ATE299144T1 - Verfahren zur herstellung einer pharmazeutisch aktiven verbindung (granisetron) - Google Patents
Verfahren zur herstellung einer pharmazeutisch aktiven verbindung (granisetron)Info
- Publication number
- ATE299144T1 ATE299144T1 AT03706845T AT03706845T ATE299144T1 AT E299144 T1 ATE299144 T1 AT E299144T1 AT 03706845 T AT03706845 T AT 03706845T AT 03706845 T AT03706845 T AT 03706845T AT E299144 T1 ATE299144 T1 AT E299144T1
- Authority
- AT
- Austria
- Prior art keywords
- granisetron
- compound
- formula
- producing
- active compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 title abstract 3
- 229960003727 granisetron Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000012442 inert solvent Substances 0.000 abstract 2
- 230000011987 methylation Effects 0.000 abstract 2
- 238000007069 methylation reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000017858 demethylation Effects 0.000 abstract 1
- 238000010520 demethylation reaction Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200200713A ES2197001B1 (es) | 2002-03-26 | 2002-03-26 | Procedimiento de obtencion de un compuesto farmaceuticamente activo. |
| PCT/IB2003/001058 WO2003080606A1 (en) | 2002-03-26 | 2003-03-21 | Process for preparing a pharmaceutically active compound (granisetron) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE299144T1 true ATE299144T1 (de) | 2005-07-15 |
Family
ID=28051970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03706845T ATE299144T1 (de) | 2002-03-26 | 2003-03-21 | Verfahren zur herstellung einer pharmazeutisch aktiven verbindung (granisetron) |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7071209B2 (de) |
| EP (1) | EP1487833B1 (de) |
| JP (1) | JP4560293B2 (de) |
| KR (1) | KR100835553B1 (de) |
| AT (1) | ATE299144T1 (de) |
| AU (1) | AU2003208552A1 (de) |
| CA (1) | CA2481703A1 (de) |
| DE (1) | DE60300986D1 (de) |
| ES (1) | ES2197001B1 (de) |
| IL (1) | IL164742A0 (de) |
| PL (1) | PL211464B1 (de) |
| PT (1) | PT1487833E (de) |
| TW (1) | TWI291959B (de) |
| WO (1) | WO2003080606A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003276919B2 (en) | 2002-09-25 | 2013-05-16 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| DE602004010299T2 (de) | 2003-12-22 | 2008-09-18 | Memory Pharmaceuticals Corp. | Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen |
| RU2417225C2 (ru) | 2004-03-25 | 2011-04-27 | Мемори Фармасьютиклз Корпорейшн | Индазолы, бензотиазолы, бензоизотиазолы, бензизоксазолы и их получение и применение |
| JP2007534692A (ja) | 2004-04-22 | 2007-11-29 | メモリー・ファーマシューティカルズ・コーポレイション | インドール、１ｈ−インダゾール、１，２−ベンズイソキサゾール、１，２−ベンゾイソチアゾール、ならびにその調製および使用 |
| JP2007538011A (ja) | 2004-05-07 | 2007-12-27 | メモリー・ファーマシューティカルズ・コーポレイション | １ｈ−インダゾール、ベンゾチアゾール、１，２−ベンゾイソキサゾール、１，２−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用 |
| BRPI0517494A (pt) | 2004-12-22 | 2008-10-14 | Memory Pharm Corp | composto, composição farmacêutica, método de ativação/estimulação seletiva de receptores nicotìnicos de a-7 em um paciente em que tal ativação/estimulação tem um efeito terapêutico, método de tratamento de um paciente que sofre de uma doença psicótica, uma doença neurodegenerativa que envolve uma disfunção do sistema colinérgico, e/ou uma condição de debilitação da memória e/ou da cognição, método de tratamento de um paciente que sofre de demência e/ou uma outra condição com perda da memória, método de tratamento de um paciente que sofre de debilitação da memória devido à debilitação cognitiva suave devido ao envelhecimento, mal de alzheimer, esquizofrenia, mal de parkinson, mal de huntington, mal de pick, mal de creutzfeldt-jakob, depressão, envelhecimento, trauma na cabeça, acidente vascular cerebral, hipoxia do snc, senilidade cerebral, demência de multiinfarto, hiv e/ou doença cardiovascular, método de tratamento e/ou prevenção da demência em um paciente com o mal de alzheimer, método de tratamento de um paciente para cortar o vìcio do álcool ou o tratamento de um paciente com a terapia anti-intoxicação, método de tratamento de um paciente para propiciar neuroproteção contra os danos associados com acidentes vasculares cerebrais e isquemia e excitotoxicidade induzida por glutamatos, método de tratamento de um paciente que sofre do vìcio da nicotina, dor, tontura do fuso horário, obesidade e/ou diabetes, método de indução do ato de parar fumar em um paciente, método de tratamento de um paciente que sofre de debilitação cognitiva suave (mci), demência vascular (vad), declìnio cognitivo associado com a idade (aacd), amnésia associada com a cirurgia com o coração aberto, parada cardìaca, anestesia geral, deficiências da memória devido à exposição a agentes anestésicos, debilitação cognitiva induzida pela privação do sono, sìndrome de fadiga crÈnica, narcolepsia, demência relacionada com a aids, debilitação cognitiva relacionada com a epilepsia, sìndrome de down, demência relacionada ao alcoolismo, debilitações da memória induzidas por drogas/substáncias, demência pugilìstica (sìndrome do boxeador), ou demência animal, método para o tratamento da perda da memória, método para o tratamento de um paciente que sofre de debilitação da memória, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da disfunção da transmissão do receptor nicotìnico de acetilcolina em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante de receptores nicotìnicos de acetilcolina defeituosos ou funcionando mal em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da transmissão suprimida do receptor nicotìnico de acetilcolina em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da perda de sinapses colinérgicas em um paciente, método para a proteção dos neurÈnios em um paciente com neurotoxicidade induzi |
| AR057661A1 (es) * | 2005-07-11 | 2007-12-12 | Tanabe Seiyaku Co | Un derivado de oxima y sus preparaciones |
| US8911751B2 (en) | 2005-10-11 | 2014-12-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions for nasal delivery |
| WO2007088557A1 (en) * | 2006-02-01 | 2007-08-09 | Natco Pharma Limited | Process for highly pure crystalline granisetron base |
| US20080242696A1 (en) * | 2007-03-27 | 2008-10-02 | Chemagis Ltd. | Crystalline granisetron base and production process therefor |
| US8304426B2 (en) | 2007-06-13 | 2012-11-06 | Inke, S.A. | Polymorphic form of Granisetron base, methods for obtaining it and formulation containing it |
| JP2012500276A (ja) * | 2008-08-19 | 2012-01-05 | サイノファーム タイワン リミテッド | グラニセトロン塩酸塩の多形体とその製造方法 |
| US20120101089A1 (en) * | 2010-10-26 | 2012-04-26 | Ashwani Agarwal | Anti-Emetic Substance |
| CN112778203B (zh) * | 2021-01-29 | 2022-02-15 | 兰州交通大学 | 1h-吲唑-3-羧酸衍生物及格拉斯琼和氯尼达明的制备方法 |
| CN115372487B (zh) * | 2021-05-18 | 2023-10-10 | 成都倍特得诺药业有限公司 | 盐酸格拉司琼中杂质e的hplc测定方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3650772T2 (de) * | 1985-04-27 | 2003-04-03 | F. Hoffmann-La Roche Ag, Basel | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
| GB9404055D0 (en) * | 1994-03-03 | 1994-04-20 | Smithkline Beecham Plc | Novel process |
| GB9602866D0 (en) * | 1996-02-13 | 1996-04-10 | Smithkline Beecham Plc | Novel process |
| GB9602862D0 (en) * | 1996-02-13 | 1996-04-10 | Smithkline Beecham Plc | Novel process |
-
2002
- 2002-03-26 ES ES200200713A patent/ES2197001B1/es not_active Expired - Fee Related
-
2003
- 2003-03-21 WO PCT/IB2003/001058 patent/WO2003080606A1/en not_active Ceased
- 2003-03-21 PT PT03706845T patent/PT1487833E/pt unknown
- 2003-03-21 EP EP03706845A patent/EP1487833B1/de not_active Expired - Lifetime
- 2003-03-21 CA CA002481703A patent/CA2481703A1/en not_active Abandoned
- 2003-03-21 KR KR1020047015135A patent/KR100835553B1/ko not_active Expired - Fee Related
- 2003-03-21 JP JP2003578360A patent/JP4560293B2/ja not_active Expired - Fee Related
- 2003-03-21 AU AU2003208552A patent/AU2003208552A1/en not_active Abandoned
- 2003-03-21 US US10/508,493 patent/US7071209B2/en not_active Expired - Fee Related
- 2003-03-21 AT AT03706845T patent/ATE299144T1/de not_active IP Right Cessation
- 2003-03-21 PL PL374447A patent/PL211464B1/pl not_active IP Right Cessation
- 2003-03-21 DE DE60300986T patent/DE60300986D1/de not_active Expired - Lifetime
- 2003-03-26 TW TW092106806A patent/TWI291959B/zh active
-
2004
- 2004-10-20 IL IL16474204A patent/IL164742A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20050124650A1 (en) | 2005-06-09 |
| ES2197001B1 (es) | 2004-11-16 |
| EP1487833B1 (de) | 2005-07-06 |
| JP2006511439A (ja) | 2006-04-06 |
| JP4560293B2 (ja) | 2010-10-13 |
| DE60300986D1 (de) | 2005-08-11 |
| WO2003080606A8 (en) | 2005-03-17 |
| KR20040099361A (ko) | 2004-11-26 |
| KR100835553B1 (ko) | 2008-06-09 |
| TW200305572A (en) | 2003-11-01 |
| TWI291959B (en) | 2008-01-01 |
| WO2003080606A1 (en) | 2003-10-02 |
| PT1487833E (pt) | 2005-11-30 |
| ES2197001A1 (es) | 2003-12-16 |
| AU2003208552A1 (en) | 2003-10-08 |
| CA2481703A1 (en) | 2003-10-02 |
| PL211464B1 (pl) | 2012-05-31 |
| IL164742A0 (en) | 2005-12-18 |
| PL374447A1 (en) | 2005-10-17 |
| EP1487833A1 (de) | 2004-12-22 |
| US7071209B2 (en) | 2006-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |