ATE293454T1 - Thrombopoietinzusammensetzungen - Google Patents

Thrombopoietinzusammensetzungen

Info

Publication number
ATE293454T1
ATE293454T1 AT96914753T AT96914753T ATE293454T1 AT E293454 T1 ATE293454 T1 AT E293454T1 AT 96914753 T AT96914753 T AT 96914753T AT 96914753 T AT96914753 T AT 96914753T AT E293454 T1 ATE293454 T1 AT E293454T1
Authority
AT
Austria
Prior art keywords
thrombopoietin
compositions
methods
physiologically acceptable
adsorption
Prior art date
Application number
AT96914753T
Other languages
English (en)
Inventor
Richard I Senderoff
Kathleen M Kontor
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of ATE293454T1 publication Critical patent/ATE293454T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/196—Thrombopoietin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Treatment Of Steel In Its Molten State (AREA)
AT96914753T 1995-06-07 1996-05-22 Thrombopoietinzusammensetzungen ATE293454T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/486,451 US6790439B1 (en) 1995-06-07 1995-06-07 Thrombopoietin compositions
PCT/US1996/007463 WO1996040217A1 (en) 1995-06-07 1996-05-22 Thrombopoietin compositions

Publications (1)

Publication Number Publication Date
ATE293454T1 true ATE293454T1 (de) 2005-05-15

Family

ID=23931938

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96914753T ATE293454T1 (de) 1995-06-07 1996-05-22 Thrombopoietinzusammensetzungen

Country Status (11)

Country Link
US (1) US6790439B1 (de)
EP (1) EP0831886B1 (de)
JP (2) JP3479082B2 (de)
KR (1) KR100265222B1 (de)
AT (1) ATE293454T1 (de)
AU (1) AU696944B2 (de)
CA (1) CA2223446A1 (de)
DE (1) DE69634633T2 (de)
NZ (2) NZ505602A (de)
TW (1) TW443934B (de)
WO (1) WO1996040217A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
JP2001501619A (ja) * 1996-10-04 2001-02-06 アムジェン インコーポレーテッド ｍｐｌリガンドを含有する医薬組成物
CA2589889C (en) * 2004-12-15 2013-07-30 Amgen Inc. Therapeutic formulations of keratinocyte growth factor
US7879318B2 (en) 2006-01-23 2011-02-01 Mcw Research Foundation, Inc. Method of reducing the effects of ischemia by administration of a thrombopoietin receptor ligand
CN101610782A (zh) * 2007-01-10 2009-12-23 爱迪生药物公司 使用具有促红细胞生成素或血小板生成素活性的化合物治疗呼吸链紊乱
JP5401446B2 (ja) * 2007-04-26 2014-01-29 バイエル ヘルスケア エルエルシー 凍結貯蔵を目的とした、組み換えタンパク質溶液の安定化
CA2724841A1 (en) * 2008-05-22 2009-11-26 Edison Pharmaceuticals, Inc. Treatment of mitochondrial diseases with an erythropoietin mimetic

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3325223A1 (de) 1983-07-13 1985-01-24 Hoechst Ag, 6230 Frankfurt Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung
US5096885A (en) 1988-04-15 1992-03-17 Genentech, Inc. Human growth hormone formulation
JPH02268681A (ja) * 1989-04-07 1990-11-02 Green Cross Corp:The ウロキナーゼ前駆体の安定化方法及び乾燥製剤
US5344644A (en) * 1991-08-01 1994-09-06 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release
MD1699F2 (ro) 1992-07-31 2001-07-31 Genentech, Inc. Compoziţie apoasă a hormonului somatotrop uman şi procedeu de prevenire a denaturării ei
US5358708A (en) * 1993-01-29 1994-10-25 Schering Corporation Stabilization of protein formulations
NZ260909A (en) * 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
US5580856A (en) * 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof

Also Published As

Publication number Publication date
AU696944B2 (en) 1998-09-24
EP0831886B1 (de) 2005-04-20
KR100265222B1 (ko) 2000-09-15
US6790439B1 (en) 2004-09-14
JP3479082B2 (ja) 2003-12-15
EP0831886A1 (de) 1998-04-01
TW443934B (en) 2001-07-01
CA2223446A1 (en) 1996-12-19
NZ505602A (en) 2001-11-30
KR19990022542A (ko) 1999-03-25
DE69634633D1 (en) 2005-05-25
JP2000198745A (ja) 2000-07-18
WO1996040217A1 (en) 1996-12-19
JPH10510841A (ja) 1998-10-20
NZ308395A (en) 2000-08-25
DE69634633T2 (de) 2006-05-18
AU5802396A (en) 1996-12-30

Similar Documents

Publication Publication Date Title
IL140710A0 (en) Pulmonary delivery of active agents
ATE120951T1 (de) Mundwasser.
DE60311830D1 (de) Wasserlöslicher behälter
BG103740A (en) Phytostyrene composition for the prevention of the alzheimer's disease
AR000649A1 (es) Composiciones líquidas de enzimas procedimientos para preparar una composición detergente y una composición detergente
ES2071924T5 (es) Composiciones detergentes.
CY1112139T1 (el) Μια φαρμακευτικη συνθεση περιλαμβανουσα κρυσταλλικη ριτοναβιρη μορφη ιι και ενα παρασκευασμα εξ αυτης
FI103754B1 (fi) Tuoliin liittyvä laite
ZA938936B (en) New taxoid-based compositions
AU1565300A (en) Anti-germinating method for tubers and bulbs using eugenol and/or isoeugenol
DE69840603D1 (de) Alpha-ketoamidhaltige multikatalytische protease inhibitoren
EP0831871A4 (de) Relaxinartiger faktor und damit zusammenhängende verfahren und verwendungen
ATE262277T1 (de) Wasser-dispergierbare agrochemische zusammensetzungen
ES2169505T3 (es) Pasta de dientes con alto contenido de humedad.
DE50014503D1 (de) Zahnpflegemittel enthaltend Perlit
DE69634633D1 (en) Thrombopoietinzusammensetzungen
ATE213937T1 (de) Spezielle halofantrinhaltige zusammensetzungen
CA2197544A1 (en) Fungicidal composition comprising metalaxyl and fludioxonil
IT1243193B (it) Composizioni farmaceutiche orali a base di melatonina
WO2001072271A3 (en) Stable alkaline hair bleaching and coloring compositions and method for use thereof
ES2144744T3 (es) Composicion anti-espuma.
DE60013889D1 (de) Waschmittelzusammensetzungen
BR0011261B1 (pt) composiÇço oral compreendendo perlita, e, uso de perlita.
BG103306A (en) Liquid allendronate compositions
MX9709388A (es) Composiciones de trombopoyetina.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0831886

Country of ref document: EP

REN Ceased due to non-payment of the annual fee