ATE298234T1 - (e)-styrylsulfone als krebsbestreitende mittel - Google Patents

(e)-styrylsulfone als krebsbestreitende mittel

Info

Publication number: ATE298234T1
Authority: AT; Austria
Prior art keywords: hydrogen; fluoro; chloro; bromo; styrylsulphones
Prior art date: 1999-04-02

Application number

AT00921553T

Other languages

English (en)

Inventor

E Premkumar Reddy

M V Ramana Reddy

Original Assignee

Univ Temple

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-02

Filing date

2000-03-31

Publication date

2005-07-15

2000-03-31 Application filed by Univ Temple filed Critical Univ Temple

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE298234T1 publication Critical patent/ATE298234T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 9
239000001257 hydrogen Substances 0.000 abstract 9
IQHSSYROJYPFDV-UHFFFAOYSA-N 2-bromo-1,3-dichloro-5-(trifluoromethyl)benzene Chemical group FC(F)(F)C1=CC(Cl)=C(Br)C(Cl)=C1 IQHSSYROJYPFDV-UHFFFAOYSA-N 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
MRTIWTGAGMZREP-VAWYXSNFSA-N [(e)-2-phenylethenyl]sulfonylmethylbenzene Chemical class C=1C=CC=CC=1/C=C/S(=O)(=O)CC1=CC=CC=C1 MRTIWTGAGMZREP-VAWYXSNFSA-N 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
-1 chloro, iodo Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
- C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT00921553T 1999-04-02 2000-03-31 (e)-styrylsulfone als krebsbestreitende mittel ATE298234T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US12768399P	1999-04-02	1999-04-02
US14397599P	1999-07-15	1999-07-15
PCT/US2000/008565 WO2000059495A1 (en)	1999-04-02	2000-03-31	(e)-styryl sulfone anticancer agents

Publications (1)

Publication Number	Publication Date
ATE298234T1 true ATE298234T1 (de)	2005-07-15

Family

ID=26825868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00921553T ATE298234T1 (de)	1999-04-02	2000-03-31	(e)-styrylsulfone als krebsbestreitende mittel

Country Status (7)

Country	Link
EP (1)	EP1173160B1 (de)
JP (1)	JP4596651B2 (de)
AT (1)	ATE298234T1 (de)
AU (1)	AU774738B2 (de)
CA (1)	CA2366750C (de)
DE (1)	DE60020954T2 (de)
WO (1)	WO2000059495A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2388343A1 (en) *	1999-11-12	2001-05-17	Mark Steven Marshall	Methods for inhibiting neurofibromatosis type 1 (nf1)
US6541475B2 (en) *	2000-04-14	2003-04-01	Temple University - Of The Commonwealth System Of Higher Education	α, β-unsaturated sulfones for treating proliferative disorders
US6486210B2 (en) *	2000-04-14	2002-11-26	Temple University—Of the Commonwealth System of Higher Education	Substituted styryl benzylsulfones for treating proliferative disorders
WO2002067913A1 (en)	2001-02-27	2002-09-06	Temple University-Of The Commonwealth System Of Higher Education	(z)-styrylbenzylsulfones and pharmaceutical uses thereof
US6667346B2 (en)	2001-02-28	2003-12-23	Temple University - Of The Commonwealth System Of Higher Education	Method for protecting cells and tissues from ionizing radiation toxicity with α, β unsaturated aryl sulfones
NZ535232A (en) *	2002-02-28	2007-05-31	Univ Temple	Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
AU2004289281C1 (en) *	2003-11-14	2011-12-08	Onconova Therapeutics, Inc.	Alpha, beta-Unsaturated sulfoxides for treating proliferative disorders
AU2005222947B2 (en) *	2004-03-16	2010-12-23	Onconova Therapeutics Inc.	Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders
US20090306207A1 (en) *	2005-01-05	2009-12-10	Reddy M V Ramana	Treatment of Drug-Resistant Proliferative Disorders
US8664272B2 (en) *	2006-08-30	2014-03-04	Temple University—Of the Commonwealth System of Higher Education	Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
US8465413B2 (en)	2010-11-25	2013-06-18	Coloplast A/S	Method of treating Peyronie's disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3463774A (en) *	1963-03-18	1969-08-26	Hoffmann La Roche	Novel 4,1-benzothiazepin-2-(1h)-ones and 4,1-benzothiazepines
JPH0641054A (ja) *	1992-07-27	1994-02-15	Mitsubishi Petrochem Co Ltd	スチリルスルホン誘導体、それを有効成分とする殺菌剤およびその製造方法
TR199801495T2 (xx) *	1995-06-07	1998-09-21	Eli Lilly And Company	Vinil s�lfoksitler ve sentezlenmeleri i�in bir i�lem.
ATE284386T1 (de) *	1997-10-03	2004-12-15	Univ Temple	Styrolsulfone als antikrebsmittel
US6201154B1 (en) *	1999-03-31	2001-03-13	Temple University-Of The Commonwealth Of Higher Education	Z-styryl sulfone anticancer agents
WO2000059494A1 (en) *	1999-04-02	2000-10-12	Temple University- Of The Commonwealth System Of Higher Education	Styryl sulfone anticancer agents
IL149064A0 (en) *	1999-10-12	2002-11-10	Univ Temple	Method for protecting normal cells from cytotoxicity of chemotherapeutic agents

2000
- 2000-03-31 WO PCT/US2000/008565 patent/WO2000059495A1/en not_active Ceased
- 2000-03-31 AT AT00921553T patent/ATE298234T1/de active
- 2000-03-31 DE DE60020954T patent/DE60020954T2/de not_active Expired - Lifetime
- 2000-03-31 JP JP2000609059A patent/JP4596651B2/ja not_active Expired - Fee Related
- 2000-03-31 AU AU41853/00A patent/AU774738B2/en not_active Ceased
- 2000-03-31 EP EP00921553A patent/EP1173160B1/de not_active Expired - Lifetime
- 2000-03-31 CA CA2366750A patent/CA2366750C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU774738B2 (en)	2004-07-08
EP1173160B1 (de)	2005-06-22
CA2366750A1 (en)	2000-10-12
EP1173160A4 (de)	2003-02-19
DE60020954T2 (de)	2006-05-11
JP4596651B2 (ja)	2010-12-08
CA2366750C (en)	2010-06-01
AU4185300A (en)	2000-10-23
WO2000059495A1 (en)	2000-10-12
JP2002541102A (ja)	2002-12-03
EP1173160A1 (de)	2002-01-23
DE60020954D1 (de)	2005-07-28

Legal Events

Date

Code

Title

Description

2006-11-15

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Publication of translation of european patent specification

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Publication	Publication Date	Title
DE60020954D1 (de)	2005-07-28	(e)-styrylsulfone als krebsbestreitende mittel
BR9915381A (pt)	2001-08-14	Uso de um composto, e, composto
ATE258790T1 (de)	2004-02-15	Z-styryl sulfonen als anti-krebsmittel
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ATE258930T1 (de)	2004-02-15	Dihydrobenzifurane
CA2405172A1 (en)	2001-10-25	Alpha,beta-unsaturated sulfones for treating proliferative disorders
NO20026095D0 (no)	2002-12-18	Koumarinderivater med COMT inhiberende aktivitet
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