ATE310725T1 - Kondensierte n-acylindole als antitumormittel - Google Patents

Kondensierte n-acylindole als antitumormittel

Info

Publication number: ATE310725T1
Authority: AT; Austria
Prior art keywords: group; substituted; formulae; acylindols; condensed
Prior art date: 1996-09-12

Application number

AT97942316T

Other languages

English (en)

Inventor

William Alexander Denny

Moana Tercel

Graham John Atwell

Original Assignee

Auckland Uniservices Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-12

Filing date

1997-09-12

Publication date

2005-12-15

1996-09-12 Priority claimed from GBGB9619082.2A external-priority patent/GB9619082D0/en

1997-04-10 Priority claimed from GBGB9707394.4A external-priority patent/GB9707394D0/en

1997-09-12 Application filed by Auckland Uniservices Ltd filed Critical Auckland Uniservices Ltd

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE310725T1 publication Critical patent/ATE310725T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title 1
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
125000003277 amino group Chemical group 0.000 abstract 2
125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
102000005367 Carboxypeptidases Human genes 0.000 abstract 1
108010006303 Carboxypeptidases Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000004459 Nitroreductase Human genes 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
108020001162 nitroreductase Proteins 0.000 abstract 1
125000000168 pyrrolyl group Chemical group 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT97942316T 1996-09-12 1997-09-12 Kondensierte n-acylindole als antitumormittel ATE310725T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9619082.2A GB9619082D0 (en)	1996-09-12	1996-09-12	Further cyclopropylindoles and their seco precursors,and their use as prodrugs
GBGB9707394.4A GB9707394D0 (en)	1997-04-10	1997-04-10	Further cyclopropylindoles and their seco precursors, and their use as prodrugs
PCT/NZ1997/000117 WO1998011101A2 (en)	1996-09-12	1997-09-12	Condensed n-aclyindoles as antitumor agents

Publications (1)

Publication Number	Publication Date
ATE310725T1 true ATE310725T1 (de)	2005-12-15

Family

ID=26310030

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97942316T ATE310725T1 (de)	1996-09-12	1997-09-12	Kondensierte n-acylindole als antitumormittel

Country Status (9)

Country	Link
EP (1)	EP0938474B1 (de)
JP (1)	JP4155598B2 (de)
AT (1)	ATE310725T1 (de)
AU (1)	AU721037B2 (de)
CA (1)	CA2265874C (de)
DE (1)	DE69734722T2 (de)
ES (1)	ES2253786T3 (de)
NZ (1)	NZ334344A (de)
WO (1)	WO1998011101A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2260570T3 (es)	1998-08-27	2006-11-01	Spirogen Limited	Pirrolobenziodiazepinas dimericas.
GB9818730D0 (en)	1998-08-27	1998-10-21	Univ Portsmouth	Collections of compounds
GB9909612D0 (en) *	1999-04-26	1999-06-23	Cancer Res Campaign Tech	N-protected amines and their use as prodrugs
US6909006B1 (en)	1999-08-27	2005-06-21	Spirogen Limited	Cyclopropylindole derivatives
SK15432002A3 (sk) *	2000-04-28	2004-01-08	Baxter Healthcare Sa	2-acylindolové deriváty a ich použitie ako protinádorového prípravku
US7214685B2 (en)	2000-05-02	2007-05-08	Lutz F. Tietze	Prodrugs for a selective cancer therapy
JP4862120B2 (ja) *	2001-02-22	2012-01-25	ユニヴァーシティオブブラッドフォード	腫瘍治療のためのプロドラッグとしてのベンズ−インドールおよびベンゾ−キノリン誘導体
AU2003228173A1 (en) *	2002-05-17	2003-12-02	Auckland Uniservices Limited	Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3h-(ring fused indol-5-yl(amine-derived)) compounds and analogues thereof, and to products obtained therefrom
GB0226593D0 (en)	2002-11-14	2002-12-24	Consultants Ltd	Compounds
ATE410161T1 (de) *	2003-05-02	2008-10-15	Elan Pharm Inc	4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazol-3- carbonsäureamid-derivate und verwandte verbindungen als bradykinin b1 rezeptor antagonisten zur behandlung von entzündlichen erkrankungen
JP2006525361A (ja) *	2003-05-02	2006-11-09	エランファーマシューティカルズ，インコーポレイテッド	ブラジキニンｂ１受容体アンタゴニストとしての選択された置換ピラゾール誘導体および関連化合物
GB0321295D0 (en)	2003-09-11	2003-10-15	Spirogen Ltd	Synthesis of protected pyrrolobenzodiazepines
NZ536107A (en) *	2004-10-22	2007-06-29	Auckland Uniservices Ltd	Nitrobenzindoles and their use in cancer therapy
WO2007059404A2 (en) *	2005-11-10	2007-05-24	Medarex, Inc.	Duocarmycin derivatives as novel cytotoxic compounds and conjugates
MX2008009956A (es) *	2006-02-02	2008-12-12	Syntarga Bv	Analogos de cc-1065 solubles en agua y sus conjugados.
WO2008039087A2 (en) *	2006-09-29	2008-04-03	Auckland Uniservices Limited	Indoline derivatives and uses thereof
TWI412367B (zh)	2006-12-28	2013-10-21	梅達雷克斯有限責任公司	化學鏈接劑與可裂解基質以及其之綴合物
JP2010519310A (ja)	2007-02-21	2010-06-03	メダレックスインコーポレイテッド	単一のアミノ酸を有する化学リンカーおよびその複合体
US9901567B2 (en)	2007-08-01	2018-02-27	Syntarga B.V.	Substituted CC-1065 analogs and their conjugates
HUE035798T2 (en)	2008-11-03	2018-05-28	Syntarga Bv	CC-1065 analogues and conjugates
DE102009051438A1 (de)	2009-10-30	2011-05-05	Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts	Fluoreszenzfarbstoffe
NO3056203T3 (de) *	2010-04-21	2018-05-12
WO2015104373A2 (en)	2014-01-10	2015-07-16	Synthon Biopharmaceuticals B.V.	Duocarmycin adcs for use in treatment of endometrial cancer
TR201810856T4 (tr)	2014-01-10	2018-08-27	Synthon Biopharmaceuticals Bv	CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul.
DK2948184T3 (en)	2014-01-10	2016-06-27	Synthon Biopharmaceuticals Bv	Duocarmycin-ADCs with improved in vivo antitumor activity
CN108653288B (zh) *	2018-05-29	2020-05-05	福建医科大学孟超肝胆医院(福州市传染病医院)	一种乏氧响应聚合物纳米粒及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU617304B2 (en) *	1986-12-19	1991-11-28	Pharmacia & Upjohn Company	Novel cc-1065 analogs
JP2642165B2 (ja) *	1988-07-22	1997-08-20	協和醗酵工業株式会社	新規ｄｃ−８９化合物およびその製造法
AU648313B2 (en) *	1990-04-25	1994-04-21	Pharmacia & Upjohn Company	Novel CC-1065 analogs
GB9516943D0 (en) *	1995-08-18	1995-10-18	Cancer Soc Auckland Div Nz Inc	Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
JPH11513391A (ja) *	1995-10-03	1999-11-16	ザスクリップスリサーチインスティテュート	Ｃｃ−１０６５及びズオカーマイシンのｃｂｉ類縁体
US5985908A (en) *	1996-03-08	1999-11-16	The Scripps Research Institute	MCBI analogs of CC-1065 and the duocarmycins

1997
- 1997-09-12 AT AT97942316T patent/ATE310725T1/de not_active IP Right Cessation
- 1997-09-12 AU AU44039/97A patent/AU721037B2/en not_active Ceased
- 1997-09-12 WO PCT/NZ1997/000117 patent/WO1998011101A2/en not_active Ceased
- 1997-09-12 EP EP97942316A patent/EP0938474B1/de not_active Expired - Lifetime
- 1997-09-12 DE DE69734722T patent/DE69734722T2/de not_active Expired - Fee Related
- 1997-09-12 JP JP53749297A patent/JP4155598B2/ja not_active Expired - Fee Related
- 1997-09-12 NZ NZ334344A patent/NZ334344A/xx unknown
- 1997-09-12 CA CA002265874A patent/CA2265874C/en not_active Expired - Fee Related
- 1997-09-12 ES ES97942316T patent/ES2253786T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0938474A2 (de)	1999-09-01
JP2000517292A (ja)	2000-12-26
DE69734722T2 (de)	2006-07-20
DE69734722D1 (de)	2005-12-29
CA2265874A1 (en)	1998-03-19
WO1998011101A3 (en)	1998-04-23
CA2265874C (en)	2007-08-28
WO1998011101A2 (en)	1998-03-19
JP4155598B2 (ja)	2008-09-24
EP0938474B1 (de)	2005-11-23
ES2253786T3 (es)	2006-06-01
AU721037B2 (en)	2000-06-22
NZ334344A (en)	2000-08-25
AU4403997A (en)	1998-04-02

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Legal Events

Date	Code	Title	Description
2006-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties