ATE299144T1 - Verfahren zur herstellung einer pharmazeutisch aktiven verbindung (granisetron) - Google Patents

Verfahren zur herstellung einer pharmazeutisch aktiven verbindung (granisetron)

Info

Publication number: ATE299144T1
Authority: AT; Austria
Prior art keywords: granisetron; compound; formula; producing; active compound
Prior art date: 2002-03-26

Application number

AT03706845T

Other languages

English (en)

Inventor

Barjoan Pere Dalmases

Torres Salvador Puig

Original Assignee

Vita Cientifica S L

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-26

Filing date

2003-03-21

Publication date

2005-07-15

2003-03-21 Application filed by Vita Cientifica S L filed Critical Vita Cientifica S L

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE299144T1 publication Critical patent/ATE299144T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 4
MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 title abstract 3
229960003727 granisetron Drugs 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
239000012442 inert solvent Substances 0.000 abstract 2
230000011987 methylation Effects 0.000 abstract 2
238000007069 methylation reaction Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
229940100198 alkylating agent Drugs 0.000 abstract 1
239000002168 alkylating agent Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000017858 demethylation Effects 0.000 abstract 1
238000010520 demethylation reaction Methods 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Otolaryngology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT03706845T 2002-03-26 2003-03-21 Verfahren zur herstellung einer pharmazeutisch aktiven verbindung (granisetron) ATE299144T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES200200713A ES2197001B1 (es)	2002-03-26	2002-03-26	Procedimiento de obtencion de un compuesto farmaceuticamente activo.
PCT/IB2003/001058 WO2003080606A1 (en)	2002-03-26	2003-03-21	Process for preparing a pharmaceutically active compound (granisetron)

Publications (1)

Publication Number	Publication Date
ATE299144T1 true ATE299144T1 (de)	2005-07-15

Family

ID=28051970

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03706845T ATE299144T1 (de)	2002-03-26	2003-03-21	Verfahren zur herstellung einer pharmazeutisch aktiven verbindung (granisetron)

Country Status (14)

Country	Link
US (1)	US7071209B2 (de)
EP (1)	EP1487833B1 (de)
JP (1)	JP4560293B2 (de)
KR (1)	KR100835553B1 (de)
AT (1)	ATE299144T1 (de)
AU (1)	AU2003208552A1 (de)
CA (1)	CA2481703A1 (de)
DE (1)	DE60300986D1 (de)
ES (1)	ES2197001B1 (de)
IL (1)	IL164742A0 (de)
PL (1)	PL211464B1 (de)
PT (1)	PT1487833E (de)
TW (1)	TWI291959B (de)
WO (1)	WO2003080606A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2499128C (en)	2002-09-25	2012-07-31	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
PL1697378T3 (pl)	2003-12-22	2008-04-30	Memory Pharm Corp	Indole, 1h-indazole, 1,2-benzoizoksazole i 1,2-benzoizotiazole oraz ich wytwarzanie i zastosowania
WO2005092890A2 (en)	2004-03-25	2005-10-06	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
DE602005024677D1 (de)	2004-04-22	2010-12-23	Memory Pharm Corp	Indole, 1h-indazole, 1,2-benzisoxazole, 1,2-benzoisothiazole, deren herstellung und verwendungen
RU2386633C2 (ru)	2004-05-07	2010-04-20	Мемори Фармасьютиклз Корпорейшн	1h-индазолы, бензотиазолы, 1, 2-бензоизоксазолы, 1, 2-бензоизотиазолы и хромоны и их получение и применения
JP2008525464A (ja)	2004-12-22	2008-07-17	メモリー・ファーマシューティカルズ・コーポレイション	α−７ニコチン性受容体リガンド並びにその製造及び使用
RU2420525C2 (ru) *	2005-07-11	2011-06-10	Мицубиси Танабе Фарма Корпорейшн	Производные оксимов и их получение
US8911751B2 (en)	2005-10-11	2014-12-16	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Compositions for nasal delivery
WO2007088557A1 (en) *	2006-02-01	2007-08-09	Natco Pharma Limited	Process for highly pure crystalline granisetron base
US20080242696A1 (en) *	2007-03-27	2008-10-02	Chemagis Ltd.	Crystalline granisetron base and production process therefor
EP2164848B1 (de)	2007-06-13	2016-02-24	Inke, S.A.	Polymorphe form von granisetronbase, verfahren zu deren gewinnung und formulierung, die diese enthält
CA2734900A1 (en) *	2008-08-19	2010-02-25	Shu-Ping Chen	Polymorphic form of granisetron hydrochloride and methods of making the same
US20120101089A1 (en) *	2010-10-26	2012-04-26	Ashwani Agarwal	Anti-Emetic Substance
CN112778203B (zh) *	2021-01-29	2022-02-15	兰州交通大学	1h-吲唑-3-羧酸衍生物及格拉斯琼和氯尼达明的制备方法
CN115372487B (zh) *	2021-05-18	2023-10-10	成都倍特得诺药业有限公司	盐酸格拉司琼中杂质e的hplc测定方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3687080T2 (de)	1985-04-27	1993-03-25	Beecham Group Plc	Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung.
GB9404055D0 (en)	1994-03-03	1994-04-20	Smithkline Beecham Plc	Novel process
GB9602862D0 (en) *	1996-02-13	1996-04-10	Smithkline Beecham Plc	Novel process
GB9602866D0 (en) *	1996-02-13	1996-04-10	Smithkline Beecham Plc	Novel process

2002
- 2002-03-26 ES ES200200713A patent/ES2197001B1/es not_active Expired - Fee Related
2003
- 2003-03-21 CA CA002481703A patent/CA2481703A1/en not_active Abandoned
- 2003-03-21 PL PL374447A patent/PL211464B1/pl not_active IP Right Cessation
- 2003-03-21 US US10/508,493 patent/US7071209B2/en not_active Expired - Fee Related
- 2003-03-21 PT PT03706845T patent/PT1487833E/pt unknown
- 2003-03-21 EP EP03706845A patent/EP1487833B1/de not_active Expired - Lifetime
- 2003-03-21 WO PCT/IB2003/001058 patent/WO2003080606A1/en not_active Ceased
- 2003-03-21 JP JP2003578360A patent/JP4560293B2/ja not_active Expired - Fee Related
- 2003-03-21 AT AT03706845T patent/ATE299144T1/de not_active IP Right Cessation
- 2003-03-21 DE DE60300986T patent/DE60300986D1/de not_active Expired - Lifetime
- 2003-03-21 AU AU2003208552A patent/AU2003208552A1/en not_active Abandoned
- 2003-03-21 KR KR1020047015135A patent/KR100835553B1/ko not_active Expired - Fee Related
- 2003-03-26 TW TW092106806A patent/TWI291959B/zh active
2004
- 2004-10-20 IL IL16474204A patent/IL164742A0/xx unknown

Also Published As

Publication number	Publication date
EP1487833B1 (de)	2005-07-06
ES2197001A1 (es)	2003-12-16
TW200305572A (en)	2003-11-01
KR100835553B1 (ko)	2008-06-09
AU2003208552A1 (en)	2003-10-08
IL164742A0 (en)	2005-12-18
US7071209B2 (en)	2006-07-04
PT1487833E (pt)	2005-11-30
JP4560293B2 (ja)	2010-10-13
PL211464B1 (pl)	2012-05-31
JP2006511439A (ja)	2006-04-06
WO2003080606A1 (en)	2003-10-02
TWI291959B (en)	2008-01-01
DE60300986D1 (de)	2005-08-11
PL374447A1 (en)	2005-10-17
EP1487833A1 (de)	2004-12-22
CA2481703A1 (en)	2003-10-02
WO2003080606A8 (en)	2005-03-17
KR20040099361A (ko)	2004-11-26
US20050124650A1 (en)	2005-06-09
ES2197001B1 (es)	2004-11-16

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Legal Events

Date	Code	Title	Description
2006-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties