ATE295541T1 - Verfahren und vorrichtung zur untersuchung von wirksstoffskandidaten und zur bestimmung ihrer pharmakokinetischen parametern - Google Patents

Verfahren und vorrichtung zur untersuchung von wirksstoffskandidaten und zur bestimmung ihrer pharmakokinetischen parametern

Info

Publication number
ATE295541T1
ATE295541T1 AT00946608T AT00946608T ATE295541T1 AT E295541 T1 ATE295541 T1 AT E295541T1 AT 00946608 T AT00946608 T AT 00946608T AT 00946608 T AT00946608 T AT 00946608T AT E295541 T1 ATE295541 T1 AT E295541T1
Authority
AT
Austria
Prior art keywords
drug candidate
binding interaction
drug
adme
pharmacokinetic parameters
Prior art date
Application number
AT00946608T
Other languages
English (en)
Inventor
Maikku Haemaelaeinen
Robert Karlsson
Stefan Loefas
Original Assignee
Biacore Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biacore Ab filed Critical Biacore Ab
Application granted granted Critical
Publication of ATE295541T1 publication Critical patent/ATE295541T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Measuring Cells (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT00946608T 1999-06-18 2000-06-19 Verfahren und vorrichtung zur untersuchung von wirksstoffskandidaten und zur bestimmung ihrer pharmakokinetischen parametern ATE295541T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33686599A 1999-06-18 1999-06-18
PCT/SE2000/001297 WO2000079268A2 (en) 1999-06-18 2000-06-19 Method and apparatus for assaying a drug candidate to estimate a pharmacokinetic parameter associated therewith

Publications (1)

Publication Number Publication Date
ATE295541T1 true ATE295541T1 (de) 2005-05-15

Family

ID=23318018

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00946608T ATE295541T1 (de) 1999-06-18 2000-06-19 Verfahren und vorrichtung zur untersuchung von wirksstoffskandidaten und zur bestimmung ihrer pharmakokinetischen parametern

Country Status (7)

Country Link
US (2) US6808938B2 (de)
EP (1) EP1188058B1 (de)
JP (1) JP4543187B2 (de)
AT (1) ATE295541T1 (de)
AU (1) AU775060B2 (de)
DE (1) DE60020119T2 (de)
WO (1) WO2000079268A2 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US7023547B2 (en) * 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US20020093654A1 (en) * 2000-07-11 2002-07-18 Lieberman Robert A. Apparatus and method for imaging
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US6833920B2 (en) * 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
EP1358612A2 (de) * 2000-07-28 2003-11-05 LION Bioscience AG Abschnittsspezifisches permeabilitäts-modell des darms
CA2416787A1 (en) * 2000-07-28 2002-02-07 Lion Bioscience Ag System and method for predicting adme/tox characteristics of a compound
JP4027048B2 (ja) * 2001-02-23 2007-12-26 富士フイルム株式会社 全反射減衰を利用した測定方法および測定装置
US20050032243A1 (en) * 2001-07-25 2005-02-10 Pollack Gary M. Method and apparatus for rapid determination of ligand-protein binding using charcoal adsorption
US20030044992A1 (en) * 2001-08-31 2003-03-06 Chao Anthony C. Cell-based multiplexing ADME analysis using focused fluid flow
JP4781628B2 (ja) * 2001-12-05 2011-09-28 センス プロテオミック リミテッド 対立遺伝子改変体のためのタンパク質アレイおよびその使用
DE10160270A1 (de) * 2001-12-07 2003-06-26 Bayer Ag Computersystem und Verfahren zur Berechnung von ADME-Eigenschaften
EP1469309A4 (de) * 2001-12-27 2007-11-21 Japan Science & Tech Agency Verfahren zur beurteilung der zellaktivität
KR100555793B1 (ko) * 2002-06-25 2006-03-03 주식회사 마크로젠 고분자 그래프팅에 의해 표면이 개질된 바이오 지지체 및 그 제조방법
AU2003280084A1 (en) * 2002-09-16 2004-04-30 Sense Proteomic Limited Protein arrays and uses thereof
EP1439394A1 (de) * 2002-12-20 2004-07-21 Graffinity Pharmaceuticals Aktiengesellschaft Verfahren und Vorrichtung zum Erstellen von ADME Profilen in der frühen Wirkstoffentwicklung
US8741577B2 (en) * 2003-04-07 2014-06-03 Bio-Rad Laboratories Inc. Surface immobilised multilayer structure of vesicles
WO2005029077A1 (en) * 2003-09-24 2005-03-31 Biacore Ab Method and system for molecular interaction analysis
US7470549B2 (en) * 2004-05-26 2008-12-30 Fujifilm Corporation Measurement method using biosensor
SE0401633D0 (sv) * 2004-06-24 2004-06-24 Biacore Ab Method for detecting molecular surface interactions
WO2006001749A1 (en) * 2004-06-24 2006-01-05 Biacore Ab Method for detecting molecular surface interactions
JP4371954B2 (ja) 2004-08-31 2009-11-25 富士フイルム株式会社 表面プラズモン共鳴分析による被験物質の解析方法
JP4580291B2 (ja) * 2005-06-30 2010-11-10 富士フイルム株式会社 バイオセンサーを用いた測定方法
US20070003559A1 (en) * 2005-07-01 2007-01-04 Wyeth Methods of determining pharmacokinetics of targeted therapies
EP2083081A1 (de) 2005-07-22 2009-07-29 Five Prime Therapeutics, Inc. Zusammensetzungen und Verfahren zur Behandlung von Krankheiten mit FGFR-Fusionsproteinen
US7704695B2 (en) * 2005-07-29 2010-04-27 Xenoport, Inc. Screening of compounds for BGT1 transporter activity
US7700300B2 (en) * 2005-07-29 2010-04-20 Xenoport, Inc. Screening of compounds for GAT2 transporter activity
WO2007016164A2 (en) * 2005-07-29 2007-02-08 Xenoport, Inc. Cat1 transporters expressed in blood brain barrier cells
ATE445843T1 (de) * 2005-08-30 2009-10-15 Perkinelmer Cellular Technolog Verfahren zum nachweis einer biochemischen interaktion
WO2008031209A1 (en) * 2006-09-16 2008-03-20 Terence Gilhuly Improved sensors and sensing for monitoring neuromuscular blockade
US7931791B2 (en) * 2006-10-25 2011-04-26 Southern Illinois University Carbondale Method of detecting analyte-biomolecule interactions
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US20120190127A1 (en) * 2009-06-15 2012-07-26 Brandeis University Systems and methods for determining process conditions in confined volumes
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーＳｐｏｔｌｉｇｈｔ Ｔｅｃｈｎｏｌｏｇｙ Ｐａｒｔｎｅｒｓ Ｌｌｃ 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
JP2013509963A (ja) 2009-11-09 2013-03-21 スポットライト テクノロジー パートナーズ エルエルシー 断片化ヒドロゲル
CN102667448B (zh) * 2009-11-30 2015-02-04 通用电气健康护理生物科学股份公司 用于相互作用分析的方法和系统
EP2507619B1 (de) * 2009-11-30 2018-04-04 GE Healthcare Bio-Sciences AB Verfahren und system zur bindungsverhaltensanalyse
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
TWI382087B (zh) * 2010-05-24 2013-01-11 Univ Taipei Medical 一種篩檢拓樸異構酶抑制劑之裝置及其方法
GB2490652A (en) * 2011-04-18 2012-11-14 Microtest Matrices Ltd Methods of quantifying antibodies, especially IgE antibodies in a sample
JP5828507B2 (ja) * 2011-09-07 2015-12-09 国立大学法人金沢大学 尿検査方法及び尿検査用キット
EP2791667B1 (de) 2011-12-13 2018-03-28 3M Innovative Properties Company Verfahren zur identifizierung und quantitativen bestimmung einer unbekannten organischen verbindung in einem gasförmigen medium
US11280782B2 (en) 2015-02-06 2022-03-22 University Of Rochester Polymer microparticle-based method for probe deposition in label-free biosensors
CN114791477B (zh) * 2021-01-25 2023-12-05 北京中医药大学 一种大蜜丸质构感官属性检测方法在质量控制中的应用
GB202401353D0 (en) * 2021-08-09 2024-03-20 Banerjee Debasish Bioavailability and bioequivalence through intrinsic activity and kd measurements, in vivio in humans
CN114112980B (zh) * 2022-01-24 2022-05-10 武汉宏韧生物医药股份有限公司 一种基于数据分析的药物组分检测方法与系统

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4548066A (en) * 1984-08-07 1985-10-22 Rca Corporation Press workpiece thickness measuring system and method
US5338659A (en) 1991-04-02 1994-08-16 Terrapin Technologies, Inc. Method for determining analyte concentration by cross-reactivity profiling
SE8902043L (sv) 1988-11-10 1990-05-11 Pharmacia Ab Foerfarande foer karakterisering av makromolekyler
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
SE8804074D0 (sv) * 1988-11-10 1988-11-10 Pharmacia Ab Sensorenhet och dess anvaendning i biosensorsystem
SE501013C2 (sv) 1990-10-01 1994-10-17 Pharmacia Biosensor Ab Förfarande för förbättring av analys med bindning till fast fas
US5395587A (en) * 1993-07-06 1995-03-07 Smithkline Beecham Corporation Surface plasmon resonance detector having collector for eluted ligate
US5485277A (en) 1994-07-26 1996-01-16 Physical Optics Corporation Surface plasmon resonance sensor and methods for the utilization thereof
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
SE9503028D0 (sv) 1995-09-01 1995-09-01 Pharmacia Biosensor Ab Method of analysing chemical and physical interactions at a sensor surface
GB9518429D0 (en) 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
AU8898198A (en) * 1997-08-08 1999-03-01 Alexander V Kabanov Methods of identifying biological agent compositions
US6289286B1 (en) * 1998-05-29 2001-09-11 Biacore Ab Surface regeneration of biosensors and characterization of biomolecules associated therewith
US6651008B1 (en) * 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics

Also Published As

Publication number Publication date
DE60020119D1 (de) 2005-06-16
US20020019019A1 (en) 2002-02-14
DE60020119T2 (de) 2005-10-06
US6808938B2 (en) 2004-10-26
WO2000079268A2 (en) 2000-12-28
JP2003502668A (ja) 2003-01-21
US20050037418A1 (en) 2005-02-17
JP4543187B2 (ja) 2010-09-15
AU6034000A (en) 2001-01-09
AU775060B2 (en) 2004-07-15
EP1188058B1 (de) 2005-05-11
WO2000079268A3 (en) 2001-07-19
EP1188058A2 (de) 2002-03-20

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