ATE295166T1 - Aktivatoren der kalium-kanäle - Google Patents
Aktivatoren der kalium-kanäleInfo
- Publication number
- ATE295166T1 ATE295166T1 AT99900312T AT99900312T ATE295166T1 AT E295166 T1 ATE295166 T1 AT E295166T1 AT 99900312 T AT99900312 T AT 99900312T AT 99900312 T AT99900312 T AT 99900312T AT E295166 T1 ATE295166 T1 AT E295166T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- amino
- aryl
- pharmaceutical composition
- alkyl
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 108020001213 potassium channel Proteins 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000004036 potassium channel stimulating agent Substances 0.000 abstract 1
- 150000003233 pyrroles Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP561398 | 1998-01-14 | ||
| JP5088898 | 1998-03-03 | ||
| PCT/JP1999/000103 WO1999036068A1 (en) | 1998-01-14 | 1999-01-13 | Potassium channel activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE295166T1 true ATE295166T1 (de) | 2005-05-15 |
Family
ID=26339581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99900312T ATE295166T1 (de) | 1998-01-14 | 1999-01-13 | Aktivatoren der kalium-kanäle |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6353016B1 (de) |
| EP (1) | EP1057485B1 (de) |
| KR (1) | KR20010034114A (de) |
| CN (1) | CN1162151C (de) |
| AT (1) | ATE295166T1 (de) |
| AU (1) | AU1890299A (de) |
| CA (1) | CA2316853A1 (de) |
| DE (1) | DE69925250T2 (de) |
| RU (1) | RU2204390C2 (de) |
| WO (1) | WO1999036068A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030019326A (ko) * | 2000-03-21 | 2003-03-06 | 니뽄 신야쿠 가부시키가이샤 | 방출 제어형 경구 투여 제제 |
| CA2415815A1 (en) * | 2000-07-06 | 2002-01-17 | Nigel H. Greig | Tetrahydrobenzothiazole analogues as neuroprotective agents |
| TWI239952B (en) * | 2001-03-14 | 2005-09-21 | Nippon Shinyaku Co Ltd | Stable crystals of pyrrole compound |
| CN1845726A (zh) * | 2003-09-04 | 2006-10-11 | 波塞东医药公司 | 用于治疗心脏心律失常的erg通道开放剂 |
| PT1773768T (pt) * | 2004-07-30 | 2018-11-30 | Exelixis Inc | Derivados de pirrol como agentes farmacêuticos |
| RU2496769C2 (ru) | 2008-04-28 | 2013-10-27 | Янссен Фармацевтика Нв | Производные бензоциклогептана и бензоксепина |
| GB201107176D0 (en) * | 2011-04-28 | 2011-06-15 | Cxr Biosciences Ltd | Pyrrolnitrin derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2113399T3 (es) * | 1991-12-26 | 1998-05-01 | Mitsubishi Chem Corp | Derivados de beta-oxo-beta-bencenopropano-tio-amida. |
| FR2698873B1 (fr) * | 1992-12-07 | 1995-02-24 | Lipha | Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. |
| JP3439249B2 (ja) * | 1993-11-18 | 2003-08-25 | 三和生薬株式会社 | 新規なピロール型化合物及び発毛・育毛促進剤 |
| ES2259795T3 (es) * | 1995-06-07 | 2006-10-16 | Nippon Shinyaku Company, Limited | Derivados de pirrol y composicion medicinal. |
| WO1997016442A1 (en) * | 1995-10-31 | 1997-05-09 | Merck & Co., Inc. | Substituted pyridyl pyrroles, compositions containing such compounds and methods of use |
| AU3044197A (en) * | 1996-07-11 | 1998-02-09 | Pfizer Inc. | Pyridylpyrrole compounds useful as interleukin- and tnf antagonists |
| WO1999061016A1 (fr) * | 1998-05-27 | 1999-12-02 | Nippon Shinyaku Co., Ltd. | Inhibiteurs de cyclo-oxygenase-2 |
-
1999
- 1999-01-13 RU RU2000121069/14A patent/RU2204390C2/ru not_active IP Right Cessation
- 1999-01-13 WO PCT/JP1999/000103 patent/WO1999036068A1/ja not_active Ceased
- 1999-01-13 AU AU18902/99A patent/AU1890299A/en not_active Abandoned
- 1999-01-13 EP EP99900312A patent/EP1057485B1/de not_active Expired - Lifetime
- 1999-01-13 CA CA002316853A patent/CA2316853A1/en not_active Abandoned
- 1999-01-13 US US09/582,743 patent/US6353016B1/en not_active Expired - Fee Related
- 1999-01-13 AT AT99900312T patent/ATE295166T1/de not_active IP Right Cessation
- 1999-01-13 KR KR1020007007727A patent/KR20010034114A/ko not_active Withdrawn
- 1999-01-13 CN CNB998021067A patent/CN1162151C/zh not_active Expired - Fee Related
- 1999-01-13 DE DE69925250T patent/DE69925250T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1057485A1 (de) | 2000-12-06 |
| KR20010034114A (ko) | 2001-04-25 |
| CN1162151C (zh) | 2004-08-18 |
| DE69925250T2 (de) | 2006-02-23 |
| RU2204390C2 (ru) | 2003-05-20 |
| EP1057485B1 (de) | 2005-05-11 |
| CA2316853A1 (en) | 1999-07-22 |
| CN1288377A (zh) | 2001-03-21 |
| WO1999036068A1 (en) | 1999-07-22 |
| US6353016B1 (en) | 2002-03-05 |
| EP1057485A4 (de) | 2001-05-09 |
| AU1890299A (en) | 1999-08-02 |
| DE69925250D1 (de) | 2005-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0213243B8 (pt) | composto heterocíclico aromático contendo um anel oxazol, tiazol ou imidazol, ou um sal farmaceuticamente aceitável do mesmo, e, composição farmacêutica | |
| EP0976748A4 (de) | Pyrrolidin-derivate die eine phospholipase-a2-hemmende wirkung haben | |
| EA200400893A1 (ru) | N-арил-2-оксазолидинон-5-карбоксамиды, их производные и их применение в качестве антибактериальных средств | |
| PT747374E (pt) | Benzopiranos substituidos com sulfonamido activadores dos canais do potassio | |
| EA200100755A1 (ru) | 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты | |
| MXPA06001274A (es) | Compuestos novedosos que poseen actividad inhibitoria contra transporador dependiente de sodio. | |
| FI950309A0 (fi) | Proliiniamidijohdannaisia | |
| IL135536A0 (en) | Ortho-anthranilamide derivatives and pharmaceutical compositions containing the same | |
| ATE260255T1 (de) | 5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate | |
| DE69514367D1 (de) | Substituierte amidderivate | |
| FI961239A0 (fi) | 3-amino-5-karboksisubstituoituja piperidiinejä ja 3-amino-5-karboksisubstituoituja pyrrolidiinejä takykiniiantagonisteina | |
| BRPI9908319B8 (pt) | composto amino cíclico, composição farmacêutica, medicamento contendo um composto amino cíclico ou um sal farmacologicamente aceitável do mesmo, e, uso de um composto amino cíclico ou um sal farmacologicamente aceitável do mesmo. | |
| NZ332960A (en) | tetrahydro-cyclopropan[c]benz[e]-indol-4-one and tetrahydro-cyclopropan[c]benzo[e]-indole derivatives and medicaments | |
| ATE343367T1 (de) | Photostabile organische sonnenschutzmittel mit antioxidativen eigenschaften und zusammensetzungen damit | |
| DK1008592T3 (da) | Cykliske amidderivater, som inhiberer cathepsin K | |
| EP1642880A4 (de) | Proteininhibitoren der hsp90-familie | |
| EP0751145A3 (de) | HIV-Protease Inhibitoren | |
| PT842923E (pt) | Derivados do pirrolo e composicoes medicinais | |
| ES2128440T3 (es) | Derivado de 4-alcoxi-2,6-di-t-butilfenol. | |
| AU579872B2 (en) | 2-amino-4-substituted oxazolines | |
| DE69925250D1 (de) | Aktivatoren der kalium-kanäle | |
| KR960037677A (ko) | 4-인돌릴피페라지닐 유도체 | |
| ES2155655T3 (es) | Compuestos de benzotiofeno, usos y formulaciones de los mismos. | |
| AR019438A1 (es) | Compuesto derivado de piperazina, usos del mismo y metodos para su fabricacion | |
| EA200500028A1 (ru) | Новые соединения 3-(4-оксо-4h-хромен-2-ил)-(1h)-хинолин-4-она, способ их получения и фармацевтические композиции, которые их содержат |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |