ATE295844T1 - Verbindungen und ihre verwendung als hemmer des glycintransports - Google Patents

Verbindungen und ihre verwendung als hemmer des glycintransports

Info

Publication number
ATE295844T1
ATE295844T1 AT01960184T AT01960184T ATE295844T1 AT E295844 T1 ATE295844 T1 AT E295844T1 AT 01960184 T AT01960184 T AT 01960184T AT 01960184 T AT01960184 T AT 01960184T AT E295844 T1 ATE295844 T1 AT E295844T1
Authority
AT
Austria
Prior art keywords
compounds
transport inhibitors
glycine transport
glycine
inhibitors
Prior art date
Application number
AT01960184T
Other languages
English (en)
Inventor
Ejner Knud Moltzen
Garrick Paul Smith
Christian Krog-Jensen
Klaus Peter Bogeso
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of ATE295844T1 publication Critical patent/ATE295844T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01960184T 2000-07-21 2001-07-19 Verbindungen und ihre verwendung als hemmer des glycintransports ATE295844T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001124 2000-07-21
PCT/DK2001/000510 WO2002008216A1 (en) 2000-07-21 2001-07-19 Novel compounds and their use as glycine transport inhibitors

Publications (1)

Publication Number Publication Date
ATE295844T1 true ATE295844T1 (de) 2005-06-15

Family

ID=8159626

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01960184T ATE295844T1 (de) 2000-07-21 2001-07-19 Verbindungen und ihre verwendung als hemmer des glycintransports

Country Status (28)

Country Link
US (1) US6921774B2 (de)
EP (1) EP1301502B1 (de)
JP (1) JP2004504393A (de)
KR (1) KR20030015889A (de)
CN (1) CN100509791C (de)
AR (1) AR032358A1 (de)
AT (1) ATE295844T1 (de)
AU (2) AU2001281740B2 (de)
BG (1) BG107530A (de)
BR (1) BR0113011A (de)
CA (1) CA2416447A1 (de)
CZ (1) CZ2003396A3 (de)
DE (1) DE60110914T2 (de)
EA (1) EA005621B1 (de)
ES (1) ES2238466T3 (de)
HR (1) HRP20030053A2 (de)
HU (1) HUP0302778A3 (de)
IL (2) IL153988A0 (de)
IS (1) IS6693A (de)
MX (1) MXPA03000642A (de)
NO (1) NO20030243L (de)
NZ (1) NZ523720A (de)
PL (1) PL364439A1 (de)
PT (1) PT1301502E (de)
SK (1) SK2022003A3 (de)
UA (1) UA75081C2 (de)
WO (1) WO2002008216A1 (de)
ZA (1) ZA200300514B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006524642A (ja) * 2003-04-30 2006-11-02 ハー・ルンドベック・アクチエゼルスカベット 芳香族オキシフェニルおよび芳香族スルファニルフェニル誘導体
CA2536275A1 (en) * 2003-08-21 2005-03-03 H. Lundbeck A/S The combination of a serotonin reuptake inhibitor and a glycine transporter type 1 inhibitor for the treatment of depression
US7163954B2 (en) * 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
JP2007528879A (ja) * 2004-03-12 2007-10-18 ハー・ルンドベック・アクチエゼルスカベット フェニルインダン誘導体
WO2005100301A1 (en) * 2004-03-31 2005-10-27 Eli Lilly And Company 2-aryloxyethyl glycine derivatives and their use as glycine transport inhibitors
WO2006000222A2 (en) * 2004-06-24 2006-01-05 H. Lundbeck A/S The combination of an antipsychotic and a glycine transporter type i inhibitor for the treatment of schizophrenia
ES2412384T3 (es) * 2006-07-18 2013-07-11 Astellas Pharma Inc. Derivado de aminoindano o sal del mismo
MX2009001869A (es) * 2006-08-30 2009-03-02 Hoffmann La Roche Inhibidores de glyt-1.
US20100083581A1 (en) * 2007-06-18 2010-04-08 Mattice Douglas A Environmental brush seal
MX353752B (es) 2009-01-20 2018-01-26 Los Angeles Biomedical Res Inst Harbor Ucla Medical Ct Los ácidos sórbico y benzoico y sus derivados aumentan la actividad de un neurofármaco.
EP2380595A1 (de) 2010-04-19 2011-10-26 Nlife Therapeutics S.L. Zusammensetzungen und Verfahren zur selektiven Abgabe von Oligonukleotidmolekülen an spezifische Neuronentypen
US9700563B2 (en) * 2012-09-06 2017-07-11 MediSynergies, LLC Kappa opioid receptor compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1166711A (en) * 1966-03-28 1969-10-08 Kefalas As Process for the Preparation of Phenyl-Indane and -Tetralin Derivatives
US3549656A (en) * 1967-12-28 1970-12-22 Kefalas As Antidepressant 1 - aminoalkyl - thiophthalanes and acid addition salts thereof
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
US5225323A (en) 1988-11-21 1993-07-06 Baylor College Of Medicine Human high-affinity neurotransmitter uptake system
WO1993010228A1 (en) 1991-11-12 1993-05-27 Synaptic Pharmaceutical Corporation Dna encoding a glycine transporter and uses thereof
US5824486A (en) 1996-05-31 1998-10-20 Allelix Neuroscience Inc. Glycine transporter-transfected cells and uses thereof
US6008015A (en) 1997-04-11 1999-12-28 Allelix Neuroscience Inc. Glycine transporter
AR021509A1 (es) * 1998-12-08 2002-07-24 Lundbeck & Co As H Derivados de benzofurano, su preparacion y uso
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
US6566550B2 (en) * 2001-06-21 2003-05-20 Pfizer Inc Substituted aromatic ethers as inhibitors of glycine transport

Also Published As

Publication number Publication date
NZ523720A (en) 2004-07-30
AU2001281740B2 (en) 2006-02-16
DE60110914D1 (de) 2005-06-23
ES2238466T3 (es) 2005-09-01
DE60110914T2 (de) 2005-10-27
EA005621B1 (ru) 2005-04-28
HUP0302778A2 (hu) 2003-12-29
NO20030243D0 (no) 2003-01-17
BR0113011A (pt) 2003-07-01
KR20030015889A (ko) 2003-02-25
IL153988A0 (en) 2003-07-31
IS6693A (is) 2003-01-20
MXPA03000642A (es) 2003-06-06
SK2022003A3 (en) 2003-06-03
HRP20030053A2 (en) 2005-02-28
JP2004504393A (ja) 2004-02-12
CZ2003396A3 (cs) 2003-05-14
CN1662519A (zh) 2005-08-31
BG107530A (bg) 2003-09-30
PL364439A1 (en) 2004-12-13
ZA200300514B (en) 2004-08-20
UA75081C2 (en) 2006-03-15
HUP0302778A3 (en) 2005-02-28
NO20030243L (no) 2003-03-06
PT1301502E (pt) 2005-09-30
EP1301502B1 (de) 2005-05-18
CA2416447A1 (en) 2002-01-31
WO2002008216A1 (en) 2002-01-31
EP1301502A1 (de) 2003-04-16
AU8174001A (en) 2002-02-05
AR032358A1 (es) 2003-11-05
EA200300180A1 (ru) 2003-06-26
US20030181445A1 (en) 2003-09-25
US6921774B2 (en) 2005-07-26
IL153988A (en) 2006-10-05
CN100509791C (zh) 2009-07-08

Similar Documents

Publication Publication Date Title
DE60123041D1 (de) Entzündungshemmende verbindungen und ihre verwendung
ATE277910T1 (de) Urazil verbindungen und deren verwendung
DE60222006D1 (de) Heterozyklische verbindungen und ihre verwendungen
ATE394102T1 (de) Substituierte chinazolin-derivate und deren verwendung als aurora-2-kinase inhibitoren
DE60208661D1 (de) Diaminothiazole und ihre verwendung als cyclinabhängige kinase inhibitoren
DE60221233D1 (de) Neue spirotricyclische derivate und deren verwendung als phosphodiesterase-7-inhibitoren
DE122011100050I1 (de) Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer.
DE60128940D1 (de) C-nitroso verbindungen and deren verwendung
ATE299875T1 (de) Benzoamid-piperidin verbindungen als substanz p- antagonisten
ATE437862T1 (de) Pyrimidin-5-onderivate als ldl-pla2 inhibitoren
ATE280163T1 (de) Substituierte phenylacetamide und ihre verwendung als glukokinase aktivatoren
ATE340166T1 (de) Diazepan derivate als faktor x inhibitor
ATE329906T1 (de) Substituierte 2-anilino-benzimidazole und ihre verwendung als nhe-inhibitoren
DE60219068D1 (de) Substituierte 2-amino-zykloalkankarboxamide und ihre verwendung als zysteinprotease-inhibitoren
DE60126143D1 (de) Guanidin- und amidin-verbindungen, und ihre verwendung als faktor xa-inhibitoren
DE50313157D1 (de) Phenylaminopyrimidine und ihre verwendung als rho-kinase inhibitoren
DE60110914D1 (de) Verbindungen und ihre verwendung als hemmer des glycintransports
DE60037183D1 (de) Neue amidinbenzylamin-derivate und ihre verwendung als thrombin-inhibitoren
DE60102151D1 (de) Neue thiochromanderivate und ihre verwendung als thrombininhibitoren
NO20025659L (no) Heterocykliske forbindelser
EP1309552A4 (de) Verbindungen und hemmer von phospholipasen
DE59906907D1 (de) Phosphororganische verbindungen und ihre verwendung
DE59902692D1 (de) Phosphororganische verbindungen und ihre verwendung
DE60103868D1 (de) N-heterocyclyl-benzen oder -pyridin-sulfonamide zur verwendung als anti-thrombogene und antikoagulierende verbindungen
NO20031091D0 (no) Fremgangsmåte for lagring av ammoniakk

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1301502

Country of ref document: EP

REN Ceased due to non-payment of the annual fee