ATE297980T1 - Verfahren zur klonierung von schweinen - Google Patents
Verfahren zur klonierung von schweinenInfo
- Publication number
- ATE297980T1 ATE297980T1 AT99958900T AT99958900T ATE297980T1 AT E297980 T1 ATE297980 T1 AT E297980T1 AT 99958900 T AT99958900 T AT 99958900T AT 99958900 T AT99958900 T AT 99958900T AT E297980 T1 ATE297980 T1 AT E297980T1
- Authority
- AT
- Austria
- Prior art keywords
- cloning
- cells
- porcine
- relates
- porcine animals
- Prior art date
Links
- 238000010367 cloning Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 241000282887 Suidae Species 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 3
- 210000002257 embryonic structure Anatomy 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8778—Swine embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/0611—Primordial germ cells, e.g. embryonic germ cells [EG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Developmental Biology & Embryology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/199,138 US6258998B1 (en) | 1998-11-24 | 1998-11-24 | Method of cloning porcine animals |
| PCT/US1999/026710 WO2000031237A2 (en) | 1998-11-24 | 1999-11-12 | Method of cloning porcine animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE297980T1 true ATE297980T1 (de) | 2005-07-15 |
Family
ID=22736378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99958900T ATE297980T1 (de) | 1998-11-24 | 1999-11-12 | Verfahren zur klonierung von schweinen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6258998B1 (de) |
| EP (2) | EP1131409B1 (de) |
| JP (1) | JP2002530105A (de) |
| AT (1) | ATE297980T1 (de) |
| AU (1) | AU774430B2 (de) |
| BR (1) | BR9915642A (de) |
| CA (1) | CA2350831A1 (de) |
| DE (1) | DE69925856T2 (de) |
| IL (1) | IL143326A0 (de) |
| NZ (1) | NZ530018A (de) |
| WO (1) | WO2000031237A2 (de) |
| ZA (1) | ZA200104230B (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2365445A (en) | 1998-10-12 | 2002-02-20 | Geron Bio Med Ltd | Porcine occcytes with improved developmental competence |
| US6700037B2 (en) * | 1998-11-24 | 2004-03-02 | Infigen, Inc. | Method of cloning porcine animals |
| US20040180430A1 (en) * | 1999-09-07 | 2004-09-16 | West Michael D. | Methods of restoring telomere length and extending cell lifespan using nuclear transfer |
| US20050255596A1 (en) * | 1999-09-07 | 2005-11-17 | West Michael D | Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer |
| WO2001035735A1 (en) * | 1999-11-19 | 2001-05-25 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
| US7074983B2 (en) | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
| US7414170B2 (en) * | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
| US7820878B2 (en) * | 1999-11-19 | 2010-10-26 | Kyowa Hakko Kirin Co., Ltd. | Production of ungulates, preferably bovines that produce human immunoglobulins |
| AU2766401A (en) * | 2000-01-04 | 2001-07-16 | University Of Connecticut, The | Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells |
| US20060174358A1 (en) * | 2001-01-04 | 2006-08-03 | Xiangzhong Yang | Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells |
| MXPA03005624A (es) * | 2000-12-22 | 2004-12-03 | Vaurox Llc | Metodos para clonar mamiferos usando cromatina reprogramada del donador o celulas donadoras. |
| US20020142397A1 (en) * | 2000-12-22 | 2002-10-03 | Philippe Collas | Methods for altering cell fate |
| US7491534B2 (en) * | 2000-12-22 | 2009-02-17 | Kirin Holdings Kabushiki Kaisha | Methods for altering cell fate to generate T-cells specific for an antigen of interest |
| AUPR247901A0 (en) * | 2001-01-10 | 2001-02-01 | Garelag Pty Ltd | Activation of nuclear transfer embryos |
| US20050177883A1 (en) | 2001-01-30 | 2005-08-11 | Rebholtz Paul C. | Systems of transferring embryos and managing recipients |
| WO2002062131A2 (en) * | 2001-02-02 | 2002-08-15 | Infigen, Inc. | Method of cloning transgenic mammalian animals using pseudonuclei |
| AU2002242854A1 (en) | 2001-03-21 | 2002-10-03 | Geron Corporation | Use of telomerase reverse transcriptase to create homozygous knockout animals |
| AUPR446701A0 (en) | 2001-04-18 | 2001-05-17 | Gene Stream Pty Ltd | Transgenic mammals for pharmacological and toxicological studies |
| US20030101469A1 (en) * | 2001-07-09 | 2003-05-29 | Kenneth Bondioli | Cloned non-human mammals from contact inhibited donor cells |
| US20030170678A1 (en) * | 2001-10-25 | 2003-09-11 | Neurogenetics, Inc. | Genetic markers for Alzheimer's disease and methods using the same |
| AU2002364945A1 (en) * | 2001-10-25 | 2003-07-09 | Neurogenetics, Inc. | Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases |
| US20030224380A1 (en) * | 2001-10-25 | 2003-12-04 | The General Hospital Corporation | Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases |
| WO2003055302A1 (en) * | 2001-12-21 | 2003-07-10 | The Curators Of The University Of Missouri | Knockout swine and methods for making the same |
| US20050076399A1 (en) * | 2001-12-29 | 2005-04-07 | Lee So H. | "Gfp-transfected clon pig, gt knock-out clon pig and methods for productions thereof |
| JP2003225089A (ja) * | 2002-02-04 | 2003-08-12 | National Institute Of Agrobiological Sciences | ブタrag−1遺伝子およびその利用 |
| US20030161818A1 (en) * | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| US20030217378A1 (en) * | 2002-04-05 | 2003-11-20 | The University Of Georgia Research Foundation, Inc | Cloning using rapidly matured oocytes |
| US7371922B2 (en) * | 2002-07-31 | 2008-05-13 | The Board Of Trustees Of The University Of Illinois | Nuclear transfer with porcine embryonic stem cells |
| AU2003257155A1 (en) * | 2002-08-02 | 2004-02-23 | The General Hospital Corporation | Methods for the production of cells and mammals with desired genetic modifications |
| EP1546392A4 (de) * | 2002-08-02 | 2006-05-24 | Stratatech Corp | Spezies-spezifischer dna-nachweis |
| DK1534819T3 (da) | 2002-08-21 | 2010-04-19 | Revivicor Inc | Griselignende dyr, som mangler enhver ekspression af funktionel alfa-1,3-galactosyltransferase |
| US20040077077A1 (en) * | 2002-10-18 | 2004-04-22 | Xiangzhong Yang | Novel methods for the production of cloned mammals, mammals cloned according to the methods, and methods of use of same |
| US7429690B2 (en) * | 2002-11-08 | 2008-09-30 | Kirin Holdings Kabushiki Kaisha | Transgenic bovines having reduced prion protein production |
| WO2005047469A2 (en) * | 2003-11-05 | 2005-05-26 | University Of Pittsburgh | PORCINE ISOGLOBOSIDE 3 SYNTHASE PROTEIN, cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION |
| AU2005223617A1 (en) * | 2004-03-17 | 2005-09-29 | Revivicor, Inc. | Tissue products from animals lacking functional alpha 1,3 galactosyl transferase |
| AU2005237494B2 (en) * | 2004-04-22 | 2010-06-10 | Kyowa Hakko Kirin Co., Ltd | Transgenic animals and uses thereof |
| JP2006081542A (ja) * | 2004-08-18 | 2006-03-30 | Institute Of Physical & Chemical Research | クローン哺乳動物の作成方法 |
| US20060080746A1 (en) * | 2004-09-28 | 2006-04-13 | Viagen, Inc. | Methods of embryo transfer |
| US20060148080A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Methods for supporting and producing human cells and tissues in non-human mammal hosts |
