ATE297929T1 - Azabicycloalkan-derivate zur verwendung als inhibitoren der serotonin-wiederaufnahme und als 5ht2a antagonisten - Google Patents

Azabicycloalkan-derivate zur verwendung als inhibitoren der serotonin-wiederaufnahme und als 5ht2a antagonisten

Info

Publication number: ATE297929T1
Authority: AT; Austria
Prior art keywords: serotonin; reuppost; azabicycloalkan; inhibitors; derivatives
Prior art date: 2000-08-03

Application number

AT01306629T

Other languages

English (en)

Inventor

Todd William Butler

Anton Franz Josef Fliri

Randall Jemes Gallaschun

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-03

Filing date

2001-08-02

Publication date

2005-07-15

2001-08-02 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE297929T1 publication Critical patent/ATE297929T1/de

Links

QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
239000005557 antagonist Substances 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
229940076279 serotonin Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
230000005764 inhibitory process Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
102000049773 5-HT2A Serotonin Receptor Human genes 0.000 abstract 1
108010072564 5-HT2A Serotonin Receptor Proteins 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000000697 serotonin reuptake Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Nutrition Science (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT01306629T 2000-08-03 2001-08-02 Azabicycloalkan-derivate zur verwendung als inhibitoren der serotonin-wiederaufnahme und als 5ht2a antagonisten ATE297929T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US22270700P	2000-08-03	2000-08-03

Publications (1)

Publication Number	Publication Date
ATE297929T1 true ATE297929T1 (de)	2005-07-15

Family

ID=22833350

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01306629T ATE297929T1 (de)	2000-08-03	2001-08-02	Azabicycloalkan-derivate zur verwendung als inhibitoren der serotonin-wiederaufnahme und als 5ht2a antagonisten

Country Status (9)

Country	Link
US (1)	US6552015B2 (de)
EP (1)	EP1178048B1 (de)
JP (1)	JP3803268B2 (de)
AT (1)	ATE297929T1 (de)
BR (1)	BR0103210A (de)
CA (1)	CA2354606C (de)
DE (1)	DE60111464T2 (de)
ES (1)	ES2241752T3 (de)
MX (1)	MXPA01007940A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1688412A3 (de) *	2001-02-16	2006-08-16	Aventis Pharmaceuticals, Inc.	Neue heterocyclische Amide-Derivate und ihre Verwendung als dopamine D3-Rezeptor-Liganden
CN1331864C (zh)	2001-03-02	2007-08-15	神经研究公司	新型2,5－二氮杂二环[2.2.1]庚烷衍生物
US7106544B2 (en) *	2003-05-09	2006-09-12	Advanced Research Corporation	Servo systems, servo heads, servo patterns for data storage especially for reading, writing, and recording in magnetic recording tape
JP2005014373A (ja) *	2003-06-25	2005-01-20	Murata Mach Ltd	記録装置
WO2006093192A1 (ja) *	2005-03-04	2006-09-08	Tokyo Medical And Dental University	覚醒剤精神病及び統合失調症の再発防止治療薬
US7785309B2 (en) *	2005-08-31	2010-08-31	Kimberly-Clark Worldwide, Inc.	Disposable garment with biaxially stretchable inner layer
US20090203708A1 (en) *	2006-07-05	2009-08-13	Korea Research Institute Of Chemical Technology	Novel substituted-1-h-quinazoline-2,4-dione derivatives, preparation method thereof and pharmaceutical composition containing the same
EP3527569B1 (de)	2014-02-03	2021-08-25	Vitae Pharmaceuticals, LLC	Dihydropyrrolopyridininhibitoren von ror-gamma zur behandlung von augentrockenheit
TWI675032B (zh)	2014-10-14	2019-10-21	美商維它藥物公司	ＲＯＲ-γ之二氫吡咯并吡啶抑制劑
US9663515B2 (en)	2014-11-05	2017-05-30	Vitae Pharmaceuticals, Inc.	Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en)	2014-11-05	2017-12-19	Vitae Pharmaceuticals, Inc.	Isoindoline inhibitors of ROR-gamma
ES2856931T3 (es)	2015-08-05	2021-09-28	Vitae Pharmaceuticals Llc	Moduladores de ROR-gamma
EP3868750A1 (de)	2015-11-20	2021-08-25	Vitae Pharmaceuticals, LLC	Modulatoren von ror-gamma
TW202220968A (zh)	2016-01-29	2022-06-01	美商維它藥物有限責任公司	ＲＯＲ－γ調節劑
US9481674B1 (en)	2016-06-10	2016-11-01	Vitae Pharmaceuticals, Inc.	Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019018975A1 (en)	2017-07-24	2019-01-31	Vitae Pharmaceuticals, Inc.	INHIBITORS OF ROR GAMMA
MA49685A (fr)	2017-07-24	2021-04-14	Vitae Pharmaceuticals Llc	INHIBITEURS DE ROR gamma
CN113698409B (zh) *	2021-08-10	2022-07-19	上海凌凯医药科技有限公司	一种多用途的二氮杂双环类化合物、制备方法及在合成药物中的应用

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US3726979A (en)	1971-04-09	1973-04-10	E Hong	Method of producing serotonin antagonism
FR2531709A1 (fr)	1982-08-13	1984-02-17	Sanofi Sa	Diazabicyclooctanes, procede pour leur preparation et compositions pharmaceutiques les renfermant
US4954502A (en)	1988-06-10	1990-09-04	Bristol-Myers Squibb Company	1-indolyalkyl-4-(substituted-pyridinyl)piperazines
US5296487A (en)	1990-01-02	1994-03-22	Fujisawa Pharmaceutical Co., Ltd.	Quinazoline derivatives and their preparation
US5498610A (en)	1992-11-06	1996-03-12	Pfizer Inc.	Neuroprotective indolone and related derivatives
GB9510459D0 (en)	1995-05-24	1995-07-19	Zeneca Ltd	Bicyclic amines
CA2287223A1 (en)	1997-04-26	1998-11-05	Tomohiro Toyoda	2-azabicyclo compounds
GB9724693D0 (en)	1997-11-21	1998-01-21	Zeneca Ltd	Chemical compounds
FR2786769B1 (fr)	1998-12-04	2002-10-25	Synthelabo	Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
US6521630B1 (en)	1999-08-31	2003-02-18	Pfizer Inc.	Tetrahydroquinazoline-2,4-diones and therapeutic uses thereof

2001
- 2001-08-01 US US09/920,500 patent/US6552015B2/en not_active Expired - Fee Related
- 2001-08-01 CA CA002354606A patent/CA2354606C/en not_active Expired - Fee Related
- 2001-08-02 MX MXPA01007940A patent/MXPA01007940A/es unknown
- 2001-08-02 DE DE60111464T patent/DE60111464T2/de not_active Expired - Fee Related
- 2001-08-02 EP EP01306629A patent/EP1178048B1/de not_active Expired - Lifetime
- 2001-08-02 ES ES01306629T patent/ES2241752T3/es not_active Expired - Lifetime
- 2001-08-02 AT AT01306629T patent/ATE297929T1/de not_active IP Right Cessation
- 2001-08-03 BR BR0103210-0A patent/BR0103210A/pt not_active IP Right Cessation
- 2001-08-03 JP JP2001236982A patent/JP3803268B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6552015B2 (en)	2003-04-22
MXPA01007940A (es)	2003-08-20
US20020052355A1 (en)	2002-05-02
EP1178048A1 (de)	2002-02-06
ES2241752T3 (es)	2005-11-01
JP3803268B2 (ja)	2006-08-02
JP2002114789A (ja)	2002-04-16
BR0103210A (pt)	2002-03-26
DE60111464D1 (de)	2005-07-21
CA2354606C (en)	2005-12-06
CA2354606A1 (en)	2002-02-03
EP1178048B1 (de)	2005-06-15
DE60111464T2 (de)	2006-05-04

Legal Events

Date	Code	Title	Description
2005-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60111464D1 (de)	2005-07-21	Azabicycloalkan-Derivate zur Verwendung als Inhibitoren der Serotonin-Wiederaufnahme und als 5HT2a Antagonisten
EA200600811A1 (ru)	2006-10-27	НОВЫЕ ПРОИЗВОДНЫЕ ТЕТРАГИДРОСПИРО {ПИПЕРИДИН-2,7'-ПИРРОЛО [3,2-b]ПИРИДИНА} И НОВЫЕ ПРОИЗВОДНЫЕ ИНДОЛА, ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАССТРОЙСТВ, СВЯЗАННЫХ С 5-HT-РЕЦЕПТОРОМ
IS2293B (is)	2007-10-15	Arýl sambrædd asapólýsýklísk efnasambönd
CA2523261A1 (en)	2004-11-18	Fused pyrimidine derivatives with crf activity
PL1716152T3 (pl)	2009-01-30	Skondensowane związki heterocykliczne i ich zastosowanie jako antagonistów receptora metabotropowego do leczenia zaburzeń żołądkowo-jelitowych
EA200301306A1 (ru)	2004-06-24	Производные 1-фенилсульфонил-1,3-дигидро-2h-индол-2-она, их получение и их терапевтическое применение
DE60038686D1 (de)	2008-06-05	Oheptan-derivate und ihre verwendung als integrin-rezeptor-antagonisten
YU8703A (sh)	2006-05-25	Derivati 4-fenil-piridina kao antagonisti receptora neurokinina-1
MXPA03011638A (es)	2004-04-02	Nuevos derivados de 4-piperazinil indol con afinidad por el receptor 5-ht6.
BRPI0408988A (pt)	2006-03-28	composto de piperidinilamino-tieno[2,3-d]pirimidina
YU53100A (sh)	2003-04-30	Derivati 2-ariletil-(piperidin-4-ilmetil)amina kao antagonisti muskarinskih receptora
ATE469157T1 (de)	2010-06-15	Tetrahydrofuroä3,4-düdioxolverbindungen und zusammensetzungen und verfahren zur inhibierung der trombozytenaggregation
MXPA04005426A (es)	2004-10-11	Derivados de pirazol de anillos fuisionados.
DE69839753D1 (de)	2008-09-04	2-(Arylphenyl)amino-imidazolin-Derivate
DE602004016177D1 (de)	2008-10-09	Methylindole und methylpyrrolopyridine als alpha-1-adrenerge agonisten
PT1254905E (pt)	2004-03-31	4-(2-piridil) piperizinas possuindo actividade agonista do receptor 5ht7
DE60102106D1 (de)	2004-04-01	Diazacyclooctanverbindungen und ihre therapeutische Verwendung
DK1083178T3 (da)	2005-01-24	Tetrahydroquinazolin-2,4-dioner og terapeutiske anvendelser deraf
MXPA06000892A (es)	2006-03-30	Compuestos azapoliciclicos arilo fusionados.
ATE415390T1 (de)	2008-12-15	Neue aminopyridinderivate als mglur5-antagonisten
BRPI0510564A (pt)	2007-11-20	compostos e tautÈmeros, estereoisÈmeros, e sais farmacologicamente aceitáveis dos mesmos, composições farmacêuticas, método para preparar composições farmacêuticas, e, uso de um composto
ATE258934T1 (de)	2004-02-15	Azaindol derivate und ihre verwendung als antithrombotische wirkstoffe
BRPI0518465A2 (pt)	2008-11-18	composto, mÉtodo para a preparaÇço de composto, composiÇço farmacÊutica, mÉtodo de preparar uma composiÇço, e, uso de um composto
NO308304B1 (no)	2000-08-28	Nye 5H-thiazol[3,2-a]pyrimidin-5-on derivater, anvendelse derav for fremstilling av farmasøytiske sammensetninger, farmasøytiske sammensetninger inneholdende derivatene, samt et preparat til behandling av psykose, schizofreni og angst