ATE295156T1 - Mehrlagige polyelektrolytkapseln mit gesteuerter und verzögerter freisetzung - Google Patents
Mehrlagige polyelektrolytkapseln mit gesteuerter und verzögerter freisetzungInfo
- Publication number
- ATE295156T1 ATE295156T1 AT01980290T AT01980290T ATE295156T1 AT E295156 T1 ATE295156 T1 AT E295156T1 AT 01980290 T AT01980290 T AT 01980290T AT 01980290 T AT01980290 T AT 01980290T AT E295156 T1 ATE295156 T1 AT E295156T1
- Authority
- AT
- Austria
- Prior art keywords
- polyelectrolyte
- release
- fluorescein
- shell
- layer
- Prior art date
Links
- 229920000867 polyelectrolyte Polymers 0.000 title abstract 7
- 239000002775 capsule Substances 0.000 title abstract 2
- 238000013270 controlled release Methods 0.000 title 1
- 238000013268 sustained release Methods 0.000 title 1
- 239000012730 sustained-release form Substances 0.000 title 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 abstract 4
- 238000004090 dissolution Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 230000035699 permeability Effects 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229920000083 poly(allylamine) Polymers 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/20—After-treatment of capsule walls, e.g. hardening
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00118615 | 2000-08-28 | ||
| EP01112600 | 2001-05-23 | ||
| PCT/EP2001/009908 WO2002017888A2 (en) | 2000-08-28 | 2001-08-28 | Controlled and sustained release properties of polyelectrolyte multilayer capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE295156T1 true ATE295156T1 (de) | 2005-05-15 |
Family
ID=26071336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01980290T ATE295156T1 (de) | 2000-08-28 | 2001-08-28 | Mehrlagige polyelektrolytkapseln mit gesteuerter und verzögerter freisetzung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040013721A1 (de) |
| EP (1) | EP1313455B1 (de) |
| JP (1) | JP2004507488A (de) |
| AT (1) | ATE295156T1 (de) |
| CA (1) | CA2420523C (de) |
| DE (1) | DE60110809T2 (de) |
| WO (1) | WO2002017888A2 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080026068A1 (en) * | 2001-08-16 | 2008-01-31 | Baxter Healthcare S.A. | Pulmonary delivery of spherical insulin microparticles |
| US7504364B2 (en) * | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
| EP1488006B1 (de) * | 2002-03-20 | 2008-05-28 | InnovativeBio.Biz | Mikrokapseln mit kontrollierter durchlässigkeit die ein nukleinsäureamplifizierungsreaktionsgemisch enthalten und deren benutzung als reaktionsgefäss für parallele reaktionen |
| US7101947B2 (en) | 2002-06-14 | 2006-09-05 | Florida State University Research Foundation, Inc. | Polyelectrolyte complex films for analytical and membrane separation of chiral compounds |
| US20040137039A1 (en) * | 2002-07-22 | 2004-07-15 | Trustees Of Stevens Institute Of Technology | Methods for controlled release of molecules from layered polymer films |
| CA2494782A1 (en) * | 2002-08-02 | 2004-02-19 | Capsulution Nanoscience Ag | Color coated layer-by-layer microcapsules serving as combinatory analysis libraries and as specific optical sensors |
| US20050037381A1 (en) * | 2002-09-16 | 2005-02-17 | Receptors Llc | Artificial receptors, building blocks, and methods |
| US20060057625A1 (en) * | 2002-09-16 | 2006-03-16 | Carlson Robert E | Scaffold-based artificial receptors and methods |
| US7469076B2 (en) * | 2003-09-03 | 2008-12-23 | Receptors Llc | Sensors employing combinatorial artificial receptors |
| US20050037429A1 (en) * | 2003-03-28 | 2005-02-17 | Receptors Llc | Artificial receptors including reversibly immobilized building blocks and methods |
| US20050136483A1 (en) * | 2003-09-03 | 2005-06-23 | Receptors Llc | Nanodevices employing combinatorial artificial receptors |
| US20040137481A1 (en) * | 2002-09-16 | 2004-07-15 | Receptors Llc | Artificial receptor building blocks, components, and kits |
| US7767219B2 (en) | 2003-01-31 | 2010-08-03 | Boston Scientific Scimed, Inc. | Localized drug delivery using drug-loaded nanocapsules |
| EP1613737A4 (de) | 2003-03-28 | 2008-12-03 | Receptors Llc | Reversibel immobilisierte bausteine beinhaltend künstliche rezeptoren und verfahren |
| DE10361084A1 (de) | 2003-06-13 | 2005-01-05 | Henkel Kgaa | Lagerstabile Bleichmittelzusammensetzungen auf Basis von Peroxycarbonsäuren |
| US7364585B2 (en) | 2003-08-11 | 2008-04-29 | Boston Scientific Scimed, Inc. | Medical devices comprising drug-loaded capsules for localized drug delivery |
| US7544770B2 (en) | 2003-08-29 | 2009-06-09 | Louisiana Tech Foundation, Inc. | Multilayer films, coatings, and microcapsules comprising polypeptides |
| US7348399B2 (en) | 2003-08-29 | 2008-03-25 | Louisiana Tech University Foundation, Inc. | Nanofabricated polypeptide multilayer films, coatings, and microcapsules |
| US7550557B2 (en) | 2003-08-29 | 2009-06-23 | Louisiana Tech University Foundation, Inc. | Multilayer films, coatings, and microcapsules comprising polypeptides |
| US7615530B2 (en) * | 2003-08-29 | 2009-11-10 | Artificial Cell Technologies, Inc. | Immunogenic compositions and methods of use |
| WO2005086976A2 (en) * | 2004-03-11 | 2005-09-22 | University Of Massachusetts | Biopolymer encapsulation and stabilization of lipid systems and methods for utilization thereof |
| EP1593374A1 (de) * | 2004-05-07 | 2005-11-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Ferngesteuerte Freisetzung verkapselter Materialien |
| US8728525B2 (en) * | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
| US8119153B2 (en) | 2004-08-26 | 2012-02-21 | Boston Scientific Scimed, Inc. | Stents with drug eluting coatings |
| US7884052B2 (en) | 2004-09-03 | 2011-02-08 | Receptors Llc | Combinatorial artificial receptors including tether building blocks on scaffolds |
| EP1789792A2 (de) * | 2004-09-11 | 2007-05-30 | Receptors LLC | Kombinatorische künstliche rezeptoren mit peptidbausteinen |
| WO2006037160A1 (en) * | 2004-10-05 | 2006-04-13 | The University Of Melbourne | Porous polyelectrolyte materials |
| WO2006041541A1 (en) | 2004-10-07 | 2006-04-20 | Christopher White | A mixing system |
| EP1833931B1 (de) * | 2004-12-17 | 2012-08-01 | Cabot Corporation | Tintenstrahltinten mit mehrschichtigen pigmenten |
| EP1885335A1 (de) * | 2005-04-27 | 2008-02-13 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Oberflächenmodifizierte mikroteilchen und verfahren zu ihrer bildung und verwendung |
| US20070048383A1 (en) * | 2005-08-25 | 2007-03-01 | Helmus Michael N | Self-assembled endovascular structures |
| DE102005044400A1 (de) * | 2005-09-16 | 2007-03-22 | Capsulution Nanoscience Ag | Verfahren zur Verkapselung und kontrollierten Freisetzung von schwer wasserlöslichen (hydrophoben) flüssigen und festen Wirkstoffen |
| CN101365724A (zh) * | 2005-10-25 | 2009-02-11 | 路易斯安那科技大学研究基金会 | 包含多肽的多层膜、涂层和微粒 |
| EP1957050B1 (de) * | 2005-11-14 | 2014-01-01 | Louisiana Tech University Research Foundation | Polypeptid-folien und verfahren dafür |
| RU2300369C1 (ru) * | 2005-12-27 | 2007-06-10 | Наталья Ивановна Ларионова | Способ получения полиэлектролитных микрочастиц, содержащих инкапсулируемое вещество, чувствительных к изменению состава окружающей среды |
| US8834912B2 (en) * | 2005-12-30 | 2014-09-16 | Boston Scientific Scimed, Inc. | Medical devices having multiple charged layers |
| US20070281031A1 (en) * | 2006-06-01 | 2007-12-06 | Guohan Yang | Microparticles and methods for production thereof |
| US20100015068A1 (en) * | 2006-07-06 | 2010-01-21 | Massachusetts Institute Of Technology | Methods and Compositions For Altering Biological Surfaces |
| CN101500616A (zh) | 2006-08-04 | 2009-08-05 | 巴克斯特国际公司 | 预防和/或逆转新发作自身免疫糖尿病的基于微球的组合物 |
| WO2008088586A2 (en) * | 2006-09-11 | 2008-07-24 | William Marsh Rice University | New phototherapeutic materials prepared through nanoparticle assembly |
| US20080213334A1 (en) * | 2006-09-29 | 2008-09-04 | Lockwood Nathan A | Polyelectrolyte media for bioactive agent delivery |
| WO2008045806A2 (en) * | 2006-10-06 | 2008-04-17 | Microislet, Inc. | Multilayered polyelectrolyte-based capsules for cell encapsulation and delivery of therapeutic compositions |
| WO2008060786A2 (en) * | 2006-10-06 | 2008-05-22 | Baxter International Inc. | Microencapsules containing surface-modified microparticles and methods of forming and using the same |
| EP2124906B1 (de) * | 2007-01-22 | 2017-08-30 | Artificial Cell Technologies, Inc. | Polypeptid-folien und verfahren dafür |
| US8093039B2 (en) | 2007-04-10 | 2012-01-10 | The Trustees Of The Stevens Institute Of Technology | Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells |
| DE102007024642A1 (de) | 2007-05-24 | 2008-11-27 | Eyesense Ag | Hydrogel-Implantat für Sensorik von Metaboliten am Auge |
| WO2008157372A2 (en) | 2007-06-14 | 2008-12-24 | Massachusetts Institute Of Technology | Self assembled films for protein and drug delivery applications |
| WO2010021973A2 (en) * | 2008-08-17 | 2010-02-25 | Massachusetts Institute Of Technology | Controlled delivery of bioactive agents from decomposable films |
| US20100047292A1 (en) * | 2008-08-20 | 2010-02-25 | Baxter International Inc. | Methods of processing microparticles and compositions produced thereby |
| US8323615B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
| US8367427B2 (en) * | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| GB0918564D0 (en) * | 2009-10-22 | 2009-12-09 | Plasticell Ltd | Nested cell encapsulation |
| WO2013103514A1 (en) | 2012-01-04 | 2013-07-11 | The Trustees Of The Stevens Institute Of Technology | Clay-containing thin films as carriers of absorbed molecules |
| EP2841056A4 (de) * | 2012-04-23 | 2015-09-16 | Massachusetts Inst Technology | Stabile schichtweise beschichtete teilchen |
| WO2014134029A1 (en) | 2013-02-26 | 2014-09-04 | Massachusetts Institute Of Technology | Nucleic acid particles, methods and use thereof |
| US9463244B2 (en) | 2013-03-15 | 2016-10-11 | Massachusetts Institute Of Technology | Compositions and methods for nucleic acid delivery |
| AU2014324916B2 (en) | 2013-09-27 | 2018-06-14 | Rohm And Haas Company | Ionic strength triggered disintegration of films and particulates |
| MX2016003236A (es) | 2013-09-27 | 2016-06-07 | Rohm & Haas | Peliculas dispersables para envasar formulaciones de alto contenido de agua. |
| CN104945764A (zh) * | 2014-03-28 | 2015-09-30 | 苏州工业园区新国大研究院 | 介电材料及使用该介电材料的电容器 |
| CN107119111B (zh) * | 2017-03-28 | 2021-02-12 | 浙江大学 | 一种dna酶包裹的dna分子层层自组装微胶囊及其制备与应用 |
| WO2019089567A1 (en) | 2017-10-30 | 2019-05-09 | Massachusetts Institute Of Technology | Layer-by-layer nanoparticles for cytokine therapy in cancer treatment |
| SG11201911961RA (en) | 2018-04-20 | 2020-01-30 | Illumina Inc | Methods of encapsulating single cells, the encapsulated cells and uses thereof |
| WO2020086843A1 (en) | 2018-10-26 | 2020-04-30 | Illumina, Inc. | Modulating polymer beads for dna processing |
| WO2021002984A1 (en) | 2019-05-30 | 2021-01-07 | Massachusetts Institute Of Technology | Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids |
| CN111855528B (zh) * | 2020-07-23 | 2023-03-28 | 西南大学 | 一种基于电场强度调控的多孔材料渗透性定向调控方法及其产品 |
| CN120282775A (zh) * | 2022-12-14 | 2025-07-08 | R·P·谢勒技术有限公司 | 软凝胶胶囊和制备软凝胶胶囊的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450198A (en) * | 1980-01-28 | 1984-05-22 | Alza Corporation | Microporous film with polymer in pores for regulating passage of fluid |
| JPS61274738A (ja) * | 1985-05-29 | 1986-12-04 | Mitsui Toatsu Chem Inc | マイクロカプセル |
| GB8902909D0 (en) * | 1989-02-09 | 1989-03-30 | Unilever Plc | Coating process |
| US5120349A (en) * | 1990-12-07 | 1992-06-09 | Landec Labs, Inc. | Microcapsule having temperature-dependent permeability profile |
| US5260002A (en) * | 1991-12-23 | 1993-11-09 | Vanderbilt University | Method and apparatus for producing uniform polymeric spheres |
| DE19519804A1 (de) * | 1995-05-31 | 1996-12-05 | Juergen Dr Schrezenmeir | Bioaktive Kapsel mit veränderlicher Hülle |
| DE69904307T2 (de) * | 1998-03-19 | 2003-09-04 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Herstellung von mit mehrlagen gestrichenen partikeln und hohlen schalen durch elektrostatische selbstorganisierung von nanokompositmehrlagen auf zersetzbaren schablonen |
| EP1064087B1 (de) * | 1998-03-19 | 2006-01-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Herstellung von nano- und mikrokapseln durch schichtweise polyelektrolyt-selbstassemblierung |
| US6756217B1 (en) * | 1998-05-29 | 2004-06-29 | Southern Illinois University | Glass composite materials containing alkoxosilane derivative having alterable charge, hydrophobic and hydrophilic groups |
| WO2000003797A1 (de) * | 1998-07-15 | 2000-01-27 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Polyelektrolythüllen auf biologischen templaten |
| US6616946B1 (en) * | 1999-11-15 | 2003-09-09 | Biocure, Inc. | Triblock copolymer hollow particles for agent delivery by permeability change |
| US20040013738A1 (en) * | 2000-08-02 | 2004-01-22 | Andreas Voigt | Encapsulation of liquid template particles |
| US20060029634A1 (en) * | 2004-08-06 | 2006-02-09 | Berg Michael C | Porous structures |
-
2001
- 2001-08-28 AT AT01980290T patent/ATE295156T1/de not_active IP Right Cessation
- 2001-08-28 DE DE60110809T patent/DE60110809T2/de not_active Expired - Lifetime
- 2001-08-28 EP EP01980290A patent/EP1313455B1/de not_active Expired - Lifetime
- 2001-08-28 WO PCT/EP2001/009908 patent/WO2002017888A2/en not_active Ceased
- 2001-08-28 CA CA2420523A patent/CA2420523C/en not_active Expired - Fee Related
- 2001-08-28 JP JP2002522862A patent/JP2004507488A/ja active Pending
- 2001-08-28 US US10/363,472 patent/US20040013721A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002017888A9 (en) | 2003-05-15 |
| EP1313455B1 (de) | 2005-05-11 |
| EP1313455A2 (de) | 2003-05-28 |
| WO2002017888A2 (en) | 2002-03-07 |
| DE60110809D1 (de) | 2005-06-16 |
| WO2002017888A3 (en) | 2002-07-25 |
| CA2420523A1 (en) | 2002-03-07 |
| US20040013721A1 (en) | 2004-01-22 |
| DE60110809T2 (de) | 2005-10-06 |
| CA2420523C (en) | 2010-05-25 |
| JP2004507488A (ja) | 2004-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |