ATE291232T1 - Immunoassay von c-peptid-enthaltenden verunreinigungen in rekombinantem human-insulin - Google Patents

Immunoassay von c-peptid-enthaltenden verunreinigungen in rekombinantem human-insulin

Info

Publication number: ATE291232T1
Authority: AT; Austria
Prior art keywords: human insulin; peptide; immunoassay; recombinant human; containing impurities
Prior art date: 1999-10-27

Application number

AT00974449T

Other languages

English (en)

Inventor

Martin Gerl

Cornelia Steinert

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-27

Filing date

2000-10-25

Publication date

2005-04-15

2000-10-25 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE291232T1 publication Critical patent/ATE291232T1/de

Links

239000012535 impurity Substances 0.000 title abstract 4
101000976075 Homo sapiens Insulin Proteins 0.000 title abstract 3
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 3
238000003018 immunoassay Methods 0.000 title 1
VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 abstract 4
108010075254 C-Peptide Proteins 0.000 abstract 4
239000000203 mixture Substances 0.000 abstract 3
239000011324 bead Substances 0.000 abstract 1
239000013024 dilution buffer Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000007420 radioactive assay Methods 0.000 abstract 1
239000000700 radioactive tracer Substances 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/62—Insulins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Biotechnology (AREA)
Endocrinology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT00974449T 1999-10-27 2000-10-25 Immunoassay von c-peptid-enthaltenden verunreinigungen in rekombinantem human-insulin ATE291232T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19951684A DE19951684A1 (de)	1999-10-27	1999-10-27	Neuer immunologischer Assay zur Bestimmung von C-peptidhaltigen Kontaminanten in Proben von Humanisulin und dessen Derivaten
PCT/EP2000/010482 WO2001031336A2 (en)	1999-10-27	2000-10-25	Immunoassay of c-peptide containing impurities in human insulin

Publications (1)

Publication Number	Publication Date
ATE291232T1 true ATE291232T1 (de)	2005-04-15

Family

ID=7927008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00974449T ATE291232T1 (de)	1999-10-27	2000-10-25	Immunoassay von c-peptid-enthaltenden verunreinigungen in rekombinantem human-insulin

Country Status (9)

Country	Link
US (1)	US7169562B1 (de)
EP (1)	EP1228374B1 (de)
JP (1)	JP4601884B2 (de)
AT (1)	ATE291232T1 (de)
AU (1)	AU1275301A (de)
DE (2)	DE19951684A1 (de)
ES (1)	ES2238323T3 (de)
PT (1)	PT1228374E (de)
WO (1)	WO2001031336A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US11524987B2 (en)	2018-09-25	2022-12-13	Amphastar Pharmaceuticals, Inc.	Highly purified recombinant human insulin (RHI) API and methods of producing the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5744327A (en) *	1990-02-20	1998-04-28	Board Of Regents, The University Of Texas System	Methods for producing insulin in response to non-glucose secretagogues
JP3044569B2 (ja) *	1990-11-09	2000-05-22	東ソー株式会社	ヒトｃ―ペプチドの測定方法
GB9307491D0 (en) *	1993-04-08	1993-06-02	Sandoz Ltd	Organic compounds
FR2764989B1 (fr) *	1997-06-20	1999-08-27	Pasteur Sanofi Diagnostics	Procede de dosage du c-peptide
US6444641B1 (en) *	1997-10-24	2002-09-03	Eli Lilly Company	Fatty acid-acylated insulin analogs

1999
- 1999-10-27 DE DE19951684A patent/DE19951684A1/de not_active Withdrawn
2000
- 2000-10-25 AU AU12753/01A patent/AU1275301A/en not_active Abandoned
- 2000-10-25 ES ES00974449T patent/ES2238323T3/es not_active Expired - Lifetime
- 2000-10-25 WO PCT/EP2000/010482 patent/WO2001031336A2/en not_active Ceased
- 2000-10-25 PT PT00974449T patent/PT1228374E/pt unknown
- 2000-10-25 EP EP00974449A patent/EP1228374B1/de not_active Expired - Lifetime
- 2000-10-25 AT AT00974449T patent/ATE291232T1/de active
- 2000-10-25 JP JP2001533423A patent/JP4601884B2/ja not_active Expired - Fee Related
- 2000-10-25 DE DE60018785T patent/DE60018785T2/de not_active Expired - Lifetime
- 2000-10-26 US US09/695,919 patent/US7169562B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU1275301A (en)	2001-05-08
JP4601884B2 (ja)	2010-12-22
DE60018785T2 (de)	2006-02-02
JP2003513243A (ja)	2003-04-08
WO2001031336A2 (en)	2001-05-03
ES2238323T3 (es)	2005-09-01
EP1228374A2 (de)	2002-08-07
WO2001031336A3 (en)	2001-11-08
DE19951684A1 (de)	2001-05-03
DE60018785D1 (de)	2005-04-21
EP1228374B1 (de)	2005-03-16
PT1228374E (pt)	2005-07-29
US7169562B1 (en)	2007-01-30

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