ATE301672T1 - Methode zur reinigung eines erythrpoietinbindenden proteins - Google Patents

Methode zur reinigung eines erythrpoietinbindenden proteins

Info

Publication number: ATE301672T1
Authority: AT; Austria
Prior art keywords: ebp; protein; epo; binding; drug design
Prior art date: 1996-01-23

Application number

AT97906426T

Other languages

English (en)

Inventor

Steven A Middleton

Dana Johnson

Frank J Mcmahon

Linda S Mulkahy

Linda K Jolliffe

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-23

Filing date

1997-01-22

Publication date

2005-08-15

1997-01-22 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2005-08-15 Application granted granted Critical

2005-08-15 Publication of ATE301672T1 publication Critical patent/ATE301672T1/de

Links

102000004169 proteins and genes Human genes 0.000 title abstract 5
108090000623 proteins and genes Proteins 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 3
102100031939 Erythropoietin Human genes 0.000 abstract 5
108010092408 Eosinophil Peroxidase Proteins 0.000 abstract 4
235000018102 proteins Nutrition 0.000 abstract 4
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 3
238000009510 drug design Methods 0.000 abstract 2
238000007876 drug discovery Methods 0.000 abstract 2
241000588724 Escherichia coli Species 0.000 abstract 1
101000852145 Homo sapiens Erythropoietin receptor Proteins 0.000 abstract 1
102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 1
108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
239000011543 agarose gel Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
238000001516 cell proliferation assay Methods 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
238000002050 diffraction method Methods 0.000 abstract 1
238000006471 dimerization reaction Methods 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
108020001507 fusion proteins Proteins 0.000 abstract 1
102000037865 fusion proteins Human genes 0.000 abstract 1
230000003100 immobilizing effect Effects 0.000 abstract 1
230000003993 interaction Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000012528 membrane Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
239000002287 radioligand Substances 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Cell Biology (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT97906426T 1996-01-23 1997-01-22 Methode zur reinigung eines erythrpoietinbindenden proteins ATE301672T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1046996P	1996-01-23	1996-01-23
US2212996P	1996-07-18	1996-07-18
PCT/US1997/000932 WO1997027219A1 (en)	1996-01-23	1997-01-22	Methods for purification and use of erythropoietin binding protein

Publications (1)

Publication Number	Publication Date
ATE301672T1 true ATE301672T1 (de)	2005-08-15

Family

ID=26681222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97906426T ATE301672T1 (de)	1996-01-23	1997-01-22	Methode zur reinigung eines erythrpoietinbindenden proteins

Country Status (7)

Country	Link
EP (1)	EP0909274B1 (de)
JP (1)	JP4060361B2 (de)
AT (1)	ATE301672T1 (de)
AU (1)	AU729540B2 (de)
DE (1)	DE69733950T2 (de)
ES (1)	ES2246506T3 (de)
WO (1)	WO1997027219A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5203199A (en) *	1998-05-26	1999-12-13	Procter & Gamble Company, The	Chimeric molecules comprising an extracellular ligand binding domain of a receptor and an ige fc or constant region, and their use in an assay system
EP3366692A1 (de)	2009-06-22	2018-08-29	Amgen, Inc	Proteinneufaltung mit einem chemisch gesteuerten redoxzustand
AU2010266093B2 (en)	2009-06-25	2013-06-27	Amgen Inc.	Capture purification processes for proteins expressed in a non-mammalian system
JP6366303B2 (ja) *	2014-03-06	2018-08-01	東ソー株式会社	エリスロポエチン結合性タンパク質

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990008822A1 (en) *	1989-02-03	1990-08-09	Genetics Institute, Inc.	Erythropoietin receptor

1997
- 1997-01-22 AU AU21122/97A patent/AU729540B2/en not_active Expired
- 1997-01-22 ES ES97906426T patent/ES2246506T3/es not_active Expired - Lifetime
- 1997-01-22 JP JP52694997A patent/JP4060361B2/ja not_active Expired - Lifetime
- 1997-01-22 AT AT97906426T patent/ATE301672T1/de not_active IP Right Cessation
- 1997-01-22 DE DE69733950T patent/DE69733950T2/de not_active Expired - Lifetime
- 1997-01-22 EP EP97906426A patent/EP0909274B1/de not_active Expired - Lifetime
- 1997-01-22 WO PCT/US1997/000932 patent/WO1997027219A1/en not_active Ceased

Also Published As

Publication number	Publication date
DE69733950T2 (de)	2006-07-06
WO1997027219A1 (en)	1997-07-31
EP0909274B1 (de)	2005-08-10
JP4060361B2 (ja)	2008-03-12
DE69733950D1 (de)	2005-09-15
AU2112297A (en)	1997-08-20
ES2246506T3 (es)	2006-02-16
EP0909274A4 (de)	2000-01-19
EP0909274A1 (de)	1999-04-21
JP2001507670A (ja)	2001-06-12
AU729540B2 (en)	2001-02-01

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Legal Events

Date	Code	Title	Description
2006-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties