ATE308754T1 - Effiziente anreicherung und detektion von ausgesäten tumorzellen - Google Patents
Effiziente anreicherung und detektion von ausgesäten tumorzellenInfo
- Publication number
- ATE308754T1 ATE308754T1 AT96929049T AT96929049T ATE308754T1 AT E308754 T1 ATE308754 T1 AT E308754T1 AT 96929049 T AT96929049 T AT 96929049T AT 96929049 T AT96929049 T AT 96929049T AT E308754 T1 ATE308754 T1 AT E308754T1
- Authority
- AT
- Austria
- Prior art keywords
- tumor cells
- cells
- detection
- efficient enrichment
- separated
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/824—Immunological separation techniques
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52004995A | 1995-08-28 | 1995-08-28 | |
| US08/667,464 US6190870B1 (en) | 1995-08-28 | 1996-06-21 | Efficient enrichment and detection of disseminated tumor cells |
| PCT/US1996/013704 WO1997008557A1 (en) | 1995-08-28 | 1996-08-23 | Efficient enrichment and detection of disseminated tumor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE308754T1 true ATE308754T1 (de) | 2005-11-15 |
Family
ID=27060032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96929049T ATE308754T1 (de) | 1995-08-28 | 1996-08-23 | Effiziente anreicherung und detektion von ausgesäten tumorzellen |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6190870B1 (de) |
| EP (1) | EP0850417B2 (de) |
| AT (1) | ATE308754T1 (de) |
| AU (1) | AU6859696A (de) |
| CA (1) | CA2229001A1 (de) |
| DE (1) | DE69635377T3 (de) |
| WO (1) | WO1997008557A1 (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19736691A1 (de) * | 1997-08-22 | 1999-02-25 | Michael Prof Dr Med Giesing | Verfahren zur Charakterisierung und Identifizierung disseminierter und metastasierter Krebszellen |
| WO1999041613A1 (en) | 1998-02-12 | 1999-08-19 | Immunivest | Methods and reagents for the rapid and efficient isolation of circulating cancer cells |
| DE60044236D1 (de) | 1999-02-17 | 2010-06-02 | Csl Ltd | Immunogene komplexe und methoden in bezug auf diese |
| EP1210597A4 (de) * | 1999-07-19 | 2003-03-12 | Chromavision Med Sys Inc | Zellanreicherung |
| EP1207961B1 (de) * | 1999-09-03 | 2006-03-15 | Miltenyi Biotec GmbH | Verfahren zur modifikation von ausgewählten zellen in einer magnetischen zelltrennungsäule |
| EP1311820B1 (de) * | 2000-07-14 | 2015-02-11 | Janssen Diagnostics, LLC | Erhöhte trenneffizienz über gesteuerte aggregation magnetischer nanopartikel |
| US6576423B2 (en) * | 2000-12-08 | 2003-06-10 | The Board Of Regents Of The University Of Nebraska | Specific mucin expression as a marker for pancreatic cancer |
| BR0207290A (pt) * | 2001-02-16 | 2005-06-07 | Immunivest Corp | Método para analisar um paciente quanto à presença de uma malignidade, célula maligna isolada das células cultivadas, vacina de tumor, molécula associada com diátese de tumor alterada, métodos para determinar alterações em moléculas associadas com diátese de tumor como um meio para predizer a eficácia da terapia, como um meio para analisar dosagem apropriada para terapia, como um meio para monitorar eficácia da terapia, como um meio para analisar progressão de câncer, para realizar uma biópsia de corpo inteiro em um paciente, e para identificar alterações em uma célula de tumor circulante relativamente a células presentes numa massa de tumor in situ, e, kit de teste para analisar uma amostra de paciente quanto à presença de uma célula maligna não-hematopoiética |
| DE10127079A1 (de) * | 2001-06-02 | 2002-12-12 | Ulrich Pachmann | Verfahren zum quantitativen Nachweis vitaler epithelialer Tumorzellen in einer Körperflüssigkeit |
| US7731648B2 (en) * | 2001-07-25 | 2010-06-08 | Aduro Biotech | Magnetic nanoscale particle compositions, and therapeutic methods related thereto |
| US6997863B2 (en) * | 2001-07-25 | 2006-02-14 | Triton Biosystems, Inc. | Thermotherapy via targeted delivery of nanoscale magnetic particles |
| US7074175B2 (en) | 2001-07-25 | 2006-07-11 | Erik Schroeder Handy | Thermotherapy via targeted delivery of nanoscale magnetic particles |
| US7951061B2 (en) * | 2001-07-25 | 2011-05-31 | Allan Foreman | Devices for targeted delivery of thermotherapy, and methods related thereto |
| WO2003019141A2 (en) * | 2001-08-23 | 2003-03-06 | Immunivest Corporation | Analysis of circulating tumor cells, fragments, and debris |
| US7863012B2 (en) * | 2004-02-17 | 2011-01-04 | Veridex, Llc | Analysis of circulating tumor cells, fragments, and debris |
| AU2002327704A1 (en) * | 2001-09-21 | 2003-04-01 | Raven Biotechnologies, Inc. | Antibodies that bind to cancer-associated antigen cytokeratin 8 and methods of use thereof |
| US8980568B2 (en) * | 2001-10-11 | 2015-03-17 | Aviva Biosciences Corporation | Methods and compositions for detecting non-hematopoietic cells from a blood sample |
| US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
| US20060210555A1 (en) * | 2001-12-21 | 2006-09-21 | Antigenics, Inc. | Compositions comprising immunoreactive reagents and saponins, and methods of use thereof |
| US8313742B2 (en) * | 2002-03-29 | 2012-11-20 | Depuy Acromed, Inc. | Cell-containing bone graft material |
| US20060008807A1 (en) * | 2002-08-23 | 2006-01-12 | O'hara Shawn M | Multiparameter analysis of comprehensive nucleic acids and morphological features on the same sample |
| EP1566639A4 (de) * | 2002-11-08 | 2006-10-11 | Hiroshi Takahashi | Verfahren zur untersuchung von krebszellen und reagens dafür |
| US20040156846A1 (en) * | 2003-02-06 | 2004-08-12 | Triton Biosystems, Inc. | Therapy via targeted delivery of nanoscale particles using L6 antibodies |
| SE0302074D0 (sv) * | 2003-07-15 | 2003-07-15 | Simon Ekstroem | Device and method for analysis of samples using a combined sample treatment and sample carrier device |
| CA2535153A1 (en) * | 2003-08-12 | 2005-05-19 | Massachusetts Institute Of Technology | Sample preparation methods and devices |
| US20050277204A1 (en) * | 2003-08-12 | 2005-12-15 | Massachusetts Institute Of Technology | Sample preparation methods and devices |
| US20050181353A1 (en) * | 2004-02-17 | 2005-08-18 | Rao Galla C. | Stabilization of cells and biological specimens for analysis |
| US9790539B2 (en) * | 2004-06-30 | 2017-10-17 | Russell Biotech, Inc. | Methods and reagents for improved selection of biological molecules |
| US20060040389A1 (en) * | 2004-08-17 | 2006-02-23 | Murry Charles E | Purified compositions of stem cell derived differentiating cells |
| JP4798801B2 (ja) * | 2004-10-06 | 2011-10-19 | ウェルスタット バイオロジクス コーポレイション | 循環する癌細胞におけるHer−2/neuタンパク質のレベルの上昇の検出および処置 |
| US7901950B2 (en) * | 2005-08-12 | 2011-03-08 | Veridex, Llc | Method for assessing disease states by profile analysis of isolated circulating endothelial cells |
| JP4902674B2 (ja) * | 2006-03-09 | 2012-03-21 | エフ.ホフマン−ラ ロシュ アーゲー | 抗薬物抗体アッセイ法 |
| WO2008060687A2 (en) * | 2006-05-12 | 2008-05-22 | San Diego State University Research Foundation | High-throughput methods for quantifying cells in environmental and laboratory samples |
| EP2029779A4 (de) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose |
| WO2008111990A1 (en) * | 2006-06-14 | 2008-09-18 | Cellpoint Diagnostics, Inc. | Rare cell analysis using sample splitting and dna tags |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
| US9277295B2 (en) * | 2006-06-16 | 2016-03-01 | Cisco Technology, Inc. | Securing media content using interchangeable encryption key |
| CA2657621A1 (en) * | 2006-07-14 | 2008-01-17 | Aviva Biosciences Corporation | Methods and compositions for detecting rare cells from a biological sample |
| MX2009002397A (es) * | 2006-09-05 | 2009-03-16 | Veridex Llc | Metodos para clasificar imagenes celulares. |
| EP2145188A4 (de) * | 2007-04-19 | 2010-06-30 | Wellstat Biologics Corp | Nachweis von her2/neu-protein aus nichtisolierten zirkulierenden krebszellen und behandlung |
| US8071395B2 (en) * | 2007-12-12 | 2011-12-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and apparatus for magnetic separation of cells |
| US8008032B2 (en) | 2008-02-25 | 2011-08-30 | Cellective Dx Corporation | Tagged ligands for enrichment of rare analytes from a mixed sample |
| US20100099074A1 (en) * | 2008-07-25 | 2010-04-22 | Garry Nolan | Collection device and method for stimulating and stabilizing a biological sample |
| US9459246B2 (en) | 2009-09-08 | 2016-10-04 | Nodality, Inc. | Induced intercellular communication |
| US8565892B2 (en) | 2009-10-31 | 2013-10-22 | Qteris, Inc. | Nanoparticle-sized magnetic absorption enhancers having three-dimensional geometries adapted for improved diagnostics and hyperthermic treatment |
| KR101122124B1 (ko) * | 2009-11-17 | 2012-03-16 | 주식회사 아모그린텍 | 분석물질의 검출 방법 및 장치 |
| US20110312503A1 (en) | 2010-01-23 | 2011-12-22 | Artemis Health, Inc. | Methods of fetal abnormality detection |
| US8695618B2 (en) | 2010-12-22 | 2014-04-15 | Carnegie Mellon University | 3D chemical pattern control in 2D fluidics devices |
| EP2756005B1 (de) * | 2011-09-14 | 2016-03-02 | Abeterno Technologies Limited | Intrazelluläre zellenauswahl |
| CN104620093B (zh) * | 2012-08-23 | 2018-04-20 | 干细胞技术公司 | 用于快速可逆生物分子标记的组合物和方法 |
| US10429393B2 (en) | 2014-01-20 | 2019-10-01 | National Centre For Cell Science | Tumor deconstruction platform for the analysis of intra-tumor heterogeneity |
| EP4253937A3 (de) | 2014-02-26 | 2023-11-08 | Brigham and Women's Hospital, Inc. | Verfahren zur zelllevetation und -überwachung |
| EP2955521A1 (de) * | 2014-06-11 | 2015-12-16 | Centre Hospitalier Universitaire Vaudois (CHUV) | Verfahren zur Trennung von Zellen |
| EP3037820A1 (de) | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Zellerkennungsverfahren und Reagenzien mit lösbarem Etikettierungsteil |
| WO2018227050A1 (en) * | 2017-06-09 | 2018-12-13 | The Trustees Of The University Of Pennsylvania | Flow cytometry-based platform for the detection, enumeration, and isolation of disseminated tumor cells in bone marrow aspirates |
| WO2019090062A1 (en) | 2017-11-03 | 2019-05-09 | Gray Mark A | Quant production and dosing |
| CN108918871A (zh) * | 2018-07-12 | 2018-11-30 | 浙江大学 | 用于外周血循环肿瘤细胞捕获的negFACs-IF:E/M方法 |
| US12023637B2 (en) | 2020-03-23 | 2024-07-02 | Mark A. Gray | Capillary tube droplet generation systems and methods |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US4965204A (en) * | 1984-02-06 | 1990-10-23 | The Johns Hopkins University | Human stem cells and monoclonal antibodies |
| US4935344A (en) * | 1984-04-30 | 1990-06-19 | Sloan-Kettering Institute For Cancer Research | Method for characterizing types of renal carcinoma and prognosis |
| US4770183A (en) | 1986-07-03 | 1988-09-13 | Advanced Magnetics Incorporated | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
| DE3720844A1 (de) * | 1987-06-24 | 1989-01-05 | Stefan Miltenyi | Trennsaeule fuer die magnetische separierung von zellen, zellaggregaten, und zellulaeren bestandteilen |
| ATE114507T1 (de) | 1988-12-28 | 1994-12-15 | Stefan Miltenyi | Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien. |
| US5385707A (en) | 1988-12-28 | 1995-01-31 | Stefan Miltenyi | Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same |
| NO180658C (no) * | 1994-03-10 | 1997-05-21 | Oeystein Fodstad | Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner |
-
1996
- 1996-06-21 US US08/667,464 patent/US6190870B1/en not_active Expired - Lifetime
- 1996-08-23 AU AU68596/96A patent/AU6859696A/en not_active Abandoned
- 1996-08-23 AT AT96929049T patent/ATE308754T1/de not_active IP Right Cessation
- 1996-08-23 DE DE69635377T patent/DE69635377T3/de not_active Expired - Lifetime
- 1996-08-23 CA CA002229001A patent/CA2229001A1/en not_active Abandoned
- 1996-08-23 WO PCT/US1996/013704 patent/WO1997008557A1/en not_active Ceased
- 1996-08-23 EP EP96929049A patent/EP0850417B2/de not_active Expired - Lifetime
-
2000
- 2000-12-22 US US09/746,941 patent/US20010000751A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20010000751A1 (en) | 2001-05-03 |
| DE69635377D1 (de) | 2005-12-08 |
| DE69635377T2 (de) | 2006-07-27 |
| US6190870B1 (en) | 2001-02-20 |
| WO1997008557A1 (en) | 1997-03-06 |
| EP0850417A4 (de) | 2001-07-11 |
| EP0850417B1 (de) | 2005-11-02 |
| CA2229001A1 (en) | 1997-03-06 |
| EP0850417B2 (de) | 2009-12-09 |
| EP0850417A1 (de) | 1998-07-01 |
| AU6859696A (en) | 1997-03-19 |
| DE69635377T3 (de) | 2010-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |