ATE303384T1 - 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren - Google Patents

1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren

Info

Publication number: ATE303384T1
Authority: AT; Austria
Prior art keywords: inhibitors; phosphodieseterase; biaryl; naphthyridine; phosphodiesterrase
Prior art date: 2001-05-24

Application number

AT02727127T

Other languages

English (en)

Inventor

Daniel Guay

Mario Girard

Pierre Hamel

Sebastien Laliberte

Richard Friesen

Yves Girard

Chun Li

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-24

Filing date

2002-05-22

Publication date

2005-09-15

2002-05-22 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

2005-09-15 Application granted granted Critical

2005-09-15 Publication of ATE303384T1 publication Critical patent/ATE303384T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
206010061218 Inflammation Diseases 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Transplantation (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02727127T 2001-05-24 2002-05-22 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren ATE303384T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29324701P	2001-05-24	2001-05-24
PCT/CA2002/000746 WO2002094823A1 (en)	2001-05-24	2002-05-22	1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4 inhibitors

Publications (1)

Publication Number	Publication Date
ATE303384T1 true ATE303384T1 (de)	2005-09-15

Family

ID=23128314

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02727127T ATE303384T1 (de)	2001-05-24	2002-05-22	1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren

Country Status (10)

Country	Link
US (1)	US6677351B2 (de)
EP (1)	EP1397359B1 (de)
JP (1)	JP4460221B2 (de)
AT (1)	ATE303384T1 (de)
AU (1)	AU2002257459B2 (de)
CA (1)	CA2447765C (de)
DE (1)	DE60205899T2 (de)
ES (1)	ES2247325T3 (de)
PE (1)	PE20030061A1 (de)
WO (1)	WO2002094823A1 (de)

Families Citing this family (21)

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ATE356808T1 (de) *	2002-06-25	2007-04-15	Merck Frosst Canada Ltd	8-(biaryl)chinolin-pde4-inhibitoren
AR042194A1 (es) *	2002-11-22	2005-06-15	Merck & Co Inc	Metodo para preparar inhibidores de fosfodiesterasa - 4
IS7839A (is) *	2002-11-22	2004-05-23	Merck Frosst Canada Ltd.	4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar
AU2003286024A1 (en) *	2002-11-22	2004-06-18	Daniel Dube	Use of phosphodiesterase-4 inhibitors as enhancers of cognition
US6909002B2 (en) *	2002-11-22	2005-06-21	Merck & Co., Inc.	Method of preparing inhibitors of phosphodiesterase-4
JP2006524638A (ja) *	2003-04-30	2006-11-02	メルクフロストカナダリミテツド	８−（３−ビアリール）フェニルキノリン系ホスホジエステラーゼ−４阻害薬
US7449481B2 (en) *	2004-04-13	2008-11-11	Cephalon, Inc.	Thio-substituted biaryl-methanesulfinyl derivatives
EP1981885A2 (de) *	2005-10-27	2008-10-22	Merck & Co., Inc.	Verfahren zur herstellung eines 4-oxo-1-(3-substituiertes phenyl)-1,4-dihydro-1,8-naphthyridin-3-carbonsäureamids als phosphodiesterase-4-inhibitor
DE602006018057D1 (de) *	2005-11-10	2010-12-16	Chemocentryx Inc	Substituierte chinolone und verwendungsverfahren
ES2378281T3 (es) *	2006-07-05	2012-04-10	Nycomed Gmbh	Combinación de atorvastatina con un inhibidor de fosfodiesterasa 4 para el tratamiento de neumopatías inflamatorias
RU2009141592A (ru) *	2007-04-11	2011-05-20	Алькон Рисерч, Лтд. (Us)	ПРИМЕНЕНИЕ ИНГИБИТОРА TNFα В СОЧЕТАНИИ С АНТИГИСТАМИННЫМ СРЕДСТВОМ ДЛЯ ЛЕЧЕНИЯ АЛЛЕРГИЧЕСКОГО РИНИТА И АЛЛЕРГИЧЕСКОГО КОНЪЮНКТИВИТА
US20090182035A1 (en) *	2007-04-11	2009-07-16	Alcon Research, Ltd.	Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
FR2917412B1 (fr) *	2007-06-13	2009-08-21	Sanofi Aventis Sa	Derives de 7-alkynyl, 1,8-naphthyridones, leur preparation et leur application en therapeutique
FR2917413B1 (fr)	2007-06-13	2009-08-21	Sanofi Aventis Sa	Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique
CN102105448B (zh)	2008-05-27	2013-11-13	阿斯利康(瑞典)有限公司	苯氧基吡啶基酰胺衍生物和它们在治疗由pde4介导的病症中的用途
RU2012117141A (ru) *	2009-10-01	2013-11-10	Алькон Рисерч, Лтд.	Композиции олопатадина и способы их применения
ES2663351T3 (es)	2009-11-17	2018-04-12	Novartis Ag	Derivados de aril-piridina como inhibidores de la aldosterona sintasa
FR2952934B1 (fr) *	2009-11-23	2012-06-22	Sanofi Aventis	Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
WO2014133020A1 (ja) *	2013-02-28	2014-09-04	エーザイ・アール・アンド・ディー・マネジメント株式会社	呼吸器疾患の予防治療剤
KR20160026897A (ko)	2013-06-27	2016-03-09	세다르스-신나이 메디칼 센터	신경퇴행성 질환의 예방 및 치료를 위한 아드레날린 수용체 길항제
US12472241B2 (en)	2018-12-28	2025-11-18	Regeneron Pharmaceuticals, Inc.	Treatment of respiratory disorders with arachidonate 15-lipoxygenase (ALOX15) inhibitors

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GB9526245D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526246D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526243D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
DE19622370A1 (de)	1996-06-04	1997-12-11	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
GB9625184D0 (en)	1996-12-04	1997-01-22	Celltech Therapeutics Ltd	Chemical compounds
ES2202663T3 (es)	1996-12-11	2004-04-01	ABBOTT GMBH & CO. KG	Cetobenzamidas como inhibidores de calpaina.
DE69835594T2 (de)	1997-02-17	2007-08-16	Altana Pharma Ag	Zusammensetzungen zur behandlung von irds oder ards die 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten
CA2268190A1 (en) *	1997-08-06	1999-02-18	Suntory Limited	1-aryl-1,8-naphthylidin-4-one derivative as type iv phosphodiesterase inhibitor
KR20010005830A (ko) *	1998-01-29	2001-01-15	도리이 신이치로	타입 ⅳ 포스포디에스테라제 억제활성을 지닌 1-사이클로알킬-1,8-나프틸리딘-4-온 유도체

2002
- 2002-05-22 EP EP02727127A patent/EP1397359B1/de not_active Expired - Lifetime
- 2002-05-22 ES ES02727127T patent/ES2247325T3/es not_active Expired - Lifetime
- 2002-05-22 AT AT02727127T patent/ATE303384T1/de not_active IP Right Cessation
- 2002-05-22 JP JP2002591496A patent/JP4460221B2/ja not_active Expired - Fee Related
- 2002-05-22 AU AU2002257459A patent/AU2002257459B2/en not_active Ceased
- 2002-05-22 DE DE60205899T patent/DE60205899T2/de not_active Expired - Lifetime
- 2002-05-22 CA CA2447765A patent/CA2447765C/en not_active Expired - Fee Related
- 2002-05-22 WO PCT/CA2002/000746 patent/WO2002094823A1/en not_active Ceased
- 2002-05-23 PE PE2002000434A patent/PE20030061A1/es not_active Application Discontinuation
- 2002-05-24 US US10/154,591 patent/US6677351B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1397359A1 (de)	2004-03-17
EP1397359B1 (de)	2005-08-31
DE60205899T2 (de)	2006-06-29
PE20030061A1 (es)	2003-02-08
DE60205899D1 (en)	2005-10-06
AU2002257459B2 (en)	2006-12-14
ES2247325T3 (es)	2006-03-01
CA2447765A1 (en)	2002-11-28
US20030096829A1 (en)	2003-05-22
JP4460221B2 (ja)	2010-05-12
WO2002094823A1 (en)	2002-11-28
US6677351B2 (en)	2004-01-13
JP2004534773A (ja)	2004-11-18
CA2447765C (en)	2011-01-25

Legal Events

Date	Code	Title	Description
2006-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
JO2311B1 (en)	2005-09-12	Alkyl inhibitors Ariel phosphodiesterase-4
DE60205899D1 (en)	2005-10-06	1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
BG108181A (bg)	2004-09-30	Нови спиротрициклични производни и тяхното използване като инхибитори на фосфодиестераза-7
DE60236102D1 (en)	2010-06-02	1h-indolderivate als hochselektive cyclooxygenase-2-inhibitoren
DE60112974D1 (en)	2005-09-29	Carbolinderivate
NO20025601L (no)	2003-01-06	Arylmetylaminderivater for anvendelse som tryptaseinhibitorer
ATE371656T1 (de)	2007-09-15	Heteroaryl-pyrimidinderivate als jak-inhibitoren
ATE484508T1 (de)	2010-10-15	Furylverbindungen
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