ATE307593T1 - Mit einem tensid co-mikronisiertes progestin, pharmazeutische zusammensetzung dieses enthaltend,verfahren zu deren herstellung sowie verwendung - Google Patents
Mit einem tensid co-mikronisiertes progestin, pharmazeutische zusammensetzung dieses enthaltend,verfahren zu deren herstellung sowie verwendungInfo
- Publication number
- ATE307593T1 ATE307593T1 AT02708426T AT02708426T ATE307593T1 AT E307593 T1 ATE307593 T1 AT E307593T1 AT 02708426 T AT02708426 T AT 02708426T AT 02708426 T AT02708426 T AT 02708426T AT E307593 T1 ATE307593 T1 AT E307593T1
- Authority
- AT
- Austria
- Prior art keywords
- progestin
- micronized
- surfactant
- pharmaceutical composition
- production
- Prior art date
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000583 progesterone congener Substances 0.000 title abstract 2
- 239000004094 surface-active agent Substances 0.000 title abstract 2
- 230000003152 gestagenic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0102814A FR2821555B1 (fr) | 2001-03-01 | 2001-03-01 | Progestatif co-micronise avec un tensioactif, composition pharmaceutique le comprenant, leurs procedes de fabrication et leurs utilisations |
| PCT/FR2002/000714 WO2002069978A1 (fr) | 2001-03-01 | 2002-02-27 | Progestatif co-micronise avec un tensioactif, composition pharmaceutique le comprenant, leurs procedes de fabrication et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE307593T1 true ATE307593T1 (de) | 2005-11-15 |
Family
ID=8860623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02708426T ATE307593T1 (de) | 2001-03-01 | 2002-02-27 | Mit einem tensid co-mikronisiertes progestin, pharmazeutische zusammensetzung dieses enthaltend,verfahren zu deren herstellung sowie verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7163699B2 (de) |
| EP (1) | EP1363641B1 (de) |
| AT (1) | ATE307593T1 (de) |
| CA (1) | CA2445308A1 (de) |
| DE (1) | DE60206883T2 (de) |
| DK (1) | DK1363641T3 (de) |
| ES (1) | ES2251577T3 (de) |
| FR (1) | FR2821555B1 (de) |
| WO (1) | WO2002069978A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| CN1299686C (zh) * | 2003-04-03 | 2007-02-14 | 上海医药工业研究院 | 黄体酮半固体骨架制剂的组合物 |
| ES2381495T3 (es) * | 2005-05-26 | 2012-05-28 | Teva Women's Health, Inc. | Formas de dosificación oral que comprenden progesterona y métodos para fabricar y usar las mismas |
| KR20090086470A (ko) * | 2006-12-28 | 2009-08-12 | 레프로스 쎄라피우틱스 아이엔씨. | 앤티프로게스틴의 개선된 생물학적 이용가능성을 위한 방법들과 제형들 |
| EA022208B1 (ru) * | 2008-10-10 | 2015-11-30 | Тева Вимен'С Хелс, Инк. | Способы лечения вазомоторных симптомов у кастрированных пациентов с раком предстательной железы низкими дозами ципротерона ацетата |
| US20140179646A1 (en) * | 2009-06-18 | 2014-06-26 | Baucom Institute for Longevity and Life Enhancement, Inc. | Hormone delivery system and method |
| US9795617B2 (en) * | 2009-06-18 | 2017-10-24 | Baucom Institute for Longevity and Life Enhancement, Inc. | Hormone delivery system and method |
| CN102811730B (zh) * | 2010-02-08 | 2014-07-09 | 杜涛 | 孕激素作为糖皮质激素增敏剂的使用 |
| US9375437B2 (en) | 2010-06-18 | 2016-06-28 | Lipocine Inc. | Progesterone containing oral dosage forms and kits |
| US20110312928A1 (en) * | 2010-06-18 | 2011-12-22 | Lipocine Inc. | Progesterone Containing Oral Dosage Forms and Related Methods |
| US8951996B2 (en) | 2011-07-28 | 2015-02-10 | Lipocine Inc. | 17-hydroxyprogesterone ester-containing oral compositions and related methods |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| ES2885523T3 (es) | 2011-11-23 | 2021-12-14 | Therapeuticsmd Inc | Formulaciones y terapias de reposición hormonal de combinación naturales |
| FR2988610B1 (fr) * | 2012-03-30 | 2014-10-31 | Effik | Progestatif co-micronise avec un polymere portant le groupe pyrrolidone, composition et utilisations |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| FR2997627B1 (fr) | 2012-11-08 | 2015-01-16 | Hra Pharma Lab | Produit de co-micronisation comprenant de l'ulipristal acetate |
| AU2013361292A1 (en) | 2012-12-19 | 2015-07-09 | Kashiv Pharma, Llc | Supersaturated stabilized nanoparticles for poorly soluble drugs |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| MX2016014281A (es) | 2014-05-22 | 2017-02-22 | Therapeuticsmd Inc | Formulaciones y terapias de reemplazo de combinación de hormonas naturales. |
| MX2016013693A (es) | 2014-07-29 | 2017-10-31 | Therapeuticsmd Inc | Crema transdermica. |
| JP2018522854A (ja) | 2015-06-22 | 2018-08-16 | リポカイン インコーポレーテッド | １７−ヒドロキシプロゲステロンエステル含有経口組成物及び関連方法 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| AU2017239645A1 (en) | 2016-04-01 | 2018-10-18 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2408345A1 (fr) * | 1976-11-30 | 1979-06-08 | Besins Jean Louis | Nouvelle composition a action anti-conceptionnelle |
| US5276022A (en) * | 1987-09-24 | 1994-01-04 | Jencap Research Ltd. | Hormone preparation and method |
| EP0335970B1 (de) | 1987-10-05 | 1992-09-02 | Pharmagyn, Inc. | Tablette zur behandlung bei progesteronmangel |
| FR2627696B1 (fr) * | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
| US5116619A (en) * | 1988-08-30 | 1992-05-26 | Lee Roy Morgan | Vaginal progesterone tablet |
| US5084277A (en) * | 1988-08-30 | 1992-01-28 | Greco John C | Vaginal progesterone tablet |
| US5976570A (en) * | 1993-12-21 | 1999-11-02 | Applied Analytical Industries, Inc. | Method for preparing low dose pharmaceutical products |
| FR2757397B1 (fr) * | 1996-12-23 | 1999-03-05 | Mazal Pharma | Composition pharmaceutique a base de rheine ou de diacerheine a biodisponibilite amelioree |
| DE19734538C1 (de) * | 1997-07-30 | 1998-12-24 | Jenapharm Gmbh | Bioadhäsive Tablette |
| FR2772617B1 (fr) * | 1997-12-19 | 2001-03-09 | Besins Iscovesco Lab | Comprime de progesterone et son procede de preparation |
| FR2775599B1 (fr) | 1998-03-09 | 2001-08-17 | Besins Iscovesco Lab | Composition pharmaceutique a base de progesterone naturelle de synthese et d'oestradiol et son procede de preparation |
| IL127129A (en) * | 1998-11-18 | 2004-06-01 | Ferring Bv | Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared |
| TW417902U (en) * | 1998-12-31 | 2001-01-01 | Hon Hai Prec Ind Co Ltd | Cable connector |
| US6544553B1 (en) * | 1999-12-28 | 2003-04-08 | Watson Pharmaceuticals, Inc. | Dosage forms and methods for oral delivery of progesterone |
-
2001
- 2001-03-01 FR FR0102814A patent/FR2821555B1/fr not_active Expired - Fee Related
-
2002
- 2002-02-27 ES ES02708426T patent/ES2251577T3/es not_active Expired - Lifetime
- 2002-02-27 AT AT02708426T patent/ATE307593T1/de active
- 2002-02-27 EP EP02708426A patent/EP1363641B1/de not_active Expired - Lifetime
- 2002-02-27 CA CA002445308A patent/CA2445308A1/fr not_active Abandoned
- 2002-02-27 DK DK02708426T patent/DK1363641T3/da active
- 2002-02-27 WO PCT/FR2002/000714 patent/WO2002069978A1/fr not_active Ceased
- 2002-02-27 DE DE60206883T patent/DE60206883T2/de not_active Expired - Lifetime
- 2002-02-27 US US10/469,441 patent/US7163699B2/en not_active Expired - Lifetime
-
2006
- 2006-07-11 US US11/483,983 patent/US20070042038A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7163699B2 (en) | 2007-01-16 |
| EP1363641A1 (de) | 2003-11-26 |
| DE60206883T2 (de) | 2006-07-27 |
| US20040131553A1 (en) | 2004-07-08 |
| EP1363641B1 (de) | 2005-10-26 |
| ES2251577T3 (es) | 2006-05-01 |
| CA2445308A1 (fr) | 2002-09-12 |
| FR2821555A1 (fr) | 2002-09-06 |
| WO2002069978A1 (fr) | 2002-09-12 |
| DE60206883D1 (de) | 2005-12-01 |
| DK1363641T3 (da) | 2006-03-13 |
| US20070042038A1 (en) | 2007-02-22 |
| FR2821555B1 (fr) | 2003-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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