| US20060147429A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Facilitated cellular reconstitution of organs and tissues |
| EP3138403A1 (de) | 2005-08-09 | 2017-03-08 | Revivicor, Inc. | Ctla4-ig exprimierende transgene huftiere und verwendungen davon |
| KR100807644B1 (ko) | 2007-03-19 | 2008-02-28 | 충남대학교산학협력단 | 체외수정 수정란 및 체세포 복제 수정란의 동시 이식에의한 돼지 생산 방법 |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| ES2680636T3 (es) | 2011-02-14 | 2018-09-10 | Revivicor Inc. | Cerdos genéticamente modificados para xenotrasplante de xenoinjertos vascularizados y derivados de los mismos |
| WO2012167151A1 (en) | 2011-06-01 | 2012-12-06 | Inguran, Llc | Compositions and methods for improving the quality of processed sperm |
| US9781919B2 (en) | 2011-06-01 | 2017-10-10 | Inguran, Llc | Compositions and methods for improving the quality of processed sperm |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| WO2014178485A1 (ko) | 2013-04-30 | 2014-11-06 | 건국대학교 산학협력단 | Cmp-아세틸뉴라미닌산 히드록실라아제 타겟팅 벡터, 그 벡터가 도입된 이종간 이식용 형질전환 동물 및 그 제조방법 |
| GB201314452D0 (en) * | 2013-08-13 | 2013-09-25 | Ostara Biomedical Ltd | Embryo implantation |
| GB201501302D0 (en) | 2015-01-27 | 2015-03-11 | Ostara Biomedical Ltd | Embryo implantation |
| GB201517523D0 (en) | 2015-10-05 | 2015-11-18 | Ostara Biomedical Ltd | Methods and compositions for managing reproduction |
| US20220211018A1 (en) | 2020-11-20 | 2022-07-07 | Revivicor, Inc. | Multi-transgenic pigs with growth hormone receptor knockout for xenotransplantation |
| CA3232376A1 (en) | 2021-09-20 | 2023-03-23 | Maria KOKKINAKI | Multitransgenic pigs comprising ten genetic modifications for xenotransplantation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4664097A (en) | 1984-05-09 | 1987-05-12 | The Wistar Institute Of Anatomy & Biology | Nuclear transplantation in the mammalian embryo by microsurgery and cell fusion |
| DE122007000007I2 (de) | 1986-04-09 | 2010-12-30 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US4994384A (en) | 1986-12-31 | 1991-02-19 | W. R. Grace & Co.-Conn. | Multiplying bovine embryos |
| US5021244A (en) | 1988-12-06 | 1991-06-04 | Cytogam, Inc. | Sex-associated membrane antibodies and their use for increasing the probability that offspring will be of a desired sex |
| US5346990A (en) | 1987-04-08 | 1994-09-13 | Cytogam, Inc. | Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex |
| US5057420A (en) | 1987-06-05 | 1991-10-15 | Granada Biosciences, Inc. | Bovine nuclear transplantation |
| US5213979A (en) | 1987-12-30 | 1993-05-25 | W. R. Grace & Co.-Conn. | In vitro culture of bovine embryos |
| US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| US5160312A (en) | 1990-02-09 | 1992-11-03 | W. R. Grace & Co.-Conn. | Cryopreservation process for direct transfer of embryos |
| US5096822A (en) | 1990-07-26 | 1992-03-17 | W. R. Grace & Co.- Conn. | Bovine embryo medium |
| DE69133557D1 (de) | 1990-08-29 | 2007-03-15 | Pharming Intellectual Pty Bv | Homologe rekombination in säugetier-zellen |
| US5858359A (en) | 1992-02-28 | 1999-01-12 | Bazin; Herve | Antibodies for and treatment to prevent or reduce the severity of xenograft rejection |
| AU4225593A (en) | 1992-05-01 | 1993-11-29 | Genzyme Corporation | Method for identifying transgenic preimplantation embryos |
| US5645986A (en) | 1992-05-13 | 1997-07-08 | Board Of Reagents, The University Of Texas System | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
| US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5589582A (en) | 1992-10-27 | 1996-12-31 | Biotransplant, Inc. | Polynucleotides en coding porcine cytokines |
| US5496720A (en) | 1993-02-10 | 1996-03-05 | Susko-Parrish; Joan L. | Parthenogenic oocyte activation |
| WO1994019935A1 (en) | 1993-03-09 | 1994-09-15 | Genzyme Corporation | Isolation of components of interest from milk |
| US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| WO1995010599A1 (en) | 1993-10-15 | 1995-04-20 | The University Of Melbourne | Embryonic stem cell-like cells |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| GB9401380D0 (en) | 1994-01-25 | 1994-03-23 | Pharmaceutical Proteins Ltd | Embryonic cell isolation |
| EP0755402B1 (de) | 1994-04-13 | 2008-05-14 | Biotransplant, Inc | Alpha(1,3)galactosyltransferase-negatives schwein |
| EP0773993A4 (de) | 1994-08-19 | 2000-07-05 | Gen Hospital Corp | Gentechnisch veränderte schweine-zellen |
| GB9417831D0 (en) | 1994-09-05 | 1994-10-26 | Biotech & Biolog Scien Res | Biological manipulation |
| GB9517780D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| US6166288A (en) | 1995-09-27 | 2000-12-26 | Nextran Inc. | Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor |
| AU1274797A (en) * | 1995-11-29 | 1997-06-19 | Utah State University | Establishment, maintenance, and transfection of totipotent embryonic stem cells from the embryos of domestic animals |
| US5905042A (en) | 1996-04-01 | 1999-05-18 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Cultured inner cell mass cell lines derived from bovine or porcine embryos |
| US6271436B1 (en) | 1996-10-11 | 2001-08-07 | The Texas A & M University System | Cells and methods for the generation of transgenic pigs |
| AU745334B2 (en) * | 1997-03-06 | 2002-03-21 | Advanced Cell Technology, Inc. | Method of cloning animals |
| WO1999009141A1 (en) * | 1997-08-14 | 1999-02-25 | Biotransplant, Inc. | Porcine totipotent cells and method for long-term culture |
-
1998
- 1998-11-24 US US09/199,138 patent/US6258998B1/en not_active Expired - Fee Related
-
1999
- 1999-11-12 EP EP99958900A patent/EP1131409B1/de not_active Expired - Lifetime
- 1999-11-12 NZ NZ530018A patent/NZ530018A/en unknown
- 1999-11-12 IL IL14332699A patent/IL143326A0/xx unknown
- 1999-11-12 WO PCT/US1999/026710 patent/WO2000031237A2/en not_active Ceased
- 1999-11-12 BR BR9915642-3A patent/BR9915642A/pt not_active IP Right Cessation
- 1999-11-12 DE DE69925856T patent/DE69925856T2/de not_active Expired - Fee Related
- 1999-11-12 JP JP2000584048A patent/JP2002530105A/ja active Pending
- 1999-11-12 CA CA002350831A patent/CA2350831A1/en not_active Abandoned
- 1999-11-12 AT AT99958900T patent/ATE297980T1/de not_active IP Right Cessation
- 1999-11-12 AU AU16175/00A patent/AU774430B2/en not_active Ceased
- 1999-11-12 EP EP05012673A patent/EP1586633A1/de not_active Withdrawn
-
2001
- 2001-05-23 ZA ZA200104230A patent/ZA200104230B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL143326A0 (en) | 2002-04-21 |
| DE69925856D1 (de) | 2005-07-21 |
| NZ530018A (en) | 2005-08-26 |
| DE69925856T2 (de) | 2006-05-11 |
| ZA200104230B (en) | 2002-08-23 |
| EP1586633A1 (de) | 2005-10-19 |
| WO2000031237A3 (en) | 2000-11-16 |
| US6258998B1 (en) | 2001-07-10 |
| EP1131409B1 (de) | 2005-06-15 |
| WO2000031237A2 (en) | 2000-06-02 |
| AU1617500A (en) | 2000-06-13 |
| BR9915642A (pt) | 2001-08-07 |
| AU774430B2 (en) | 2004-06-24 |
| JP2002530105A (ja) | 2002-09-17 |
| CA2350831A1 (en) | 2000-06-02 |
| EP1131409A2 (de) | 2001-09-12 |
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