ATE296894T1 - Genverabreichende vektoren mit gewebetropismus für glatte muskelzellen und/oder endothelzellen - Google Patents
Genverabreichende vektoren mit gewebetropismus für glatte muskelzellen und/oder endothelzellenInfo
- Publication number
- ATE296894T1 ATE296894T1 AT99203878T AT99203878T ATE296894T1 AT E296894 T1 ATE296894 T1 AT E296894T1 AT 99203878 T AT99203878 T AT 99203878T AT 99203878 T AT99203878 T AT 99203878T AT E296894 T1 ATE296894 T1 AT E296894T1
- Authority
- AT
- Austria
- Prior art keywords
- tissue tropism
- smooth muscle
- adenovirus
- cells
- endothelial cells
- Prior art date
Links
- 230000005100 tissue tropism Effects 0.000 title abstract 4
- 210000002889 endothelial cell Anatomy 0.000 title abstract 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
- 210000000234 capsid Anatomy 0.000 abstract 3
- 241000701161 unidentified adenovirus Species 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 108700026758 Adenovirus hexon capsid Proteins 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203921 | 1998-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE296894T1 true ATE296894T1 (de) | 2005-06-15 |
Family
ID=8234363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99203878T ATE296894T1 (de) | 1998-11-20 | 1999-11-19 | Genverabreichende vektoren mit gewebetropismus für glatte muskelzellen und/oder endothelzellen |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JP4683682B2 (de) |
| AT (1) | ATE296894T1 (de) |
| AU (1) | AU770780B2 (de) |
| CA (1) | CA2318492C (de) |
| DE (1) | DE69925567T2 (de) |
| ES (1) | ES2244145T3 (de) |
| IL (1) | IL133032A (de) |
| MX (1) | MXPA99010682A (de) |
| NO (1) | NO995697L (de) |
| NZ (1) | NZ501214A (de) |
| WO (1) | WO2000031285A1 (de) |
| ZA (1) | ZA997213B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6783980B2 (en) | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| ATE403006T1 (de) * | 1999-03-04 | 2008-08-15 | Crucell Holland Bv | Verwendung eines adenovirusvektors zur transduktion von synovialen zellen |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| CA2410665C (en) | 2000-05-31 | 2017-11-07 | University Of Saskatchewan | Modified bovine adenovirus having altered tropism |
| EP1322774A2 (de) * | 2000-09-20 | 2003-07-02 | Crucell Holland B.V. | Transduktion von dendritischen zellen durch verwendung der adenovirenvektoren |
| DE60138403D1 (de) | 2000-09-26 | 2009-05-28 | Crucell Holland Bv | Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten |
| US6905678B2 (en) * | 2001-07-07 | 2005-06-14 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for mesenchymal stem cells |
| PL215165B1 (pl) | 2002-04-25 | 2013-10-31 | Crucell Holland Bv | Rekombinowany wektor adenowirusowy oraz sposób wytwarzania rekombinowanego wektora adenowirusowego |
| EP1482052A1 (de) * | 2003-05-27 | 2004-12-01 | Cytos Biotechnology AG | Modifizierte Polypeptide zur Zielrichtung des Zelleintritts von Subtyp B Adenoviren |
| KR102702230B1 (ko) | 2017-05-26 | 2024-09-03 | 에피센트알엑스, 인코포레이티드 | 트랜스진을 보유하는 재조합 아데노바이러스 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| KR100470180B1 (ko) * | 1995-06-15 | 2005-02-04 | 크루셀 홀란드 비.브이. | 유전자 요법에 사용할 수 있는 인간의 재조합아데노바이러스 패키징 시스템 |
| JP3420586B2 (ja) * | 1995-11-28 | 2003-06-23 | ジェンベク、インコーポレイティッド | 細胞への遣伝子導入のためのベクターおよび方法 |
| US5877011A (en) * | 1996-11-20 | 1999-03-02 | Genzyme Corporation | Chimeric adenoviral vectors |
| FR2758822B1 (fr) * | 1997-01-30 | 1999-07-02 | Centre Nat Rech Scient | Utilisation d'un polypeptide a titre de recepteur cellulaire des adenovirus |
| FR2761689B1 (fr) * | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
-
1999
- 1999-11-18 IL IL133032A patent/IL133032A/en not_active IP Right Cessation
- 1999-11-19 DE DE69925567T patent/DE69925567T2/de not_active Expired - Lifetime
- 1999-11-19 ES ES99203878T patent/ES2244145T3/es not_active Expired - Lifetime
- 1999-11-19 AT AT99203878T patent/ATE296894T1/de not_active IP Right Cessation
- 1999-11-19 ZA ZA9907213A patent/ZA997213B/xx unknown
- 1999-11-19 NO NO995697A patent/NO995697L/no not_active Application Discontinuation
- 1999-11-19 MX MXPA99010682A patent/MXPA99010682A/es not_active IP Right Cessation
- 1999-11-22 NZ NZ501214A patent/NZ501214A/en not_active IP Right Cessation
- 1999-11-22 JP JP33203399A patent/JP4683682B2/ja not_active Expired - Fee Related
- 1999-11-22 CA CA2318492A patent/CA2318492C/en not_active Expired - Fee Related
- 1999-11-22 WO PCT/NL1999/000717 patent/WO2000031285A1/en not_active Ceased
- 1999-11-22 AU AU59600/99A patent/AU770780B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP4683682B2 (ja) | 2011-05-18 |
| DE69925567D1 (de) | 2005-07-07 |
| IL133032A (en) | 2007-06-03 |
| NO995697L (no) | 2000-05-22 |
| DE69925567T2 (de) | 2006-05-04 |
| ZA997213B (en) | 2000-05-22 |
| ES2244145T3 (es) | 2005-12-01 |
| CA2318492A1 (en) | 2000-06-02 |
| CA2318492C (en) | 2010-05-11 |
| MXPA99010682A (es) | 2002-03-08 |
| AU770780B2 (en) | 2004-03-04 |
| AU5960099A (en) | 2000-05-25 |
| IL133032A0 (en) | 2001-03-19 |
| WO2000031285A1 (en) | 2000-06-02 |
| NO995697D0 (no) | 1999-11-19 |
| JP2000157289A (ja) | 2000-06-13 |
| NZ501214A (en) | 2002-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |