ATE305801T1 - Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle - Google Patents
Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküleInfo
- Publication number
- ATE305801T1 ATE305801T1 AT01911481T AT01911481T ATE305801T1 AT E305801 T1 ATE305801 T1 AT E305801T1 AT 01911481 T AT01911481 T AT 01911481T AT 01911481 T AT01911481 T AT 01911481T AT E305801 T1 ATE305801 T1 AT E305801T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- naked
- acid molecules
- encoding nucleic
- intratumoral administration
- Prior art date
Links
- 230000002601 intratumoral effect Effects 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00101108 | 2000-01-20 | ||
| PCT/EP2001/000363 WO2001052874A2 (en) | 2000-01-20 | 2001-01-12 | Intra-tumoral administration of il-12 encoding nucleic acid molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE305801T1 true ATE305801T1 (de) | 2005-10-15 |
Family
ID=8167670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01911481T ATE305801T1 (de) | 2000-01-20 | 2001-01-12 | Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7141550B2 (de) |
| EP (1) | EP1248654B1 (de) |
| JP (1) | JP2003525222A (de) |
| AT (1) | ATE305801T1 (de) |
| AU (1) | AU4050801A (de) |
| DE (1) | DE60113805T2 (de) |
| ES (1) | ES2246314T3 (de) |
| WO (1) | WO2001052874A2 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE305801T1 (de) | 2000-01-20 | 2005-10-15 | Univ Zuerich Inst Fuer Medizin | Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle |
| PL2251034T3 (pl) | 2005-12-02 | 2018-07-31 | Icahn School Of Medicine At Mount Sinai | Chimeryczne wirusy prezentujące nienatywne białka powierzchniowe i zastosowania tych wirusów |
| AU2011230619C1 (en) | 2010-03-25 | 2016-06-23 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
| HUE037408T2 (hu) | 2011-06-10 | 2018-08-28 | Univ Oregon Health & Science | CMV glikoproteinek és rekombináns vektorok |
| CA2789539A1 (en) | 2011-09-12 | 2013-03-12 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| EP2766035B1 (de) | 2011-10-11 | 2018-03-28 | Universität Zürich Prorektorat MNW | Kombinationsmedikament mit il-12 und einem mittel zur blockade von t-zellen-hemmer-molekülen zur tumortherapie |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| EP2968525A4 (de) | 2013-03-14 | 2016-10-26 | Icahn School Med Mount Sinai | Morbus-newcastle-viren und verwendungen davon |
| EP2848937A1 (de) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Verfahren zur Identifizierung neuartiger HIV-1-Immunogene |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| EP3110443A4 (de) | 2014-02-27 | 2017-11-15 | Viralytics Limited | Kombinationsverfahren zur behandlung von krebs |
| EP3069730A3 (de) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Lösliche hiv-1-hüllglykoproteintrimere |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| CN108064176A (zh) | 2015-04-22 | 2018-05-22 | 库瑞瓦格股份公司 | 用于治疗肿瘤疾病的含有rna的组合物 |
| WO2017083291A1 (en) | 2015-11-09 | 2017-05-18 | Immune Design Corp. | Compositions comprising lentiviral vectors expressing il-12 and methods of use thereof |
| JP2019519516A (ja) | 2016-05-18 | 2019-07-11 | モデルナティーエックス， インコーポレイテッド | がんの治療のためのｍＲＮＡ併用療法 |
| SI3458083T1 (sl) * | 2016-05-18 | 2023-03-31 | Modernatx, Inc. | Polinukleotidi, ki kodirajo interlevkin-12 (IL12) in njihova uporaba |
| CN109715205A (zh) * | 2016-08-19 | 2019-05-03 | 库瑞瓦格股份公司 | 用于癌症治疗的rna |
| TW202428301A (zh) | 2017-02-28 | 2024-07-16 | 法商賽諾菲公司 | 治療性rna |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| JP7285220B2 (ja) | 2017-05-18 | 2023-06-01 | モデルナティエックス インコーポレイテッド | 連結したインターロイキン－１２（ｉｌ１２）ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子 |
| MY206158A (en) | 2017-05-24 | 2024-12-02 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer |
| CN111701012A (zh) * | 2017-09-07 | 2020-09-25 | 康立泰药业有限公司 | Il-12在术后抗肿瘤方面的应用 |
| WO2020037215A1 (en) | 2018-08-17 | 2020-02-20 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE305801T1 (de) | 2000-01-20 | 2005-10-15 | Univ Zuerich Inst Fuer Medizin | Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle |
| JP4147724B2 (ja) * | 2000-06-09 | 2008-09-10 | ソニー株式会社 | アンテナ装置及び無線装置 |
-
2001
- 2001-01-12 AT AT01911481T patent/ATE305801T1/de not_active IP Right Cessation
- 2001-01-12 AU AU40508/01A patent/AU4050801A/en not_active Abandoned
- 2001-01-12 ES ES01911481T patent/ES2246314T3/es not_active Expired - Lifetime
- 2001-01-12 WO PCT/EP2001/000363 patent/WO2001052874A2/en not_active Ceased
- 2001-01-12 EP EP01911481A patent/EP1248654B1/de not_active Expired - Lifetime
- 2001-01-12 JP JP2001552921A patent/JP2003525222A/ja active Pending
- 2001-01-12 DE DE60113805T patent/DE60113805T2/de not_active Expired - Lifetime
- 2001-12-01 US US10/181,794 patent/US7141550B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001052874A9 (en) | 2003-05-30 |
| WO2001052874A3 (en) | 2001-12-20 |
| JP2003525222A (ja) | 2003-08-26 |
| AU4050801A (en) | 2001-07-31 |
| WO2001052874A2 (en) | 2001-07-26 |
| DE60113805D1 (de) | 2006-02-16 |
| ES2246314T3 (es) | 2006-02-16 |
| US20030118564A1 (en) | 2003-06-26 |
| EP1248654B1 (de) | 2005-10-05 |
| EP1248654A2 (de) | 2002-10-16 |
| US7141550B2 (en) | 2006-11-28 |
| DE60113805T2 (de) | 2006-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |