ATE309196T1 - Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukte - Google Patents
Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukteInfo
- Publication number
- ATE309196T1 ATE309196T1 AT00917868T AT00917868T ATE309196T1 AT E309196 T1 ATE309196 T1 AT E309196T1 AT 00917868 T AT00917868 T AT 00917868T AT 00917868 T AT00917868 T AT 00917868T AT E309196 T1 ATE309196 T1 AT E309196T1
- Authority
- AT
- Austria
- Prior art keywords
- arylpropylamines
- aryloxy
- producing
- intermediate products
- methylpyrrolidinone
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 2
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000006073 displacement reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Luminescent Compositions (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12848099P | 1999-04-09 | 1999-04-09 | |
| PCT/US2000/006423 WO2000061540A1 (en) | 1999-04-09 | 2000-03-22 | Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE309196T1 true ATE309196T1 (de) | 2005-11-15 |
Family
ID=22435565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00917868T ATE309196T1 (de) | 1999-04-09 | 2000-03-22 | Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukte |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6541668B1 (de) |
| EP (1) | EP1171417B1 (de) |
| JP (1) | JP2002541235A (de) |
| AT (1) | ATE309196T1 (de) |
| AU (1) | AU3877500A (de) |
| CA (1) | CA2362185C (de) |
| DE (1) | DE60023870T2 (de) |
| DK (1) | DK1171417T3 (de) |
| ES (1) | ES2249256T3 (de) |
| WO (1) | WO2000061540A1 (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2305221T3 (es) | 2001-03-06 | 2008-11-01 | Eli Lilly And Company | Inhibidor de la captacion de monoamina. |
| WO2003062219A1 (en) * | 2002-01-24 | 2003-07-31 | Eli Lilly And Company | Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine |
| GB0229583D0 (en) * | 2002-12-19 | 2003-01-22 | Cipla Ltd | A process for preparing duloxetine and intermediates for use therein |
| ATE526954T1 (de) * | 2003-07-28 | 2011-10-15 | Leslie Joe Dunaway | Atomoxetin zur behandlung von allergischer rhinitis und asthma |
| US20050197503A1 (en) * | 2004-03-05 | 2005-09-08 | Boehringer Ingelheim International Gmbh | Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines |
| US7317127B2 (en) * | 2004-06-28 | 2008-01-08 | Teva Pharmaceutical Fine Chemicals S.R.L | Process for the optical resolution and recycling of tomoxetine |
| US7439399B2 (en) * | 2004-06-28 | 2008-10-21 | Teva Pharmaceutical Fine Chemicals | Processes for the preparation of atomoxetine hydrochloride |
| CA2568629A1 (en) * | 2004-07-22 | 2006-02-23 | Teva Pharmaceutical Fine Chemicals S.R.L. | Polymorphs of atomoxetine hydrochloride |
| US7550605B2 (en) * | 2004-08-05 | 2009-06-23 | Sun Pharmaceutical Industries Ltd. | Process for preparation of an anitdepressant compound |
| WO2006037055A1 (en) * | 2004-09-27 | 2006-04-06 | Dr. Reddy's Laboratories Ltd. | Synthesis of atomoxetine hydrochloride |
| TWI306858B (en) * | 2004-12-23 | 2009-03-01 | Teva Pharma | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof |
| WO2006096809A1 (en) * | 2005-03-08 | 2006-09-14 | Teva Pharmaceutical Industries Ltd. | Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine oxalate and the preparation thereof |
| TW200639162A (en) * | 2005-03-14 | 2006-11-16 | Teva Pharma | Pure duloxetine hydrochloride |
| EP1889828A1 (de) * | 2005-04-05 | 2008-02-20 | Teva Pharmaceutical Fine Chemicals S.R.L. | Stabiles Atomoxetinhydrochlorid, Herstellungsverfahren und analytische Steuerung seiner Stabilität |
| MX2007010268A (es) * | 2005-04-05 | 2008-02-19 | Teva Pharm Fine Chemicals Srl | Clorhidrato de atomoxetina estable, un proceso para la preparacion del mismo, y un control analitico de su estabilidad. |
| US7485754B2 (en) * | 2005-07-08 | 2009-02-03 | Apotex Pharmachem Inc. | Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers |
| CZ2005473A3 (cs) * | 2005-07-21 | 2006-02-15 | Zentiva, A. S | Zpusob výroby hydrochloridu (R)-N-methyl-3-(2-methylfenoxy)-3-fenylpropylaminu (atomoxetinu) |
| US20080207923A1 (en) * | 2005-09-22 | 2008-08-28 | Santiago Ini | Pure DNT-maleate and methods of preparation thereof |
| WO2007038253A2 (en) * | 2005-09-22 | 2007-04-05 | Teva Pharmaceutical Industries Ltd. | Dnt-maleate and methods of preparation thereof |
| EP1863782A1 (de) | 2005-12-05 | 2007-12-12 | Teva Pharmaceutical Industries Ltd. | 2-(n-methyl-propanamin)-3-(2-naphthol) thiophen, eine verunreinigung von duloxetin hydrochlorid |
| EP1971593A2 (de) | 2005-12-12 | 2008-09-24 | Medichem, S.A. | Verbesserte synthese und zubereitungen von duloxetinsalzen |
| EP1798215A1 (de) * | 2005-12-14 | 2007-06-20 | SOLMAG S.p.A. | Polymorph von Atomoxetin-hydrochloride in kristalliner Form |
| US7538232B2 (en) | 2006-01-19 | 2009-05-26 | Eli Lilly And Company | Process for the asymmetric synthesis of duloxetine |
| WO2007086948A1 (en) * | 2006-01-23 | 2007-08-02 | Teva Pharmaceutical Industries Ltd. | Dnt-fumarate and methods of preparation thereof |
| WO2007084193A1 (en) * | 2006-01-23 | 2007-07-26 | Teva Pharmaceutical Industries Ltd. | Dnt-succinate and methods of preparation thereof |
| CA2640212A1 (en) * | 2006-02-13 | 2007-08-23 | Teva Pharmaceutical Industries Ltd. | A process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate |
| EP1888554A2 (de) * | 2006-02-21 | 2008-02-20 | Teva Pharmaceutical Industries Ltd | Verfahren zur herstellung von (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamin, einem duloxetin-zwischenprodukt |
| US20080146675A1 (en) * | 2006-04-05 | 2008-06-19 | Eugenio Castelli | Stable Atomoxetine Hydrochloride, a process for the preparation thereof, and an analytical control of its stability |
| US20080027128A1 (en) * | 2006-05-23 | 2008-01-31 | Santiago Ini | Duloxetine HCL polymorphs |
| TW200813002A (en) * | 2006-05-31 | 2008-03-16 | Teva Pharma | Process for preparing duloxetine and intermediates thereof |
| CN100430370C (zh) * | 2006-11-03 | 2008-11-05 | 华东理工大学 | 一种丙胺衍生物及其在制备托莫西汀中的应用 |
| US20080145318A1 (en) * | 2006-12-13 | 2008-06-19 | Midha Kamal K | Atomoxetine formulations and associated methods |
| CN101657438A (zh) | 2006-12-22 | 2010-02-24 | 斯索恩有限公司 | 制备度洛西汀和相关化合物的方法 |
| US8269023B2 (en) * | 2007-03-05 | 2012-09-18 | Lupin Ltd. | Process for preparation of duloxetine hydrochloride |
| WO2009019719A2 (en) * | 2007-08-09 | 2009-02-12 | Ind-Swift Laboratories Limited | Process for the preparation of 3-aryloxy-3-arylpropanamines |
| EP2060559A1 (de) | 2007-11-19 | 2009-05-20 | Cadila Pharmaceuticals Limited | Herstellungsverfahren für enantiomerenreine 3-Hydroxy-3-Arylpropylamine und ihrer optischen Stereoisomere |
| WO2009087463A2 (en) * | 2007-12-26 | 2009-07-16 | Orchid Chemicals & Pharmaceuticals Limited | A method for the preparation of duloxetine hydrochloride |
| CN101939004A (zh) * | 2008-01-25 | 2011-01-05 | 阿尔法制药有限公司 | 度洛西汀的缓释药物组合物 |
| WO2009141833A2 (en) * | 2008-04-17 | 2009-11-26 | Ind-Swift Laboratories Limited | An improved process for synthesizing highly pure atomoxetine |
| EP2329013B1 (de) | 2008-08-27 | 2015-10-28 | Codexis, Inc. | Ketoreduktasepolypeptide zur herstellung von einem 3-aryl-3-hydroxypropanamin aus einem 3-aryl-3-ketopropanamin |
| WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2011128370A1 (en) | 2010-04-13 | 2011-10-20 | Krka, D.D., Novo Mesto | Synthesis of duloxetine and/or pharmaceutically acceptable salts thereof |
| CN102863344B (zh) * | 2012-07-20 | 2015-06-03 | 葫芦岛国帝药业有限责任公司 | 一种托莫西汀药物制备方法 |
| CN106916074A (zh) * | 2017-02-14 | 2017-07-04 | 万特制药(海南)有限公司 | 盐酸托莫西汀的制备 |
| CN108929236A (zh) * | 2017-05-26 | 2018-12-04 | 万特制药(海南)有限公司 | 盐酸托莫西汀的制备 |
| CN110294680A (zh) * | 2018-03-22 | 2019-10-01 | 北京深蓝海生物医药科技有限公司 | 一种盐酸阿托莫西汀的制备方法 |
| CN111302958B (zh) * | 2020-03-24 | 2023-05-02 | 合肥医工医药股份有限公司 | 一种光学纯的（r）-n-甲基-3-苯基-3-（邻-甲苯氧基）-丙胺盐酸盐制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL233786A1 (de) | 1980-11-14 | 1982-05-24 | Lilly Co Eli | |
| JPS6023656A (ja) | 1983-07-20 | 1985-02-06 | Nissan Motor Co Ltd | 自動変速機の遊星歯車列 |
| US4868344A (en) | 1988-03-30 | 1989-09-19 | Aldrich-Boranes, Inc. | Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein |
| FI81083C (fi) * | 1989-03-03 | 1990-09-10 | Orion Yhtymae Oy | Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid. |
| US5166437A (en) | 1989-03-03 | 1992-11-24 | Orion-Yhtyma Oy | Process for the preparation of fluoxetine |
| US5104899A (en) | 1990-08-13 | 1992-04-14 | Sepracor, Inc. | Methods and compositions for treating depression using optically pure fluoxetine |
| US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
| ES2120368B1 (es) * | 1996-06-14 | 1999-07-01 | Almirall Prodesfarma Sa | Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables. |
| IT1283141B1 (it) * | 1996-07-11 | 1998-04-07 | Laporte Organics Francis S P A | Procedimento per la preparazione di n-metil-3-(p-trifluorometilfenossi)-3-fenilpropilamina e dei suoi |
| TW514634B (en) | 1997-10-14 | 2002-12-21 | Lilly Co Eli | Process to make chiral compounds |
-
2000
- 2000-03-22 AT AT00917868T patent/ATE309196T1/de not_active IP Right Cessation
- 2000-03-22 AU AU38775/00A patent/AU3877500A/en not_active Abandoned
- 2000-03-22 WO PCT/US2000/006423 patent/WO2000061540A1/en not_active Ceased
- 2000-03-22 EP EP00917868A patent/EP1171417B1/de not_active Expired - Lifetime
- 2000-03-22 DK DK00917868T patent/DK1171417T3/da active
- 2000-03-22 US US09/936,468 patent/US6541668B1/en not_active Expired - Lifetime
- 2000-03-22 JP JP2000610817A patent/JP2002541235A/ja active Pending
- 2000-03-22 ES ES00917868T patent/ES2249256T3/es not_active Expired - Lifetime
- 2000-03-22 CA CA002362185A patent/CA2362185C/en not_active Expired - Fee Related
- 2000-03-22 DE DE60023870T patent/DE60023870T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1171417B1 (de) | 2005-11-09 |
| ES2249256T3 (es) | 2006-04-01 |
| US6541668B1 (en) | 2003-04-01 |
| DK1171417T3 (da) | 2006-02-20 |
| EP1171417A1 (de) | 2002-01-16 |
| AU3877500A (en) | 2000-11-14 |
| JP2002541235A (ja) | 2002-12-03 |
| WO2000061540A1 (en) | 2000-10-19 |
| DE60023870D1 (de) | 2005-12-15 |
| CA2362185C (en) | 2009-06-02 |
| DE60023870T2 (de) | 2006-06-14 |
| CA2362185A1 (en) | 2000-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1171417 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |