ATE306941T1 - Gesteigerte abgabe von auf nukleinsäuren basierenden arzneimitteln - Google Patents
Gesteigerte abgabe von auf nukleinsäuren basierenden arzneimittelnInfo
- Publication number
- ATE306941T1 ATE306941T1 AT00927515T AT00927515T ATE306941T1 AT E306941 T1 ATE306941 T1 AT E306941T1 AT 00927515 T AT00927515 T AT 00927515T AT 00927515 T AT00927515 T AT 00927515T AT E306941 T1 ATE306941 T1 AT E306941T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- medicinal products
- increased delivery
- based medicinal
- based drug
- Prior art date
Links
- 229940126601 medicinal product Drugs 0.000 title 1
- 229940127024 acid based drug Drugs 0.000 abstract 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 abstract 2
- 239000003623 enhancer Substances 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 abstract 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 abstract 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960002446 octanoic acid Drugs 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13260399P | 1999-05-05 | 1999-05-05 | |
| PCT/GB2000/001726 WO2000067798A2 (en) | 1999-05-05 | 2000-05-05 | Enhanced delivery of nucleic acid-based drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE306941T1 true ATE306941T1 (de) | 2005-11-15 |
Family
ID=22454795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00927515T ATE306941T1 (de) | 1999-05-05 | 2000-05-05 | Gesteigerte abgabe von auf nukleinsäuren basierenden arzneimitteln |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1173217B1 (de) |
| JP (1) | JP2002544175A (de) |
| AT (1) | ATE306941T1 (de) |
| AU (1) | AU4591200A (de) |
| CA (1) | CA2371095A1 (de) |
| DE (1) | DE60023285D1 (de) |
| WO (1) | WO2000067798A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| IL301221A (en) * | 2020-09-17 | 2023-05-01 | Astrazeneca Ab | Pharmaceutical compositions comprising an antisense oligonucleotide for oral administration |
| AU2023258547A1 (en) | 2022-04-29 | 2024-12-05 | Haya Therapeutics Sa | Compositions and methods of modulating long noncoding transcripts associated with ards induced pulmonary fibrosis |
| WO2024241091A2 (en) | 2023-05-22 | 2024-11-28 | Haya Therapeutics Sa | Compositions and methods to modulate transposable elements governing cell-state transitions |
| WO2024261531A2 (en) | 2023-06-23 | 2024-12-26 | Haya Therapeutics Sa | Compositions and methods to modulate tumor microenvironment associated long noncoding rnas |
| WO2025056973A2 (en) | 2023-09-13 | 2025-03-20 | Haya Therapeutics Sa | Compositions and methods for modulating wisp2 super-enhancer-associated rna |
| WO2025088373A1 (en) | 2023-10-25 | 2025-05-01 | Haya Therapeutics Sa | Compositions and methods of modulating long noncoding transcripts associated with ards induced pulmonary fibrosis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5739118A (en) * | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| AU707186B2 (en) * | 1997-07-01 | 1999-07-01 | Transgene S.A. | Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy |
| EP1012331B1 (de) * | 1997-07-01 | 2006-03-29 | Isis Pharmaceuticals, Inc. | Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre |
| CA2329252A1 (en) * | 1998-05-21 | 1999-11-25 | Isis Pharmaceuticals Inc. | Compositions and methods for topical delivery of oligonucleotides |
| AU5093199A (en) * | 1998-07-08 | 2000-02-01 | Oryxe | Transdermal delivery system |
-
2000
- 2000-05-05 AU AU45912/00A patent/AU4591200A/en not_active Abandoned
- 2000-05-05 DE DE60023285T patent/DE60023285D1/de not_active Expired - Lifetime
- 2000-05-05 WO PCT/GB2000/001726 patent/WO2000067798A2/en not_active Ceased
- 2000-05-05 JP JP2000616823A patent/JP2002544175A/ja active Pending
- 2000-05-05 AT AT00927515T patent/ATE306941T1/de not_active IP Right Cessation
- 2000-05-05 EP EP00927515A patent/EP1173217B1/de not_active Expired - Lifetime
- 2000-05-05 CA CA002371095A patent/CA2371095A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1173217A2 (de) | 2002-01-23 |
| AU4591200A (en) | 2000-11-21 |
| EP1173217B1 (de) | 2005-10-19 |
| DE60023285D1 (de) | 2006-03-02 |
| WO2000067798A3 (en) | 2001-02-08 |
| WO2000067798A2 (en) | 2000-11-16 |
| CA2371095A1 (en) | 2000-11-16 |
| JP2002544175A (ja) | 2002-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |