ATE302783T1 - Phosphinsäure pseudo-peptidderivate - Google Patents

Phosphinsäure pseudo-peptidderivate

Info

Publication number: ATE302783T1
Authority: AT; Austria
Prior art keywords: sub; peptide derivatives; derivatives; amino acid; phosphine acid
Prior art date: 2002-01-18

Application number

AT03717341T

Other languages

English (en)

Inventor

Jo Cotton

Dimitri Georgiadis

Vincent Dive

Original Assignee

Commissariat Energie Atomique

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-18

Filing date

2003-01-16

Publication date

2005-09-15

2003-01-16 Application filed by Commissariat Energie Atomique filed Critical Commissariat Energie Atomique

2005-09-15 Application granted granted Critical

2005-09-15 Publication of ATE302783T1 publication Critical patent/ATE302783T1/de

Links

XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 title 2
239000002253 acid Substances 0.000 title 1
229910000073 phosphorus hydride Inorganic materials 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3276—Esters with cycloaliphatic alcohols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/303—Cycloaliphatic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT03717341T 2002-01-18 2003-01-16 Phosphinsäure pseudo-peptidderivate ATE302783T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0200599A FR2834989B1 (fr)	2002-01-18	2002-01-18	Derives de pseudo-peptides phosphiniques inhibant selectivement le site actif c-terminal de l'enzyme de conversion de l'angiotensine i(ace)
PCT/FR2003/000129 WO2003062247A2 (fr)	2002-01-18	2003-01-16	Derives de pseudo-peptides phosphiniques

Publications (1)

Publication Number	Publication Date
ATE302783T1 true ATE302783T1 (de)	2005-09-15

Family

ID=27589514

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03717341T ATE302783T1 (de)	2002-01-18	2003-01-16	Phosphinsäure pseudo-peptidderivate

Country Status (9)

Country	Link
US (1)	US7105483B2 (de)
EP (1)	EP1468003B1 (de)
JP (1)	JP2005522420A (de)
AT (1)	ATE302783T1 (de)
AU (1)	AU2003222329A1 (de)
CA (1)	CA2473047A1 (de)
DE (1)	DE60301387T2 (de)
FR (1)	FR2834989B1 (de)
WO (1)	WO2003062247A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2934267B1 (fr) *	2008-07-23	2010-08-13	Pharmaleads	Derives aminophosphiniques utiles dans le traitement de la douleur

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0361341A3 (de) *	1988-09-28	1991-07-03	Miles Inc.	Therapeutika für AIDS auf der Basis von HIV-Protease-Inhibitoren
FR2676059B1 (fr)	1991-05-02	1993-07-23	Commissariat Energie Atomique	Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.
US5476847A (en) *	1994-06-29	1995-12-19	Schering Corporation	Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors
FR2730235A1 (fr) *	1995-02-06	1996-08-09	Commissariat Energie Atomique	Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15
FR2781230B1 (fr) *	1998-07-02	2000-09-01	Commissariat Energie Atomique	Derives de peptides utilisables comme inhibiteur selectif du site n-terminal de l'enzyme de conversion de l'angiotensine humaine

2002
- 2002-01-18 FR FR0200599A patent/FR2834989B1/fr not_active Expired - Fee Related
2003
- 2003-01-16 EP EP03717341A patent/EP1468003B1/de not_active Expired - Lifetime
- 2003-01-16 CA CA002473047A patent/CA2473047A1/fr not_active Abandoned
- 2003-01-16 AT AT03717341T patent/ATE302783T1/de not_active IP Right Cessation
- 2003-01-16 WO PCT/FR2003/000129 patent/WO2003062247A2/fr not_active Ceased
- 2003-01-16 DE DE60301387T patent/DE60301387T2/de not_active Expired - Lifetime
- 2003-01-16 US US10/500,891 patent/US7105483B2/en not_active Expired - Fee Related
- 2003-01-16 JP JP2003562124A patent/JP2005522420A/ja active Pending
- 2003-01-16 AU AU2003222329A patent/AU2003222329A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE60301387T2 (de)	2006-06-08
DE60301387D1 (en)	2005-09-29
FR2834989A1 (fr)	2003-07-25
US20050070505A1 (en)	2005-03-31
EP1468003B1 (de)	2005-08-24
US7105483B2 (en)	2006-09-12
FR2834989B1 (fr)	2005-05-20
WO2003062247A3 (fr)	2004-03-11
WO2003062247A2 (fr)	2003-07-31
EP1468003A2 (de)	2004-10-20
CA2473047A1 (fr)	2003-07-31
AU2003222329A1 (en)	2003-09-02
JP2005522420A (ja)	2005-07-28

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Legal Events

Date	Code	Title	Description
2006-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties