ATE301648T1 - Verfahren zur herstellung von 4- oxytetrahydropyran-2-onen - Google Patents

Verfahren zur herstellung von 4- oxytetrahydropyran-2-onen

Info

Publication number: ATE301648T1
Authority: AT; Austria
Prior art keywords: ones; oxytetrahydropyran; producing; reaction; reagent
Prior art date: 2002-03-26

Application number

AT03710622T

Other languages

English (en)

Inventor

Silvo Zupancic

Dusan Krasovec

Pavel Zupet

Original Assignee

Krka Tovarna Zdravil D D Novo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-26

Filing date

2003-03-17

Publication date

2005-08-15

2003-03-17 Application filed by Krka Tovarna Zdravil D D Novo filed Critical Krka Tovarna Zdravil D D Novo

2005-08-15 Application granted granted Critical

2005-08-15 Publication of ATE301648T1 publication Critical patent/ATE301648T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
238000006243 chemical reaction Methods 0.000 abstract 2
239000003153 chemical reaction reagent Substances 0.000 abstract 2
PARWIGJQSWCJKP-UHFFFAOYSA-N 4-silyloxyoxan-2-one Chemical class [SiH3]OC1CCOC(=O)C1 PARWIGJQSWCJKP-UHFFFAOYSA-N 0.000 abstract 1
102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 abstract 1
108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 abstract 1
RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000005828 desilylation reaction Methods 0.000 abstract 1
IKGLACJFEHSFNN-UHFFFAOYSA-N hydron;triethylazanium;trifluoride Chemical compound F.F.F.CCN(CC)CC IKGLACJFEHSFNN-UHFFFAOYSA-N 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 1
229960002855 simvastatin Drugs 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT03710622T 2002-03-26 2003-03-17 Verfahren zur herstellung von 4- oxytetrahydropyran-2-onen ATE301648T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SI200200086A SI21187A (sl)	2002-03-26	2002-03-26	Postopek za pripravo 4-oksitetrahidropiran-2-onov
PCT/SI2003/000009 WO2003080591A1 (en)	2002-03-26	2003-03-17	Process for the preparation of 4-oxytetrahydropyran-2-ones

Publications (1)

Publication Number	Publication Date
ATE301648T1 true ATE301648T1 (de)	2005-08-15

Family

ID=28450345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03710622T ATE301648T1 (de)	2002-03-26	2003-03-17	Verfahren zur herstellung von 4- oxytetrahydropyran-2-onen

Country Status (13)

Country	Link
US (1)	US7094912B2 (de)
EP (1)	EP1487814B1 (de)
JP (1)	JP2005523303A (de)
KR (1)	KR20040106306A (de)
CN (1)	CN1281596C (de)
AT (1)	ATE301648T1 (de)
AU (1)	AU2003214791A1 (de)
DE (1)	DE60301267T2 (de)
EA (1)	EA007012B1 (de)
HR (1)	HRP20040885B1 (de)
PL (1)	PL208279B1 (de)
SI (1)	SI21187A (de)
WO (1)	WO2003080591A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2239543B1 (es) *	2004-03-15	2006-08-01	Ercros Industrial, S.A.	Procedimiento para la obtencion de simvastatina.
WO2007096753A2 (en) *	2006-02-21	2007-08-30	Cadila Healthcare Limited	Process for preparing highly pure simvastatin

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU548996B2 (en)	1980-02-04	1986-01-09	Merck & Co., Inc.	Tetrahydro-2h-pyran-2-one derivatives
DE3480923D1 (de)	1983-10-11	1990-02-08	Merck & Co Inc	Verfahren zur c-methylierung von 2-methylbutyraten.
US4820850A (en)	1987-07-10	1989-04-11	Merck & Co., Inc.	Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4894466A (en) *	1988-02-29	1990-01-16	Merck & Co., Inc.	Intermediates and processes for β-6-hydroxymethyl HMG-CoA reductable inhibitors
FI893004L (fi) *	1988-06-29	1989-12-30	Merck & Co Inc	5-oxygenerade hmg-coa-reduktas -inhibitorer.
CA2036962C (en)	1990-02-26	1998-09-15	Ann E. Decamp	Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one
US5393893A (en) *	1993-11-08	1995-02-28	Apotex, Inc.	Process for producing simvastatin and analogs thereof
US5763653A (en)	1997-03-13	1998-06-09	Ranbaxy Laboratories, Ltd.	Key intermediates in the manufacture of simvastatin
US5763646A (en)	1997-03-13	1998-06-09	Ranbaxy Laboratories, Ltd.	Process for manufacturing simvastatin from lovastatin or mevinolinic acid
ES2197465T3 (es)	1997-01-28	2004-01-01	Plus Chemicals B.V.	Proceso para la produccion de estatinas semisinteticas a traves de nuevos intermedios.
SI20159A (sl) *	1999-02-04	2000-08-31	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Nov postopek za odstranitev sililoksi zaščitne skupine iz 4-sililoksi tetrahidro-piran-2-on-ov
JP3946521B2 (ja)	2000-03-30	2007-07-18	チェイルジェダンコーポレイション	シンバスタチンの製造方法
AU2001237752A1 (en) *	2001-02-27	2001-07-03	Chong Kun Dang Pharmaceutical Corp.	An improved process for preparing simvastatin

2002
- 2002-03-26 SI SI200200086A patent/SI21187A/sl not_active IP Right Cessation
2003
- 2003-03-17 EA EA200401253A patent/EA007012B1/ru not_active IP Right Cessation
- 2003-03-17 DE DE60301267T patent/DE60301267T2/de not_active Expired - Lifetime
- 2003-03-17 JP JP2003578346A patent/JP2005523303A/ja active Pending
- 2003-03-17 KR KR10-2004-7015123A patent/KR20040106306A/ko not_active Ceased
- 2003-03-17 HR HRP20040885AA patent/HRP20040885B1/xx not_active IP Right Cessation
- 2003-03-17 EP EP03710622A patent/EP1487814B1/de not_active Expired - Lifetime
- 2003-03-17 WO PCT/SI2003/000009 patent/WO2003080591A1/en not_active Ceased
- 2003-03-17 AT AT03710622T patent/ATE301648T1/de not_active IP Right Cessation
- 2003-03-17 PL PL372360A patent/PL208279B1/pl unknown
- 2003-03-17 AU AU2003214791A patent/AU2003214791A1/en not_active Abandoned
- 2003-03-17 US US10/509,611 patent/US7094912B2/en not_active Expired - Fee Related
- 2003-03-17 CN CNB038089475A patent/CN1281596C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1487814A1 (de)	2004-12-22
EP1487814B1 (de)	2005-08-10
WO2003080591A1 (en)	2003-10-02
JP2005523303A (ja)	2005-08-04
SI21187A (sl)	2003-10-31
HRP20040885B1 (en)	2012-09-30
PL208279B1 (pl)	2011-04-29
CN1646517A (zh)	2005-07-27
DE60301267T2 (de)	2006-06-01
PL372360A1 (en)	2005-07-25
AU2003214791A1 (en)	2003-10-08
DE60301267D1 (de)	2005-09-15
US20050182263A1 (en)	2005-08-18
EA200401253A1 (ru)	2005-04-28
HRP20040885A2 (en)	2005-04-30
KR20040106306A (ko)	2004-12-17
EA007012B1 (ru)	2006-06-30
CN1281596C (zh)	2006-10-25
US7094912B2 (en)	2006-08-22

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Legal Events

Date	Code	Title	Description
2006-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties