ATE291444T1 - Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers - Google Patents

Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers

Info

Publication number
ATE291444T1
ATE291444T1 AT99915349T AT99915349T ATE291444T1 AT E291444 T1 ATE291444 T1 AT E291444T1 AT 99915349 T AT99915349 T AT 99915349T AT 99915349 T AT99915349 T AT 99915349T AT E291444 T1 ATE291444 T1 AT E291444T1
Authority
AT
Austria
Prior art keywords
propylene
fumarate
produced
propylene glycol
poly
Prior art date
Application number
AT99915349T
Other languages
English (en)
Inventor
Susan J Peter
Laura J Suggs
Paul S Engel
Antonios G Mikos
Original Assignee
Univ Wm Marsh Rice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wm Marsh Rice filed Critical Univ Wm Marsh Rice
Application granted granted Critical
Publication of ATE291444T1 publication Critical patent/ATE291444T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/52—Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
    • C08G63/56—Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds other than from esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/52—Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Composite Materials (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT99915349T 1998-04-10 1999-04-09 Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers ATE291444T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8140598P 1998-04-10 1998-04-10
US8130898P 1998-04-10 1998-04-10
US8218298P 1998-04-16 1998-04-16
PCT/US1999/007912 WO1999052469A1 (en) 1998-04-10 1999-04-09 Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger

Publications (1)

Publication Number Publication Date
ATE291444T1 true ATE291444T1 (de) 2005-04-15

Family

ID=27373944

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99915349T ATE291444T1 (de) 1998-04-10 1999-04-09 Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers

Country Status (7)

Country Link
US (2) US6124373A (de)
EP (1) EP1079869B1 (de)
JP (1) JP2002539275A (de)
AT (1) ATE291444T1 (de)
CA (1) CA2327730A1 (de)
DE (1) DE69924369D1 (de)
WO (1) WO1999052469A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486232B1 (en) * 1997-04-18 2002-11-26 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for internal fixation devices and bone cements
CA2327730A1 (en) 1998-04-10 1999-10-21 Wm Marsh Rice University Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger
WO2000063268A1 (en) 1999-04-16 2000-10-26 Wm. Marsh Rice University Poly(propylene fumarate) cross linked with poly(ethylene glycol)
US6884778B2 (en) * 2000-04-14 2005-04-26 William Marsh Rice University Biocompatible macromers
DE10032220A1 (de) * 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung
WO2002085246A2 (en) * 2001-04-19 2002-10-31 Case Western Reserve University Fabrication of a polymeric prosthetic implant
DE60226242T2 (de) * 2001-06-28 2009-05-28 William Marsh Rice University, Houston Photoquervernetzung von biologischen materialien aus fumarsäurediethylester/poly(propylenfumarat)
US7629388B2 (en) 2001-11-20 2009-12-08 William Marsh Rice University Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion
US20030180344A1 (en) * 2002-02-05 2003-09-25 Cambridge Scientific, Inc. Bioresorbable osteoconductive compositions for bone regeneration
US6884432B2 (en) * 2002-04-25 2005-04-26 Mayo Foundation For Medical Education And Research Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery
US7273523B2 (en) 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
US20070065652A1 (en) * 2003-03-13 2007-03-22 Willaim Marsh Rice University Composite injectable and pre-fabricated bone replacement material and method for the production of such bone replacement material
ES2545328T3 (es) 2003-03-14 2015-09-10 Depuy Spine, Inc. Dispositivo hidráulico de inyección de cemento óseo en vertebroplastia percutánea
US8066713B2 (en) 2003-03-31 2011-11-29 Depuy Spine, Inc. Remotely-activated vertebroplasty injection device
US8415407B2 (en) 2004-03-21 2013-04-09 Depuy Spine, Inc. Methods, materials, and apparatus for treating bone and other tissue
WO2006011152A2 (en) * 2004-06-17 2006-02-02 Disc-O-Tech Medical Technologies, Ltd. Methods for treating bone and other tissue
CA2528150A1 (en) * 2003-07-01 2005-01-20 Mayo Foundation For Medical Education And Research Self-crosslinkable poly(caprolactone fumarate)
US7252686B2 (en) * 2003-08-13 2007-08-07 Boston Scientific Scimed Methods for reducing bone compression fractures using wedges
WO2005030034A2 (en) 2003-09-26 2005-04-07 Depuy Spine, Inc. Device for delivering viscous material
US20060018949A1 (en) * 2004-04-07 2006-01-26 Bausch & Lomb Incorporated Injectable biodegradable drug delivery system
ES2396133T3 (es) 2004-04-27 2013-02-19 Kyphon SÀRl Composiciones de sustitución osea y método de uso
JP5108523B2 (ja) * 2004-11-12 2012-12-26 メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ 光架橋性ポリ（カプロラクトンフマレート）
EP1812481B1 (de) * 2004-11-18 2012-01-11 Mayo Foundation for Medical Education and Research Blockcopolymere aus polycaprolacton und poly (propylenfumarat)
CA2606396A1 (en) * 2005-04-29 2006-11-09 Mayo Foundation For Medical Education And Research Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof
US9381024B2 (en) 2005-07-31 2016-07-05 DePuy Synthes Products, Inc. Marked tools
US9918767B2 (en) 2005-08-01 2018-03-20 DePuy Synthes Products, Inc. Temperature control system
US7651701B2 (en) * 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
US8360629B2 (en) 2005-11-22 2013-01-29 Depuy Spine, Inc. Mixing apparatus having central and planetary mixing elements
US7754005B2 (en) * 2006-05-02 2010-07-13 Kyphon Sarl Bone cement compositions comprising an indicator agent and related methods thereof
US7507286B2 (en) * 2006-06-08 2009-03-24 Sanatis Gmbh Self-foaming cement for void filling and/or delivery systems
US20100069786A1 (en) * 2006-06-29 2010-03-18 Depuy Spine, Inc. Integrated bone biopsy and therapy apparatus
CA2663447A1 (en) 2006-09-14 2008-03-20 Depuy Spine, Inc. Polymeric bone cement and methods of use thereof
AU2007300585A1 (en) * 2006-09-21 2008-04-03 Kyphon Sarl Diammonium phosphate and other ammonium salts and their use in preventing clotting
EP2091818B1 (de) 2006-10-19 2016-06-08 DePuy Spine, Inc. Fluidzufuhrsystem und darauf bezogenes verfahren
US20080195223A1 (en) * 2006-11-03 2008-08-14 Avram Allan Eddin Materials and Methods and Systems for Delivering Localized Medical Treatments
ATE551967T1 (de) * 2007-07-30 2012-04-15 Purzer Pharmaceutical Co Ltd Biologisch abbaubarer knochenzement und herstellungsverfahren dafür
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
US7968616B2 (en) * 2008-04-22 2011-06-28 Kyphon Sarl Bone cement composition and method
EP2590605A1 (de) 2010-07-09 2013-05-15 Board of Regents of the University of Texas System Biologisch abbaubare gerüste
EP3511027A1 (de) 2010-08-20 2019-07-17 Case Western Reserve University Generative fertigung von implantaten durch bearbeitung mit kontinuierlichem digitalen licht
US11865785B2 (en) * 2010-08-20 2024-01-09 H. David Dean Continuous digital light processing additive manufacturing of implants
KR102514110B1 (ko) 2014-05-05 2023-03-24 어드밴스드 메디칼 솔루션스 이스라엘 (실란티스) 엘티디. 생물학적 접착제 및 밀봉제, 그리고 이들을 이용하는 방법
JP6826990B2 (ja) * 2014-11-18 2021-02-10 アクロン大学 明確に定義された分解性ポリ（プロピレンフマレート）ポリマー及びその合成のための拡張可能な方法
JP2020506990A (ja) 2017-02-02 2020-03-05 アクロン大学 マグネシウム触媒を用いる開環重合によって作製する官能化ポリ（プロピレンフマラート）ポリマー
GB2594243A (en) * 2020-04-15 2021-10-27 Arterius Ltd A bone cement
EP4181924A1 (de) * 2020-07-15 2023-05-24 The University of Akron Synthese von poly(propylenmaleat-co-succinat) durch zeitabhängige reduktion von zink- und essigsäurevermittelten poly(propylenmaleat)-doppelbindungen

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3701748A (en) 1966-07-20 1972-10-31 Rohm & Haas Unsaturated polyester resinous compositions
DE1770548A1 (de) * 1967-06-02 1972-02-10 Gen Tire & Rubber Co Polyester und ihre Herstellung
US5286763A (en) * 1983-03-22 1994-02-15 Massachusetts Institute Of Technology Bioerodible polymers for drug delivery in bone
US4722948A (en) * 1984-03-16 1988-02-02 Dynatech Corporation Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone
US5989579A (en) 1986-10-02 1999-11-23 Escalon Medical Corp. Ocular insert with anchoring protrusions
US4843112A (en) * 1987-03-12 1989-06-27 The Beth Israel Hospital Association Bioerodable implant composition
US4888413A (en) 1988-01-11 1989-12-19 Domb Abraham J Poly(propylene glycol fumarate) compositions for biomedical applications
AU639645B2 (en) 1989-10-10 1993-07-29 Wm. Wrigley Jr. Company Gradual release structures made from fiber spinning techniques
FR2661682B1 (fr) 1990-05-04 1993-12-10 Norsolor Nouvelles compositions resineuses a base de resines polyesters non saturees et de nouveaux additifs anti-retrait.
DE69329594T2 (de) 1992-02-28 2001-05-31 Board Of Regents, The University Of Texas System Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung
US5733951A (en) * 1994-04-28 1998-03-31 Yaszemski; Michael J. Poly(propylene fumarate)
US5527864A (en) * 1995-08-08 1996-06-18 Suggs; Laura J. Poly(propylene fumarate-co-ethylene oxide)
US5946457A (en) 1995-12-25 1999-08-31 Sharp Kabushiki Kaisha Image forming system having transfer device for communicating between image forming apparatus and image processing apparatus
US5998362A (en) 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6071982A (en) * 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
US5854382A (en) 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
CA2327730A1 (en) 1998-04-10 1999-10-21 Wm Marsh Rice University Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger

Also Published As

Publication number Publication date
WO1999052469A9 (en) 2000-03-23
US6124373A (en) 2000-09-26
EP1079869A4 (de) 2002-08-07
WO1999052469A1 (en) 1999-10-21
CA2327730A1 (en) 1999-10-21
JP2002539275A (ja) 2002-11-19
US6355755B1 (en) 2002-03-12
EP1079869A1 (de) 2001-03-07
DE69924369D1 (de) 2005-04-28
EP1079869B1 (de) 2005-03-23

Similar Documents

Publication Publication Date Title
DE69924369D1 (de) Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers
Takahashi et al. Chemical reactions by polyethylene glycol-modified enzymes in chlorinated hydrocarbons
Inoue et al. Stereochemistry of copolymerization of carbon dioxide with epoxycyclohexane
BG47032A3 (en) Method for preparing of glycols from ethylenic oxide
TW264489B (de)
ES500632A0 (es) Procedimiento para la sintesis de alil carbonatos de alcoho-les polihidricos y sus derivados
JPS62175477A (ja) ２−オキソ−１、３−ジオキソランの製法
FR2439801A1 (fr) Procede de preparation de polycarbonates
EP2778169B1 (de) Hyperverzweigte symmetrische silikonmodifizierte polymerisierbare Verbindung und modularisiertes Herstellungsverfahren dafür
AU2660700A (en) Method for producing highly branched glycidol-based polyols
Collman et al. Hydrolytic cleavage of N-terminal peptide bonds by a cobalt chelate
ATE263797T1 (de) Verfahren zur herstellung von aliphatischen oligocarbonatdiolen
GB1395783A (en) Divinyl compounds and adhesive compositions containing them
Inoue Copolymerization of carbon dioxide and epoxide: functionality of the copolymer
NZ323390A (en) Process for the preparation of alkylene glycols
JP2001192497A (ja) ポリカーボネートの新規な分解方法
MY133435A (en) Synthesis of polyol fatty acid polyesters using column with improved inert gas sparging
KR20220049355A (ko) 에탄올을 이용한 폴리카보네이트의 분해 방법
DE59906071D1 (de) Herstellung von polytetrahydrofuran mit endständigen hydroxylgruppen durch wechsel von kontinuierlicher und disperser phase
KR850004396A (ko) 네오카르지노스타틴 유도체의 제조방법
JPS61176580A (ja) 光学活性３，４−エポキシ−１−ブタノ−ルの製法
Nakagawa et al. Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V
SU1377278A1 (ru) Способ получени моноформиата этиленгликол
GB1380678A (en) Process for the co-polymerisation of oxirane derivatives and catalyst therefor
JPS6451429A (en) Production of carboxyl-terminated polycarbonate resin

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties