ATE291737T1 - Screening-assays unter verwendung von intramitochondrialem kalzium - Google Patents
Screening-assays unter verwendung von intramitochondrialem kalziumInfo
- Publication number
- ATE291737T1 ATE291737T1 AT01912665T AT01912665T ATE291737T1 AT E291737 T1 ATE291737 T1 AT E291737T1 AT 01912665 T AT01912665 T AT 01912665T AT 01912665 T AT01912665 T AT 01912665T AT E291737 T1 ATE291737 T1 AT E291737T1
- Authority
- AT
- Austria
- Prior art keywords
- mitochondrial
- agents
- screening assay
- calcium
- detect
- Prior art date
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052791 calcium Inorganic materials 0.000 title abstract 2
- 239000011575 calcium Substances 0.000 title abstract 2
- 238000007423 screening assay Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 230000004898 mitochondrial function Effects 0.000 abstract 2
- 102100034161 Calcium uniporter protein, mitochondrial Human genes 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 108010024786 mitochondrial calcium uniporter Proteins 0.000 abstract 1
- 230000002438 mitochondrial effect Effects 0.000 abstract 1
- 230000006540 mitochondrial respiration Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
- G01N33/5079—Mitochondria
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17638400P | 2000-01-14 | 2000-01-14 | |
| PCT/US2001/001500 WO2001051923A2 (en) | 2000-01-14 | 2001-01-16 | Screening assays using intramitochondrial calcium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE291737T1 true ATE291737T1 (de) | 2005-04-15 |
Family
ID=22644141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01912665T ATE291737T1 (de) | 2000-01-14 | 2001-01-16 | Screening-assays unter verwendung von intramitochondrialem kalzium |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6808873B2 (de) |
| EP (1) | EP1247093B1 (de) |
| AT (1) | ATE291737T1 (de) |
| AU (1) | AU2001241420A1 (de) |
| DE (1) | DE60109571D1 (de) |
| WO (1) | WO2001051923A2 (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US8022058B2 (en) * | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| AU2001276846A1 (en) * | 2000-06-29 | 2002-01-14 | Mitokor | Methods for identifying mitochondrial divalent cation transporters |
| US7498408B2 (en) * | 2002-09-23 | 2009-03-03 | E. I. Du Pont De Nemours And Company | Ryanodine receptor polypeptides |
| US7544678B2 (en) | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
| AU2003275939A1 (en) * | 2002-11-08 | 2004-06-07 | Novo Nordisk A/S | Safe chemical uncouplers for the treatment of obesity |
| GB0228139D0 (en) * | 2002-12-03 | 2003-01-08 | Kozlova Zwinderman Olga | Fungal biosensor for contaminant detection |
| US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
| US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
| US8926959B2 (en) | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| EP1919497B1 (de) | 2005-07-22 | 2020-02-12 | The Board of Trustees of the Leland Stanford Junior University | Lichtaktivierter kationenkanal und dessen verwendung |
| US10052497B2 (en) | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| US9238150B2 (en) | 2005-07-22 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Optical tissue interface method and apparatus for stimulating cells |
| US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7897401B2 (en) * | 2005-11-29 | 2011-03-01 | University Of Maryland, College Park | Control of apoptosis by controlling the propensity of ceramide channel formation |
| US8398692B2 (en) | 2007-01-10 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| US8795609B2 (en) | 2007-02-08 | 2014-08-05 | Biokit, S.A. | Magnetic particle washing station |
| US8401609B2 (en) | 2007-02-14 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System, method and applications involving identification of biological circuits such as neurological characteristics |
| WO2008106694A2 (en) | 2007-03-01 | 2008-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Systems, methods and compositions for optical stimulation of target cells |
| US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
| US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
| BRPI0911448A2 (pt) | 2008-04-23 | 2019-02-26 | The Board Of Trustees For The Leland Stanford Junior University | sistemas, métodos e composições para simulação óticas de células alvo |
| CA2726128C (en) | 2008-05-29 | 2016-10-18 | The Board Of Trustees Of The Leland Stanford Junior University | Cell line, system and method for optical control of secondary messengers |
| US10711242B2 (en) | 2008-06-17 | 2020-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for controlling cellular development |
| EP2304435A1 (de) * | 2008-06-25 | 2011-04-06 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Neuer mitochondrienfarbstoff |
| WO2010006049A1 (en) | 2008-07-08 | 2010-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
| NZ602416A (en) | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
| WO2010111208A1 (en) * | 2009-03-23 | 2010-09-30 | University Of Miami | Mitochondrial inhibitors and uses thereof |
| EP2547762B1 (de) | 2010-03-17 | 2018-04-25 | The Board of Trustees of the Leland Stanford Junior University | Lichtempfindliche ionendurchgangsmoleküle |
| JP6355335B2 (ja) | 2010-11-05 | 2018-07-11 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 報酬関連行動の光遺伝学的制御 |
| CN106947741A (zh) | 2010-11-05 | 2017-07-14 | 斯坦福大学托管董事会 | 光活化嵌合视蛋白及其使用方法 |
| CA2816990A1 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Stabilized step function opsin proteins and methods of using the same |
| CA2816968C (en) | 2010-11-05 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Optically-controlled cns dysfunction |
| CN103313752B (zh) | 2010-11-05 | 2016-10-19 | 斯坦福大学托管董事会 | 用于光遗传学方法的光的上转换 |
| EP2635295B1 (de) | 2010-11-05 | 2017-12-20 | The Board of Trustees of the Leland Stanford Junior University | Steuerung und charakterisierung von speicherfunktionen |
| US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
| CN103687959B (zh) * | 2011-04-08 | 2016-10-12 | 贝斯泰医学中心公司 | 用于测定线粒体功能的方法、组合物和试剂盒 |
| CN107936097A (zh) | 2011-12-16 | 2018-04-20 | 斯坦福大学托管董事会 | 视蛋白多肽及其使用方法 |
| US20140024701A1 (en) | 2012-02-21 | 2014-01-23 | Circuit Therapeutics, Inc. | Compositions and Methods for Treating Neurogenic Disorders of the Pelvic Floor |
| US9636380B2 (en) | 2013-03-15 | 2017-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of inputs to the ventral tegmental area |
| CN105246550A (zh) | 2013-03-15 | 2016-01-13 | 小利兰·斯坦福大学托管委员会 | 行为状态的光遗传学控制 |
| WO2014179331A2 (en) | 2013-04-29 | 2014-11-06 | The Board Of Trustees Of The Leland Stanford Junior University | Devices, systems and methods for optogenetic modulation of action potentials in target cells |
| AU2014306679A1 (en) | 2013-08-14 | 2016-03-10 | Circuit Therapeutics, Inc. | Compositions and methods for controlling pain |
| US10568516B2 (en) | 2015-06-22 | 2020-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging and/or optogenetic control of light-responsive neurons |
| US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
| CA3063450A1 (en) | 2017-05-19 | 2018-11-22 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
| AU2020318633A1 (en) * | 2019-07-24 | 2022-02-24 | Luca Science Inc. | Method of obtaining mitochondria from cells and obtained mitochondria |
| CN113069530B (zh) * | 2021-03-31 | 2022-01-25 | 河南大学 | 萘酰亚胺-多胺衍生物联合环孢素a在制备抗肿瘤药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5015568A (en) * | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
| US5049673A (en) * | 1987-10-30 | 1991-09-17 | The Regents Of The University Of California | Fluorescent indicator dyes for calcium working at long wavelengths |
| US5501980A (en) * | 1994-05-20 | 1996-03-26 | Molecular Probes, Inc. | Benzazolylcoumarin-based ion indicators |
| US5888498A (en) * | 1995-03-03 | 1999-03-30 | Mitokor | Cellular and animal models for diseases associated with mitochondrial defects |
| US6183948B1 (en) * | 1998-04-15 | 2001-02-06 | Johns Hopkins University | Methods to identify compounds affecting mitochondria |
-
2001
- 2001-01-16 AT AT01912665T patent/ATE291737T1/de not_active IP Right Cessation
- 2001-01-16 AU AU2001241420A patent/AU2001241420A1/en not_active Abandoned
- 2001-01-16 DE DE60109571T patent/DE60109571D1/de not_active Expired - Lifetime
- 2001-01-16 WO PCT/US2001/001500 patent/WO2001051923A2/en not_active Ceased
- 2001-01-16 EP EP01912665A patent/EP1247093B1/de not_active Expired - Lifetime
- 2001-01-16 US US09/765,104 patent/US6808873B2/en not_active Expired - Fee Related
-
2004
- 2004-10-26 US US10/974,484 patent/US20050170329A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60109571D1 (de) | 2005-04-28 |
| EP1247093B1 (de) | 2005-03-23 |
| US20050170329A1 (en) | 2005-08-04 |
| AU2001241420A1 (en) | 2001-07-24 |
| WO2001051923A2 (en) | 2001-07-19 |
| US6808873B2 (en) | 2004-10-26 |
| EP1247093A2 (de) | 2002-10-09 |
| WO2001051923A3 (en) | 2002-05-02 |
| US20010046664A1 (en) | 2001-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |