ATE30719T1 - IMINO-2-PYRROLIDINES, PROCESSES FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE. - Google Patents

IMINO-2-PYRROLIDINES, PROCESSES FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE.

Info

Publication number
ATE30719T1
ATE30719T1 AT84400081T AT84400081T ATE30719T1 AT E30719 T1 ATE30719 T1 AT E30719T1 AT 84400081 T AT84400081 T AT 84400081T AT 84400081 T AT84400081 T AT 84400081T AT E30719 T1 ATE30719 T1 AT E30719T1
Authority
AT
Austria
Prior art keywords
pyrrolidines
imino
processes
production
therapeutic use
Prior art date
Application number
AT84400081T
Other languages
German (de)
Inventor
Jacques Maillard
Van Tri Vo
Jacky Legeai
Marguerite Benharkate
Original Assignee
Logeais Labor Jacques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Logeais Labor Jacques filed Critical Logeais Labor Jacques
Application granted granted Critical
Publication of ATE30719T1 publication Critical patent/ATE30719T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

This invention relates to therapeutically useful compounds, particularly in the cardiovascular field, having the formula: <IMAGE> (I)
AT84400081T 1983-01-28 1984-01-13 IMINO-2-PYRROLIDINES, PROCESSES FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE. ATE30719T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8301360A FR2540109B1 (en) 1983-01-28 1983-01-28 IMINO-2 PYRROLIDINES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS
EP84400081A EP0117771B1 (en) 1983-01-28 1984-01-13 Imino-2 pyrrolidines, process for their preparation and their therapeutical use

Publications (1)

Publication Number Publication Date
ATE30719T1 true ATE30719T1 (en) 1987-11-15

Family

ID=9285402

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84400081T ATE30719T1 (en) 1983-01-28 1984-01-13 IMINO-2-PYRROLIDINES, PROCESSES FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE.

Country Status (15)

Country Link
US (2) US4556674A (en)
EP (1) EP0117771B1 (en)
JP (1) JPS59141558A (en)
AT (1) ATE30719T1 (en)
AU (1) AU562183B2 (en)
CA (1) CA1223597A (en)
DE (1) DE3467346D1 (en)
DK (1) DK39084A (en)
ES (1) ES529223A0 (en)
FI (1) FI77021C (en)
FR (1) FR2540109B1 (en)
HU (1) HU189402B (en)
IE (1) IE56547B1 (en)
OA (1) OA07642A (en)
ZA (1) ZA84562B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540109B1 (en) * 1983-01-28 1985-08-30 Logeais Labor Jacques IMINO-2 PYRROLIDINES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS
AU688811B2 (en) * 1993-10-21 1998-03-19 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
ES2206571T3 (en) * 1995-04-20 2004-05-16 G.D. SEARLE &amp; CO. CYCLING AMIDINO AGENTS USED AS INHIBITORS OF NITRICO SINTASA OXIDE.
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
CA2333691A1 (en) 1998-06-10 1999-12-16 G.D. Searle & Co. Heterobicyclic and tricyclic nitric oxide synthase inhibitors
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
DE10214832A1 (en) * 2002-04-04 2003-10-16 Merck Patent Gmbh Phenyl derivatives 4
JP5483880B2 (en) * 2006-10-23 2014-05-07 武田薬品工業株式会社 Iminopyridine derivatives and uses thereof
KR20100130235A (en) * 2008-04-23 2010-12-10 다케다 야쿠힌 고교 가부시키가이샤 Iminopyridine Derivatives and Uses thereof
US20110039892A1 (en) * 2008-04-23 2011-02-17 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
US8481569B2 (en) * 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
US11465988B2 (en) 2018-12-15 2022-10-11 Natco Pharma Limited Process for the preparation of Tipiracil hydrochloride and intermediates thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1516776A (en) * 1966-07-21 1968-03-15 Rhone Poulenc Sa New pyrrole derivatives and their preparation
DE1770752A1 (en) * 1968-06-29 1971-11-25 Mcneilab Inc 2-imino-methylenimines
GB1210848A (en) * 1968-07-01 1970-11-04 Mcneilab Inc 2-imino-methyleneimines
US3632604A (en) * 1970-04-09 1972-01-04 Sandoz Ag 2-substituted-4-phenyl and substituted phenyl-1-pyrrolines
US3887569A (en) * 1970-10-30 1975-06-03 Mcneilab Inc 2-Imino-piperidines
US3725435A (en) * 1970-11-05 1973-04-03 Mc Neil Labor Inc 2-imino-pyrrolidines
FR2186236B1 (en) * 1972-05-03 1975-08-01 Logeais Labor Jacques
US4055561A (en) * 1973-04-25 1977-10-25 Richardson-Merrell Inc. α-Alkylbenzyl lactamimides
NZ179580A (en) * 1974-12-30 1978-04-03 Mcneilab Inc 2-or 3-(w-tertiaryaminoalkyl)-thioindoles and the corresponding sulfinyl and sulfonyl analogs
FR2431494A1 (en) * 1978-07-17 1980-02-15 Logeais Labor Jacques NOVEL BENZOFURAN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR2540109B1 (en) * 1983-01-28 1985-08-30 Logeais Labor Jacques IMINO-2 PYRROLIDINES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS

Also Published As

Publication number Publication date
AU2371184A (en) 1984-08-02
IE840085L (en) 1984-07-28
DK39084D0 (en) 1984-01-27
OA07642A (en) 1985-05-23
IE56547B1 (en) 1991-08-28
ES8500226A1 (en) 1984-10-01
FR2540109A1 (en) 1984-08-03
FR2540109B1 (en) 1985-08-30
US4556674A (en) 1985-12-03
FI840322A7 (en) 1984-07-29
US4699918A (en) 1987-10-13
JPS59141558A (en) 1984-08-14
FI77021C (en) 1989-01-10
FI840322A0 (en) 1984-01-26
ZA84562B (en) 1984-09-26
AU562183B2 (en) 1987-06-04
HU189402B (en) 1986-07-28
FI77021B (en) 1988-09-30
EP0117771A1 (en) 1984-09-05
CA1223597A (en) 1987-06-30
EP0117771B1 (en) 1987-11-11
ES529223A0 (en) 1984-10-01
DE3467346D1 (en) 1987-12-17
DK39084A (en) 1984-07-29

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