ATE294185T1 - Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediäre zur herstellung der derivate - Google Patents

Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediäre zur herstellung der derivate

Info

Publication number
ATE294185T1
ATE294185T1 AT02028152T AT02028152T ATE294185T1 AT E294185 T1 ATE294185 T1 AT E294185T1 AT 02028152 T AT02028152 T AT 02028152T AT 02028152 T AT02028152 T AT 02028152T AT E294185 T1 ATE294185 T1 AT E294185T1
Authority
AT
Austria
Prior art keywords
derivatives
salts
production
intermediaries
pharmaceutical compositions
Prior art date
Application number
AT02028152T
Other languages
English (en)
Inventor
Hiroyuki Egawa
Yousuke Furuta
Jun Sugita
Sayuri Uehara
Shoichi Hamamoto
Kenji Yonezawa
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Application granted granted Critical
Publication of ATE294185T1 publication Critical patent/ATE294185T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT02028152T 2000-02-16 2001-02-14 Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediäre zur herstellung der derivate ATE294185T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000037486 2000-02-16
JP2000040439 2000-02-18
JP2000090071 2000-03-29

Publications (1)

Publication Number Publication Date
ATE294185T1 true ATE294185T1 (de) 2005-05-15

Family

ID=27342371

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02028152T ATE294185T1 (de) 2000-02-16 2001-02-14 Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediäre zur herstellung der derivate
AT01904434T ATE288443T1 (de) 2000-02-16 2001-02-14 Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediate zu beider herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01904434T ATE288443T1 (de) 2000-02-16 2001-02-14 Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediate zu beider herstellung

Country Status (15)

Country Link
US (1) US6800629B2 (de)
EP (2) EP1295890B1 (de)
JP (2) JP4379767B2 (de)
KR (3) KR100589935B1 (de)
CN (1) CN1239511C (de)
AT (2) ATE294185T1 (de)
AU (1) AU2001232287A1 (de)
BR (2) BRPI0108374B8 (de)
CA (1) CA2398620C (de)
DE (2) DE60108724T2 (de)
DK (1) DK1295890T3 (de)
ES (2) ES2237550T3 (de)
MX (1) MXPA02007890A (de)
PT (2) PT1295890E (de)
WO (1) WO2001060834A1 (de)

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BRPI0515896A (pt) * 2004-09-24 2008-08-12 Idenix Cayman Ltd E Ct Nat De composto ou um sal ou éster farmaceuticamente aceitável do mesmo, método para o tratamento ou profilaxia de um hospedeiro infectado com uma infecção por flavivìrus, pestivìrus ou hepacivìrus, e, composição farmacêutica para o tratamento de um hospedeiro infectado com uma infecção por flavivìrus, pestivìrus ou hepacivìrus
WO2007070947A1 (en) * 2005-12-22 2007-06-28 Alchemia Ltd Antibacterial agents
EP2022786B1 (de) * 2006-05-31 2011-10-26 Toyama Chemical Co., Ltd. Mittel gegen das maul- und- klauenseuche-virus für tiere, die zur familie der suidae oder schafe gehören, und verfahren zur prävention oder behandlung von maul- und- klauenseuche bei zur familie der suidae oder schafe gehörenden tieren
DK2192117T3 (da) 2007-09-27 2014-06-30 Toyama Chemical Co Ltd Organisk aminsalt af 6-fluor-3-hydroxy-2-pyrazincarbonitril og fremgangsmåde til fremstilling deraf
JP5364327B2 (ja) * 2008-09-26 2013-12-11 富士フイルム株式会社 ハロピラジンカルボキサミド化合物の製造方法
KR101297541B1 (ko) 2009-01-28 2013-08-14 닛뽕소다 가부시키가이샤 디클로로피라진 유도체의 제조 방법
JP5559604B2 (ja) * 2009-05-27 2014-07-23 富山化学工業株式会社 ３，６−ジクロロ−２−ピラジンカルボニトリルの製造法
SG189161A1 (en) 2010-09-30 2013-05-31 Toyama Chemical Co Ltd Sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
MY161757A (en) 2010-09-30 2017-05-15 Toyama Chemical Co Ltd Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
CN103347884B (zh) * 2010-11-12 2015-12-02 富士胶片株式会社 吡嗪并[2,3-d]异*唑衍生物
WO2013004141A1 (zh) * 2011-07-01 2013-01-10 中国人民解放军军事医学科学院毒物药物研究所 3－烷氧基取代－2－吡嗪甲酰氨类化合物及其用途
CN102846617B (zh) * 2011-07-01 2016-01-13 中国人民解放军军事医学科学院毒物药物研究所 3－(丁基氧基)－2－吡嗪甲酰氨的制备方法和用途
CN105732748B (zh) * 2014-12-12 2019-01-01 浙江医药股份有限公司新昌制药厂 一种核苷酸类似物及其制备方法、以及含有核苷酸类似物的药物组合物及其应用
WO2016172205A1 (en) * 2015-04-20 2016-10-27 Emory University Managing ebola viral infections
LT3309149T (lt) 2015-06-09 2021-06-25 Fujifilm Toyama Chemical Co., Ltd. 6-brom-3-hidroksi-2-pirazinkarboksamido kristalas ir jo gamybos būdas
CN104961691A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(2-氟苯氧基)吡嗪-2-羧酸的制备方法
CN105017166A (zh) * 2015-07-11 2015-11-04 长沙深橙生物科技有限公司 3-(3-溴苯氧基)吡嗪-2-羧酸的制备方法
CN105037281A (zh) * 2015-07-11 2015-11-11 长沙深橙生物科技有限公司 3-(3-氟苯氧基)吡嗪-2-羧酸的制备方法
CN104961690A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(4-氟苯氧基)吡嗪-2-羧酸的制备方法
CN107641106A (zh) * 2016-07-22 2018-01-30 大连鸿凯化工科技发展有限公司 法匹拉韦中间体以及法匹拉韦的合成方法
CN110678473A (zh) * 2017-04-25 2020-01-10 大原药品工业株式会社 核苷类抗癌药或抗病毒药的5’位二苄基单磷酸酯衍生物
CN111265528A (zh) 2020-01-21 2020-06-12 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
CN113248450B (zh) * 2020-02-07 2024-04-12 北京四环制药有限公司 一种法匹拉韦的制备方法
CN113735784A (zh) * 2020-05-28 2021-12-03 南京桦冠生物技术有限公司 6-氟-3-羟基吡嗪-2-甲酰胺的制备方法
WO2021255681A1 (en) * 2020-06-17 2021-12-23 Hikal Limited A simple process for the preparation of favipiravir and its intermediates thereof
CN111704582B (zh) * 2020-06-23 2021-06-11 杭州煌森生物科技有限公司 一种法匹拉韦及其衍生物的制备方法
WO2022009036A1 (en) * 2020-07-06 2022-01-13 Optimus Drugs (P) Ltd Synthesis of favipiravir
CN114656412A (zh) * 2020-12-22 2022-06-24 山东特珐曼药业有限公司 一种法匹拉韦的合成方法
CN112552245B (zh) * 2020-12-29 2022-08-02 苏州正济药业有限公司 法匹拉韦的合成方法
CN112851589B (zh) * 2021-01-25 2022-10-11 山东邹平大展新材料有限公司 一种法匹拉韦中间体6-溴-3-羟基吡嗪-2-甲酰胺的制备方法
CN118488831A (zh) 2021-12-23 2024-08-13 苏宾特罗有限公司 包含油酸的新抗病毒组合物
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法
CN120607562B (zh) * 2025-08-12 2025-10-10 南京艾镁特生物科技有限公司 一种苯甲酰基修饰核苷的合成方法

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EP0394464A4 (en) * 1988-08-22 1991-04-03 Idemitsu Kosan Company Limited Oxirane derivatives and herbicides containing same as active ingredients
EP0532916B1 (de) * 1991-08-17 1997-11-05 Hoechst Aktiengesellschaft 2-Fluorpyrazine, Verfahren zu ihrer Herstellung und ihre Verwendung in flüssigkristallinen Mischungen
TR200100574T2 (tr) * 1998-08-20 2001-07-23 Toyama Chemical Co., Ltd. Nitrojenöz heteroksiklik karboksamid türevlerini içeren antiviral ajanlar

Also Published As

Publication number Publication date
BRPI0116967B1 (pt) 2018-05-22
BR0108374A (pt) 2003-03-18
CA2398620A1 (en) 2001-08-23
EP1256588B1 (de) 2005-02-02
KR100589935B1 (ko) 2006-06-15
US6800629B2 (en) 2004-10-05
ATE288443T1 (de) 2005-02-15
KR20030034120A (ko) 2003-05-01
BRPI0108374B1 (pt) 2017-10-10
DE60110415T2 (de) 2005-09-29
EP1295890A1 (de) 2003-03-26
KR20030048108A (ko) 2003-06-18
WO2001060834A1 (en) 2001-08-23
BRPI0116967A2 (pt) 2009-07-14
DE60108724D1 (de) 2005-03-10
BRPI0108374B8 (pt) 2021-05-25
BRPI0116967B8 (pt) 2021-05-25
ES2240645T3 (es) 2005-10-16
CN1239511C (zh) 2006-02-01
US20030130213A1 (en) 2003-07-10
PT1295890E (pt) 2005-06-30
JP2009161553A (ja) 2009-07-23
DK1295890T3 (da) 2005-05-17
MXPA02007890A (es) 2002-10-31
PT1256588E (pt) 2005-05-31
JP5038345B2 (ja) 2012-10-03
KR100604955B1 (ko) 2006-07-26
CN1418220A (zh) 2003-05-14
AU2001232287A1 (en) 2001-08-27
CA2398620C (en) 2009-06-23
EP1256588A4 (de) 2003-03-26
EP1256588A1 (de) 2002-11-13
KR20030032918A (ko) 2003-04-26
ES2237550T3 (es) 2005-08-01
DE60108724T2 (de) 2005-06-23
EP1295890B1 (de) 2005-04-27
JP4379767B2 (ja) 2009-12-09
DE60110415D1 (de) 2005-06-02

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