ATE292799T1 - Struktur und verfahren zur kapillaren hämatokritabtrennung - Google Patents

Struktur und verfahren zur kapillaren hämatokritabtrennung

Info

Publication number
ATE292799T1
ATE292799T1 AT00123020T AT00123020T ATE292799T1 AT E292799 T1 ATE292799 T1 AT E292799T1 AT 00123020 T AT00123020 T AT 00123020T AT 00123020 T AT00123020 T AT 00123020T AT E292799 T1 ATE292799 T1 AT E292799T1
Authority
AT
Austria
Prior art keywords
capillary
reaction region
obstructions
inlet port
capillary pathway
Prior art date
Application number
AT00123020T
Other languages
English (en)
Inventor
Raghbir S Bhullar
Christopher D Wilsey
Jeffrey N Shelton
Original Assignee
Roche Diagnostics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Corp filed Critical Roche Diagnostics Corp
Application granted granted Critical
Publication of ATE292799T1 publication Critical patent/ATE292799T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • External Artificial Organs (AREA)
AT00123020T 1999-10-28 2000-10-24 Struktur und verfahren zur kapillaren hämatokritabtrennung ATE292799T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/428,691 US6319719B1 (en) 1999-10-28 1999-10-28 Capillary hematocrit separation structure and method

Publications (1)

Publication Number Publication Date
ATE292799T1 true ATE292799T1 (de) 2005-04-15

Family

ID=23699972

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00123020T ATE292799T1 (de) 1999-10-28 2000-10-24 Struktur und verfahren zur kapillaren hämatokritabtrennung

Country Status (6)

Country Link
US (1) US6319719B1 (de)
EP (1) EP1096254B1 (de)
JP (1) JP4520620B2 (de)
AT (1) ATE292799T1 (de)
CA (1) CA2324131C (de)
DE (1) DE60019228T2 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749814B1 (en) * 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US6406672B1 (en) * 2000-01-28 2002-06-18 Roche Diagnostics Plasma retention structure providing internal flow
US6555387B1 (en) * 2000-09-27 2003-04-29 Becton, Dickinson And Company Method for producing thin liquid samples for microscopic analysis
US6814843B1 (en) * 2000-11-01 2004-11-09 Roche Diagnostics Corporation Biosensor
SE0201738D0 (sv) * 2002-06-07 2002-06-07 Aamic Ab Micro-fluid structures
US20040019300A1 (en) * 2002-07-26 2004-01-29 Leonard Leslie Anne Microfluidic blood sample separations
JP2005538383A (ja) * 2002-09-10 2005-12-15 プラコア・インコーポレーテッド 血小板機能を監視する方法および装置
JP4075765B2 (ja) * 2002-10-30 2008-04-16 日本電気株式会社 分離装置およびその製造方法、ならびに分析システム
JP2004354364A (ja) * 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
DE10305050A1 (de) * 2003-02-07 2004-08-19 Roche Diagnostics Gmbh Analytisches Testelement und Verfahren für Blutuntersuchungen
WO2004097393A1 (ja) * 2003-04-28 2004-11-11 Matsushita Electric Industrial Co., Ltd. フィルタとそれを備えたバイオセンサ
US8071030B2 (en) * 2003-06-20 2011-12-06 Roche Diagnostics Operations, Inc. Test strip with flared sample receiving chamber
US8679853B2 (en) 2003-06-20 2014-03-25 Roche Diagnostics Operations, Inc. Biosensor with laser-sealed capillary space and method of making
JP4447009B2 (ja) * 2003-06-20 2010-04-07 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト スロットベント開口を有するテストストリップ
KR20070100362A (ko) * 2003-06-20 2007-10-10 에프. 호프만-라 로슈 아게 전기화학 바이오센서에 관한 장치 및 방법
DE10352535A1 (de) * 2003-11-07 2005-06-16 Steag Microparts Gmbh Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit
GB0329220D0 (en) * 2003-12-17 2004-01-21 Inverness Medical Switzerland System
DE102004027422A1 (de) * 2004-06-04 2005-12-29 Boehringer Ingelheim Microparts Gmbh Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen
EP1787129A1 (de) * 2004-08-21 2007-05-23 LG Life Sciences, Ltd. Mikrofluidvorrichtung sowie diagnose- und analysegerät unter verwendung davon
WO2006031095A1 (en) * 2004-09-13 2006-03-23 Leja Holding B.V. Capillary-loading slide and method of microscopic research with correction of the serge silberberg effect
WO2006116361A2 (en) * 2005-04-25 2006-11-02 Placor Inc. Methods and devices for monitoring platelet function
DE102005048236A1 (de) * 2005-10-07 2007-04-12 Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg Vorrichtung und Verfahren zur Bestimmung der Volumenanteile der Phasen in einer Suspension
JP2007309741A (ja) * 2006-05-17 2007-11-29 Olympus Corp 血液分離方法および血液分離装置
DE102006025477B4 (de) * 2006-05-30 2009-01-15 Ekf - Diagnostic Gmbh Küvette und Verfahren zu ihrer Herstellung
WO2008070324A2 (en) * 2006-10-25 2008-06-12 Placor, Inc. Methods and devices for monitoring platelet function
KR100897524B1 (ko) 2006-12-04 2009-05-15 한국전자통신연구원 혈장 분리용 마이크로 필터 소자
JP5309312B2 (ja) * 2007-11-01 2013-10-09 Ｊｆｅテクノス株式会社 マイクロチップ、マイクロチップデバイス及びマイクロチップを用いた蒸発操作方法
US8470259B2 (en) 2008-03-07 2013-06-25 Advanced Microdevices Pvt Ltd Method and device for particle removal and droplet preparation for qualitative and quantitative bioanalysis
JP5438351B2 (ja) * 2009-03-30 2014-03-12 Ｊｆｅテクノス株式会社 マイクロチップを用いたｐｅｔ用標識化合物の調剤方法及び装置
SG184592A1 (en) * 2011-03-18 2012-10-30 Univ Singapore Isolating target cells from a biological fluid
JP5490492B2 (ja) * 2009-10-30 2014-05-14 学校法人立命館 血漿分離器及び血液分析装置
EP2375249B1 (de) 2010-04-09 2019-12-25 F. Hoffmann-La Roche AG Vorrichtungen und Verfahren zum Trennen von Plasma aus einer Blutprobe
ES2715828T3 (es) * 2010-04-15 2019-06-06 Cytogen Co Ltd Dispositivo microfluídico y métodos para aislar dianas
US20110301049A1 (en) * 2010-06-04 2011-12-08 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluid Flow Contour Control Using Flow Resistance
TWI439689B (zh) 2010-09-23 2014-06-01 Bionime Corp Electrochemical test specimen
RU2477645C1 (ru) * 2011-08-24 2013-03-20 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) Устройство для отделения частиц от жидкости
EP2587248A1 (de) * 2011-10-25 2013-05-01 Koninklijke Philips Electronics N.V. Filtern von Partikeln aus Blut oder anderen Medien
WO2013082273A1 (en) 2011-11-30 2013-06-06 Wellstat Diagnostics, Llc. Filtration module
JP6073072B2 (ja) * 2012-04-27 2017-02-01 株式会社キコーコーポレーション ナノファイバー不織布を用いたろ過装置
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
BR112015002561A2 (pt) * 2012-08-08 2018-05-22 Koninklijke Philips Nv sistema para separação de um analito heterogêneo, e método para separação de um analito heterogêneo.
US9535082B2 (en) 2013-03-13 2017-01-03 Abbott Laboratories Methods and apparatus to agitate a liquid
USD978375S1 (en) 2013-03-13 2023-02-14 Abbott Laboratories Reagent container
USD962471S1 (en) 2013-03-13 2022-08-30 Abbott Laboratories Reagent container
US10058866B2 (en) * 2013-03-13 2018-08-28 Abbott Laboratories Methods and apparatus to mitigate bubble formation in a liquid
KR101727447B1 (ko) 2013-03-15 2017-04-14 에프. 호프만-라 로슈 아게 바이오센서 알고리즘들을 구성하는데 사용된 데이터를 스케일링하는 방법들 뿐만 아니라 이를 통합한 기기들, 장치들 및 시스템들
ES2634896T3 (es) 2013-03-15 2017-09-29 F. Hoffmann-La Roche Ag Métodos anti-error para mediciones electroquímicas de un analito, así como dispositivos, aparatos y sistemas que los incorporan
JP6356707B2 (ja) 2013-03-15 2018-07-11 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 電気化学的測定中に高抗酸化物質レベルを検出してそれから分析物濃度をフェイルセイフする方法並びにそれを組み込んだデバイス、装置、及びシステム
JP6352954B2 (ja) 2013-03-15 2018-07-04 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 電気化学的な分析物測定において回復パルスからの情報を使用する方法およびデバイス、装置とそれらを組み込むシステム
MX2015014478A (es) 2013-04-15 2016-02-05 Becton Dickinson Co Dispositivo de transferencia de fluidos biologicos y sistema de muestreo de fluidos biologicos.
CA3005826C (en) 2013-04-15 2021-11-23 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
ES2726188T3 (es) 2013-04-15 2019-10-02 Becton Dickinson Co Dispositivo de toma de muestra de fluido biológico
WO2014172232A1 (en) 2013-04-15 2014-10-23 Becton, Dickinson And Company Medical device for collection of a biological sample
CA2909367C (en) 2013-04-15 2019-01-08 Becton, Dickinson And Company Biological fluid separation device and biological fluid separation and testing system
MX365006B (es) 2013-04-15 2019-05-20 Becton Dickinson Co Dispositivo de recogida de fluidos biologicos y sistema de separacion y analisis de fluidos biologicos.
JP6240308B2 (ja) 2013-04-15 2017-11-29 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生体液分離装置並びに生体液の分離および検査システム
ES2748062T3 (es) 2013-04-15 2020-03-12 Becton Dickinson Co Dispositivo de transferencia de muestreo de fluido biológico y sistema de separación y ensayo de fluido biológico
MX368793B (es) 2013-04-15 2019-10-16 Becton Dickinson Co Dispositivo de recogida de fluidos biologicos y sistema de separacion y analisis de fluidos biologicos.
ES2663791T3 (es) 2013-04-15 2018-04-17 Becton, Dickinson And Company Dispositivo de transferencia de muestras de sangre
JP6101400B2 (ja) 2013-04-15 2017-03-22 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 血液サンプリング移送デバイスならびに血液分離および検査実施システム
WO2014172243A1 (en) 2013-04-15 2014-10-23 Becton, Dickinson And Company Biological fluid collection device and biological fluid collection and testing system
BR112015026139B1 (pt) 2013-04-15 2022-12-06 Becton, Dickinson And Company Dispositivo de coleta de fluido biológico, dispositivo de separação de fluido biológico e sistema de separação e teste de fluido biológico
ES2662110T3 (es) 2013-04-15 2018-04-05 Becton, Dickinson And Company Dispositivo de transferencia de muestras de fluidos biológicos y sistema de separación y de análisis de fluidos biológicos
US10663379B2 (en) 2015-03-31 2020-05-26 Roche Molecular Systems, Inc. Plasma separation card
MX2018001352A (es) 2015-08-06 2018-05-22 Becton Dickinson Co Dispositivo de recoleccion de fluido biologico y sistema de recoleccion de fluido biologico.
EP3523639B1 (de) 2016-10-05 2024-12-18 F. Hoffmann-La Roche AG Nachweisreagenzien und elektrodenanordnungen für diagnostische multianalyttestelemente sowie verfahren zur verwendung davon
EP3529612B1 (de) 2016-10-24 2024-12-11 F. Hoffmann-La Roche AG Verfahren zur korrektur der unkompensierten widerstände in den leitenden elementen von biosensoren sowie vorrichtungen und systeme
KR101872780B1 (ko) * 2017-01-24 2018-06-29 광주과학기술원 헤링본 타입 유체유도유닛 및 이를 이용한 세포 농축 장치
GB2583106A (en) * 2019-04-16 2020-10-21 Univ Warwick Motile cell sorting device

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5113428B1 (de) * 1970-05-09 1976-04-28
DE2757384A1 (de) * 1976-12-29 1978-07-06 Rosemount Inc Nach dem prinzip der wirbelabloesung arbeitender durchflussmesser
US4233029A (en) 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
US4310399A (en) 1979-07-23 1982-01-12 Eastman Kodak Company Liquid transport device containing means for delaying capillary flow
US4271119A (en) 1979-07-23 1981-06-02 Eastman Kodak Company Capillary transport device having connected transport zones
US4302313A (en) 1979-07-23 1981-11-24 Eastman Kodak Company Electrode-containing device with capillary transport between electrodes
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4473457A (en) 1982-03-29 1984-09-25 Eastman Kodak Company Liquid transport device providing diversion of capillary flow into a non-vented second zone
US4439526A (en) 1982-07-26 1984-03-27 Eastman Kodak Company Clustered ingress apertures for capillary transport devices and method of use
US4549952A (en) 1982-11-22 1985-10-29 Eastman Kodak Company Capillary transport device having means for increasing the viscosity of the transported liquid
US4618476A (en) 1984-02-10 1986-10-21 Eastman Kodak Company Capillary transport device having speed and meniscus control means
US5144139A (en) 1985-08-05 1992-09-01 Biotrack, Inc. Capillary flow device
US5204525A (en) 1985-08-05 1993-04-20 Biotrack Capillary flow device
US5004923A (en) 1985-08-05 1991-04-02 Biotrack, Inc. Capillary flow device
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US5140161A (en) 1985-08-05 1992-08-18 Biotrack Capillary flow device
US4948961A (en) 1985-08-05 1990-08-14 Biotrack, Inc. Capillary flow device
US5164598A (en) 1985-08-05 1992-11-17 Biotrack Capillary flow device
US4756884A (en) * 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US5135719A (en) 1986-10-29 1992-08-04 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US4753776A (en) 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US4849340A (en) 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
DE3851458T2 (de) * 1987-04-08 1995-02-09 Hitachi Ltd Vorrichtung mit einer scheideförmigen Durchflusszelle.
GB8709882D0 (en) 1987-04-27 1987-06-03 Genetics Int Inc Membrane configurations
US5051237A (en) * 1988-06-23 1991-09-24 P B Diagnostic Systems, Inc. Liquid transport system
US5208147A (en) * 1988-07-21 1993-05-04 Radiometer A/S Means for measuring a characteristic in a sample fluid
US4957582A (en) 1989-03-16 1990-09-18 Eastman Kodak Company Capillary transport zone coated with adhesive
EP0388782A1 (de) 1989-03-20 1990-09-26 Quantai Biotronics Inc. Verfahren zum Nachweis von Analyten
US5039617A (en) 1989-04-20 1991-08-13 Biotrack, Inc. Capillary flow device and method for measuring activated partial thromboplastin time
US5135716A (en) 1989-07-12 1992-08-04 Kingston Diagnostics, L.P. Direct measurement of HDL cholesterol via dry chemistry strips
CA2020029A1 (en) 1989-07-12 1991-01-13 Yatin B. Thakore Device and method for separation of plasma from blood and determination of blood analytes
CA2019865A1 (en) 1989-07-12 1991-01-12 Yatin B. Thakore Device and method for separation of fluid components for component testing
AU640162B2 (en) 1989-08-28 1993-08-19 Lifescan, Inc. Blood separation and analyte detection techniques
US5620863A (en) 1989-08-28 1997-04-15 Lifescan, Inc. Blood glucose strip having reduced side reactions
US5230866A (en) 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US5540888A (en) 1991-11-11 1996-07-30 British Technology Group Limited Liquid transfer assay devices
WO1993022058A1 (en) * 1992-05-01 1993-11-11 Trustees Of The University Of Pennsylvania Polynucleotide amplification analysis using a microfabricated device
US6019944A (en) 1992-05-21 2000-02-01 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6156270A (en) * 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5458852A (en) * 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
GB9309797D0 (en) 1993-05-12 1993-06-23 Medisense Inc Electrochemical sensors
US6113855A (en) * 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
US5798031A (en) 1997-05-12 1998-08-25 Bayer Corporation Electrochemical biosensor
DE19753849A1 (de) 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Analytisches Testelement mit sich verjüngendem Kapillarkanal
GB9907665D0 (en) 1999-04-01 1999-05-26 Cambridge Molecular Tech Fluidic devices

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DE60019228D1 (de) 2005-05-12
CA2324131A1 (en) 2001-04-28
US6319719B1 (en) 2001-11-20
EP1096254B1 (de) 2005-04-06
EP1096254A3 (de) 2001-06-13
JP4520620B2 (ja) 2010-08-11
DE60019228T2 (de) 2006-05-11
JP2001183363A (ja) 2001-07-06
CA2324131C (en) 2007-07-31
EP1096254A2 (de) 2001-05-02

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