ATE294391T1 - Methode mit hohem durchsatz - Google Patents

Methode mit hohem durchsatz

Info

Publication number
ATE294391T1
ATE294391T1 AT98930081T AT98930081T ATE294391T1 AT E294391 T1 ATE294391 T1 AT E294391T1 AT 98930081 T AT98930081 T AT 98930081T AT 98930081 T AT98930081 T AT 98930081T AT E294391 T1 ATE294391 T1 AT E294391T1
Authority
AT
Austria
Prior art keywords
bound
high throughput
solid supports
inhibition
assay
Prior art date
Application number
AT98930081T
Other languages
English (en)
Inventor
Jonathan J Burbaum
Thomas D Y Chung
Gregory L Kirk
James Inglese
Daniel Chelsky
Original Assignee
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25351362&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE294391(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacopeia Inc filed Critical Pharmacopeia Inc
Application granted granted Critical
Publication of ATE294391T1 publication Critical patent/ATE294391T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869Interleukin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Steroid Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT98930081T 1997-06-03 1998-06-01 Methode mit hohem durchsatz ATE294391T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/868,280 US5876946A (en) 1997-06-03 1997-06-03 High-throughput assay
PCT/US1998/011749 WO1998055866A1 (en) 1997-06-03 1998-06-01 High-throughput assay

Publications (1)

Publication Number Publication Date
ATE294391T1 true ATE294391T1 (de) 2005-05-15

Family

ID=25351362

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98930081T ATE294391T1 (de) 1997-06-03 1998-06-01 Methode mit hohem durchsatz

Country Status (8)

Country Link
US (2) US5876946A (de)
EP (1) EP1002233B1 (de)
JP (1) JP4007459B2 (de)
AT (1) ATE294391T1 (de)
AU (1) AU741376B2 (de)
CA (1) CA2291621A1 (de)
DE (1) DE69829973T2 (de)
WO (1) WO1998055866A1 (de)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
EP0912757A4 (de) * 1996-05-14 2003-03-05 Univ Manitoba Bestimmung biologisch aktiver substanzen mit hilfe von festphasen
US6171780B1 (en) 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US6517781B1 (en) * 1997-06-02 2003-02-11 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
EP1025217B1 (de) * 1997-10-24 2006-10-04 Invitrogen Corporation Rekombinatorisches klonieren unter verwendung von nukleinsaüren mit rekombinationsstellen
US6242262B1 (en) 1997-10-24 2001-06-05 The University Of North Carolina At Chapel Hill Method and apparatus for screening catalyst libraries
US7321023B2 (en) * 1997-11-07 2008-01-22 Incyte Corporation SP16 protein
US6790652B1 (en) * 1998-01-08 2004-09-14 Bioimage A/S Method and apparatus for high density format screening for bioactive molecules
US6861035B2 (en) 1998-02-24 2005-03-01 Aurora Discovery, Inc. Multi-well platforms, caddies, lids and combinations thereof
US20030036855A1 (en) * 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US6274088B1 (en) * 1998-04-06 2001-08-14 Pharmacopeia, Inc. Methods and apparatus for high throughput plate to plate or plate to membrane transfer
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6541669B1 (en) * 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
US6190667B1 (en) 1998-06-30 2001-02-20 Institut Pasteur Methods of inhibiting Helicobacter pylori
WO2000005357A1 (en) * 1998-07-22 2000-02-03 Japan As Represented By Director-General Of Agency Of Industrial Science And Technology Labeled complex, process for producing the same and process for utilizing the same
AU1344400A (en) * 1998-11-18 2000-06-05 Incyte Pharmaceuticals, Inc. Inflammation-associated genes
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US20040185432A1 (en) * 1999-01-08 2004-09-23 Bioimage A/S Method and apparatus for high density format screening for bioactive molecules
JP3649319B2 (ja) * 1999-01-25 2005-05-18 東洋紡績株式会社 レセプター結合能の測定方法および測定用試薬
DE19903576C2 (de) 1999-01-29 2001-02-22 Bodenseewerk Perkin Elmer Co Quantitative Bestimmung von Analyten in einem heterogenen System
US20030096433A1 (en) * 1999-03-03 2003-05-22 Evotec Analytical Systems Gmbh Homogeneous fluorescence assay
US7105315B2 (en) * 1999-06-16 2006-09-12 Incyte Genomics, Inc. Transmembrane protein differentially expressed in cancer
US7932213B2 (en) * 1999-05-11 2011-04-26 President And Fellows Of Harvard College Small molecule printing
US6824987B1 (en) 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
US6632636B1 (en) 1999-06-18 2003-10-14 Elitra Pharmaceuticals Inc. Nucleic acids encoding 3-ketoacyl-ACP reductase from Moraxella catarrahalis
US6140500A (en) * 1999-09-03 2000-10-31 Pe Corporation Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use
US20050069956A1 (en) * 1999-11-22 2005-03-31 Michael Seul Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
WO2001075443A2 (en) * 2000-03-31 2001-10-11 Glaxo Group Limited Method and reagents for investigating functional molecular interactions
CA2405332A1 (en) * 2000-04-03 2001-10-11 Bristol-Myers Squibb Company Fluorescence assay for gamma-secretase activity and inhibitors
DE60117556T2 (de) 2000-06-21 2006-11-02 Bioarray Solutions Ltd. Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
KR100545945B1 (ko) * 2000-07-03 2006-01-25 갈라 디자인, 인크. 발현 벡터
AU2001271614B2 (en) * 2000-07-03 2007-05-31 Catalent Pharma Solutions, Llc Host cells containing multiple integrating vectors
US20040235173A1 (en) * 2000-07-03 2004-11-25 Gala Design, Inc. Production of host cells containing multiple integrating vectors by serial transduction
US20030224415A1 (en) * 2001-06-29 2003-12-04 Gala Design, Inc. Selection free growth of host cells containing multiple integrating vectors
US20020146741A1 (en) * 2000-07-28 2002-10-10 Halbleib Cale M. Processes for receptpor screening
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
DE10045808C2 (de) * 2000-09-07 2002-08-08 Imb Inst Fuer Molekulare Biote Verfahren zur Detektion der Aktivität von Wirkstoffen
EP1343973B2 (de) 2000-11-16 2020-09-16 California Institute Of Technology Vorrichtung und verfahren zur durchführung von assays und screening mit hohem durchsatz
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
WO2002049634A2 (en) * 2000-12-20 2002-06-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dissociated glucocorticoid receptor antagonists for the treatment of clucocorticoid associated side-effect
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
US20020123068A1 (en) * 2001-01-31 2002-09-05 Dwyer Brian P. Water-soluble, fluorescent, & electrophoretically mobile peptidic substrates for enzymatic reactions and methods for their use in high-throughput screening assays
EP1239284A1 (de) * 2001-03-08 2002-09-11 The Technology Partnership Public Limited Company Nicht-trennender Testverfahren und System mit opaken Partikeln
EP1384022A4 (de) 2001-04-06 2004-08-04 California Inst Of Techn Nukleinsäure-amplifikation verwendende mikrofluidvorrichtungen
WO2002082082A2 (en) * 2001-04-09 2002-10-17 Boehringer Ingelheim Pharmaceuticals, Inc. Fluorescence polarization assay
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
CA2497740C (en) 2001-10-15 2011-06-21 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by probe elongation-mediated detection
US7442512B2 (en) * 2001-11-30 2008-10-28 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
US7871619B2 (en) * 2001-11-30 2011-01-18 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US7413866B2 (en) * 2001-11-30 2008-08-19 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
US7253007B2 (en) * 2001-11-30 2007-08-07 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
US20040038304A1 (en) * 2002-03-28 2004-02-26 Gala Design, Inc. Antibody libraries
US7384738B2 (en) * 2002-03-28 2008-06-10 Bremel Robert D Retrovirus-based genomic screening
AU2003224817B2 (en) * 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
EP3006043B1 (de) 2002-04-04 2019-05-29 Zoetis Belgium S.A. Immunostimulatorische g,u-haltige oligoribonucleotide
WO2003095989A1 (en) 2002-05-10 2003-11-20 Applera Corporation Imaging system for reduction of interstitial image regions and its related method
US20030228621A1 (en) * 2002-05-24 2003-12-11 Yong Qin Common ligand universal enzyme assay and compositions for use therein
US20060086309A1 (en) * 2002-06-24 2006-04-27 Fluiding Corporation Recirculating fluidic network and methods for using the same
EP1539993A4 (de) * 2002-08-01 2006-11-22 Merck & Co Inc Neuartiges verfahren zur anzucht, abbildung und auszahlung von mikrobenkolonien für serologische oder screening-assays
WO2004027378A2 (en) 2002-09-20 2004-04-01 Promega Corporation Luminescence-based methods and probes for measuring cytochrome p450 activity
JP2006501056A (ja) 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
KR101061352B1 (ko) * 2002-12-20 2011-08-31 케모센트릭스 인간 종양-발현된 ccxckr2의 저해물질
US20040185445A1 (en) * 2003-03-19 2004-09-23 Ye Fang Universal readout for target identification using biological microarrays
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
CA2539824C (en) 2003-09-22 2015-02-03 Xinwen Wang Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US20050142608A1 (en) * 2003-09-22 2005-06-30 Yokogawa Electric Corporation Screening method and device, and new drug screening method and device
CA2544041C (en) 2003-10-28 2015-12-08 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
CA2544202C (en) 2003-10-29 2012-07-24 Bioarray Solutions Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US20100247540A1 (en) * 2003-10-30 2010-09-30 Chemocentryx, Inc. Methods and Compositions For Modulating Angiogenesis
WO2005054438A2 (en) * 2003-12-01 2005-06-16 Invitrogen Corporation Nucleic acid molecules containing recombination sites and methods of using the same
US20050221429A1 (en) * 2004-01-16 2005-10-06 Cardinal Health Pts, Llc Host cells containing multiple integrating vectors comprising an amplifiable marker
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20090305321A1 (en) * 2005-03-23 2009-12-10 Astrazeneca Ab Assays for Allosteric Modulators of G-Protein Coupled Receptors (GPCRs)
US20060246576A1 (en) * 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
ES2434852T3 (es) * 2005-04-21 2013-12-17 Chemocentryx, Inc. Anticuerpos que se unen a CCX-CKR2
AU2006241149A1 (en) * 2005-04-26 2006-11-02 Coley Pharmaceutical Gmbh Modified oligoribonucleotide analogs with enhanced immunostimulatory activity
EP2778234B1 (de) 2005-05-31 2017-09-27 Promega Corporation Luminogene und fluorogene verbindungen und verfahren für den nachweis von molekülen oder leiden
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US7718131B2 (en) * 2005-07-06 2010-05-18 Genetix Limited Methods and apparatus for imaging and processing of samples in biological sample containers
WO2007044888A2 (en) * 2005-10-11 2007-04-19 The Johns Hopkins Univerisity Microfluidic device and method for high-throughput cellular gradient and dose response studies
US8822206B2 (en) * 2005-10-11 2014-09-02 The Johns Hopkins University Device for high-throughput stimulation, immunostaining, and visualization of single cells
CN101300489A (zh) * 2005-11-03 2008-11-05 红点生物公司 Trpm5离子通道的高通量筛选实验
SG176453A1 (en) * 2006-01-03 2011-12-29 Harvard College Small molecule printing
US20090170091A1 (en) * 2006-01-17 2009-07-02 Kenneth Giuliano Method For Predicting Biological Systems Responses
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
EP2027465A2 (de) 2006-05-17 2009-02-25 Cellumen, Inc. Verfahren für automatisierte gewebeanalyse
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
WO2008058004A2 (en) * 2006-11-02 2008-05-15 Winnik Mitchell A Particles containing detectable elemental code
WO2008060483A2 (en) * 2006-11-10 2008-05-22 Cellumen, Inc. Protein-protein interaction biosensors and methods of use thereof
JP5580598B2 (ja) * 2007-11-15 2014-08-27 エーザイ・アール・アンド・ディー・マネジメント株式会社 γ−セクレターゼの新規基質EphA7を利用したスクリーニング方法
US7892769B2 (en) * 2007-11-30 2011-02-22 Eisai R&D Management Co., Ltd. Processing of EphA4 polypeptide by γ-secretase activity
US8815214B2 (en) * 2008-01-18 2014-08-26 Visen Medical, Inc. Fluorescent imaging agents
JP5597200B2 (ja) * 2008-08-18 2014-10-01 プロメガ コーポレイション ルミネッセンスを生じる化合物およびチトクロムp4503a酵素を検出するための方法
US20120322085A1 (en) 2009-11-05 2012-12-20 Osaka University Therapeutic agent for autoimmune diseases or allergy, and method for screening for the therapeutic agent
JP6059017B2 (ja) 2010-12-17 2017-01-11 エーザイ・アール・アンド・ディー・マネジメント株式会社 ゼラチナーゼによるEphA4の切断反応を指標としたスクリーニング方法
US10018631B2 (en) 2011-03-17 2018-07-10 Cernostics, Inc. Systems and compositions for diagnosing Barrett's esophagus and methods of using the same
JP5961608B2 (ja) 2011-04-25 2016-08-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 EphA4細胞外ドメインの測定による認知機能障害を伴う神経系疾患の検出方法
US9790537B2 (en) 2014-01-29 2017-10-17 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
DE102017114537A1 (de) * 2017-06-29 2019-01-03 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und optischer Sensor
AR119303A1 (es) 2019-07-01 2021-12-09 Eisai R&D Man Co Ltd Anticuerpo anti-epha4 humano
MX2022004566A (es) * 2019-10-17 2022-07-21 Univ Copenhagen Agonista del receptor de taquiquinina 2 (tacr2).

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
US5032720A (en) * 1988-04-21 1991-07-16 White John G Confocal imaging system
EP1245987B1 (de) * 1988-07-13 2008-01-23 Optiscan Pty Ltd Konfokales Rastermikroskop
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
GB9015793D0 (en) * 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5260578A (en) * 1991-04-10 1993-11-09 Mayo Foundation For Medical Education And Research Confocal imaging system for visible and ultraviolet light
US5210636A (en) * 1991-07-19 1993-05-11 Baer Stephen C Rotational oscillatory optical scanning device
US5351152A (en) * 1991-07-23 1994-09-27 The Board Of Governers Of Wayne State University Direct-view stereoscopic confocal microscope
US5162941A (en) * 1991-07-23 1992-11-10 The Board Of Governors Of Wayne State University Confocal microscope
US5114477A (en) * 1991-09-03 1992-05-19 Xerox Corporation Liquid ink compositions
US5323079A (en) * 1992-04-15 1994-06-21 Westinghouse Electric Corp. Half-coil configuration for stator
JP3474589B2 (ja) * 1992-04-17 2003-12-08 株式会社デンソー 相補型misトランジスタ装置
US5313079A (en) * 1992-06-22 1994-05-17 Vlsi Technology, Inc. Gate array bases with flexible routing
US5355215A (en) * 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
FI953569A7 (fi) * 1993-01-29 1995-09-25 Neurospheres Ltd Neuraalisten kantasolujen geneettinen modifikaatio
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
US5547849A (en) * 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
WO1996010090A1 (en) * 1994-09-29 1996-04-04 Merck & Co., Inc. A high capacity screen for immunoregulants
DE4435727A1 (de) * 1994-10-06 1996-04-11 Boehringer Mannheim Gmbh Bindematrix und Analyseelement zur Simultananalyse verschiedener Analyte
DE19631395A1 (de) * 1996-08-02 1998-02-05 Basf Ag Verfahren zum Wirkstoff-Screening
CA2276462C (en) * 1996-12-31 2007-06-12 High Throughput Genomics, Inc. Multiplexed molecular analysis system apparatus and method
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
GB9718477D0 (en) * 1997-09-02 1997-11-05 Photonic Research Systems Limi Luminescence detection
KR100560588B1 (ko) * 1998-03-16 2006-03-16 에머샘 바이오사이언시즈 코프 공초점 마이크로스코피 영상 시스템

Also Published As

Publication number Publication date
JP2002511140A (ja) 2002-04-09
DE69829973D1 (de) 2005-06-02
EP1002233B1 (de) 2005-04-27
CA2291621A1 (en) 1998-12-10
EP1002233A1 (de) 2000-05-24
US5876946A (en) 1999-03-02
JP4007459B2 (ja) 2007-11-14
EP1002233A4 (de) 2002-06-26
DE69829973T2 (de) 2006-03-09
AU7955198A (en) 1998-12-21
US6156520A (en) 2000-12-05
WO1998055866A1 (en) 1998-12-10
AU741376B2 (en) 2001-11-29

Similar Documents

Publication Publication Date Title
ATE294391T1 (de) Methode mit hohem durchsatz
GB9903555D0 (en) Chemical and biological assay method and apparatus
WO2002035260A3 (en) Light detection device
DK1131471T3 (da) Et system til cellebaseret screening
CA2325597A1 (en) Multiparameter facs assays to detect alterations in cellular parameters and to screen small molecule libraries
WO2000050872A3 (en) A system for cell-based screening
WO2000017643A3 (en) A system for cell-based screening
DK1244808T3 (da) Fremgangsmåde til screening af multipel transformerede celler ved anvendelse af bicistronisk ekspression af fluorescerende proteiner
WO2009038668A3 (en) Highly multiplexed confocal detection systems and methods of using same
GR3032843T3 (en) Methods and compositions for detecting binding of ligand pair using non-fluorescent label
DK0529065T3 (da) Receptorbaserede fremgangsmåder til screening for amylinagonister og -antagonister
WO1998010068A3 (en) Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals
DK0983498T3 (da) System for cellebaseret screening
DK0921857T3 (da) Flerbröndsplader med lav baggrund til fluorescensmålinger af biologiske og biokemiske pröver
ATE461450T1 (de) Verwendung von kontrollflächen zur detektion von störproben in einem nachweisverfahren
DK0726322T4 (da) Assay for homocystein
WO2000007017A3 (en) Method of high-throughput screening
WO2001011341A3 (en) A system for cell-based screening
Nakajima et al. Capillary affinity electrophoresis for the screening of post-translational modification of proteins with carbohydrates
ATE426158T1 (de) Mikrofluidisches extraktionsverfahren
McIlvin et al. Online nanoflow two-dimension comprehensive active modulation reversed phase–reversed phase liquid chromatography high-resolution mass spectrometry for metaproteomics of environmental and microbiome samples
WO2000070342A3 (en) Optical system analysis of cells
CA2473708A1 (en) A rapid and sensitive assay for the detection and quantification of coregulators of nucleic acid binding factors
Edwards Immunodiagnostics: a practical approach
WO2002072789A3 (en) Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties