ATE305801T1 - Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle - Google Patents
Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküleInfo
- Publication number
- ATE305801T1 ATE305801T1 AT01911481T AT01911481T ATE305801T1 AT E305801 T1 ATE305801 T1 AT E305801T1 AT 01911481 T AT01911481 T AT 01911481T AT 01911481 T AT01911481 T AT 01911481T AT E305801 T1 ATE305801 T1 AT E305801T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- naked
- acid molecules
- encoding nucleic
- intratumoral administration
- Prior art date
Links
- 230000002601 intratumoral effect Effects 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00101108 | 2000-01-20 | ||
| PCT/EP2001/000363 WO2001052874A2 (en) | 2000-01-20 | 2001-01-12 | Intra-tumoral administration of il-12 encoding nucleic acid molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE305801T1 true ATE305801T1 (de) | 2005-10-15 |
Family
ID=8167670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01911481T ATE305801T1 (de) | 2000-01-20 | 2001-01-12 | Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7141550B2 (de) |
| EP (1) | EP1248654B1 (de) |
| JP (1) | JP2003525222A (de) |
| AT (1) | ATE305801T1 (de) |
| AU (1) | AU4050801A (de) |
| DE (1) | DE60113805T2 (de) |
| ES (1) | ES2246314T3 (de) |
| WO (1) | WO2001052874A2 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1248654B1 (de) | 2000-01-20 | 2005-10-05 | Universität Zürich Institut für Medizinische Virologie | Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle |
| JP5603012B2 (ja) | 2005-12-02 | 2014-10-08 | トヘ モウント シナイ スクール オフ メディシネ オフ ニューヨーク ウニベルシトイ | 非天然表面タンパク質を提示するキメラウイルス及びその使用 |
| CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| CA2832109C (en) | 2011-06-10 | 2021-07-06 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| EP2568289A3 (de) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunselektion von rekombinantem vesikulärem Stomatitisvirus mit Expression von HIV-1-Proteinen durch Breitbandneutralisierungs-Antikörper |
| AU2012322999B2 (en) | 2011-10-11 | 2017-08-10 | Universitat Zurich Prorektorat Mnw | Combination medicament comprising IL-12 and an agent for blockade of T-cell inhibitory molecules for tumour therapy |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| MD4655C1 (ro) | 2013-03-14 | 2020-06-30 | Icahn School Of Medicine At Mount Sinai | Virusurile bolii de Newcastle şi utilizarea acestora |
| US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| EP3110443A4 (de) | 2014-02-27 | 2017-11-15 | Viralytics Limited | Kombinationsverfahren zur behandlung von krebs |
| US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| DK3326641T3 (da) * | 2015-04-22 | 2019-09-30 | Curevac Ag | Rna-holdig sammensætning til behandling af tumorsygdomme |
| BR112018008911A2 (pt) | 2015-11-09 | 2018-11-27 | Immune Design Corp | composições compreendendo vetores lentivirais que expressam il-12 e métodos de uso das mesmas |
| WO2017201352A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Mrna combination therapy for the treatment of cancer |
| RS63912B1 (sr) | 2016-05-18 | 2023-02-28 | Modernatx Inc | Polinukleotidi koji kodiraju interleukin-12 (il12) i njihove upotrebe |
| SG10201913631TA (en) * | 2016-08-19 | 2020-03-30 | Curevac Ag | Rna for cancer therapy |
| CN110337305A (zh) | 2017-02-28 | 2019-10-15 | 赛诺菲 | 治疗性rna |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| JP7285220B2 (ja) | 2017-05-18 | 2023-06-01 | モデルナティエックス インコーポレイテッド | 連結したインターロイキン－１２（ｉｌ１２）ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子 |
| JP7791642B2 (ja) | 2017-05-24 | 2025-12-24 | ノバルティス アーゲー | 抗体－サイトカイングラフト化タンパク質及び癌の治療における使用方法 |
| CN111701012A (zh) * | 2017-09-07 | 2020-09-25 | 康立泰药业有限公司 | Il-12在术后抗肿瘤方面的应用 |
| WO2020037215A1 (en) | 2018-08-17 | 2020-02-20 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1248654B1 (de) | 2000-01-20 | 2005-10-05 | Universität Zürich Institut für Medizinische Virologie | Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle |
| JP4147724B2 (ja) * | 2000-06-09 | 2008-09-10 | ソニー株式会社 | アンテナ装置及び無線装置 |
-
2001
- 2001-01-12 EP EP01911481A patent/EP1248654B1/de not_active Expired - Lifetime
- 2001-01-12 AT AT01911481T patent/ATE305801T1/de not_active IP Right Cessation
- 2001-01-12 AU AU40508/01A patent/AU4050801A/en not_active Abandoned
- 2001-01-12 JP JP2001552921A patent/JP2003525222A/ja active Pending
- 2001-01-12 DE DE60113805T patent/DE60113805T2/de not_active Expired - Lifetime
- 2001-01-12 WO PCT/EP2001/000363 patent/WO2001052874A2/en not_active Ceased
- 2001-01-12 ES ES01911481T patent/ES2246314T3/es not_active Expired - Lifetime
- 2001-12-01 US US10/181,794 patent/US7141550B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60113805D1 (de) | 2006-02-16 |
| AU4050801A (en) | 2001-07-31 |
| US7141550B2 (en) | 2006-11-28 |
| JP2003525222A (ja) | 2003-08-26 |
| ES2246314T3 (es) | 2006-02-16 |
| DE60113805T2 (de) | 2006-07-13 |
| EP1248654A2 (de) | 2002-10-16 |
| US20030118564A1 (en) | 2003-06-26 |
| WO2001052874A3 (en) | 2001-12-20 |
| WO2001052874A9 (en) | 2003-05-30 |
| WO2001052874A2 (en) | 2001-07-26 |
| EP1248654B1 (de) | 2005-10-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE305801T1 (de) | Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle | |
| BR0211546A (pt) | Composição farmacêutica e/ou de diagnóstico e uso de microrganismo ou célula | |
| BR0009505A (pt) | Compostos e processos para terapia e diagnóstico de câncer de pulmão | |
| IS6491A (is) | Pteridínefnasambönd til meðhöndlunar á sóríasis | |
| DK0910647T3 (da) | Human DNase i hyperaktive varianter | |
| BR9807824A (pt) | Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz | |
| HUP0401534A2 (hu) | Módosított humán IX. faktor | |
| GB0003154D0 (en) | Novel compounds | |
| CY1113421T1 (el) | Πυρηνικα οξεα και πολυπεπτιδια υποδοχεα | |
| DE60030263D1 (de) | Neue phosphor enthaltende medikamentenvorläuferverbindungen | |
| BR9907259A (pt) | Compostos para terapia e diagnóstico de câncer de pulmão e processos para o seu uso | |
| NZ543467A (en) | The severe acute respiratory syndrome coronavirus | |
| BR9808881A (pt) | Compostos para imunoterapia de câncer de próstata e métodos para seu uso | |
| WO2007110231A3 (en) | MODIFIED INTERFERON-β (IFN-β) POLYPEPTIDES | |
| ATE556720T1 (de) | Verfahren und zusammensetzungen zur rnai vermittelten inhibierung der genexpression in säugetieren | |
| BRPI0407648A (pt) | uso de uma proteìna ligante sìtio-especìfica ativa juntamente com um vetor terapêutico codificando uma proteìna para manufatura de um medicamente | |
| WO2002014485A3 (en) | Kallikrein gene | |
| CY1109361T1 (el) | Υποκατεστημενες 4-αμινοκυκλοεξανολες | |
| BR9911349A (pt) | Genes para a biossìntese de epotilonas | |
| YU68702A (sh) | Novi lhrh-antagonisti, njihova proizvodnja i upotreba kao leka | |
| SE0102716D0 (sv) | Novel compounds | |
| CY1107231T1 (el) | Υποκατεστημενα παραγωγα 4-αμινοκυκλοεξανολης | |
| IL151647A0 (en) | Novel lhrh-antagonists, production and use thereof as medicament | |
| FR2804127B1 (fr) | Gene srn1 implique dans le syndrome nephrotique cortico- resistant, proteine codee par ce gene et utilisations diagnostiques et therapeutiques | |
| WO2001057069A3 (en) | Targeting peptides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |