ATE305932T1 - Rapanycin29-enole - Google Patents

Rapanycin29-enole

Info

Publication number: ATE305932T1
Authority: AT; Austria
Prior art keywords: enole; enols; useful; treatment; solid tumors
Prior art date: 2001-08-22

Application number

AT02768642T

Other languages

English (en)

Inventor

Tianmin Zhu

Mahdi Bakir Fawzi

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-22

Filing date

2002-08-21

Publication date

2005-10-15

2002-08-21 Application filed by Wyeth Corp filed Critical Wyeth Corp

2005-10-15 Application granted granted Critical

2005-10-15 Publication of ATE305932T1 publication Critical patent/ATE305932T1/de

Links

206010028980 Neoplasm Diseases 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
230000000508 neurotrophic effect Effects 0.000 abstract 1
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 1
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 1
229960002930 sirolimus Drugs 0.000 abstract 1
208000019553 vascular disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT02768642T 2001-08-22 2002-08-21 Rapanycin29-enole ATE305932T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US31421101P	2001-08-22	2001-08-22
PCT/US2002/026622 WO2003018573A1 (en)	2001-08-22	2002-08-21	Rapamycin 29-enols

Publications (1)

Publication Number	Publication Date
ATE305932T1 true ATE305932T1 (de)	2005-10-15

Family

ID=23219037

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02768642T ATE305932T1 (de)	2001-08-22	2002-08-21	Rapanycin29-enole

Country Status (12)

Country	Link
US (1)	US6677357B2 (de)
EP (1)	EP1419154B1 (de)
JP (1)	JP2005501868A (de)
CN (1)	CN1310908C (de)
AT (1)	ATE305932T1 (de)
BR (1)	BR0211986A (de)
CA (1)	CA2455308A1 (de)
DE (1)	DE60206512T2 (de)
DK (1)	DK1419154T3 (de)
ES (1)	ES2246409T3 (de)
MX (1)	MXPA04001524A (de)
WO (1)	WO2003018573A1 (de)

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US20070142422A1 (en) *	2005-12-20	2007-06-21	Wyeth	Control of CCI-779 dosage form stability through control of drug substance impurities
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US8414910B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US8430055B2 (en)	2008-08-29	2013-04-30	Lutonix, Inc.	Methods and apparatuses for coating balloon catheters
US8425459B2 (en)	2006-11-20	2013-04-23	Lutonix, Inc.	Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8998846B2 (en)	2006-11-20	2015-04-07	Lutonix, Inc.	Drug releasing coatings for balloon catheters
US8414909B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US20080276935A1 (en)	2006-11-20	2008-11-13	Lixiao Wang	Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US9700704B2 (en)	2006-11-20	2017-07-11	Lutonix, Inc.	Drug releasing coatings for balloon catheters
US20100104626A1 (en) *	2007-02-16	2010-04-29	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
AU2008224988A1 (en) *	2007-03-14	2008-09-18	Endocyte, Inc.	Binding ligand linked drug delivery conjugates of tubulysins
JP2008305262A (ja) *	2007-06-08	2008-12-18	Konica Minolta Business Technologies Inc	サーバ及びシンクライアント環境でのプリンタ紹介方法
CN101784565B (zh)	2007-06-25	2014-12-10	恩多塞特公司	含有亲水性间隔区接头的共轭物
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
CN101909441B (zh)	2007-10-25	2015-05-13	恩多塞特公司	微管蛋白抑制剂及其制备方法
ES2645692T3 (es)	2008-11-11	2017-12-07	The Board Of Regents,The University Of Texas System	Microcápsulas de rapamicina y su uso para el tratamiento del cáncer
WO2015161139A1 (en)	2014-04-16	2015-10-22	Rapamycin Holdings, Llc	Oral rapamycin preparation and use for stomatitis
US9283211B1 (en)	2009-11-11	2016-03-15	Rapamycin Holdings, Llc	Oral rapamycin preparation and use for stomatitis
WO2013013708A1 (en)	2011-07-26	2013-01-31	Fundació Institut D'investigació Biomèdica De Bellvitge	Treatment of acute rejection in renal transplant
EP2589383A1 (de)	2011-11-06	2013-05-08	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin	FKBP-subtypspezifisches Rapamycin-Analogon zur Verwendung bei der Behandlung von Erkrankungen
US10080805B2 (en)	2012-02-24	2018-09-25	Purdue Research Foundation	Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
CN103705925B (zh)	2012-09-29	2018-03-30	段磊	抑制PI3K/AKT/mTOR信号通路的药物组合
US9750728B2 (en)	2012-09-29	2017-09-05	Targeted Therapeutics, Llc	Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway
WO2014059295A1 (en)	2012-10-12	2014-04-17	The Board Of Regents Of The University Of Texas System	Use of mtor inhibitors to treat vascular cognitive impairment
BR112015008365A2 (pt)	2012-10-16	2017-07-04	Endocyte Inc	composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente
WO2014160328A1 (en)	2013-03-13	2014-10-02	The Board Of Regents Of The University Of Texas System	Mtor inhibitors for prevention of intestinal polyp growth
US9700544B2 (en)	2013-12-31	2017-07-11	Neal K Vail	Oral rapamycin nanoparticle preparations
EP3089737B1 (de)	2013-12-31	2021-11-03	Rapamycin Holdings, LLC	Orale rapamycinnanopartikelzubereitungen und verwendung
WO2017181115A1 (en)	2016-04-14	2017-10-19	Spinnaker Biosciences, Inc.	Porous silicon materials comprising a metal silicate for delivery of therapeutic agents
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EP3952937A1 (de)	2019-04-08	2022-02-16	Bard Peripheral Vascular, Inc.	Medizinische vorrichtung mit wirkstofffreisetzender beschichtung auf modifizierter vorrichtungsoberfläche
GB202415232D0 (en)	2024-10-16	2024-11-27	Nacamed As	Composition

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2002
- 2002-08-21 DK DK02768642T patent/DK1419154T3/da active
- 2002-08-21 MX MXPA04001524A patent/MXPA04001524A/es active IP Right Grant
- 2002-08-21 CA CA002455308A patent/CA2455308A1/en not_active Withdrawn
- 2002-08-21 WO PCT/US2002/026622 patent/WO2003018573A1/en not_active Ceased
- 2002-08-21 BR BR0211986-2A patent/BR0211986A/pt not_active IP Right Cessation
- 2002-08-21 EP EP02768642A patent/EP1419154B1/de not_active Expired - Lifetime
- 2002-08-21 AT AT02768642T patent/ATE305932T1/de not_active IP Right Cessation
- 2002-08-21 JP JP2003523235A patent/JP2005501868A/ja active Pending
- 2002-08-21 ES ES02768642T patent/ES2246409T3/es not_active Expired - Lifetime
- 2002-08-21 DE DE60206512T patent/DE60206512T2/de not_active Expired - Fee Related
- 2002-08-21 CN CNB028163052A patent/CN1310908C/zh not_active Expired - Fee Related
- 2002-08-22 US US10/224,971 patent/US6677357B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1419154B1 (de)	2005-10-05
DK1419154T3 (da)	2006-01-09
DE60206512D1 (de)	2006-02-16
CN1310908C (zh)	2007-04-18
BR0211986A (pt)	2004-09-28
ES2246409T3 (es)	2006-02-16
JP2005501868A (ja)	2005-01-20
EP1419154A1 (de)	2004-05-19
DE60206512T2 (de)	2006-06-22
WO2003018573A1 (en)	2003-03-06
US6677357B2 (en)	2004-01-13
US20030114477A1 (en)	2003-06-19
CA2455308A1 (en)	2003-03-06
CN1545511A (zh)	2004-11-10
MXPA04001524A (es)	2004-05-31

Legal Events

Date	Code	Title	Description
2006-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60206512D1 (de)	2006-02-16	Rapanycin29-enole
MXPA04001523A (es)	2004-05-31	Dialdehidos de rapamicina.
DE50306232D1 (de)	2007-02-15	Ampholytisches copolymer und dessen verwendung
WO2002026746A3 (en)	2002-08-15	1-oxorapamycins
YU9404A (sh)	2006-08-17	Multimerna, usmerena kontrastna sredstva na bazi peptida
BR0113975A (pt)	2003-07-29	ésteres de rapamicina solúveis em água
SG149063A1 (en)	2009-01-29	Use of modified cyclosporins for the treatment of hcv disorders
NO20034056D0 (no)	2003-09-12	Proliferative sykdommer
CO5611160A2 (es)	2006-02-28	Conjugados de agentes terapeuticos o citotoxicos y peptidos biologicamente activos
DE60137337D1 (de)	2009-02-26	Vorbeugende und therapeutsche monoklonale antikörper gegen vacciniavirusantigene
WO2002028867A3 (en)	2002-08-29	Ethers of 7-desmethylrapamycin for use in immunosuppression
BRPI0307673A2 (pt)	2016-11-08	métodos de tratar doença vascular.
EP1432714A4 (de)	2005-10-19	Chemische verbindungen
WO2003101401A3 (en)	2004-12-09	Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer
WO2002028866A3 (en)	2002-08-15	Hydroxyesters of 7-desmethylrapamycin
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WO2007059341A3 (en)	2007-11-29	Pyrazolothiazole protein kinase modulators
NO20053903D0 (no)	2005-08-22	Nukleotidlipidesterderivater.
DE60041198D1 (de)	2009-02-05	Antimikrobielle zusammensetzungen
WO2003039484A3 (en)	2004-08-12	Novel compositions and methods for cancer