ATE299499T1 - Gastrin und cholecystokinin rezeptor ligande - Google Patents

Gastrin und cholecystokinin rezeptor ligande

Info

Publication number: ATE299499T1
Authority: AT; Austria
Prior art keywords: gastrin; chr12; hydrocarbyl; bond; receptor ligands
Prior art date: 1998-11-09

Application number

AT99954196T

Other languages

English (en)

Inventor

Sarkis Barret Kalindjian

Ildiko Maria Buck

Ian Duncan Linney

Paul Trevor Wright

Iain Mair Mcdonald

Katherine Isobel Mary Steel

Robert Antony David Hull

Sonia Patricia Roberts

John David Gaffen

Jeremy Gilbert Vinter

Martin Keith Walker

James Whyte Black

Gillian Fairfull Watt

Elaine Anne Harper

Nigel Paul Shankley

Matthew John Tozer

David John Dunstone

Michael John Pether

Elliot James Lilley

David Andrew Sykes

Caroline Minli Rachel Low

Eric Peter Griffin

Laurence Wright

Original Assignee

Black James Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-09

Filing date

1999-11-09

Publication date

2005-07-15

1998-11-09 Priority claimed from GBGB9824536.8A external-priority patent/GB9824536D0/en

1999-11-09 Application filed by Black James Foundation filed Critical Black James Foundation

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE299499T1 publication Critical patent/ATE299499T1/de

Links

108010089448 Cholecystokinin B Receptor Proteins 0.000 title abstract 2
102000004859 Cholecystokinin Receptors Human genes 0.000 title abstract 2
108090001085 Cholecystokinin Receptors Proteins 0.000 title abstract 2
102000052874 Gastrin receptors Human genes 0.000 title abstract 2
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 title abstract 2
239000003446 ligand Substances 0.000 title abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003831 tetrazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrrole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT99954196T 1998-11-09 1999-11-09 Gastrin und cholecystokinin rezeptor ligande ATE299499T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9824536.8A GB9824536D0 (en)	1998-11-09	1998-11-09	Gastrin and cholecystokinin receptor ligands
GBGB9916786.8A GB9916786D0 (en)	1998-11-09	1999-07-16	Gastrin and cholecystokinin receptor ligands
PCT/GB1999/003733 WO2000027823A1 (en)	1998-11-09	1999-11-09	Gastrin and cholecystokinin receptor ligands

Publications (1)

Publication Number	Publication Date
ATE299499T1 true ATE299499T1 (de)	2005-07-15

Family

ID=26314641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99954196T ATE299499T1 (de)	1998-11-09	1999-11-09	Gastrin und cholecystokinin rezeptor ligande

Country Status (13)

Country	Link
US (1)	US6479531B1 (de)
EP (1)	EP1178969B1 (de)
JP (1)	JP2002529455A (de)
CN (1)	CN1325385A (de)
AT (1)	ATE299499T1 (de)
AU (1)	AU1061500A (de)
BR (1)	BR9915194A (de)
CA (1)	CA2346108A1 (de)
DE (1)	DE69926148D1 (de)
HU (1)	HUP0104038A3 (de)
NO (1)	NO20012288L (de)
PL (1)	PL347591A1 (de)
WO (1)	WO2000027823A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0011095D0 (en) *	2000-05-08	2000-06-28	Black James Foundation	astrin and cholecystokinin receptor ligands (III)
GB0011098D0 (en) *	2000-05-08	2000-06-28	Black James Foundation	Pharmaceutical compositions comprising protpn pump inhibitors and gastrin/cholecystokinin receptor ligands
GB0011094D0 (en) *	2000-05-08	2000-06-28	Black James Foundation	Gastrin and cholecystokinin receptor ligands (III)
GB0319124D0 (en) *	2003-08-14	2003-09-17	Smithkline Beecham Corp	Chemical compounds
WO2005080367A1 (en) *	2004-02-12	2005-09-01	Pharmagene Laboratories Limited	Ep2 receptor agonists
WO2005121132A1 (ja) *	2004-06-11	2005-12-22	Shionogi & Co., Ltd.	抗ｈｃｖ作用を有する縮合ヘテロ環化合物
CA2573426C (en)	2004-07-30	2015-11-17	Exelixis, Inc.	Pyrrole derivatives as pharmaceutical agents
CA2618486A1 (en)	2005-08-09	2007-02-15	Asterand Uk Limited	Ep2 receptor agonists
WO2007052843A1 (ja) *	2005-11-04	2007-05-10	Takeda Pharmaceutical Company Limited	複素環アミド化合物およびその用途
JP5182088B2 (ja)	2006-04-19	2013-04-10	アステラス製薬株式会社	アゾールカルボキサミド誘導体
US8558002B2 (en)	2006-11-16	2013-10-15	Allergan, Inc.	Sulfoximines as kinase inhibitors
EP2099757B1 (de)	2006-11-16	2014-06-25	Allergan, Inc.	Sulfoximine als kinaseinhibitoren
US8143410B2 (en)	2006-11-16	2012-03-27	Allergan, Inc.	Kinase inhibitors
JPWO2008136428A1 (ja) *	2007-04-27	2010-07-29	武田薬品工業株式会社	含窒素５員複素環化合物
RS56990B1 (sr)	2007-09-10	2018-05-31	Janssen Pharmaceutica Nv	Postupak za dobijanje jedinjenja koja su korisna kao inhibitori sglt
AU2008310660A1 (en) *	2007-10-11	2009-04-16	Vertex Pharmaceuticals Incorporated	Heteroaryl amides useful as inhibitors of voltage-gated sodium channels
EP2206707B1 (de)	2007-10-24	2014-07-23	Astellas Pharma Inc.	Azolecarboxamidverbindung oder salz daraus
US9447049B2 (en)	2010-03-01	2016-09-20	University Of Tennessee Research Foundation	Compounds for treatment of cancer
US9056850B2 (en)	2008-10-17	2015-06-16	Janssen Pharmaceutica N.V.	Process for the preparation of compounds useful as inhibitors of SGLT
EA022417B1 (ru) *	2008-10-21	2015-12-30	Саймабэй Терапевтикс, Инк.	Арильные агонисты рецептора gpr120 и их применение
EP2253617A1 (de) *	2009-05-20	2010-11-24	Bayer CropScience AG	Halogen-substituierte Verbindungen als Pestizide
US20110009347A1 (en)	2009-07-08	2011-01-13	Yin Liang	Combination therapy for the treatment of diabetes
HUE031375T2 (en)	2009-10-14	2017-07-28	Janssen Pharmaceutica Nv	Process for the preparation of compounds useful as inhibitors of sglt2
SG10201506114UA (en)	2010-05-11	2015-09-29	Janssen Pharmaceutica Nv	Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt
JP5855095B2 (ja)	2010-06-07	2016-02-09	ノボメディックス, エルエルシーNovomedix, Llc	フラニル化合物およびその使用
JP5996532B2 (ja)	2010-07-15	2016-09-21	バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＧｍｂＨ	有害生物防除剤としての新規複素環式化合物
CA2807198A1 (en) *	2010-08-03	2012-02-09	Graffinity Pharmaceuticals Gmbh	Ligands for antibody and fc-fusion protein purification by affinity chromatography
EP2697218B1 (de)	2011-04-13	2016-05-25	Janssen Pharmaceutica NV	Verfahren zur herstellung von verbindungen die als sglt2 inhibitoren verwendbar sind
TWI542596B (zh)	2011-05-09	2016-07-21	健生藥品公司	（２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
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ES2859102T3 (es)	2013-07-12	2021-10-01	Gilead Sciences Inc	Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH
NO2865735T3 (de)	2013-07-12	2018-07-21
TWI677489B (zh) *	2014-06-20	2019-11-21	美商基利科學股份有限公司	多環型胺甲醯基吡啶酮化合物之合成
NO2717902T3 (de)	2014-06-20	2018-06-23
TW201613936A (en)	2014-06-20	2016-04-16	Gilead Sciences Inc	Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
CN107949380B (zh) *	2015-02-11	2021-07-06	西奈山伊坎医学院	用于尼曼-匹克病和其他溶酶体贮积症的npc1的苯磺酰胺上调剂
US20170071970A1 (en)	2015-09-15	2017-03-16	Janssen Pharmaceutica Nv	Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
JP2022532718A (ja) *	2019-05-14	2022-07-19	メタボメッドリミテッド	Ａｃｓｓ２阻害剤およびその使用方法
KR20230128471A (ko) *	2020-12-04	2023-09-05	에우불루스 바이오테라퓨틱스 인코포레이티드	헤테로아릴-아세틸렌, 이의 약제학적 조성물, 및 이의치료적 적용
JP2024016314A (ja) *	2020-12-24	2024-02-07	小野薬品工業株式会社	一般式（ｉ－ａ）で示される化合物、その薬学的に許容される塩、またはそれらの水和物と免疫チェックポイント阻害薬および／またはｅｐ４受容体拮抗薬との組み合わせ

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5202344A (en) *	1990-12-11	1993-04-13	G. D. Searle & Co.	N-substituted lactams useful as cholecystokinin antagonists
NZ249202A (en) *	1992-02-20	1996-06-25	Black James Foundation	Bicyclo[2.2.2.]octane derivatives, preparation and pharmaceutical compositions thereof
CA2167154A1 (en)	1993-08-10	1995-02-16	Sarkis Barret Kalindjian	Gastrin and cck receptor ligands
GB9409150D0 (en) *	1994-05-09	1994-06-29	Black James Foundation	Cck and gastrin receptor ligands
AU679887B2 (en)	1995-09-11	1997-07-10	Nihon Nohyaku Co., Ltd.	Azole derivatives, their use, production and usage
ATE255090T1 (de)	1996-08-01	2003-12-15	Merckle Gmbh	Acylpyrroldicarbonsäuren und acylindoldicarbonsäuren sowie ihre derivate als hemmstoffe der cytosolischen phospholipase a2

1999
- 1999-11-09 AT AT99954196T patent/ATE299499T1/de not_active IP Right Cessation
- 1999-11-09 AU AU10615/00A patent/AU1061500A/en not_active Abandoned
- 1999-11-09 PL PL99347591A patent/PL347591A1/xx not_active Application Discontinuation
- 1999-11-09 US US09/831,385 patent/US6479531B1/en not_active Expired - Fee Related
- 1999-11-09 HU HU0104038A patent/HUP0104038A3/hu unknown
- 1999-11-09 EP EP99954196A patent/EP1178969B1/de not_active Expired - Lifetime
- 1999-11-09 DE DE69926148T patent/DE69926148D1/de not_active Expired - Lifetime
- 1999-11-09 CA CA002346108A patent/CA2346108A1/en not_active Abandoned
- 1999-11-09 JP JP2000581003A patent/JP2002529455A/ja active Pending
- 1999-11-09 CN CN99813085A patent/CN1325385A/zh active Pending
- 1999-11-09 WO PCT/GB1999/003733 patent/WO2000027823A1/en not_active Ceased
- 1999-11-09 BR BR9915194-4A patent/BR9915194A/pt not_active Application Discontinuation
2001
- 2001-05-09 NO NO20012288A patent/NO20012288L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1325385A (zh)	2001-12-05
HUP0104038A2 (hu)	2002-05-29
BR9915194A (pt)	2001-08-07
WO2000027823A1 (en)	2000-05-18
DE69926148D1 (en)	2005-08-18
PL347591A1 (en)	2002-04-08
NO20012288D0 (no)	2001-05-09
JP2002529455A (ja)	2002-09-10
HUP0104038A3 (en)	2002-07-29
EP1178969B1 (de)	2005-07-13
EP1178969A1 (de)	2002-02-13
US6479531B1 (en)	2002-11-12
AU1061500A (en)	2000-05-29
NO20012288L (no)	2001-07-02
CA2346108A1 (en)	2000-05-18

Legal Events

Date	Code	Title	Description
2006-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE299499T1 (de)	2005-07-15	Gastrin und cholecystokinin rezeptor ligande
AR001081A1 (es)	1997-09-24	Un proceso para preparar ciertos aza ciclohexapeptidos y compuestos preparados mediante dicho proceso
IN2001KN01110A (de)	2015-06-05
UA76409C2 (uk)	2006-08-15	Трифенілалкенові похідні і їх застосування як селективних модуляторів рецепторів естрогену
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TR200102957T2 (tr)	2004-12-21	Sitalopram hazırlanması için metod.
ES2036551T3 (es)	1996-07-16	Compuestos heterociclicos.
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GB2377442A (en)	2003-01-15	Gastrin and cholecystokinin receptor ligands (III)
HU9402444D0 (en)	1994-10-28	Diacyl-substituted guanidine derivatives, process for producing them and pharmaceutical compositions containing them
ATE168679T1 (de)	1998-08-15	Neue tetracyclische verbindungen
SE8305307D0 (sv)	1983-09-29	Sulfurerade bensylidenderivat
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DK0779895T3 (da)	2000-03-13	Forbedret fremgangsmåde til fremstilling af sidekædederivater af cyclohexapeptidyl-lipopeptider
HRP980646B1 (en)	2008-02-29	Novel oleandomycin derivatives
ATE190334T1 (de)	2000-03-15	Azlacton-derivatisierte polyamide
NZ291855A (en)	1999-08-30	Bridged azabicyclo-piperazin-1-yl-2-phenyl-butan-1-one derivatives as 5-ht1a antagonists
EP0794178A4 (de)	1998-02-25	Chinazolin-derivate