ATE291625T1 - Streptococcus toxinmutanten und verfahren zu deren anwendung - Google Patents

Streptococcus toxinmutanten und verfahren zu deren anwendung

Info

Publication number
ATE291625T1
ATE291625T1 AT96921589T AT96921589T ATE291625T1 AT E291625 T1 ATE291625 T1 AT E291625T1 AT 96921589 T AT96921589 T AT 96921589T AT 96921589 T AT96921589 T AT 96921589T AT E291625 T1 ATE291625 T1 AT E291625T1
Authority
AT
Austria
Prior art keywords
spe
toxin
vaccine
toxins
wild type
Prior art date
Application number
AT96921589T
Other languages
English (en)
Inventor
Patrick M Schlievert
Manuela Roggiani
Jennifer Stoehr
Douglas Ohlendorf
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Application granted granted Critical
Publication of ATE291625T1 publication Critical patent/ATE291625T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT96921589T 1995-06-07 1996-06-07 Streptococcus toxinmutanten und verfahren zu deren anwendung ATE291625T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48026195A 1995-06-07 1995-06-07
PCT/US1996/010252 WO1996040930A1 (en) 1995-06-07 1996-06-07 Mutants of streptococcal toxin a and methods of use

Publications (1)

Publication Number Publication Date
ATE291625T1 true ATE291625T1 (de) 2005-04-15

Family

ID=23907283

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96921589T ATE291625T1 (de) 1995-06-07 1996-06-07 Streptococcus toxinmutanten und verfahren zu deren anwendung

Country Status (12)

Country Link
US (3) US6632441B2 (de)
EP (2) EP1538208A3 (de)
JP (1) JPH11514844A (de)
KR (1) KR100456594B1 (de)
AT (1) ATE291625T1 (de)
AU (1) AU723116B2 (de)
CA (1) CA2221480A1 (de)
DE (1) DE69634510T2 (de)
DK (1) DK0832241T3 (de)
ES (1) ES2239332T3 (de)
PT (1) PT832241E (de)
WO (1) WO1996040930A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW517061B (en) * 1996-03-29 2003-01-11 Pharmacia & Amp Upjohn Ab Modified/chimeric superantigens and their use
CN1211487C (zh) 1996-12-06 2005-07-20 明尼苏达大学董事会 链球菌毒素a突变体及其使用方法
US6774218B2 (en) 1996-12-06 2004-08-10 Regents Of The University Of Minnesota Mutants of streptococcal toxin C and methods of use
CN1148449C (zh) 1996-12-06 2004-05-05 明尼苏达大学董事会 链球菌毒素c突变体及其使用方法
US6075119A (en) 1997-04-07 2000-06-13 The Rockefeller University Peptides useful for reducing symptoms of toxic shock syndrome
US7087235B2 (en) 1997-06-25 2006-08-08 The United States Of America As Represented By The Secretary Of The Army Fusion protein of streptococcal pyrogenic exotoxins
US6872394B1 (en) 1997-12-02 2005-03-29 Idaho Research Foundation, Inc. Non-toxic immune stimulating enterotoxin compositions
WO2000020598A1 (en) * 1998-10-07 2000-04-13 The Rockefeller University Peptides useful for reducing symptoms of toxic shock syndrome and septic shock
WO2002083169A1 (en) * 2001-04-13 2002-10-24 Idaho Research Foundation, Inc. Modified staphylococcal enterotoxins and expression systems therefore
SE0102327D0 (sv) * 2001-06-28 2001-06-28 Active Biotech Ab A novel engineered superantigen for human therapy
US20070178113A1 (en) * 2005-11-22 2007-08-02 Backstrom B T Superantigen conjugate
CA2683748C (en) 2007-04-13 2016-02-16 The Board Of Regents Of The University Of Oklahoma Mutants of cholesterol-dependent cytolysins and uses thereof
RU2380316C1 (ru) * 2008-10-13 2010-01-27 Закрытое акционерное общество "Макполимер" Способ получения органоглины
WO2015200833A2 (en) 2014-06-27 2015-12-30 Abbott Laboratories COMPOSITIONS AND METHODS FOR DETECTING HUMAN PEGIVIRUS 2 (HPgV-2)
ES2993430T3 (en) 2014-11-21 2024-12-30 Univ Oklahoma Pneumolysin mutants and methods of use thereof
EA201891601A1 (ru) 2016-01-10 2019-03-29 Неоткс Терапьютикс Лтд. Способы и композиции, усиливающие эффективность опосредованной суперантигеном иммунотерапии злокачественных опухолей
EA202193121A1 (ru) 2019-05-15 2022-02-21 Неоткс Терапьютикс Лтд. Лечение рака
AU2021357520A1 (en) 2020-03-05 2022-09-29 Neotx Therapeutics Ltd. Methods and compositions for treating cancer with immune cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4784948A (en) * 1983-08-10 1988-11-15 The Rockefeller University Production of streptococcal m protein immunogens and molecular probes
US5336598A (en) 1989-11-15 1994-08-09 National Jewish Center For Immunology And Respiratory Medicine Method for diagnosing a superantigen caused pathologial condition via assay of T-cells
US5298396A (en) 1989-11-15 1994-03-29 National Jewish Center For Immunology And Respiratory Medicine Method for identifying T cells disease involved in autoimmune disease
AU681341B2 (en) 1992-01-28 1997-08-28 National Jewish Center For Immunology And Respiratory Medicine Protective effects of mutated superantigens

Also Published As

Publication number Publication date
DE69634510T2 (de) 2006-01-26
PT832241E (pt) 2005-08-31
AU6278296A (en) 1996-12-30
WO1996040930A1 (en) 1996-12-19
EP0832241B1 (de) 2005-03-23
US6870042B1 (en) 2005-03-22
AU723116B2 (en) 2000-08-17
EP1538208A3 (de) 2007-05-23
KR19990022750A (ko) 1999-03-25
DE69634510D1 (de) 2005-04-28
US6632441B2 (en) 2003-10-14
EP0832241A1 (de) 1998-04-01
JPH11514844A (ja) 1999-12-21
US20060039925A1 (en) 2006-02-23
KR100456594B1 (ko) 2005-06-17
ES2239332T3 (es) 2005-09-16
CA2221480A1 (en) 1996-12-19
DK0832241T3 (da) 2005-08-01
US20020054887A1 (en) 2002-05-09
EP1538208A2 (de) 2005-06-08

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