdermal system
US5368704A (en) 1993-08-06 1994-11-29 Teknekron Corporation Micro-electrochemical valves and method
US5900160A (en) 1993-10-04 1999-05-04 President And Fellows Of Harvard College Methods of etching articles via microcontact printing
US5490962A (en) 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US6129685A (en) 1994-02-09 2000-10-10 The University Of Iowa Research Foundation Stereotactic hypothalamic obesity probe
US5651900A (en) 1994-03-07 1997-07-29 The Regents Of The University Of California Microfabricated particle filter
US5798042A (en) 1994-03-07 1998-08-25 Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US5660680A (en) 1994-03-07 1997-08-26 The Regents Of The University Of California Method for fabrication of high vertical aspect ratio thin film structures
US5893974A (en) 1994-03-07 1999-04-13 Regents Of University Of California Microfabricated capsules for immunological isolation of cell transplants
US5985328A (en) 1994-03-07 1999-11-16 Regents Of The University Of California Micromachined porous membranes with bulk support
US5770076A (en) 1994-03-07 1998-06-23 The Regents Of The University Of California Micromachined capsules having porous membranes and bulk supports
US5971931A (en) 1994-03-29 1999-10-26 Raff; Gilbert Lewis Biologic micromonitoring methods and systems
US5504026A (en) 1995-04-14 1996-04-02 Analog Devices, Inc. Methods for planarization and encapsulation of micromechanical devices in semiconductor processes
US7611533B2 (en) 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US5992769A (en) 1995-06-09 1999-11-30 The Regents Of The University Of Michigan Microchannel system for fluid delivery
SE9502258D0 (sv) 1995-06-21 1995-06-21 Pharmacia Biotech Ab Method for the manufacture of a membrane-containing microstructure
US5662689A (en) 1995-09-08 1997-09-02 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain
US5939923A (en) 1995-12-27 1999-08-17 Texas Instruments Incorporated Selectable low power signal line and method of operation
US6051017A (en) 1996-02-20 2000-04-18 Advanced Bionics Corporation Implantable microstimulator and systems employing the same
US5736154A (en) * 1996-03-11 1998-04-07 Fuisz Technologies Ltd. Transdermal delivery system
DE19610293C1 (de) 1996-03-15 1997-07-31 Fraunhofer Ges Forschung Vorrichtung zur gekapselten Aufnahme eines Materials
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
CA2272326C (en) 1996-11-21 2005-03-29 Carole Rossi Miniature valve for filling the reservoir of an apparatus for the transdermal administration of medicine
FI965067A0 (fi) 1996-12-17 1996-12-17 Jvs Polymers Oy Implantmaterial som kan plastiseras
JPH10285274A (ja) 1997-04-04 1998-10-23 Murata Mach Ltd 通信端末装置
US5938923A (en) 1997-04-15 1999-08-17 The Regents Of The University Of California Microfabricated filter and capsule using a substrate sandwich
DE19716683C1 (de) 1997-04-21 1998-06-04 Fraunhofer Ges Forschung Vorrichtung zur getrennten, gekapselten Aufnahme einer Mehrzahl gleicher oder unterschiedlicher Stoffe
IL121286A0 (en) 1997-07-11 1998-01-04 Pets N People Ltd Apparatus and methods for dispensing pet care substances
US5949187A (en) 1997-07-29 1999-09-07 Motorola, Inc. Organic electroluminescent device with plural microcavities
US5961492A (en) 1997-08-27 1999-10-05 Science Incorporated Fluid delivery device with temperature controlled energy source
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US6081736A (en) 1997-10-20 2000-06-27 Alfred E. Mann Foundation Implantable enzyme-based monitoring systems adapted for long term use
US6001090A (en) 1998-02-09 1999-12-14 Lenhart; Douglas Thermal pharmaceutical delivery system
US6757560B1 (en) 1999-04-09 2004-06-29 Novosis Pharma Ag Transdermal delivery system (TDS) with electrode network
US6319241B1 (en) 1998-04-30 2001-11-20 Medtronic, Inc. Techniques for positioning therapy delivery elements within a spinal cord or a brain
US6161047A (en) 1998-04-30 2000-12-12 Medtronic Inc. Apparatus and method for expanding a stimulation lead body in situ
US6941171B2 (en) 1998-07-06 2005-09-06 Advanced Bionics Corporation Implantable stimulator methods for treatment of incontinence and pain
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6201980B1 (en) 1998-10-05 2001-03-13 The Regents Of The University Of California Implantable medical sensor system
US6232150B1 (en) 1998-12-03 2001-05-15 The Regents Of The University Of Michigan Process for making microstructures and microstructures made thereby
US6289237B1 (en) 1998-12-22 2001-09-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Apparatus for energizing a remote station and related method
US6178349B1 (en) 1999-04-15 2001-01-23 Medtronic, Inc. Drug delivery neural stimulation device for treatment of cardiovascular disorders
US6923784B2 (en) 1999-04-30 2005-08-02 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
US6587719B1 (en) 1999-07-01 2003-07-01 Cyberonics, Inc. Treatment of obesity by bilateral vagus nerve stimulation
US6804558B2 (en) 1999-07-07 2004-10-12 Medtronic, Inc. System and method of communicating between an implantable medical device and a remote computer system or health care provider
US6334859B1 (en) 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
ATE290364T1 (de) 1999-08-18 2005-03-15 Microchips Inc Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien
EP2308522A3 (de) 1999-11-17 2012-02-29 Boston Scientific Limited Miniaturisierte Vorrichtungen zur Abgabe von Molekülen in einer Trägerflüssigkeit
ATE323470T1 (de) 1999-12-10 2006-05-15 Massachusetts Inst Technology Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren
US6384353B1 (en) 2000-02-01 2002-05-07 Motorola, Inc. Micro-electromechanical system device
DE60144142D1 (de) 2000-03-02 2011-04-14 Microchips Inc Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
AU2001265128A1 (en) 2000-05-30 2001-12-11 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
AU2001283358A1 (en) 2000-08-14 2002-02-25 Pharmacia Corporation Drug delivery system with burst electrode
DE60116520T2 (de) 2000-10-10 2006-08-31 Microchips, Inc., Bedford Microchip-reservoir-vorrichtungen mit drahtloser übertragung von energie und daten
AU2002224453A1 (en) 2000-10-11 2002-04-22 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
EP1330287B1 (de) 2000-10-26 2009-07-29 Medtronic, Inc. Gerät zur minimierung der wirkungen einer herzverletzung
CA2426810A1 (en) 2000-10-26 2002-06-13 Medtronic, Inc. Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac comditions
CA2426944A1 (en) 2000-10-26 2002-05-02 Medtronic, Inc. Method and apparatus to minimize the effects of a cardiac insult
DE10061057A1 (de) 2000-12-08 2002-06-13 Pharmed Holding Gmbh Chip-Systeme zur kontrollierten Emission chemosensorisch wirkender Stoffe
DE10063612C2 (de) 2000-12-20 2002-11-07 Fraunhofer Ges Forschung Mikrosystem zur Kontrolle der Wirkstoffabgabe aus einem Wirkstoffreservoir sowie Implantat mit Mikrosystem
WO2002055058A2 (en) 2001-01-09 2002-07-18 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US6824521B2 (en) 2001-01-22 2004-11-30 Integrated Sensing Systems, Inc. Sensing catheter system and method of fabrication
US6571125B2 (en) 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
US7338522B2 (en) 2001-02-13 2008-03-04 Second Sight Medical Products, Inc. Implantable retinal electrode array configuration for minimal retinal damage and method of reducing retinal stress
US20020144548A1 (en) 2001-04-06 2002-10-10 Cohn Michael B. High precision accelerometer
EP1387671A1 (de) 2001-05-03 2004-02-11 MASSACHUSETTS EYE & EAR INFIRMARY Implantierbare arzneistoffverabreichungsvorrichtung und verwendung derselben
US6733485B1 (en) 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
JP2004533297A (ja) 2001-05-29 2004-11-04 メドトロニック・インコーポレーテッド 心臓病の予防及び処置のための閉ループ神経調節システム
US6973718B2 (en) 2001-05-30 2005-12-13 Microchips, Inc. Methods for conformal coating and sealing microchip reservoir devices
WO2002099457A1 (en) 2001-05-31 2002-12-12 Massachusetts Inst Technology Microchip devices with improved reservoir opening
US6827250B2 (en) 2001-06-28 2004-12-07 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
US6663615B1 (en) 2001-09-04 2003-12-16 The Ohio State University Dual stage microvalve and method of use
US7354597B2 (en) 2001-12-03 2008-04-08 Massachusetts Institute Of Technology Microscale lyophilization and drying methods for the stabilization of molecules
AU2003278766A1 (en) 2002-09-04 2004-03-29 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
AU2003278881A1 (en) 2002-09-23 2004-04-08 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
AU2003279842A1 (en) 2002-10-04 2004-05-04 Microchips, Inc. Medical device for controlled drug delivery and cardiac monitoring and/or stimulation
KR101556457B1 (ko) 2003-09-11 2015-10-01 테라노스, 인코포레이티드 피분석물의 모니터링 및 약물 전달을 위한 의료 기기

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EP1210064B1 (de) 2005-03-09
DE60018582T2 (de) 2006-01-19
US6669683B2 (en) 2003-12-30
AU6639400A (en) 2001-03-13
WO2001012157A1 (en) 2001-02-22
US7473248B2 (en) 2009-01-06
JP4397558B2 (ja) 2010-01-13
CA2381951A1 (en) 2001-02-22
US8016817B2 (en) 2011-09-13
US20030105455A1 (en) 2003-06-05
DE60018582D1 (de) 2005-04-14
JP2007283117A (ja) 2007-11-01
EP1210064A1 (de) 2002-06-05
JP2003506477A (ja) 2003-02-18
US6527762B1 (en) 2003-03-04
US20040143236A1 (en) 2004-07-22

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