ATE304021T1 - Lektin-ähnliche domäne von thrombomodulin und therapeutische verwendung davon - Google Patents
Lektin-ähnliche domäne von thrombomodulin und therapeutische verwendung davonInfo
- Publication number
- ATE304021T1 ATE304021T1 AT02738105T AT02738105T ATE304021T1 AT E304021 T1 ATE304021 T1 AT E304021T1 AT 02738105 T AT02738105 T AT 02738105T AT 02738105 T AT02738105 T AT 02738105T AT E304021 T1 ATE304021 T1 AT E304021T1
- Authority
- AT
- Austria
- Prior art keywords
- domain
- lectin
- thrombomodulin
- meaning
- inflammatory
- Prior art date
Links
- 102000012607 Thrombomodulin Human genes 0.000 title abstract 3
- 108010079274 Thrombomodulin Proteins 0.000 title abstract 3
- 230000000503 lectinlike effect Effects 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 241000699670 Mus sp. Species 0.000 abstract 3
- 206010015866 Extravasation Diseases 0.000 abstract 1
- 241001529936 Murinae Species 0.000 abstract 1
- 101800004937 Protein C Proteins 0.000 abstract 1
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 1
- 101800001700 Saposin-D Proteins 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000036251 extravasation Effects 0.000 abstract 1
- 230000006801 homologous recombination Effects 0.000 abstract 1
- 238000002744 homologous recombination Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000023404 leukocyte cell-cell adhesion Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 239000003805 procoagulant Substances 0.000 abstract 1
- 229960000856 protein c Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01201979 | 2001-05-25 | ||
| PCT/EP2002/005727 WO2002096947A2 (en) | 2001-05-25 | 2002-05-24 | The lectin-like domain of thrombomodulin and its therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE304021T1 true ATE304021T1 (de) | 2005-09-15 |
Family
ID=8180374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02738105T ATE304021T1 (de) | 2001-05-25 | 2002-05-24 | Lektin-ähnliche domäne von thrombomodulin und therapeutische verwendung davon |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7341992B2 (de) |
| EP (1) | EP1390407B1 (de) |
| AT (1) | ATE304021T1 (de) |
| CA (1) | CA2447629A1 (de) |
| DE (1) | DE60206037T2 (de) |
| ES (1) | ES2249586T3 (de) |
| WO (1) | WO2002096947A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002096947A2 (en) | 2001-05-25 | 2002-12-05 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | The lectin-like domain of thrombomodulin and its therapeutic use |
| US20060148695A1 (en) * | 2005-01-03 | 2006-07-06 | National Cheng Kung University | Novel angiogenic composition and use thereof |
| EP2014296A1 (de) * | 2007-07-10 | 2009-01-14 | PAION Deutschland GmbH | Neuartige Strategien zur Erhöhung der Reperfusion in einem verstopften Blutgefäß |
| AR067345A1 (es) * | 2007-07-10 | 2009-10-07 | Paion Deutschland Gmbh | Uso de trombomodulina para la preparacion de un medicamento trombolitico |
| US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
| US20100113568A1 (en) * | 2008-10-30 | 2010-05-06 | Hua-Lin Wu | Methods for binding lewis y antigen |
| US9775885B2 (en) * | 2016-01-29 | 2017-10-03 | Kaohsiung Medical Univeristy | TMD1 protein for treating bone loss diseases |
| EP3811777B1 (de) | 2019-10-27 | 2024-07-31 | Shanghai RAAS Blood Products Co., Ltd. | Genetisch modifizierte nicht-menschliche tiere |
| CN111296364B (zh) * | 2019-10-27 | 2022-06-24 | 上海莱士血液制品股份有限公司 | 一种基因改造的小鼠动物模型基因改造方法及其应用 |
| US11338019B2 (en) * | 2020-05-24 | 2022-05-24 | Yi-Hsun Huang | Recombinant thrombomodulin domain 1 for use in treating eye diseases associated with pathological ocular angiogenesis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912207A (en) * | 1987-05-06 | 1990-03-27 | Washington University | DNA clone of human thrombomodulin and portions thereof |
| JP3189052B2 (ja) * | 1990-06-27 | 2001-07-16 | 持田製薬株式会社 | 抗血液凝固活性を有するポリペプチド |
| EP0965597A4 (de) * | 1996-12-27 | 2003-01-08 | Mochida Pharm Co Ltd | Zellmembran-wirksame medikamente |
| JP4256497B2 (ja) * | 1998-08-06 | 2009-04-22 | 旭化成ファーマ株式会社 | 血管炎治療剤 |
| DE10106852A1 (de) * | 2001-02-14 | 2002-09-05 | T Luger | Entzündungshemmende Verbindungen |
| WO2002096947A2 (en) | 2001-05-25 | 2002-12-05 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | The lectin-like domain of thrombomodulin and its therapeutic use |
-
2002
- 2002-05-24 WO PCT/EP2002/005727 patent/WO2002096947A2/en not_active Ceased
- 2002-05-24 CA CA002447629A patent/CA2447629A1/en not_active Abandoned
- 2002-05-24 US US10/478,360 patent/US7341992B2/en not_active Expired - Fee Related
- 2002-05-24 EP EP02738105A patent/EP1390407B1/de not_active Expired - Lifetime
- 2002-05-24 DE DE60206037T patent/DE60206037T2/de not_active Expired - Lifetime
- 2002-05-24 ES ES02738105T patent/ES2249586T3/es not_active Expired - Lifetime
- 2002-05-24 AT AT02738105T patent/ATE304021T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002096947A2 (en) | 2002-12-05 |
| US20050014220A1 (en) | 2005-01-20 |
| WO2002096947A3 (en) | 2003-09-04 |
| EP1390407B1 (de) | 2005-09-07 |
| DE60206037T2 (de) | 2006-07-13 |
| US7341992B2 (en) | 2008-03-11 |
| CA2447629A1 (en) | 2002-12-05 |
| ES2249586T3 (es) | 2006-04-01 |
| DE60206037D1 (de) | 2005-10-13 |
| WO2002096947A8 (en) | 2003-02-13 |
| EP1390407A2 (de) | 2004-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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