ATE306810T1 - Durch inzucht erzeugte von embryonalen stammzellen abgeleitete mäuse - Google Patents
Durch inzucht erzeugte von embryonalen stammzellen abgeleitete mäuseInfo
- Publication number
- ATE306810T1 ATE306810T1 AT03743372T AT03743372T ATE306810T1 AT E306810 T1 ATE306810 T1 AT E306810T1 AT 03743372 T AT03743372 T AT 03743372T AT 03743372 T AT03743372 T AT 03743372T AT E306810 T1 ATE306810 T1 AT E306810T1
- Authority
- AT
- Austria
- Prior art keywords
- inbreeded
- mice
- stem cell
- embryonal stem
- derived mice
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36216302P | 2002-03-05 | 2002-03-05 | |
| PCT/EP2003/002180 WO2003073843A2 (en) | 2002-03-05 | 2003-03-04 | Inbred embryonic stem-cell derived mice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE306810T1 true ATE306810T1 (de) | 2005-11-15 |
Family
ID=27789146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03743372T ATE306810T1 (de) | 2002-03-05 | 2003-03-04 | Durch inzucht erzeugte von embryonalen stammzellen abgeleitete mäuse |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20030204862A1 (de) |
| EP (1) | EP1480515B1 (de) |
| AT (1) | ATE306810T1 (de) |
| AU (1) | AU2003210405A1 (de) |
| DE (1) | DE60301953T2 (de) |
| WO (1) | WO2003073843A2 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006044962A1 (en) | 2004-10-19 | 2006-04-27 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| GB0615327D0 (en) * | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
| EP1999249B8 (de) * | 2006-03-30 | 2012-02-15 | The University Court Of The University of Edinburgh | Kulturmedium mit kinasehemmern und verwendung |
| WO2007127254A2 (en) * | 2006-04-25 | 2007-11-08 | President And Fellows Of Harvard College | Compositions and methods for generating transgenic animals |
| JP5951254B2 (ja) * | 2008-03-17 | 2016-07-13 | ザ スクリプス リサーチ インスティテュート | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| CN104711218B (zh) | 2010-06-11 | 2018-09-25 | 瑞泽恩制药公司 | 由xy es细胞制备能育的xy雌性动物 |
| AU2011349446C1 (en) | 2010-12-22 | 2016-01-21 | Fate Therapauetics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
| EP2471554A1 (de) | 2010-12-28 | 2012-07-04 | Hexal AG | Pharmazeutische Formulierung mit biopharmazeutischem Arzneimittel |
| EP2511293A1 (de) | 2011-04-13 | 2012-10-17 | LEK Pharmaceuticals d.d. | Verfahren zur Steuerung der Hauptkomplex-N-Glycan-Strukturen und der sauren Varianten und Variabilität in Bioprozessen, die rekombinante Proteine produzieren |
| US9856502B2 (en) | 2013-07-23 | 2018-01-02 | Biocon Limited | Methods for controlling fucosylation levels in proteins |
| SG11201606934SA (en) | 2014-03-04 | 2016-09-29 | Fate Therapeutics Inc | Improved reprogramming methods and cell culture platforms |
| WO2015196072A2 (en) | 2014-06-19 | 2015-12-23 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| PT3161128T (pt) * | 2014-06-26 | 2018-11-21 | Regeneron Pharma | Métodos e composições para modificações genéticas alvejadas e métodos de utilização |
| US10893666B2 (en) | 2015-09-17 | 2021-01-19 | Regeneron Pharmaceuticals, Inc. | Production of fertile XY female animals by silencing of genes on the Y chromosome |
| CA3001917A1 (en) | 2015-10-16 | 2017-04-20 | Fate Therapeutics, Inc. | Platform for the induction & maintenance of ground state pluripotency |
| EP3403649A1 (de) | 2017-05-16 | 2018-11-21 | Bayer Pharma Aktiengesellschaft | Inhibitoren und antagonisten von gpr84 zur behandlung von endometriose |
| EP3406253A1 (de) | 2017-05-24 | 2018-11-28 | Bayer Aktiengesellschaft | Inhibitoren und antagonisten von humanem pycr1 |
| WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
| WO2019233810A1 (en) | 2018-06-04 | 2019-12-12 | Bayer Aktiengesellschaft | Inhibitors of shp2 |
| KR102398485B1 (ko) | 2019-02-18 | 2022-05-16 | 에이티비 테라퓨틱스 | 식물 세포 또는 식물 전체에서 결합제-독소 융합 단백질의 생산 방법 |
| EP3946416A2 (de) | 2019-04-04 | 2022-02-09 | Bayer Aktiengesellschaft | Agonisten von adiponectin |
| CN113993534A (zh) | 2019-04-09 | 2022-01-28 | 特殊外科医院 | 针对iRhom2的蛋白结合物 |
| US20240287172A1 (en) | 2019-09-30 | 2024-08-29 | Scirhom Gmbh | Protein binders to irhom2 epitopes |
| US20230034584A1 (en) | 2019-12-04 | 2023-02-02 | Bayer Aktiengesellschaft | Inhibitors of shp2 |
| JP7818834B2 (ja) | 2020-08-17 | 2026-02-24 | エーティービー セラピューティクス | リボトキシンまたはＲＮＡｓｅを含む組換え免疫毒素 |
| CA3211686A1 (en) | 2021-02-26 | 2022-09-01 | Bayer Aktiengesellschaft | Inhibitors of il-11 or il-11ra for use in the treatment of abnormal uterine bleeding |
| AU2022229740A1 (en) | 2021-03-01 | 2023-08-24 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Humanized antibodies against irhom2 |
| WO2022207652A1 (en) | 2021-03-29 | 2022-10-06 | Scirhom Gmbh | Methods of treatment using protein binders to irhom2 epitopes |
| US12371667B2 (en) | 2021-05-13 | 2025-07-29 | Washington University | Enhanced methods for inducing and maintaining naive human pluripotent stem cells |
| US20230190806A1 (en) | 2021-10-06 | 2023-06-22 | Immatics Biotechnologies Gmbh | Methods of treating metastatic lesions and compositions thereof |
| US20230192886A1 (en) | 2021-11-08 | 2023-06-22 | Immatics Biotechnologies Gmbh | Adoptive cell therapy combination treatment and compositions thereof |
| JP2025508742A (ja) | 2022-02-17 | 2025-04-10 | エーティービー セラピューティクス | リボソーム不活性化タンパク質を含む組換え免疫毒素 |
| WO2024023246A1 (en) | 2022-07-28 | 2024-02-01 | Philogen S.P.A. | Antibody binding to pd1 |
| EP4568997A1 (de) | 2022-08-08 | 2025-06-18 | ATB Therapeutics | Humanisierte antikörper gegen cd79b |
| EP4659023A1 (de) | 2023-02-03 | 2025-12-10 | Immusmol SAS | Verfahren zur vorhersage des erfolgs einer krebstherapie |
| EP4719367A1 (de) | 2023-06-05 | 2026-04-08 | Pure Biologics Spólka Akcyjna | Anti-ror1-antikörper und verfahren zur verwendung |
| KR20260022341A (ko) | 2023-06-05 | 2026-02-19 | 퓨어 바이올로직스 스푸우카 아크치이나 | 항 garp 항체 및 이의 사용 방법 |
| WO2025040598A2 (en) | 2023-08-18 | 2025-02-27 | Immatics Biotechnologies Gmbh | Peptides displayed by mhc for use in immunotherapy against different types of cancer |
| WO2025180665A1 (en) | 2024-02-28 | 2025-09-04 | Evotec International Gmbh | Antibodies binding to cd2, and multifunctional molecules comprising such antibodies |
| WO2025242726A1 (en) | 2024-05-21 | 2025-11-27 | Onconick Ltd. | Antibody binding to FGFR1 and conjugates comprising the same |
| CN119699269B (zh) * | 2024-07-10 | 2025-10-17 | 太原市中心医院 | 基于sbsn 600位赖氨酸发生二羟基异丁酰化修饰的用于银屑病研究的小鼠模型构建方法 |
| WO2026094023A1 (en) | 2024-11-04 | 2026-05-07 | Nanodetection Technology, Inc. | Recombinant antibody binding to penicillin binding protein 2a (pbp2a) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9819912D0 (en) * | 1998-09-11 | 1998-11-04 | Univ Edinburgh | Propagation and/or derivation of embryonic stem cells |
-
2003
- 2003-03-04 AT AT03743372T patent/ATE306810T1/de not_active IP Right Cessation
- 2003-03-04 EP EP03743372A patent/EP1480515B1/de not_active Expired - Lifetime
- 2003-03-04 DE DE60301953T patent/DE60301953T2/de not_active Expired - Fee Related
- 2003-03-04 WO PCT/EP2003/002180 patent/WO2003073843A2/en not_active Ceased
- 2003-03-04 AU AU2003210405A patent/AU2003210405A1/en not_active Abandoned
- 2003-03-04 US US10/379,370 patent/US20030204862A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1480515A2 (de) | 2004-12-01 |
| AU2003210405A1 (en) | 2003-09-16 |
| DE60301953D1 (de) | 2005-11-24 |
| WO2003073843A2 (en) | 2003-09-12 |
| EP1480515B1 (de) | 2005-10-19 |
| WO2003073843A3 (en) | 2004-01-22 |
| US20030204862A1 (en) | 2003-10-30 |
| DE60301953T2 (de) | 2006-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1480515 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |