ATE309214T1 - Verfahren zur herstellung von 1,3,5- triaminobenzol und dessen hydrolyse zu hochreinem phloroglucinol - Google Patents
Verfahren zur herstellung von 1,3,5- triaminobenzol und dessen hydrolyse zu hochreinem phloroglucinolInfo
- Publication number
- ATE309214T1 ATE309214T1 AT03757119T AT03757119T ATE309214T1 AT E309214 T1 ATE309214 T1 AT E309214T1 AT 03757119 T AT03757119 T AT 03757119T AT 03757119 T AT03757119 T AT 03757119T AT E309214 T1 ATE309214 T1 AT E309214T1
- Authority
- AT
- Austria
- Prior art keywords
- phloroglucinol
- preparing
- prepared
- hydrolysis
- temperature
- Prior art date
Links
- JPYHHZQJCSQRJY-UHFFFAOYSA-N Phloroglucinol Natural products CCC=CCC=CCC=CCC=CCCCCC(=O)C1=C(O)C=C(O)C=C1O JPYHHZQJCSQRJY-UHFFFAOYSA-N 0.000 title abstract 5
- QCDYQQDYXPDABM-UHFFFAOYSA-N phloroglucinol Chemical compound OC1=CC(O)=CC(O)=C1 QCDYQQDYXPDABM-UHFFFAOYSA-N 0.000 title abstract 5
- 229960001553 phloroglucinol Drugs 0.000 title abstract 5
- RPHKINMPYFJSCF-UHFFFAOYSA-N benzene-1,3,5-triamine Chemical compound NC1=CC(N)=CC(N)=C1 RPHKINMPYFJSCF-UHFFFAOYSA-N 0.000 title abstract 4
- 230000007062 hydrolysis Effects 0.000 title abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 238000005576 amination reaction Methods 0.000 abstract 2
- 229910021529 ammonia Inorganic materials 0.000 abstract 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 150000001879 copper Chemical class 0.000 abstract 2
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 abstract 2
- 150000005171 halobenzenes Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 abstract 1
- 229940011051 isopropyl acetate Drugs 0.000 abstract 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/10—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to carbon atoms of six-membered aromatic rings or from amines having nitrogen atoms bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/045—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis by substitution of a group bound to the ring by nitrogen
- C07C37/05—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis by substitution of a group bound to the ring by nitrogen by substitution of a NH2 group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0207177A FR2840608B1 (fr) | 2002-06-11 | 2002-06-11 | Procede de preparation de 1,3,5-triaminobenzene et son hydrolyse en phloroglucinol de haute purete |
| PCT/FR2003/001703 WO2003104194A1 (fr) | 2002-06-11 | 2003-06-06 | Procede de preparation de 1,3,5-triaminobenzene et son hydrolyse en phloroglucinol de haute purete |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE309214T1 true ATE309214T1 (de) | 2005-11-15 |
Family
ID=29559141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03757119T ATE309214T1 (de) | 2002-06-11 | 2003-06-06 | Verfahren zur herstellung von 1,3,5- triaminobenzol und dessen hydrolyse zu hochreinem phloroglucinol |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7217840B2 (de) |
| EP (1) | EP1511726B1 (de) |
| JP (1) | JP2005534659A (de) |
| CN (1) | CN1312128C (de) |
| AT (1) | ATE309214T1 (de) |
| AU (1) | AU2003260577A1 (de) |
| BR (1) | BRPI0311786B1 (de) |
| CA (1) | CA2487973C (de) |
| CY (1) | CY1104964T1 (de) |
| DE (1) | DE60302248T2 (de) |
| DK (1) | DK1511726T3 (de) |
| ES (1) | ES2252690T3 (de) |
| FR (1) | FR2840608B1 (de) |
| IL (1) | IL165602A (de) |
| WO (1) | WO2003104194A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2921656B1 (fr) | 2007-09-28 | 2012-11-02 | Centre Nat Rech Scient | Procede de synthese d'arylamines |
| KR101045846B1 (ko) | 2009-12-09 | 2011-07-01 | 국방과학연구소 | 마이크로웨이브 반응기를 이용한 1,3,5-트리히드록시벤젠의 제조방법 |
| CN102838457A (zh) * | 2012-09-20 | 2012-12-26 | 山东潍坊润丰化工有限公司 | 一种2,5-二氯苯酚的合成方法 |
| CN105461001A (zh) * | 2014-08-21 | 2016-04-06 | 辽宁大唐国际阜新煤制天然气有限责任公司 | 处理含高浓度酚类的煤气化废水的方法、装置及萃取剂用途 |
| CN109053382B (zh) * | 2018-08-06 | 2021-07-30 | 国药集团化学试剂有限公司 | 一种间苯三酚的制备方法 |
| CN111925278A (zh) * | 2020-07-15 | 2020-11-13 | 杭州蓝然环境技术股份有限公司 | 一种膜法改进间苯三酚的制备工艺 |
| CN116754664A (zh) * | 2023-05-17 | 2023-09-15 | 南京科默生物医药有限公司 | 一种间苯三酚中芳香胺类遗传毒性杂质残留检测的方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102358C (de) | ||||
| US2461498A (en) * | 1943-12-08 | 1949-02-08 | Edwal Lab Inc | Preparation of symmetrical triaminobenzene compounds |
| GB693752A (en) | 1950-03-30 | 1953-07-08 | Edwal Lab Inc | Preparation of symmetrical trihydroxybenzene compounds |
| US2773908A (en) * | 1952-08-07 | 1956-12-11 | Heyden Chemical Corp | Separation and purification of phloroglucinol |
| US3028410A (en) * | 1958-06-26 | 1962-04-03 | Hooker Chemical Corp | Synthesis of polyhydroxy aromatic compounds |
| FR1289647A (fr) | 1961-02-25 | 1962-04-06 | France Etat | Procédé de préparation de triaminobenzène |
| US3230266A (en) * | 1961-11-17 | 1966-01-18 | Morton Int Inc | Preparation of phloroglucinol |
| DE1195327B (de) | 1963-03-22 | 1965-06-24 | Kalle Ag | Verfahren zur Herstellung von symmetrischen Trihydroxybenzolen |
| GB1022733A (en) | 1964-05-19 | 1966-03-16 | Whiffen & Sons Ltd | Triaminobenzene |
| GB1106088A (en) | 1964-09-10 | 1968-03-13 | Fisons Ind Chemicals Ltd | Process for the preparation of phloroglucinol |
| GB1274551A (en) * | 1969-02-18 | 1972-05-17 | Fisons Ind Chemicals Ltd | Improvements in a process for the production of triaminobenzene |
| GB1388840A (en) * | 1971-06-24 | 1975-03-26 | Oce Andeno Bv | Preparation of phloroglucinol and its monomethyl ether |
| US3959388A (en) * | 1972-06-23 | 1976-05-25 | Andeno B.V. | Preparation of phloroglucinol or its monomethyl ether |
| DE2502429C3 (de) * | 1975-01-22 | 1979-06-21 | Akzo Gmbh, 5600 Wuppertal | Verfahren zur Herstellung von Phloroglucin |
| US4115451A (en) * | 1976-05-14 | 1978-09-19 | Akzona Incorporated | Benzene-1,3,5-tris-acetoxime and the process for making phloroglucinol therewith |
| DE2621431C3 (de) * | 1976-05-14 | 1980-05-29 | Akzo Gmbh, 5600 Wuppertal | Verfahren zur Herstellung von Phloroglucin |
| AT359668B (de) * | 1978-05-03 | 1980-11-25 | Voest Alpine Ag | Schutzvorrichtung zum verhueten von schaeden an einer brammenstranggiessanlage |
| DE2840597A1 (de) | 1978-09-18 | 1980-03-27 | Akzo Gmbh | Verfahren zur herstellung von phloroglucin |
| NL7901342A (nl) | 1979-02-21 | 1980-08-25 | Oce Andeno Bv | Geflegmatiseerd tnt: methode en toepassing. |
| JPS56152443A (en) * | 1980-04-24 | 1981-11-26 | Ishihara Sangyo Kaisha Ltd | Preparation of 1,3,5-triaminobenzene |
| JPS57178235A (en) * | 1981-04-28 | 1982-11-02 | Konishiroku Photo Ind Co Ltd | Photographic sensitive silver halide material |
| JPS5896035A (ja) * | 1981-12-01 | 1983-06-07 | Sumitomo Chem Co Ltd | フロログルシンの精製方法 |
| US4389670A (en) * | 1981-12-30 | 1983-06-21 | The United States Of America As Represented By The United States Department Of Energy | Electronic method for autofluorography of macromolecules on two-D matrices |
| JPS58150530A (ja) * | 1982-03-02 | 1983-09-07 | Mitsui Petrochem Ind Ltd | フロログルシンの分離方法 |
| DE3607924C1 (de) * | 1986-03-11 | 1987-08-20 | Degussa | Verfahren zur Herstellung von Trihydroxybenzolen durch Hydroxylierung von Resorcin |
| DE3607923A1 (de) | 1986-03-11 | 1987-09-17 | Degussa | Verfahren zur herstellung substituierter trihydroxybenzole |
| DE3632075A1 (de) * | 1986-09-20 | 1988-03-24 | Degussa | Verfahren zur herstellung von trihydroxy- bzw. alkoxyhydroxybenzolen |
| JP2672144B2 (ja) * | 1989-04-13 | 1997-11-05 | 三井石油化学工業株式会社 | フロログルシンおよびレゾルシンの製造方法 |
| DE69115758T2 (de) * | 1990-06-06 | 1996-05-15 | Sds Biotech Corp | Verfahren zur Herstellung von 3,5-Difluoranilin und dessen Derivat |
| FR2709959B1 (fr) * | 1993-09-14 | 1995-12-08 | Lafon Labor | Nouvelle forme galénique de phloroglucinol. |
| AU3886000A (en) | 1999-03-23 | 2000-10-09 | Board Of Trustees Of Michigan State University | Synthesis of 1,2,3,4-tetrahydroxybenzenes and 1,2,3-trihydroxybenzenes using myo-inositol-1-phosphate synthase and myo-inositol 2-dehydrogenase |
-
2002
- 2002-06-11 FR FR0207177A patent/FR2840608B1/fr not_active Expired - Lifetime
-
2003
- 2003-06-06 CN CNB038166313A patent/CN1312128C/zh not_active Expired - Lifetime
- 2003-06-06 BR BRPI0311786A patent/BRPI0311786B1/pt not_active IP Right Cessation
- 2003-06-06 DK DK03757119T patent/DK1511726T3/da active
- 2003-06-06 WO PCT/FR2003/001703 patent/WO2003104194A1/fr not_active Ceased
- 2003-06-06 EP EP03757119A patent/EP1511726B1/de not_active Expired - Lifetime
- 2003-06-06 JP JP2004511264A patent/JP2005534659A/ja active Pending
- 2003-06-06 CA CA2487973A patent/CA2487973C/fr not_active Expired - Fee Related
- 2003-06-06 ES ES03757119T patent/ES2252690T3/es not_active Expired - Lifetime
- 2003-06-06 DE DE60302248T patent/DE60302248T2/de not_active Expired - Lifetime
- 2003-06-06 US US10/517,716 patent/US7217840B2/en not_active Expired - Fee Related
- 2003-06-06 AT AT03757119T patent/ATE309214T1/de active
- 2003-06-06 AU AU2003260577A patent/AU2003260577A1/en not_active Abandoned
-
2004
- 2004-12-07 IL IL165602A patent/IL165602A/en active IP Right Grant
-
2006
- 2006-02-01 CY CY20061100129T patent/CY1104964T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003104194A1 (fr) | 2003-12-18 |
| IL165602A0 (en) | 2006-01-15 |
| JP2005534659A (ja) | 2005-11-17 |
| CN1668586A (zh) | 2005-09-14 |
| US20050165256A1 (en) | 2005-07-28 |
| CY1104964T1 (el) | 2009-11-04 |
| ES2252690T3 (es) | 2006-05-16 |
| FR2840608A1 (fr) | 2003-12-12 |
| DE60302248D1 (de) | 2005-12-15 |
| CA2487973C (fr) | 2011-01-11 |
| IL165602A (en) | 2009-11-18 |
| DE60302248T2 (de) | 2006-08-03 |
| DK1511726T3 (da) | 2006-03-27 |
| AU2003260577A1 (en) | 2003-12-22 |
| EP1511726A1 (de) | 2005-03-09 |
| EP1511726B1 (de) | 2005-11-09 |
| CN1312128C (zh) | 2007-04-25 |
| FR2840608B1 (fr) | 2005-07-01 |
| US7217840B2 (en) | 2007-05-15 |
| BRPI0311786B1 (pt) | 2015-11-03 |
| CA2487973A1 (fr) | 2003-12-18 |
| BR0311786A (pt) | 2005-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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