ATE309264T1 - Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren - Google Patents
Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitorenInfo
- Publication number
- ATE309264T1 ATE309264T1 AT98915572T AT98915572T ATE309264T1 AT E309264 T1 ATE309264 T1 AT E309264T1 AT 98915572 T AT98915572 T AT 98915572T AT 98915572 T AT98915572 T AT 98915572T AT E309264 T1 ATE309264 T1 AT E309264T1
- Authority
- AT
- Austria
- Prior art keywords
- amino
- peptidyl
- protease inhibitors
- acids
- cysteine protease
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title 1
- 239000002852 cysteine proteinase inhibitor Substances 0.000 title 1
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 1
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4467697P | 1997-04-18 | 1997-04-18 | |
| US09/060,491 US6348448B1 (en) | 1997-04-18 | 1998-04-15 | Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors |
| PCT/US1998/007499 WO1998047523A1 (en) | 1997-04-18 | 1998-04-15 | Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE309264T1 true ATE309264T1 (de) | 2005-11-15 |
Family
ID=26721855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98915572T ATE309264T1 (de) | 1997-04-18 | 1998-04-15 | Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6348448B1 (de) |
| EP (1) | EP0975353B1 (de) |
| JP (1) | JP4144811B2 (de) |
| AT (1) | ATE309264T1 (de) |
| AU (1) | AU733420B2 (de) |
| CA (1) | CA2286722C (de) |
| DE (1) | DE69832268T2 (de) |
| ES (1) | ES2252831T3 (de) |
| NZ (1) | NZ500045A (de) |
| WO (1) | WO1998047523A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1034164B1 (de) * | 1997-11-24 | 2004-05-19 | Merck & Co., Inc. | Beta-alanin-derivate als zell-adhäsions-inhibitoren |
| US6645939B1 (en) | 1997-11-24 | 2003-11-11 | Merck & Co., Inc. | Substituted β-alanine derivatives as cell adhesion inhibitors |
| WO2003024923A1 (en) * | 2001-09-14 | 2003-03-27 | Axys Pharmaceuticals, Inc. | Sulfonamide compounds as protease inhibitors |
| CN104039151A (zh) * | 2011-06-17 | 2014-09-10 | 维罗贝股份有限公司 | 治疗中枢神经系统中小神经胶质细胞介导的神经元缺失的组织蛋白酶抑制剂 |
| MX350874B (es) | 2011-07-01 | 2017-09-19 | Novozymes As | Composicion de detergente liquido. |
| US9085750B2 (en) | 2011-07-01 | 2015-07-21 | Novozymes A/S | Stabilized subtilisin composition |
| CN105189724A (zh) | 2013-03-14 | 2015-12-23 | 诺维信公司 | 含有酶和抑制剂的水溶性膜 |
| US20160075976A1 (en) | 2013-05-03 | 2016-03-17 | Novozymes A/S | Microencapsulation of Detergent Enzymes |
| US20170121646A1 (en) | 2014-07-03 | 2017-05-04 | Novozymes A/S | Improved Stabilization of Non-Protease Enzyme |
| DK3234093T3 (da) | 2014-12-19 | 2020-08-17 | Novozymes As | Proteasevarianter og polynukleotider, som koder for dem |
| WO2017005816A1 (en) | 2015-07-06 | 2017-01-12 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| CN120005686A (zh) | 2017-05-05 | 2025-05-16 | 诺维信公司 | 包含脂肪酶和亚硫酸根的组合物 |
| CN111108183A (zh) | 2017-06-30 | 2020-05-05 | 诺维信公司 | 酶浆液组合物 |
| EP4379029A1 (de) | 2017-11-01 | 2024-06-05 | Novozymes A/S | Polypeptide und zusammensetzungen mit solchen polypeptiden |
| CN111479919A (zh) | 2017-11-01 | 2020-07-31 | 诺维信公司 | 多肽以及包含此类多肽的组合物 |
| CN111770788B (zh) | 2018-03-13 | 2023-07-25 | 诺维信公司 | 使用氨基糖低聚物进行微囊化 |
| EP3647398B1 (de) | 2018-10-31 | 2024-05-15 | Henkel AG & Co. KGaA | Reinigungszusammensetzungen mit dispersinen v |
| EP3647397A1 (de) | 2018-10-31 | 2020-05-06 | Henkel AG & Co. KGaA | Reinigungsmittel mit dispersins iv |
| MX2021015894A (es) | 2019-07-01 | 2022-02-03 | Basf Se | Peptidos acetales para estabilizar enzimas. |
| EP4077656A2 (de) | 2019-12-20 | 2022-10-26 | Novozymes A/S | Polypeptide mit proteolytischer aktivität und verwendung davon |
| US20240301328A1 (en) | 2021-03-12 | 2024-09-12 | Novozymes A/S | Polypeptide variants |
| CN120344647A (zh) | 2022-12-23 | 2025-07-18 | 诺维信公司 | 包含过氧化氢酶和淀粉酶的洗涤剂组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3481913D1 (de) | 1983-04-27 | 1990-05-17 | Ici America Inc | Prolin-derivate. |
| JPH075634B2 (ja) * | 1987-10-30 | 1995-01-25 | 日東紡績株式会社 | トリペプチド類及びこれを含有する抗プラスミン剤 |
| DE4101895C1 (de) | 1991-01-23 | 1991-12-05 | Forschungszentrum Juelich Gmbh, 5170 Juelich, De | |
| US5436229A (en) | 1994-03-04 | 1995-07-25 | Eli Lilly And Company | Bisulfite adducts of arginine aldehydes |
| CA2237936A1 (en) | 1995-11-16 | 1997-05-22 | G.D. Searle & Co. | N-protected/n-substituted-beta-amino hydroxy sulfonates |
-
1998
- 1998-04-15 CA CA2286722A patent/CA2286722C/en not_active Expired - Fee Related
- 1998-04-15 NZ NZ500045A patent/NZ500045A/en not_active IP Right Cessation
- 1998-04-15 WO PCT/US1998/007499 patent/WO1998047523A1/en not_active Ceased
- 1998-04-15 AT AT98915572T patent/ATE309264T1/de active
- 1998-04-15 US US09/060,491 patent/US6348448B1/en not_active Expired - Lifetime
- 1998-04-15 AU AU69720/98A patent/AU733420B2/en not_active Ceased
- 1998-04-15 ES ES98915572T patent/ES2252831T3/es not_active Expired - Lifetime
- 1998-04-15 JP JP54613398A patent/JP4144811B2/ja not_active Expired - Fee Related
- 1998-04-15 EP EP98915572A patent/EP0975353B1/de not_active Expired - Lifetime
- 1998-04-15 DE DE69832268T patent/DE69832268T2/de not_active Expired - Lifetime
-
2000
- 2000-01-18 US US09/484,713 patent/US6500802B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU733420B2 (en) | 2001-05-17 |
| JP2001520674A (ja) | 2001-10-30 |
| CA2286722A1 (en) | 1998-10-29 |
| NZ500045A (en) | 2001-02-23 |
| DE69832268D1 (en) | 2005-12-15 |
| HK1025511A1 (en) | 2000-11-17 |
| US6500802B1 (en) | 2002-12-31 |
| ES2252831T3 (es) | 2006-05-16 |
| EP0975353B1 (de) | 2005-11-09 |
| JP4144811B2 (ja) | 2008-09-03 |
| EP0975353A4 (de) | 2001-11-28 |
| EP0975353A1 (de) | 2000-02-02 |
| DE69832268T2 (de) | 2006-07-13 |
| CA2286722C (en) | 2010-10-19 |
| WO1998047523A1 (en) | 1998-10-29 |
| AU6972098A (en) | 1998-11-13 |
| US6348448B1 (en) | 2002-02-19 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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