ATE291225T1 - Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung - Google Patents

Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung

Info

Publication number
ATE291225T1
ATE291225T1 AT96943641T AT96943641T ATE291225T1 AT E291225 T1 ATE291225 T1 AT E291225T1 AT 96943641 T AT96943641 T AT 96943641T AT 96943641 T AT96943641 T AT 96943641T AT E291225 T1 ATE291225 T1 AT E291225T1
Authority
AT
Austria
Prior art keywords
platform
moving fluid
centrifugal acceleration
informatics
automatic laboratory
Prior art date
Application number
AT96943641T
Other languages
English (en)
Inventor
Alec Mian
Stephen G Kieffer-Higgins
George D Corey
Original Assignee
Gamera Bioscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gamera Bioscience Corp filed Critical Gamera Bioscience Corp
Application granted granted Critical
Publication of ATE291225T1 publication Critical patent/ATE291225T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71725—Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/14—Surface shaping of articles, e.g. embossing; Apparatus therefor by plasma treatment
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C1/00—Circuit elements having no moving parts
    • F15C1/005—Circuit elements having no moving parts for measurement techniques, e.g. measuring from a distance; for detection devices, e.g. for presence detection; for sorting measured properties (testing); for gyrometers; for analysis; for chromatography
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0015—Diaphragm or membrane valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0017—Capillary or surface tension valves, e.g. using electro-wetting or electro-capillarity effects
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0028—Valves having multiple inlets or outlets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0048—Electric operating means therefor using piezoelectric means
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0057—Operating means specially adapted for microvalves actuated by fluids the fluid being the circulating fluid itself, e.g. check valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00871—Communications between instruments or with remote terminals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00822—Metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00826—Quartz
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00828—Silicon wafers or plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00963—Pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00986—Microprocessor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00993—Design aspects
    • B01J2219/00995—Mathematical modeling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/024—Storing results with means integrated into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0661—Valves, specific forms thereof with moving parts shape memory polymer valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/008—Multi-layer fabrications
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00782—Type of codes reprogrammmable code
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Ecology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Theoretical Computer Science (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Micromachines (AREA)
  • Fluid-Pressure Circuits (AREA)
AT96943641T 1995-12-05 1996-12-05 Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung ATE291225T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US821595P 1995-12-05 1995-12-05
US826795P 1995-12-06 1995-12-06
US881995P 1995-12-18 1995-12-18
US2375696P 1996-08-12 1996-08-12
PCT/US1996/019514 WO1997021090A1 (en) 1995-12-05 1996-12-05 Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics

Publications (1)

Publication Number Publication Date
ATE291225T1 true ATE291225T1 (de) 2005-04-15

Family

ID=27485750

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96943641T ATE291225T1 (de) 1995-12-05 1996-12-05 Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung

Country Status (11)

Country Link
EP (1) EP0865606B1 (de)
JP (1) JP2002503331A (de)
KR (1) KR100306951B1 (de)
CN (1) CN1208464A (de)
AT (1) ATE291225T1 (de)
AU (1) AU702403B2 (de)
CA (1) CA2239613A1 (de)
DE (1) DE69634490T2 (de)
MX (1) MX9804463A (de)
NO (1) NO982563L (de)
WO (1) WO1997021090A1 (de)

Families Citing this family (274)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143247A (en) * 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US6342349B1 (en) 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
CA2260361A1 (en) 1996-07-08 1998-01-15 Burstein Laboratories, Inc Cleavable signal element device and method
GB9620934D0 (en) 1996-10-08 1996-11-27 Molecular Drives Limited Multi-well containers
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
CA2301230A1 (en) 1996-09-20 1998-03-26 Digital Drives, Inc. Spatially addressable combinatorial chemical arrays in cd-rom format
BR9808653A (pt) * 1997-02-28 2001-07-31 Burstein Lab Inc Laboratório em um disco
AU746892B2 (en) * 1997-04-04 2002-05-02 Caliper Life Sciences, Inc. Closed-loop biochemical analyzers
DE19716683C1 (de) * 1997-04-21 1998-06-04 Fraunhofer Ges Forschung Vorrichtung zur getrennten, gekapselten Aufnahme einer Mehrzahl gleicher oder unterschiedlicher Stoffe
JP3469585B2 (ja) * 1997-05-23 2003-11-25 ガメラ バイオサイエンス コーポレイション ミクロ流体工学システムでの流動運動を駆動するために向心的加速を使用するための装置および方法
DE19729352A1 (de) * 1997-07-09 1999-01-14 Basf Ag Zentrifugierverfahren zur Probencharakterisierung
US6073482A (en) * 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US6293012B1 (en) 1997-07-21 2001-09-25 Ysi Incorporated Method of making a fluid flow module
US5932799A (en) * 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
WO1999009394A1 (en) * 1997-08-15 1999-02-25 Alexion Pharmaceuticals, Inc. Apparatus for performing assays at reaction sites
AU2002306207B2 (en) * 1997-08-15 2005-02-24 Bioprocessors, Corp. Apparatus for performing assays at reaction sites
US6143152A (en) * 1997-11-07 2000-11-07 The Regents Of The University Of California Microfabricated capillary array electrophoresis device and method
IL136978A0 (en) * 1997-12-30 2001-06-14 Remacle Jose Method comprising capture molecule fixed on disc surface
EP1420252A3 (de) * 1997-12-30 2004-08-04 Remacle, José Methode zur Detektion und/oder Quantifizierung eines Zielmoleküls durch Binden an ein Bindungsmolekül, das auf eine Disc-Oberfläche fixiert ist
US6857449B1 (en) 1998-01-20 2005-02-22 Caliper Life Sciences, Inc. Multi-layer microfluidic devices
US6100535A (en) * 1998-01-29 2000-08-08 The Regents Of The University Of California Rotary confocal scanner for detection of capillary arrays
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US6196979B1 (en) 1998-08-24 2001-03-06 Burstein Technologies, Inc. Cassette and applicator for biological and chemical sample collection
DE19852835A1 (de) * 1998-11-17 2000-05-18 Stratec Biomedical Systems Ag Probenträger
DE19858443A1 (de) * 1998-12-17 2000-07-06 Inst Mikrotechnik Mainz Gmbh Verfahren zum Abgeben eines Fluids, fluidisches Bauteil sowie Vorrichtung zur Handhabung solcher Bauteile
GB9828785D0 (en) * 1998-12-30 1999-02-17 Amersham Pharm Biotech Ab Sequencing systems
US6503359B2 (en) 1999-03-05 2003-01-07 Burstein Technologies, Inc. Monomolecular adhesion methods for manufacturing microfabricated multilaminate devices
SE9901100D0 (sv) * 1999-03-24 1999-03-24 Amersham Pharm Biotech Ab Surface and tis manufacture and uses
AU4713400A (en) * 1999-05-14 2000-12-05 Gamera Bioscience Corporation A centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
US7332326B1 (en) 1999-05-14 2008-02-19 Tecan Trading Ag Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
MXPA01011915A (es) 1999-05-19 2003-09-04 Advanced Array Technologies S Metodo para la identificacion y/o la cuantificacion de un compuesto diana.
US6406605B1 (en) 1999-06-01 2002-06-18 Ysi Incorporated Electroosmotic flow controlled microfluidic devices
ATE272213T1 (de) 1999-06-18 2004-08-15 Gamera Bioscience Corp Vorrichtungen und verfahren zur durchführung miniaturisierter homogener tests
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
ATE395136T1 (de) * 1999-06-22 2008-05-15 Tecan Trading Ag Vorrichtungen zur durchfuehrung von miniaturisierten in vitro amplifizierungsassays
WO2001006228A2 (en) 1999-07-16 2001-01-25 Pe Corporation High density electrophoresis device and method
US6495104B1 (en) * 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
US7088650B1 (en) 1999-08-23 2006-08-08 Worthington Mark O Methods and apparatus for optical disc data acquisition using physical synchronization markers
US6888951B1 (en) 1999-08-23 2005-05-03 Nagaoka & Co., Ltd. Methods and apparatus for analyzing operational and analyte data acquired from optical disc
GB2355717A (en) * 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
US7390459B2 (en) * 1999-12-13 2008-06-24 Illumina, Inc. Oligonucleotide synthesizer
SE9904802D0 (sv) * 1999-12-23 1999-12-23 Amersham Pharm Biotech Ab Microfluidic surfaces
US6884395B2 (en) 2000-05-12 2005-04-26 Gyros Ab Integrated microfluidic disc
ATE329691T1 (de) * 1999-12-23 2006-07-15 Gyros Patent Ab Verfahren zur behandlung einer matrixnukleinsäure unter verwendung einer integrierten mikrofluidischen platte
KR100359820B1 (ko) * 2000-05-10 2002-11-07 엘지전자 주식회사 생체시료 검출 및 분석장치, 및 이의 이용방법
US6818435B2 (en) 2000-05-15 2004-11-16 Tecan Trading Ag Microfluidics devices and methods for performing cell based assays
US6720187B2 (en) * 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
JP4773035B2 (ja) * 2000-06-28 2011-09-14 スリーエム イノベイティブ プロパティズ カンパニー 強化サンプル処理装置、システムおよび方法
ES2449445T3 (es) * 2000-06-28 2014-03-19 3M Innovative Properties Co. Dispositivos, sistemas y métodos mejorados para el tratamiento de muestras
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
EP1410044A2 (de) * 2000-11-08 2004-04-21 Burstein Technologies, Inc. Interaktives system zur analyse biologischer proben und zur verarbeitung damit im zusammenhang stehender angaben und verwendung davon
US7087203B2 (en) 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
US7026131B2 (en) 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
SE0004296D0 (sv) * 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
WO2002042498A2 (en) * 2000-11-27 2002-05-30 Burstein Technologies, Inc. Dual bead assays including optical biodiscs and methods relating thereto
WO2002046721A2 (en) 2000-12-08 2002-06-13 Burstein Technologies, Inc. Optical discs for measuring analytes
US7054258B2 (en) 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
US6760298B2 (en) 2000-12-08 2004-07-06 Nagaoka & Co., Ltd. Multiple data layer optical discs for detecting analytes
EP1410026A2 (de) * 2000-12-08 2004-04-21 Burstein Technologies, Inc. Verfahren zum nachweis von analyten mittels optischen platten und lesegeräte für optische platten
US7091034B2 (en) 2000-12-15 2006-08-15 Burstein Technologies, Inc. Detection system for disk-based laboratory and improved optical bio-disc including same
US6653625B2 (en) 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
WO2002068697A2 (en) * 2001-02-28 2002-09-06 Burstein Technologies, Inc. Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems
WO2002075775A1 (en) 2001-03-19 2002-09-26 Gyros Ab A microfluidic system (edi)
JP2004529463A (ja) * 2001-03-19 2004-09-24 ユィロス・アクチボラグ マイクロ流体システム（ｍｓ）
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
JP4323806B2 (ja) 2001-03-19 2009-09-02 ユィロス・パテント・アクチボラグ 反応可変要素の特徴付け
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
WO2002075776A1 (en) * 2001-03-19 2002-09-26 Gyros Ab A microfluidic system (ms)
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
WO2003087827A2 (en) 2001-04-11 2003-10-23 Burstein Technologies, Inc. Multi-parameter assays including analysis discs and methods relating thereto
US7201873B2 (en) 2001-04-16 2007-04-10 Tosoh Corporation Fine channel device, method for producing the fine channel device and use of the same
USRE44943E1 (en) 2001-04-23 2014-06-10 Commonwealth Scientific And Industrial Research Organisation Fluid properties evaluation
AUPR458201A0 (en) * 2001-04-23 2001-05-24 Commonwealth Scientific And Industrial Research Organisation Fluid properties evaluation
US7273702B2 (en) * 2001-05-25 2007-09-25 Hitachi, Ltd. Apparatus for purifying nucleic acid and method of purifying nucleic acid
US7141416B2 (en) 2001-07-12 2006-11-28 Burstein Technologies, Inc. Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
EP2269736B1 (de) 2001-08-28 2013-04-24 Gyros Patent Ab Mikrokammern und mikrofluidische Strukturen zur Handhabung kleiner Flüssigkeitsmengen
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US20030129665A1 (en) * 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
JP2005502872A (ja) * 2001-09-07 2005-01-27 バースタイン テクノロジーズ，インコーポレイティド 光バイオディスクシステムを使用した、核の形態に基づく白血球の型の識別および定量
DE60237289D1 (de) 2001-09-17 2010-09-23 Gyros Patent Ab Einen kontrollierten strom in einer mikrofluidvorrichtung ermöglichende funktionseinheit
SE0103108D0 (sv) 2001-09-17 2001-09-17 Gyros Microlabs Ab Rotary drive in an instrument for analysis of microscale liquid sample volumes
WO2003025585A1 (en) * 2001-09-17 2003-03-27 Gyros Ab Method handler for microfluidic instruments
WO2003036337A2 (en) * 2001-10-24 2003-05-01 Burstein Technologies, Inc. Optical biological disk analyser
WO2003043403A2 (en) * 2001-11-19 2003-05-30 Burstein Technologies, Inc. Methods and apparatus for blood typing with optical bio-discs
WO2003044481A2 (en) * 2001-11-20 2003-05-30 Burstein Technologies, Inc. Optical bio-discs and microfluidic devices for analysis of cells
NL1019446C2 (nl) * 2001-11-28 2003-06-02 Ibis Technologies B V Drager voor gebruik bij het bepalen van deeltjes in een monster en werkwijze voor de vervaardiging van zo een drager, en werkwijze voor het bepalen van deeltjes in een monster.
NL1019875C2 (nl) * 2001-11-28 2003-06-02 Ibis Technologies B V Drager voor gebruik bij het bepalen van deeltjes in een monster en werkwijze voor de vervaardiging van zo een drager, en werkwijze voor het bepalen van deeltjes in een monster.
EP1462805B1 (de) * 2001-12-14 2010-02-10 Arkray, Inc. Probenmessvorrichtung
US7192560B2 (en) * 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
AU2002232786A1 (en) * 2001-12-21 2003-07-24 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US7221783B2 (en) 2001-12-31 2007-05-22 Gyros Patent Ab Method and arrangement for reducing noise
EP1490292A1 (de) * 2002-03-31 2004-12-29 Gyros AB Effiziente mikrofluidvorrichtungen
US6955738B2 (en) 2002-04-09 2005-10-18 Gyros Ab Microfluidic devices with new inner surfaces
DE60328392D1 (de) * 2002-04-30 2009-08-27 Gyros Patent Ab Mittels einer integrierten mikrofluidischen vorrichtung
ATE256870T1 (de) * 2002-05-03 2004-01-15 Trace Biotech Ag Vorrichtung und verfahren zum lysieren von zellen
US7083974B2 (en) 2002-07-12 2006-08-01 Applera Corporation Rotatable sample disk and method of loading a sample disk
US7198759B2 (en) 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
US7135147B2 (en) 2002-07-26 2006-11-14 Applera Corporation Closing blade for deformable valve in a microfluidic device and method
US7201881B2 (en) 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
WO2004011365A2 (en) * 2002-07-26 2004-02-05 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
JP4575162B2 (ja) * 2002-10-13 2010-11-04 ピコセプ アクティーゼルスカブ 二次元ミクロ流体生体分子分離システム
AU2003283064B2 (en) * 2002-11-20 2009-06-04 Qiagen Gmbh Centrifugal device and method for performing binding assays
AU2002952797A0 (en) * 2002-11-20 2002-12-05 Bio-Molecular Holdings Pty Limited Centrifugal device and method using same
CN101158447B (zh) * 2002-12-04 2012-12-26 斯宾克斯公司 流体的可程控微量控制用装置和方法
US7094354B2 (en) * 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
USD502775S1 (en) 2002-12-19 2005-03-08 3M Innovative Properties Company Extended port sample processing device
US7332129B2 (en) 2003-01-09 2008-02-19 3M Innovative Properties Company Sample processing device having process chambers with bypass slots
EP1594798B1 (de) 2003-01-30 2018-12-19 Gyros Patent Ab Innenwände mikrofluidischer vorrichtungen
KR20050111785A (ko) * 2003-03-24 2005-11-28 소니 가부시끼 가이샤 마이크로칩, 핵산 추출용 키트 및 핵산의 추출 방법
CN1280428C (zh) * 2003-05-19 2006-10-18 清华大学 一种基于微小颗粒的生物芯片系统及其应用
US7247487B2 (en) 2003-06-18 2007-07-24 Ortho-Clinical Diagnostics Reducing working fluid dilution in liquid systems
US7390464B2 (en) 2003-06-19 2008-06-24 Burstein Technologies, Inc. Fluidic circuits for sample preparation including bio-discs and methods relating thereto
US7238269B2 (en) * 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
JP4996248B2 (ja) 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド 粒子含有サンプルの処理
WO2005012916A1 (ja) * 2003-08-05 2005-02-10 Taiyo Yuden Co., Ltd. 試料分析装置及びディスク状試料分析媒体
KR101135138B1 (ko) * 2003-08-13 2012-04-16 루미넥스 코포레이션 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의제어 방법
US7723099B2 (en) 2003-09-10 2010-05-25 Abbott Point Of Care Inc. Immunoassay device with immuno-reference electrode
US7718133B2 (en) 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
USD513075S1 (en) 2003-10-20 2005-12-20 3M Innovative Properties Company Sample processing device
US7582261B2 (en) 2003-11-18 2009-09-01 Sharp Kabuhsiki Kaisha Electricity supplying device, electricity supplying apparatus, sample detection device, and sample detection apparatus
US20050130177A1 (en) * 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7322254B2 (en) 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
CA2559778C (en) * 2004-03-26 2011-07-05 Infectio Recherche Inc. Removable microfluidic flow cell
US7156117B2 (en) 2004-03-31 2007-01-02 Lifescan Scotland Limited Method of controlling the movement of fluid through a microfluidic circuit using an array of triggerable passive valves
US7059352B2 (en) 2004-03-31 2006-06-13 Lifescan Scotland Triggerable passive valve for use in controlling the flow of fluid
US7665303B2 (en) 2004-03-31 2010-02-23 Lifescan Scotland, Ltd. Method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit
WO2005103670A1 (ja) * 2004-04-21 2005-11-03 Toray Industries, Inc. ラボオンチップ用基板
US7815854B2 (en) * 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
WO2006035830A1 (ja) * 2004-09-30 2006-04-06 Arkray, Inc. 分析装置
WO2006080140A1 (ja) 2005-01-28 2006-08-03 Matsushita Electric Industrial Co., Ltd. 血液処理装置及び血液導入方法
JP2006242613A (ja) * 2005-03-01 2006-09-14 Matsushita Electric Ind Co Ltd 試料分析装置
EP1899064A2 (de) * 2005-06-03 2008-03-19 Spinx, Inc. Dosimeter zur programmierbaren manipulation von fluiden auf mikromassstab
DE102005025640A1 (de) 2005-06-03 2006-12-07 Scienion Ag Mikrodispenser und zugehöriges Betriebsverfahren
FR2887241B1 (fr) * 2005-06-15 2008-01-11 Rhodia Chimie Sa Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ou chimique, et son utilisation
DE602006015637D1 (de) * 2005-06-15 2010-09-02 Rhodia Operations Mikrofluidikzirkulationsvorrichtung zur bestimmung von parametern einer physikalischen und/oder chemischen transformation und verwendung davon
WO2007005974A2 (en) 2005-07-01 2007-01-11 Honeywell International, Inc. A flow metered analyzer
USD564667S1 (en) 2005-07-05 2008-03-18 3M Innovative Properties Company Rotatable sample processing disk
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
JP2007040814A (ja) * 2005-08-03 2007-02-15 Matsushita Electric Ind Co Ltd 吸光度測定用センサ及び吸光度測定方法
JP4664785B2 (ja) * 2005-09-16 2011-04-06 株式会社Eci ディスク及び該ディスクを用いた光学式顕微鏡による細胞の計数観察装置
DE102005048260A1 (de) * 2005-10-07 2007-04-12 Albert-Ludwigs-Universität Freiburg Verfahren und Vorrichtung zum Handhaben einer flüssigen Probe unter Verwendung einer Rotation mit einem zeitlich veränderlichen Drehvektor
DE102005048233A1 (de) * 2005-10-07 2007-04-12 Albert-Ludwigs-Universität Freiburg Vorrichtung und Verfahren zum Handhaben einer flüssigen Probe unter Verwendung einer Siphon-Struktur
JP4531677B2 (ja) * 2005-10-24 2010-08-25 パナソニック株式会社 アッセイ方法、それを実施するためのセンサデバイス、およびセンサデバイス用測定装置
EP1963016B1 (de) 2005-11-14 2017-04-26 Rijk Zwaan Zaadteelt en Zaadhandel B.V. Verfahren zum entfernen eines fluids aus einem behälter und vorrichtung dafür
EP2237037A1 (de) 2005-12-12 2010-10-06 Gyros Patent Ab Mikrofluid-Vorrichtung und deren Verwendung
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
WO2007112114A2 (en) 2006-03-24 2007-10-04 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
KR101407433B1 (ko) * 2006-05-09 2014-06-17 코닌클리케 필립스 엔.브이. 분석 시험 디바이스
US8273310B2 (en) * 2006-09-05 2012-09-25 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device
KR100851980B1 (ko) * 2006-09-05 2008-08-12 삼성전자주식회사 열 활성 유닛을 구비한 원심력 기반의 미세유동 장치, 이를포함하는 미세유동 시스템 및 상기 미세유동 시스템의구동방법
KR101343034B1 (ko) 2006-09-05 2013-12-18 삼성전자 주식회사 원심력 기반의 단백질 검출용 미세유동 장치 및 이를포함하는 미세유동 시스템
FR2907226B1 (fr) * 2006-10-13 2008-12-12 Rhodia Recherches & Tech Dispositif d'analyse fluidique,dispositif de determination de caracteristiques d'un fluide comprenant ce dispositif d'analyse,procedes de mise en oeuvre et procede de criblage correspondants
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
EP2095103A2 (de) * 2006-11-21 2009-09-02 Bioscale, Inc. Verfahren und vorrichtung zur aufarbeitung von analyten
JP4969236B2 (ja) * 2006-12-22 2012-07-04 ローム株式会社 生体分子または生体関連物質の測定方法
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
CA2891142C (en) 2007-02-05 2018-10-09 Intelligent Bio-Systems, Inc. A method of nucleic acid sequencing comprising first and second flow cells
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
KR101239764B1 (ko) 2007-04-05 2013-03-06 삼성전자주식회사 원심력 기반의 미세유동 시스템 및 상기 미세유동 시스템용바이오 카트리지
WO2008126404A1 (ja) 2007-04-09 2008-10-23 Panasonic Corporation チャンバを含む流路部位を有する基板、およびそれを用いて液体を移送する方法
KR101278154B1 (ko) * 2007-04-16 2013-06-27 삼성전자주식회사 원심력 기반의 미세유동 장치, 이를 구비한 미세유동시스템 및, 상기 미세유동 장치의 홈 위치 결정 방법
US8414848B2 (en) 2007-05-10 2013-04-09 Panasonic Corporation Substrate including channel part having chamber, and multistage liquid feed device comprising the same
DE102007030347A1 (de) * 2007-06-29 2009-01-02 Ducrée, Jens, Dr. Integrierter Rotor
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
DE102007046305A1 (de) * 2007-09-27 2009-04-02 Robert Bosch Gmbh Mikrofluidisches Bauelement sowie Herstellungsverfahren
CN102879558B (zh) * 2007-10-04 2015-09-16 松下健康医疗器械株式会社 分析用仪器和使用该分析用仪器的分析装置及分析方法
KR101368178B1 (ko) 2008-01-07 2014-02-26 삼성전자주식회사 미세유동장치 내의 유체 흐름 경로에 필터를 형성하는 방법
WO2009091187A2 (en) * 2008-01-15 2009-07-23 Lg Electronics Inc. Bio-disc
DK3381359T3 (da) * 2008-07-01 2021-05-25 Icagen Llc Fremgangsmåde til måling af transport af analyt over barrierer ved hjælp af røntgenrør
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8037354B2 (en) 2008-09-18 2011-10-11 Honeywell International Inc. Apparatus and method for operating a computing platform without a battery pack
WO2010038952A2 (en) 2008-10-01 2010-04-08 Samsung Electronics Co., Ltd., Centrifugal-based microfluid apparatus, method of fabricationg the same, and method of testing samples using the microfluidic apparatus
GB2464721C (en) 2008-10-23 2013-08-14 Biosurfit Sa Jet deflection device
GB2466644B (en) 2008-12-30 2011-05-11 Biosurfit Sa Liquid handling
KR20100101526A (ko) * 2009-03-09 2010-09-17 삼성전자주식회사 스트로보 박막 화학 분석 장치 및 이를 이용한 분석 방법
KR20110009022A (ko) * 2009-07-20 2011-01-27 삼성전자주식회사 디스크형 미세유동장치 및 이를 이용하는 혈액검사장치
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
GB2476474B (en) 2009-12-22 2012-03-28 Biosurfit Sa Surface plasmon resonance detection system
US8828246B2 (en) * 2010-02-18 2014-09-09 Anpac Bio-Medical Science Co., Ltd. Method of fabricating micro-devices
GB2479139A (en) 2010-03-29 2011-10-05 Biosurfit Sa A liquid distribution and metering device
CN101907631B (zh) * 2010-07-19 2012-07-25 中国科学院长春光学精密机械与物理研究所 微流控芯片内的双液体毛细微流控制阀及其制作方法
CN102441356B (zh) * 2010-10-12 2013-08-21 扬博科技股份有限公司 离心式微流体装置
JP5654048B2 (ja) * 2010-12-28 2015-01-14 株式会社日立ハイテクノロジーズ 検体前処理システムおよび遠心分離装置
GB201100152D0 (en) * 2011-01-06 2011-02-23 Epistem Ltd Genedrive RFID
DE102011008788B3 (de) * 2011-01-14 2012-05-03 Institut Für Photonische Technologien E.V. Anordnung zur Durchführung einer Einzelprobenanalyse und -manipulation für die Raman-Mikrospektroskopie
CA2827614C (en) * 2011-03-08 2019-07-02 Universite Laval Fluidic centripetal device
AU2012242510B2 (en) 2011-04-15 2015-05-14 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
KR101992503B1 (ko) 2011-05-18 2019-06-24 디아소린 에스.피.에이. 샘플 처리 장치에서 선택된 부피의 물질의 존재를 검출하기 위한 시스템 및 방법
US9067205B2 (en) 2011-05-18 2015-06-30 3M Innovative Properties Company Systems and methods for valving on a sample processing device
KR20140022399A (ko) 2011-05-18 2014-02-24 쓰리엠 이노베이티브 프로퍼티즈 컴파니 샘플 처리 장치 상의 체적 계량을 위한 시스템 및 방법
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
JP6117217B2 (ja) 2011-09-30 2017-04-19 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ ユニット化された試薬ストリップ
WO2013062152A1 (ko) * 2011-10-26 2013-05-02 한국기초과학지원연구원 나선형 미세유로를 이용한 단백질 결정화 조건 고속 스크리닝 장치 및 방법
EP2773892B1 (de) 2011-11-04 2020-10-07 Handylab, Inc. Vorrichtung zur vorbereitung von polynukleotidproben
US10265647B2 (en) 2011-12-07 2019-04-23 Royal Melbourne Institute Of Technology Centrifugal microfluidic device
US9933348B2 (en) 2011-12-08 2018-04-03 Biosurfit, S.A. Sequential aliqoting and determination of an indicator of sedimentation rate
KR101252259B1 (ko) * 2011-12-12 2013-04-08 포항공과대학교 산학협력단 디스크형 미세 유체 시스템 및 혈액 상태 확인 방법
KR101252260B1 (ko) 2011-12-12 2013-04-08 포항공과대학교 산학협력단 디스크형 미세 유체 시스템 및 혈구의 변형도 측정 방법
US8741235B2 (en) * 2011-12-27 2014-06-03 Honeywell International Inc. Two step sample loading of a fluid analysis cartridge
EP2798327B1 (de) 2011-12-29 2016-10-19 Ibis Biosciences, Inc. Zusammensetzungen und verfahren zur probenvorbereitung
ES2978107T3 (es) 2012-02-03 2024-09-05 Becton Dickinson Co Archivos externos para distribución de pruebas de diagnóstico molecular y determinación de compatibilidad entre pruebas
KR20140009607A (ko) * 2012-07-11 2014-01-23 삼성전자주식회사 검사장치 및 그 제어방법
US10082505B2 (en) 2012-10-08 2018-09-25 General Electric Company Centripetal microfluidic platform for LAL-reactive substances testing
EP2781919A1 (de) 2013-03-19 2014-09-24 Roche Diagniostics GmbH Verfahren/Vorrichtung zur Erzeugung eines korrigierten Werts einer Analytenkonzentration in einer Körperflüssigkeitsprobe
JP6506747B2 (ja) * 2013-06-25 2019-04-24 ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション サンプル体積の自己デジタル処理
EP3213081A4 (de) * 2014-10-30 2018-08-15 Sightline Innovation Inc. System, verfahren und vorrichtung zur pathogenfdetektion
JP6729558B2 (ja) * 2015-03-31 2020-07-22 ソニー株式会社 電気的特性測定装置、電気的特性測定方法、血液状態解析システム、及び該方法をコンピューターに実現させるための電気的特性測定用プログラム
KR101738765B1 (ko) 2015-08-25 2017-06-08 한국과학기술원 나노 입자 합성 고속대량스크리닝용 마이크로 디바이스 및 이를 이용한 나노 입자 합성 방법
US10086368B2 (en) * 2015-09-07 2018-10-02 EXIAS Medical GmbH Movable measurement cell
CN105717186B (zh) * 2016-02-01 2018-06-29 常熟理工学院 回转式介电电泳微流控分析装置
FR3050664B1 (fr) * 2016-04-27 2018-05-25 Microfactory Systeme d'evaluation in vitro de l'efficacite d'un deodorant.
WO2018020264A1 (en) * 2016-07-28 2018-02-01 Medisieve Ltd. Magnetic mixer and method
ES2960079T3 (es) 2016-10-03 2024-02-29 Terumo Bct Inc Dispositivo centrífugo de separación de fluidos
EP3315963A1 (de) * 2016-10-26 2018-05-02 Fuchs Petrolub SE Probenaufnahmeelement, analysenset und verfahren zur analyse eines liquids, insbesondere einer kühlschmierstoffemulsion
EP3450959A1 (de) * 2017-09-05 2019-03-06 Biosurfit, S.A. Detektionsverfahren
US10344328B2 (en) * 2017-11-17 2019-07-09 Ultima Genomics, Inc. Methods for biological sample processing and analysis
US11499962B2 (en) 2017-11-17 2022-11-15 Ultima Genomics, Inc. Methods and systems for analyte detection and analysis
CN108287134B (zh) * 2017-12-28 2020-11-24 南京邮电大学 单颗粒生物探针及其等离子体生物存储器的构建方法
CN108279192A (zh) * 2018-01-29 2018-07-13 北京市劳动保护科学研究所 一种可吸入颗粒物粒径分级装置
CN108514897A (zh) * 2018-04-11 2018-09-11 刘涵青 一种用于中学化学学生实验的微流控芯片
KR101872667B1 (ko) * 2018-04-14 2018-06-28 주식회사 스탠더드시험연구소 밸브조립체의 검증시험을 위한 열수력 성능시험설비
CN108490331B (zh) * 2018-04-17 2023-11-17 西安派瑞功率半导体变流技术股份有限公司 Gct芯片门/阴极阻断特性圆周法测试台
CN108970655A (zh) * 2018-06-04 2018-12-11 东莞东阳光科研发有限公司 一种微流控芯片的磁珠转移装置
CA3106136A1 (en) * 2018-07-09 2020-01-16 Sandstone Diagnostics, Inc. Devices and methods for plasma separation and storage
KR20200009859A (ko) * 2018-07-20 2020-01-30 재단법인대구경북과학기술원 원심 밸브 제어 장치
WO2020100039A1 (en) * 2018-11-13 2020-05-22 National Research Council Of Canada World-to-chip automated interface for centrifugal microfluidic platforms
US12239980B2 (en) 2018-12-07 2025-03-04 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection
US10512911B1 (en) 2018-12-07 2019-12-24 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection
US10900078B2 (en) 2019-03-14 2021-01-26 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis
US11118223B2 (en) 2019-03-14 2021-09-14 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis
CN110404599B (zh) * 2019-08-23 2024-08-02 上海汉赞迪生命科技有限公司 一种用于学习人工移液操作的移液枪
CN111167528B (zh) * 2019-11-25 2021-09-07 北京世纪沃德生物科技有限公司 一种微流控芯片的反应腔室
KR102309531B1 (ko) * 2020-01-29 2021-10-07 성균관대학교산학협력단 땀 속의 바이오 분자 검출을 위한 미세유체소자 및 이를 이용한 웨어러블 바이오센서 패치
CN111380743B (zh) * 2020-03-16 2022-09-23 东华理工大学 一种混杂样品顺次软电离装置
US20230393139A1 (en) 2020-10-23 2023-12-07 Tauns Laboratories, Inc. Target substance detection method, device, and reagent
JP7763776B2 (ja) * 2020-10-28 2025-11-04 株式会社 堀場アドバンスドテクノ 水質計データ処理装置、水質計データ処理システム、水質計データ処理方法、及びプログラム
CN112834498B (zh) * 2021-02-22 2025-03-14 杉木(深圳)生物科技有限公司 微流控芯片、尿液分析方法及装置、马桶
WO2022242549A1 (zh) * 2021-05-16 2022-11-24 深圳市品学优技术有限公司 一种反应及其驱动装置
CN113295645A (zh) * 2021-05-20 2021-08-24 天津工业大学 基于四叶草型的太赫兹混合网络检测芯片
KR102704928B1 (ko) * 2021-08-25 2024-09-10 한국기계연구원 순차적 유동 개시가 가능한 미세유로소자
KR102788594B1 (ko) * 2021-09-13 2025-04-02 한국기계연구원 순차적 유동 병합을 위한 미세유로소자
KR102622195B1 (ko) * 2021-12-02 2024-01-05 세메스 주식회사 약액 검사 장치와, 이를 포함하는 기판 처리 장치 및 기판을 처리하는 약액을 검사하는 방법
DE102021214281A1 (de) * 2021-12-14 2023-06-15 Robert Bosch Gesellschaft mit beschränkter Haftung Vorrichtung und Verfahren zum Splitten dreidimensionaler Agglomerate
KR102623409B1 (ko) * 2021-12-27 2024-01-10 세메스 주식회사 약액 검사 장치 및 이를 포함하는 기판 처리 장치
WO2023204315A1 (ja) 2022-04-22 2023-10-26 株式会社タウンズ 標的物質の検出方法および試薬
CN114965995B (zh) * 2022-05-20 2023-04-11 河南申友医学检验所有限公司 一种免疫层析分析检测系统及方法
CN115144310B (zh) * 2022-07-01 2024-07-19 重庆交通大学 一种旋桨式絮凝沉降试验装置及方法
KR102839509B1 (ko) * 2022-07-20 2025-07-25 연세대학교 산학협력단 광학 기반 유체 제어 바이오칩 및 이의 제조와 유체 제어 방법
US20240201152A1 (en) * 2022-12-17 2024-06-20 Msa Technology, Llc Gas detector device accessory identification and analysis
CN116593356B (zh) * 2023-06-05 2023-11-17 南京工业大学 一种利用磁纳米毛刷搅拌检测微量溶液粘度的方法
LU504853B1 (de) * 2023-08-03 2025-02-03 Dermagnostix GmbH Probenträger zum Verwenden in einem rotationsbasierten Verfahren zur Vervielfältigung von DNA und/oder Bestimmung von Nukleinsäuren

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3679367A (en) * 1970-09-14 1972-07-25 Technicon Instr Apparatus for determining the pack volume of particulates in liquid mixtures
US4940527A (en) * 1987-06-01 1990-07-10 Abbott Laboratories Two-part test cartridge for centrifuge
CA1333850C (en) * 1987-08-27 1995-01-10 Michael M. Gorin Apparatus and method for dilution and mixing of liquid samples
US4999304A (en) * 1987-12-28 1991-03-12 Miles Inc. Dynamic braking centrifuge
CA2028829A1 (en) * 1989-03-07 1990-09-08 Minoru Takase Analyzer of liquid sample and analyzing method of liquid sample using said analyzer
JPH03245049A (ja) * 1990-02-22 1991-10-31 Idemitsu Petrochem Co Ltd 液体試料分析用ディスク
WO1993022058A1 (en) * 1992-05-01 1993-11-11 Trustees Of The University Of Pennsylvania Polynucleotide amplification analysis using a microfabricated device
JPH06265447A (ja) * 1993-03-16 1994-09-22 Hitachi Ltd 微量反応装置およびこれを使用する微量成分測定装置
DE4410224C2 (de) * 1994-03-24 1996-02-29 Meinhard Prof Dr Knoll Miniaturisiertes Durchfluß-Analysesystem

Also Published As

Publication number Publication date
CN1208464A (zh) 1999-02-17
AU702403B2 (en) 1999-02-18
AU1283397A (en) 1997-06-27
KR100306951B1 (ko) 2001-11-15
DE69634490T2 (de) 2006-03-02
EP0865606A1 (de) 1998-09-23
EP0865606B1 (de) 2005-03-16
CA2239613A1 (en) 1997-06-12
NO982563D0 (no) 1998-06-04
JP2002503331A (ja) 2002-01-29
NO982563L (no) 1998-08-05
WO1997021090A1 (en) 1997-06-12
KR19990072013A (ko) 1999-09-27
DE69634490D1 (de) 2005-04-21
MX9804463A (es) 1998-12-31

Similar Documents

Publication Publication Date Title
ATE291225T1 (de) Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung
DE60012562D1 (de) Vorrichtungen und verfahren zur durchführung miniaturisierter homogener tests
WO2004058406A3 (en) Microfluidics devices and methods for diluting samples and reagents
WO2001087485A3 (en) Microfluidics devices and methods for high throughput screening
WO1998053311A3 (en) Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
ATE265889T1 (de) Vorrichtung und verfahren zur tropfenmikrochemie
DE69012195D1 (de) Kapillare Durchflussvorrichtung und Verfahren zur Messung der aktivierten partiellen Thromboplastinzeit.
ATE395136T1 (de) Vorrichtungen zur durchfuehrung von miniaturisierten in vitro amplifizierungsassays
DE69432122D1 (de) Verfahren und vorrichtung zum nachweis von hämolysis in flüssigen proben
DE68925493D1 (de) Gerät zum Einsammeln von Blut
WO2001087487A3 (en) Bidirectional flow centrifugal microfluidic devices
ES2023189B3 (es) Sistema de separacion mediante tecnicas de coalescencia.
EP1959255A3 (de) Biochemische Analysatoren mit geschlossenem Regelkreis
DE60006975T2 (de) Analytische testvorrichtung mit orientierte durchgehende kanäle besitzendem substrat und verbessertes verfahren und vorrichtung zum gebrauch derselben
DE69229478D1 (de) Vorrichtung und verfahren zur dosierung von flüssigkeitsproben
DE69716543D1 (de) Vorrichtung zum Entnehmen und Analysieren von flüssigen Proben, wie Blutproben
DE69719782D1 (de) Vorrichtung und verfahren zum durchfuehren von assays
ATE263963T1 (de) Vorrichtung zur feststellung von viskositätsänderungen in fluidproben, sowie ein verfahren dazu
ATE75045T1 (de) Verfahren und vorrichtung zum bestimmen der zeitspanne, die eine fluessigkeit zur aenderung ihres physischen zustandes benoetigt.
DE69023079D1 (de) Vorrichtung und Verfahren zum Gebrauch bei der Analyse von Flüssigkeitseinschlüssen.
DE69021851D1 (de) Verfahren und Vorrichtung zum Abscheiden von Kohlenwasserstoffmonoxid aus Wasserstoff enthaltenden Gasgemischen.
WO2003006946A3 (en) Method and instrument for automated analysis of fluid-based processing systems
DE69926845D1 (de) Verfahren zum überwachen von gas(en) in einer dielektrischen flüssigkeit
ATE70131T1 (de) Test kit zum durchfuehren von chemischen analysen.
ATE200303T1 (de) Verfahren und vorrichtung zur schnellen trennung und/oder umwandlung von substraten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties