ATE295166T1 - Aktivatoren der kalium-kanäle - Google Patents
Aktivatoren der kalium-kanäleInfo
- Publication number
- ATE295166T1 ATE295166T1 AT99900312T AT99900312T ATE295166T1 AT E295166 T1 ATE295166 T1 AT E295166T1 AT 99900312 T AT99900312 T AT 99900312T AT 99900312 T AT99900312 T AT 99900312T AT E295166 T1 ATE295166 T1 AT E295166T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- amino
- aryl
- pharmaceutical composition
- alkyl
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 108020001213 potassium channel Proteins 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000004036 potassium channel stimulating agent Substances 0.000 abstract 1
- 150000003233 pyrroles Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Detergent Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP561398 | 1998-01-14 | ||
| JP5088898 | 1998-03-03 | ||
| PCT/JP1999/000103 WO1999036068A1 (en) | 1998-01-14 | 1999-01-13 | Potassium channel activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE295166T1 true ATE295166T1 (de) | 2005-05-15 |
Family
ID=26339581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99900312T ATE295166T1 (de) | 1998-01-14 | 1999-01-13 | Aktivatoren der kalium-kanäle |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6353016B1 (de) |
| EP (1) | EP1057485B1 (de) |
| KR (1) | KR20010034114A (de) |
| CN (1) | CN1162151C (de) |
| AT (1) | ATE295166T1 (de) |
| AU (1) | AU1890299A (de) |
| CA (1) | CA2316853A1 (de) |
| DE (1) | DE69925250T2 (de) |
| RU (1) | RU2204390C2 (de) |
| WO (1) | WO1999036068A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1283040A4 (de) * | 2000-03-21 | 2008-05-14 | Nippon Shinyaku Co Ltd | Orale heilmittelform für dauerverabreichung |
| AU7887501A (en) * | 2000-07-06 | 2002-01-21 | Us Gov Health & Human Serv | Tetrahydrobenzothiazole analogues as neuroprotective agents |
| TWI239952B (en) * | 2001-03-14 | 2005-09-21 | Nippon Shinyaku Co Ltd | Stable crystals of pyrrole compound |
| WO2005023237A1 (en) * | 2003-09-04 | 2005-03-17 | Poseidon Pharmaceuticals A/S | Erg channel openers for the treatment of cardiac arrhythmias |
| EP1773768B8 (de) * | 2004-07-30 | 2018-12-26 | Exelixis, Inc. | Pyrrolderivate als pharmazeutische wirkstoffe |
| EP2297089B1 (de) * | 2008-04-28 | 2013-07-31 | Janssen Pharmaceutica, N.V. | Benzocycloheptan- und benzoxepinderivate |
| GB201107176D0 (en) * | 2011-04-28 | 2011-06-15 | Cxr Biosciences Ltd | Pyrrolnitrin derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2113399T3 (es) * | 1991-12-26 | 1998-05-01 | Mitsubishi Chem Corp | Derivados de beta-oxo-beta-bencenopropano-tio-amida. |
| FR2698873B1 (fr) * | 1992-12-07 | 1995-02-24 | Lipha | Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. |
| JP3439249B2 (ja) * | 1993-11-18 | 2003-08-25 | 三和生薬株式会社 | 新規なピロール型化合物及び発毛・育毛促進剤 |
| BR9608502A (pt) * | 1995-06-07 | 1999-07-06 | Nippon Shinyaku Co Ltd | Derivado da pirrola e composição medicinal |
| EP0859771A4 (de) * | 1995-10-31 | 2000-03-15 | Merck & Co Inc | Substituierte pyridylpyrrole, solche verbindungen enthaltende zubereitungen und verfahren zu deren nutzung |
| EP0912548A1 (de) * | 1996-07-11 | 1999-05-06 | Pfizer Inc. | Pyridylpyrrol-derivate verwendbar als interleukin- und tnf- antagonisten |
| WO1999061016A1 (fr) * | 1998-05-27 | 1999-12-02 | Nippon Shinyaku Co., Ltd. | Inhibiteurs de cyclo-oxygenase-2 |
-
1999
- 1999-01-13 KR KR1020007007727A patent/KR20010034114A/ko not_active Withdrawn
- 1999-01-13 AT AT99900312T patent/ATE295166T1/de not_active IP Right Cessation
- 1999-01-13 WO PCT/JP1999/000103 patent/WO1999036068A1/ja not_active Ceased
- 1999-01-13 CN CNB998021067A patent/CN1162151C/zh not_active Expired - Fee Related
- 1999-01-13 DE DE69925250T patent/DE69925250T2/de not_active Expired - Fee Related
- 1999-01-13 AU AU18902/99A patent/AU1890299A/en not_active Abandoned
- 1999-01-13 RU RU2000121069/14A patent/RU2204390C2/ru not_active IP Right Cessation
- 1999-01-13 EP EP99900312A patent/EP1057485B1/de not_active Expired - Lifetime
- 1999-01-13 CA CA002316853A patent/CA2316853A1/en not_active Abandoned
- 1999-01-13 US US09/582,743 patent/US6353016B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1057485A4 (de) | 2001-05-09 |
| CN1288377A (zh) | 2001-03-21 |
| EP1057485A1 (de) | 2000-12-06 |
| DE69925250T2 (de) | 2006-02-23 |
| WO1999036068A1 (en) | 1999-07-22 |
| DE69925250D1 (de) | 2005-06-16 |
| CN1162151C (zh) | 2004-08-18 |
| AU1890299A (en) | 1999-08-02 |
| CA2316853A1 (en) | 1999-07-22 |
| US6353016B1 (en) | 2002-03-05 |
| RU2204390C2 (ru) | 2003-05-20 |
| KR20010034114A (ko) | 2001-04-25 |
| EP1057485B1 (de) | 2005-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |