ATE296815T1 - Substituierte benzylthiazolidin-2,4-dion derivate - Google Patents
Substituierte benzylthiazolidin-2,4-dion derivateInfo
- Publication number
- ATE296815T1 ATE296815T1 AT00953477T AT00953477T ATE296815T1 AT E296815 T1 ATE296815 T1 AT E296815T1 AT 00953477 T AT00953477 T AT 00953477T AT 00953477 T AT00953477 T AT 00953477T AT E296815 T1 ATE296815 T1 AT E296815T1
- Authority
- AT
- Austria
- Prior art keywords
- dione derivatives
- unsubstituted
- substituted benzylthiazolidine
- substituents
- action
- Prior art date
Links
- JIMXJAFZPUUCAD-UHFFFAOYSA-N 3-benzyl-1,3-thiazolidine-2,4-dione Chemical class O=C1CSC(=O)N1CC1=CC=CC=C1 JIMXJAFZPUUCAD-UHFFFAOYSA-N 0.000 title abstract 3
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 2
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23552999 | 1999-08-23 | ||
| JP2000242707 | 2000-08-10 | ||
| PCT/JP2000/005521 WO2001014351A1 (en) | 1999-08-23 | 2000-08-18 | Substituted benzylthiazolidine-2,4-dione derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE296815T1 true ATE296815T1 (de) | 2005-06-15 |
Family
ID=26532181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00953477T ATE296815T1 (de) | 1999-08-23 | 2000-08-18 | Substituierte benzylthiazolidin-2,4-dion derivate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6734199B1 (de) |
| EP (1) | EP1207157B1 (de) |
| KR (1) | KR100700304B1 (de) |
| CN (1) | CN1167691C (de) |
| AT (1) | ATE296815T1 (de) |
| AU (1) | AU778721B2 (de) |
| CA (1) | CA2382573C (de) |
| DE (1) | DE60020573T2 (de) |
| HU (1) | HUP0202701A3 (de) |
| WO (1) | WO2001014351A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI262185B (en) * | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| IL156445A0 (en) | 2001-01-26 | 2004-01-04 | Schering Corp | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| KR20070120617A (ko) | 2001-01-26 | 2007-12-24 | 쉐링 코포레이션 | 치환된 아제티딘온 화합물을 포함하는 약제학적 조성물 |
| US7507767B2 (en) * | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| EP1429756B1 (de) | 2001-09-21 | 2006-11-22 | Schering Corporation | Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US20060233902A1 (en) * | 2002-02-14 | 2006-10-19 | Kirin Beer Kabushiki Kaisha | Compositions and foods for improving lipid metabolism |
| WO2003088962A1 (en) * | 2002-04-16 | 2003-10-30 | Merck & Co., Inc. | Combination therapy using a ppar alpha/gamma agonist |
| CA2504916A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
| DE602004018617D1 (de) | 2003-03-07 | 2009-02-05 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| WO2004081002A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| WO2004081004A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| KR20050068860A (ko) | 2003-12-30 | 2005-07-05 | 엘지.필립스 엘시디 주식회사 | 듀얼 플레이트 유기전계 발광소자용 상부기판 및 그의제조방법 |
| MX2007001634A (es) * | 2004-08-11 | 2007-04-23 | Kyorin Seiyaku Kk | Nuevo derivado de acido amino benzoico ciclico. |
| US20090036489A1 (en) * | 2005-03-22 | 2009-02-05 | Masahiro Nomura | Novel Cyclic Aminophenylalkanoic Acid Derivative |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI904414A7 (fi) * | 1988-03-08 | 1990-09-07 | Pfizer | Tiatsolidiinidioni-hypoglykeemisesti vaikuttavat aineet |
| JP3929512B2 (ja) * | 1995-06-02 | 2007-06-13 | 杏林製薬株式会社 | Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| JP3144624B2 (ja) * | 1995-06-02 | 2001-03-12 | 杏林製薬株式会社 | Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| WO1997032863A1 (en) * | 1996-03-08 | 1997-09-12 | Torii Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivatives |
| NZ314406A (en) | 1996-03-18 | 2000-12-22 | Sankyo Co | Treatment or prophylaxis of pancreatitis with a medicament containing an insulin sensitiser including oxazoles and thiazoles |
| JPH09301963A (ja) * | 1996-05-17 | 1997-11-25 | Kyorin Pharmaceut Co Ltd | Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| GB0127805D0 (en) | 2001-11-20 | 2002-01-09 | Smithkline Beecham Plc | Pharmaceutical composition |
-
2000
- 2000-08-18 CA CA002382573A patent/CA2382573C/en not_active Expired - Fee Related
- 2000-08-18 WO PCT/JP2000/005521 patent/WO2001014351A1/ja not_active Ceased
- 2000-08-18 AU AU65947/00A patent/AU778721B2/en not_active Ceased
- 2000-08-18 DE DE60020573T patent/DE60020573T2/de not_active Expired - Fee Related
- 2000-08-18 US US10/049,904 patent/US6734199B1/en not_active Expired - Fee Related
- 2000-08-18 HU HU0202701A patent/HUP0202701A3/hu unknown
- 2000-08-18 AT AT00953477T patent/ATE296815T1/de not_active IP Right Cessation
- 2000-08-18 KR KR1020027002065A patent/KR100700304B1/ko not_active Expired - Fee Related
- 2000-08-18 EP EP00953477A patent/EP1207157B1/de not_active Expired - Lifetime
- 2000-08-18 CN CNB008147078A patent/CN1167691C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1167691C (zh) | 2004-09-22 |
| KR20020022813A (ko) | 2002-03-27 |
| EP1207157A4 (de) | 2002-09-18 |
| CA2382573C (en) | 2007-05-22 |
| EP1207157B1 (de) | 2005-06-01 |
| AU778721B2 (en) | 2004-12-16 |
| EP1207157A1 (de) | 2002-05-22 |
| US6734199B1 (en) | 2004-05-11 |
| HUP0202701A3 (en) | 2004-12-28 |
| CA2382573A1 (en) | 2001-03-01 |
| HUP0202701A2 (hu) | 2002-12-28 |
| KR100700304B1 (ko) | 2007-03-29 |
| DE60020573T2 (de) | 2006-03-16 |
| WO2001014351A1 (en) | 2001-03-01 |
| AU6594700A (en) | 2001-03-19 |
| DE60020573D1 (de) | 2005-07-07 |
| CN1382128A (zh) | 2002-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |