ATE297193T1 - Parenterales pimaricin zur behandlung von systemischen infektionen - Google Patents

Parenterales pimaricin zur behandlung von systemischen infektionen

Info

Publication number: ATE297193T1
Authority: AT; Austria
Prior art keywords: composition; pimaricin; pharmaceutically acceptable; mammal; antifungal
Prior art date: 1997-08-15

Application number

AT98939905T

Other languages

English (en)

Inventor

Borje S Andersson

Elias J Anaissie

Original Assignee

Univ Texas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-15

Filing date

1998-08-07

Publication date

2005-06-15

1998-08-07 Application filed by Univ Texas filed Critical Univ Texas

2005-06-15 Application granted granted Critical

2005-06-15 Publication of ATE297193T1 publication Critical patent/ATE297193T1/de

Links

NCXMLFZGDNKEPB-UHFFFAOYSA-N Pimaricin Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCC(C)OC(=O)C=CC2OC2CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 NCXMLFZGDNKEPB-UHFFFAOYSA-N 0.000 title abstract 3
NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 title abstract 3
229960003255 natamycin Drugs 0.000 title abstract 3
230000009885 systemic effect Effects 0.000 title abstract 2
208000015181 infectious disease Diseases 0.000 title 1
239000000203 mixture Substances 0.000 abstract 5
241000124008 Mammalia Species 0.000 abstract 3
206010017533 Fungal infection Diseases 0.000 abstract 2
208000031888 Mycoses Diseases 0.000 abstract 2
230000000843 anti-fungal effect Effects 0.000 abstract 2
229940121375 antifungal agent Drugs 0.000 abstract 2
239000000010 aprotic solvent Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000007911 parenteral administration Methods 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
239000012871 anti-fungal composition Substances 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Saccharide Compounds (AREA)

AT98939905T 1997-08-15 1998-08-07 Parenterales pimaricin zur behandlung von systemischen infektionen ATE297193T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/911,607 US6045815A (en)	1997-08-15	1997-08-15	Parenteral pimaricin as treatment of systemic infections
PCT/US1998/016661 WO1999008663A1 (en)	1997-08-15	1998-08-07	Parenteral pimaricin as treatment of systemic infections

Publications (1)

Publication Number	Publication Date
ATE297193T1 true ATE297193T1 (de)	2005-06-15

Family

ID=25430556

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98939905T ATE297193T1 (de)	1997-08-15	1998-08-07	Parenterales pimaricin zur behandlung von systemischen infektionen

Country Status (7)

Country	Link
US (3)	US6045815A (de)
EP (1)	EP1007013B1 (de)
JP (1)	JP2001515031A (de)
AT (1)	ATE297193T1 (de)
CA (1)	CA2295478A1 (de)
DE (1)	DE69830496D1 (de)
WO (1)	WO1999008663A1 (de)

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WO2003041500A1 (en) *	2001-11-14	2003-05-22	Board Of Regents, The University Of Texas System	Topical formulations of natamycin/pimaricin
CA2519064A1 (en) *	2003-03-21	2004-09-30	Dsm Ip Assets B.V.	Stable aqueous solution of a polyene fungicide
US9050317B2 (en) *	2008-10-31	2015-06-09	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US9060926B2 (en) *	2008-10-31	2015-06-23	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US20100111857A1 (en) *	2008-10-31	2010-05-06	Boyden Edward S	Compositions and methods for surface abrasion with frozen particles
US9072799B2 (en) *	2008-10-31	2015-07-07	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US9072688B2 (en) *	2008-10-31	2015-07-07	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US20100111834A1 (en) *	2008-10-31	2010-05-06	Searete Llc, A Limited Liability Corporation Of The State Of Delaware	Compositions and methods for therapeutic delivery with frozen particles
US8731841B2 (en) *	2008-10-31	2014-05-20	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US8731840B2 (en)	2008-10-31	2014-05-20	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US8788211B2 (en) *	2008-10-31	2014-07-22	The Invention Science Fund I, Llc	Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US8762067B2 (en) *	2008-10-31	2014-06-24	The Invention Science Fund I, Llc	Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US8725420B2 (en) *	2008-10-31	2014-05-13	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US20100111841A1 (en) *	2008-10-31	2010-05-06	Searete Llc	Compositions and methods for surface abrasion with frozen particles
US8721583B2 (en) *	2008-10-31	2014-05-13	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US8793075B2 (en) *	2008-10-31	2014-07-29	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US8414356B2 (en)	2008-10-31	2013-04-09	The Invention Science Fund I, Llc	Systems, devices, and methods for making or administering frozen particles
US9050070B2 (en) *	2008-10-31	2015-06-09	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US9060931B2 (en) *	2008-10-31	2015-06-23	The Invention Science Fund I, Llc	Compositions and methods for delivery of frozen particle adhesives
US20100111835A1 (en) *	2008-10-31	2010-05-06	Searete Llc, A Limited Liability Corporation Of The State Of Delaware	Compositions and methods for therapeutic delivery with frozen particles
US20100111836A1 (en) *	2008-10-31	2010-05-06	Searete Llc, A Limited Liability Corporation Of The State Of Delaware	Compositions and methods for therapeutic delivery with frozen particles
US9050251B2 (en)	2008-10-31	2015-06-09	The Invention Science Fund I, Llc	Compositions and methods for delivery of frozen particle adhesives
US8613937B2 (en) *	2008-10-31	2013-12-24	The Invention Science Fund I, Llc	Compositions and methods for biological remodeling with frozen particle compositions
US20100111831A1 (en) *	2008-10-31	2010-05-06	Searete Llc, A Limited Liability Corporation Of The State Of Delaware	Compositions and methods for surface abrasion with frozen particles
US9060934B2 (en) *	2008-10-31	2015-06-23	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US8858912B2 (en) *	2008-10-31	2014-10-14	The Invention Science Fund I, Llc	Frozen compositions and methods for piercing a substrate
US8858366B2 (en)	2010-08-20	2014-10-14	Nike, Inc.	Golf ball having layers with specified moduli and hardnesses
CN105067734B (zh) *	2015-07-21	2017-05-17	中国农业大学	一种葡萄酒中纳他霉素含量的测定方法
WO2017043972A1 (en) *	2015-09-09	2017-03-16	Arec Crop Protection B.V.	An antifungal composition comprising natamycin and c4-c22 fatty acids, monoglycerides of these fatty acids and/or derivatives of these fatty acids
CN113583067B (zh) *	2021-05-31	2023-12-05	华东理工大学	低毒匹马霉素衍生物及其制备方法和应用

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US6045815A (en) *	1997-08-15	2000-04-04	Board Of Regents, The University Of Texas System	Parenteral pimaricin as treatment of systemic infections
US6844004B2 (en) *	1997-08-15	2005-01-18	Board Of Regents, The University Of Texas System	Topical formulations of natamycin/pimaricin
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1997
- 1997-08-15 US US08/911,607 patent/US6045815A/en not_active Expired - Lifetime
1998
- 1998-08-07 JP JP2000509403A patent/JP2001515031A/ja not_active Withdrawn
- 1998-08-07 AT AT98939905T patent/ATE297193T1/de not_active IP Right Cessation
- 1998-08-07 WO PCT/US1998/016661 patent/WO1999008663A1/en not_active Ceased
- 1998-08-07 CA CA002295478A patent/CA2295478A1/en not_active Abandoned
- 1998-08-07 EP EP98939905A patent/EP1007013B1/de not_active Expired - Lifetime
- 1998-08-07 DE DE69830496T patent/DE69830496D1/de not_active Expired - Lifetime
1999
- 1999-10-08 US US09/415,890 patent/US7153838B2/en not_active Expired - Fee Related
2003
- 2003-05-15 US US10/439,252 patent/US7220726B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1007013B1 (de)	2005-06-08
CA2295478A1 (en)	1999-02-25
US20040037907A1 (en)	2004-02-26
US7220726B2 (en)	2007-05-22
EP1007013A1 (de)	2000-06-14
DE69830496D1 (de)	2005-07-14
EP1007013A4 (de)	2001-08-29
US20020155141A1 (en)	2002-10-24
WO1999008663A1 (en)	1999-02-25
JP2001515031A (ja)	2001-09-18
US6045815A (en)	2000-04-04
US7153838B2 (en)	2006-12-26

Legal Events

Date	Code	Title	Description
2005-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69830496D1 (de)	2005-07-14	Parenterales pimaricin zur behandlung von systemischen infektionen
NO20000157D0 (no)	2000-01-12	Sammensetning og fremgangsmåte ved behandling av penil erektil dysfunksjon
ATE423566T1 (de)	2009-03-15	Augenbehandlung unter verwendung von cyclosporin a derivaten
RU99102246A (ru)	2001-01-27	Стабильный водный препарат пептидов (варианты), способ его получения (варианты), способ лечения субъекта (варианты)
ATE173603T1 (de)	1998-12-15	Behandlung von erektionversagen
NO982730L (no)	1998-08-13	Antagonister av det gonadotropinfrigj°rende hormon
ES2033429T3 (es)	1993-03-16	Un metodo de preparacion de una composicion farmaceutica.
DE60112102D1 (de)	2005-08-25	Kombination aus einem no-donor und einem antioxidans zur behanndlung sexueller störungen
ATE63220T1 (de)	1991-05-15	Transdermal resorbierbare, wasserhaltige zubereitungen von arylpropionsaeurederivaten und verfahren zur herstellung derselben.
PT933993E (pt)	2006-10-31	Compostos de ciclopentano substituidos, uteis como inibidores de neuraminidase
DE60004793D1 (de)	2003-10-02	Echinocandin-kohlenhydrate-komplexe
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WO1998006265A3 (en)	1998-03-19	Treatment of fungal infections using a combination of an anti-fungal compound and an n-alkyl-heterocyclic compound, especially n-dodecyl-morpholine
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DK1207861T3 (da)	2005-09-12	Behandling af svampeinfektioner under anvendelse af svampevækstmedium
ATE194492T1 (de)	2000-07-15	Topische behandlung von blepharitis
IE43886L (en)	1977-06-01	Antifungal compositions
EP0788799A3 (de)	1998-10-21	LHRH-Antagoniste für Behandlung von Fruchtbarkeitsstörungen
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ES2180345T3 (es)	2003-02-01	Nuevo procedimiento para la crio-conservacion de plantas.
NO965591L (no)	1996-12-27	Kombinasjonsbehandling av HIV-infeksjon
AR005730A1 (es)	1999-07-14	Forma de fanciclovir, procedimiento para prepararla, composiciones farmaceuticas que la contienen y metodo para el tratamiento o profilaxis deinfecciones virales y el uso de dicha forma -fanciclovir monoidrato.