ATE291573T1 - Triterpen-derivate und ihre verwendung als antiproliferative wirkstoffe - Google Patents
Triterpen-derivate und ihre verwendung als antiproliferative wirkstoffeInfo
- Publication number
- ATE291573T1 ATE291573T1 AT01931948T AT01931948T ATE291573T1 AT E291573 T1 ATE291573 T1 AT E291573T1 AT 01931948 T AT01931948 T AT 01931948T AT 01931948 T AT01931948 T AT 01931948T AT E291573 T1 ATE291573 T1 AT E291573T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- antiproliferative
- actives
- relates
- compound
- Prior art date
Links
- 230000001028 anti-proliverative effect Effects 0.000 title 1
- 150000003648 triterpenes Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000013078 crystal Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0012532A GB0012532D0 (en) | 2000-05-23 | 2000-05-23 | Triterpenoid derivatives |
| GB0012825A GB2362650A (en) | 2000-05-25 | 2000-05-25 | Triterpenoid derivatives |
| PCT/GB2001/002341 WO2001090096A2 (en) | 2000-05-23 | 2001-05-23 | Triterpenoid derivatives and their use as antiproliferative agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE291573T1 true ATE291573T1 (de) | 2005-04-15 |
Family
ID=26244333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01931948T ATE291573T1 (de) | 2000-05-23 | 2001-05-23 | Triterpen-derivate und ihre verwendung als antiproliferative wirkstoffe |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1289977B1 (de) |
| AT (1) | ATE291573T1 (de) |
| AU (1) | AU2001258631A1 (de) |
| DE (1) | DE60109605T2 (de) |
| WO (1) | WO2001090096A2 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ2008723A3 (cs) | 2008-11-13 | 2010-01-13 | Univerzita Palackého v Olomouci | 2-Deoxyglykosidy triterpenoidu, zpusob jejich prípravy a jejich použití jako lécivo |
| CN105534995B (zh) * | 2016-02-24 | 2018-05-18 | 上海交通大学医学院附属仁济医院 | 化合物Hu-17单独或联合酪氨酸激酶抑制剂在制备治疗慢性粒细胞白血病药物中的应用 |
| CN109180775B (zh) * | 2018-09-05 | 2021-03-23 | 常州大学怀德学院 | C-28亚胺取代白桦脂醇异构体衍生物及其制备方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998032443A1 (de) * | 1997-01-24 | 1998-07-30 | Marigen S.A. | Ultramikroemulsionen aus spontan dispergierbaren konzentraten enthaltend antitumoral, antiviral und antiparasitär wirksame ester von pentacyclischen triterpenen |
-
2001
- 2001-05-23 AT AT01931948T patent/ATE291573T1/de not_active IP Right Cessation
- 2001-05-23 EP EP01931948A patent/EP1289977B1/de not_active Expired - Lifetime
- 2001-05-23 AU AU2001258631A patent/AU2001258631A1/en not_active Abandoned
- 2001-05-23 DE DE60109605T patent/DE60109605T2/de not_active Expired - Lifetime
- 2001-05-23 WO PCT/GB2001/002341 patent/WO2001090096A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1289977B1 (de) | 2005-03-23 |
| WO2001090096A2 (en) | 2001-11-29 |
| EP1289977A2 (de) | 2003-03-12 |
| DE60109605D1 (de) | 2005-04-28 |
| AU2001258631A1 (en) | 2001-12-03 |
| WO2001090096A3 (en) | 2002-03-07 |
| DE60109605T2 (de) | 2006-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |