ATE307812T1 - Imidazopyridinverbindungen als 5-ht4- rezeptormodulatoren - Google Patents

Imidazopyridinverbindungen als 5-ht4- rezeptormodulatoren

Info

Publication number: ATE307812T1
Authority: AT; Austria
Prior art keywords: hydrogen; alkyl; halo; arylalkyl; amido
Prior art date: 2001-10-22

Application number

AT02777598T

Other languages

English (en)

Inventor

David Roy Fenwick

Geoffrey E Gymer

Alan Stobie

Chikara Uchida

Hirohide Noguchi

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-22

Filing date

2002-10-03

Publication date

2005-11-15

2002-10-03 Application filed by Pfizer filed Critical Pfizer

2005-11-15 Application granted granted Critical

2005-11-15 Publication of ATE307812T1 publication Critical patent/ATE307812T1/de

Links

239000001257 hydrogen Substances 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
150000002431 hydrogen Chemical class 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000003368 amide group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
201000006549 dyspepsia Diseases 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
108091005482 5-HT4 receptors Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
230000027455 binding Effects 0.000 abstract 1
208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Nutrition Science (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02777598T 2001-10-22 2002-10-03 Imidazopyridinverbindungen als 5-ht4- rezeptormodulatoren ATE307812T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US34337101P	2001-10-22	2001-10-22
US41248502P	2002-09-20	2002-09-20
PCT/IB2002/004098 WO2003035649A1 (en)	2001-10-22	2002-10-03	Imidazopyridine compounds as 5-ht4 receptor modulators

Publications (1)

Publication Number	Publication Date
ATE307812T1 true ATE307812T1 (de)	2005-11-15

Family

ID=26993446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02777598T ATE307812T1 (de)	2001-10-22	2002-10-03	Imidazopyridinverbindungen als 5-ht4- rezeptormodulatoren

Country Status (9)

Country	Link
EP (1)	EP1440071B1 (de)
JP (1)	JP2005526003A (de)
AT (1)	ATE307812T1 (de)
BR (1)	BR0213026A (de)
CA (1)	CA2461159A1 (de)
DE (1)	DE60206952T2 (de)
ES (1)	ES2248616T3 (de)
MX (1)	MXPA04002495A (de)
WO (1)	WO2003035649A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0211230D0 (en)	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
JP2006502180A (ja) *	2002-09-20	2006-01-19	ファイザー株式会社	５−ｈｔ４レセプターモジュレーターとしてのｎ−置換されたピペリジニル−イミダゾピリジン化合物
DOP2003000703A (es) *	2002-09-20	2004-03-31	Pfizer	Compuestos de imidazopiradina como agonistas del receptor 5-ht4
WO2004094418A1 (en) *	2003-04-21	2004-11-04	Pfizer Inc.	Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity
DE102004024772A1 (de)	2004-05-17	2005-12-22	Grünenthal GmbH	Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
EP1756050A1 (de) *	2004-06-01	2007-02-28	Eli Lilly And Company	Aminomethylazacyclusderivate als inhibitoren der monoaminaufnahme
JP5160764B2 (ja) *	2006-10-13	2013-03-13	全薬工業株式会社	特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤
CA2670636A1 (en)	2006-11-27	2008-06-05	H. Lundbeck A/S	Heteroaryl amide derivatives
US8852216B2 (en)	2007-03-23	2014-10-07	Ethicon Endo-Surgery, Inc.	Tissue approximation methods
AU2008236649B2 (en) *	2007-04-10	2013-05-02	H. Lundbeck A/S	Heteroaryl amide analogues as P2X7 antagonists
MX368017B (es)	2013-12-16	2019-09-13	Suven Life Sciences Ltd	Compuestos de indazol como agonistas del receptor de 5-ht4.
CN107001379B (zh)	2014-11-06	2022-11-01	Bial研发投资股份有限公司	取代的吡唑并[1,5-a]嘧啶以及它们在治疗医学障碍中的用途
AU2015342883B2 (en)	2014-11-06	2020-07-02	Bial - R&D Investments, S.A.	Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders
WO2016073889A1 (en)	2014-11-06	2016-05-12	Lysosomal Therapeutics Inc.	Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
CN106146386A (zh) *	2015-04-21	2016-11-23	江苏威凯尔医药科技有限公司	一种制备普卡必利中间体的新工艺
WO2017176960A1 (en)	2016-04-06	2017-10-12	Lysosomal Therapeutics Inc.	Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
US10787454B2 (en)	2016-04-06	2020-09-29	BIAL—BioTech Investments, Inc.	Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
WO2017176962A1 (en)	2016-04-06	2017-10-12	Lysosomal Therapeutics, Inc.	Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
MX389579B (es)	2016-05-05	2025-03-20	Bial R&D Invest S A	IMIDAZO[1,2-b]PIRIDAZINAS SUSTITUIDAS, IMIDAZO[1,5-b]PIRIDAZINAS SUSTITUIDAS, COMPUESTOS RELACIONADOS Y SU USO EN EL TRATAMIENTO DE TRASTORNOS MÉDICOS
WO2017192931A1 (en) *	2016-05-05	2017-11-09	Lysosomal Therapeutics Inc.	SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5260303A (en) *	1991-03-07	1993-11-09	G. D. Searle & Co.	Imidazopyridines as serotonergic 5-HT3 antagonists
GB9221468D0 (en) *	1992-10-13	1992-11-25	Smithkline Beecham Plc	Pharmaceuticals

2002
- 2002-10-03 JP JP2003538165A patent/JP2005526003A/ja not_active Withdrawn
- 2002-10-03 BR BR0213026-2A patent/BR0213026A/pt not_active IP Right Cessation
- 2002-10-03 AT AT02777598T patent/ATE307812T1/de not_active IP Right Cessation
- 2002-10-03 CA CA002461159A patent/CA2461159A1/en not_active Abandoned
- 2002-10-03 ES ES02777598T patent/ES2248616T3/es not_active Expired - Lifetime
- 2002-10-03 WO PCT/IB2002/004098 patent/WO2003035649A1/en not_active Ceased
- 2002-10-03 MX MXPA04002495A patent/MXPA04002495A/es unknown
- 2002-10-03 EP EP02777598A patent/EP1440071B1/de not_active Expired - Lifetime
- 2002-10-03 DE DE60206952T patent/DE60206952T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2248616T3 (es)	2006-03-16
JP2005526003A (ja)	2005-09-02
DE60206952T2 (de)	2006-06-22
DE60206952D1 (de)	2005-12-01
WO2003035649A1 (en)	2003-05-01
EP1440071B1 (de)	2005-10-26
EP1440071A1 (de)	2004-07-28
CA2461159A1 (en)	2003-05-01
MXPA04002495A (es)	2004-05-31
BR0213026A (pt)	2004-10-05

Legal Events

Date	Code	Title	Description
2006-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60206952D1 (de)	2005-12-01	Imidazopyridinverbindungen als 5-ht4-rezeptormodulatoren
AR036906A1 (es)	2004-10-13	Compuestos de imidazopiridin como moduladores del receptor 5-ht4
BRPI0507180A (pt)	2007-06-26	derivados de 1-isopropil-2-oxo-1,2-diidropiridina-3-carboxamida tendo atividade agonìstica de receptor 5-ht4
MXPA05011270A (es)	2006-01-24	Compuestos de imidazopiridina que tienen actividad agonista del receptor 5-ht4 y actividad antagonista del receptor 5-ht3.
EE200300403A (et)	2003-12-15	N-asendatud mittearomaatne heterotsükliline ühend, seda sisaldav ravimkompositsioon ning ühendi kasutamine ravimina
FR2842804B1 (fr)	2004-09-03	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
NO20080456L (no)	2008-03-04	Nye 2,4-dianilinopyrimidinderivater, fremstilling derav og deres anvendelse som medikamenter, farmasoytiske sammensetninger og, spesielt, som IKK inhibitorer
BG107171A (bg)	2003-07-31	Производни на пурин
SE0104140D0 (sv)	2001-12-07	Novel Compounds
HUP0301573A2 (hu)	2003-12-29	Szubsztituált arilpirazinok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
EA200400617A1 (ru)	2004-10-28	Гетероариламины в качестве ингибиторов гликогенсинтаза-киназы 3-бета (ингибиторов gsk3)
EA200700099A1 (ru)	2007-08-31	Производные пиридина
DE60101000D1 (de)	2003-11-20	N-heterocyclische derivate als nos inhibitoren
NO20050418L (no)	2005-04-28	Kondenserte pyridiner og pyrimidiner med TIE2(TEK) aktivitet
DK0773943T3 (da)	2002-03-04	Forbindelser, der er anvendelige som antiproliferative midler og garft-inhibitorer
YU24503A (sh)	2006-03-03	Novi tiadiazoli i oksadiazoli i njihova upotreba kao inhibitora fosfodiesteraze-7
NO20056192L (no)	2005-12-27	Kapaseinhibitorer og anvendelse derav
HUP0402261A2 (hu)	2005-02-28	Piperidinszármazékok és alkalmazásuk kemokin receptor aktivitás modulátoraiként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
DE69924292D1 (de)	2005-04-21	Pyrazol verbindungen und ihre verwendung
NO20075617L (no)	2007-12-03	4-fenyl-5-okso-1,4,5,6,7,8-heksahydrokinolinderivater for behandling av infertilitet
NO20040589L (no)	2004-03-19	Arylsulfonylderivater med 5-HT6 reseptor affinitet.
ATE503746T1 (de)	2011-04-15	Neue imidazolidinderivate
TR200200125T2 (tr)	2002-09-23	Yeni aminotiyazol türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar.
EA200600688A1 (ru)	2006-10-27	Арилинденпиридины и арилинденпиримидины и их применение в качестве антагонистов аденозинового рецептора а2а
DE60208694D1 (de)	2006-04-06	Piperidinylmorpholinylderivate als modulatoren der aktivität des chemokinrezeptors