ATE307198T1 - Polyketides und deren herstellung und anwendung - Google Patents

Polyketides und deren herstellung und anwendung

Info

Publication number
ATE307198T1
ATE307198T1 AT98924463T AT98924463T ATE307198T1 AT E307198 T1 ATE307198 T1 AT E307198T1 AT 98924463 T AT98924463 T AT 98924463T AT 98924463 T AT98924463 T AT 98924463T AT E307198 T1 ATE307198 T1 AT E307198T1
Authority
AT
Austria
Prior art keywords
rapamycin
gene
produced
cluster
rapl
Prior art date
Application number
AT98924463T
Other languages
English (en)
Inventor
Peter Francis Leadlay
James Staunton
Lake Ee Khaw
Original Assignee
Biotica Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotica Tech Ltd filed Critical Biotica Tech Ltd
Application granted granted Critical
Publication of ATE307198T1 publication Critical patent/ATE307198T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Catalysts (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98924463T 1997-05-28 1998-05-28 Polyketides und deren herstellung und anwendung ATE307198T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9710962.3A GB9710962D0 (en) 1997-05-28 1997-05-28 Polyketides and their synthesis
PCT/GB1998/001559 WO1998054308A2 (en) 1997-05-28 1998-05-28 Polyketides and their synthesis and use

Publications (1)

Publication Number Publication Date
ATE307198T1 true ATE307198T1 (de) 2005-11-15

Family

ID=10813155

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98924463T ATE307198T1 (de) 1997-05-28 1998-05-28 Polyketides und deren herstellung und anwendung

Country Status (8)

Country Link
US (3) US7018808B2 (de)
EP (1) EP0983348B1 (de)
AT (1) ATE307198T1 (de)
AU (1) AU7666198A (de)
DE (1) DE69831943T2 (de)
ES (1) ES2251084T3 (de)
GB (1) GB9710962D0 (de)
WO (1) WO1998054308A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
CA2359801A1 (en) 1999-02-09 2000-08-17 Rajesh S. Gokhale Methods to mediate polyketide synthase module effectiveness
WO2001034816A1 (en) * 1999-10-29 2001-05-17 Kosan Biosciences, Inc. Rapamycin analogs
FR2825717B1 (fr) 2001-06-08 2005-02-18 Rhodia Chimie Sa Preparation stereoselective de l-acides amines cycliques
ES2544624T3 (es) 2002-07-16 2015-09-02 Buck Institute For Research On Aging Producción de policétidos
JP2007505932A (ja) * 2003-09-18 2007-03-15 マクサイト, インコーポレイテッド 経強膜送達
EP1751168A1 (de) 2004-04-14 2007-02-14 Wyeth Prolin cci-779 (prolin-rapamycin 42-ester mit 2,2-bis(hydroxymethyl)propionsäure) und zweistufige enzymatische synthese von prolin cci-779 und cci-779 mit mikrobieller lipase
GB0417852D0 (en) * 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
CA2597590A1 (en) 2005-02-09 2006-08-17 Macusight, Inc. Formulations for ocular treatment
US8663639B2 (en) * 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
KR101478164B1 (ko) 2006-02-09 2014-12-31 산텐 세이야꾸 가부시키가이샤 안정한 제제와 그 제조 및 사용 방법
AU2007230964B2 (en) 2006-03-23 2012-07-19 Santen Pharmaceutical Co., Ltd. Formulations and methods for vascular permeability-related diseases or conditions
US20080265343A1 (en) * 2007-04-26 2008-10-30 International Business Machines Corporation Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2106034A1 (en) * 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
ZA938349B (en) * 1992-11-10 1994-08-01 Smithkline Beecham Corp Rapamycin derivatives.

Also Published As

Publication number Publication date
US7381546B2 (en) 2008-06-03
EP0983348B1 (de) 2005-10-19
US7018808B2 (en) 2006-03-28
WO1998054308A2 (en) 1998-12-03
AU7666198A (en) 1998-12-30
GB9710962D0 (en) 1997-07-23
DE69831943T2 (de) 2006-07-06
US20060105436A1 (en) 2006-05-18
ES2251084T3 (es) 2006-04-16
DE69831943D1 (de) 2006-03-02
EP0983348A2 (de) 2000-03-08
US20030104585A1 (en) 2003-06-05
US20080287483A1 (en) 2008-11-20
WO1998054308A3 (en) 1999-04-08

Similar Documents

Publication Publication Date Title
DE69831943D1 (de) Polyketides und deren herstellung und anwendung
ATE311460T1 (de) Hefestämme zur herstellung von milchsäure
EP1088088B8 (de) Diacylglyzerin o-acyltransferase
MY127636A (en) Bioconversion of a fermentable carbon source to 1, 3- propanediol by a single microorganism
BR9806822A (pt) Método para a produção de ácidos dicarboxìlicos.
CA2237849A1 (en) Processes for producing sugar nucleotides and complex carbohydrates
AU9519501A (en) Production of polyketides
CY1110827T1 (el) Μια μεθοδος παραγωγης ηλεκτρικου οξεος απο ακατεργαστα υδρολυματα
AU2223601A (en) Process for producing l-amino acid and novel gene
AU6296400A (en) Method for preparing 1,3-propanediol by a recombinant micro-organism in the absence of coenzyme b12 or one of its precursors
ID24801A (id) Proses untuk produksi asam l-amino dengan fermentasi yang menggunakan bakteri corynefrom
DE68915692D1 (de) Fermentationsverfahren zur Herstellung von 2-Keto-L-Gulonsäure.
DE3682557D1 (de) Hydroxy-ml-236b-derivate, deren herstellung und anwendung.
AU6821900A (en) Process for the fermentative preparation of l-amino acids with amplification of the zwf gene
EP1106679A4 (de) Verfahren zur herstellung eines fermentationsproduktes
WO2002086137A3 (en) Process for the production of l-amino acids by fermentation using coryneform bacteria
DE69332146D1 (de) Morphinone reduktase zur herstellung von hydromorphone und hydrocodone
ID26177A (id) Proses pembuatan asam l-amino melalui fermentasi dengan menggunakan bakteri coryneform
WO2003029457A1 (fr) Procede de production d'acide amine
EP1313870B8 (de) Verfahren zur verbesserten herstellung und isolierung von trans-dihydroxy-cyclohexadien-carbonsäuren und/oder deren folgeprodukte sowie ein dazu geeigneter genetisch veränderter organismus
AU6301796A (en) Process to increase the production of clavam antibiotics
HUT50360A (en) Process for producing antibiotic uk-61689 by microbiological way and pharmaceutical composition comprising the active ingredient and mycelium
TR200000201T2 (tr) Ampisilinin hazırlanması için proses
DE69722852D1 (de) Fermentative Herstellung von Biotin
CA2298427A1 (en) Microbial conversion of 2-methylquinoxaline

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0983348

Country of ref document: EP