ATE311189T1 - N-heterosubstituierten salicylaten zur behandlung von krebs - Google Patents

N-heterosubstituierten salicylaten zur behandlung von krebs

Info

Publication number: ATE311189T1
Authority: AT; Austria
Prior art keywords: cancer; treatment; salicylates; cystine; heterosubstituted
Prior art date: 2000-04-28

Application number

AT01927530T

Other languages

English (en)

Inventor

Peter Wilhelm Gout

Nicholas Bruchovsky

Original Assignee

Univ British Columbia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-28

Filing date

2001-04-27

Publication date

2005-12-15

2000-04-28 Priority claimed from CA002307278A external-priority patent/CA2307278A1/en

2001-04-27 Application filed by Univ British Columbia filed Critical Univ British Columbia

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE311189T1 publication Critical patent/ATE311189T1/de

Links

206010028980 Neoplasm Diseases 0.000 title abstract 4
201000011510 cancer Diseases 0.000 title abstract 4
150000003873 salicylate salts Chemical class 0.000 title abstract 4
LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 abstract 4
229960003067 cystine Drugs 0.000 abstract 4
230000004700 cellular uptake Effects 0.000 abstract 3
230000002401 inhibitory effect Effects 0.000 abstract 2
229960001860 salicylate Drugs 0.000 abstract 2
UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 abstract 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 abstract 1
229960001940 sulfasalazine Drugs 0.000 abstract 1
NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/625—Salicylic acid; Derivatives thereof having heterocyclic substituents, e.g. 4-salicycloylmorpholine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Hydrogenated Pyridines (AREA)

AT01927530T 2000-04-28 2001-04-27 N-heterosubstituierten salicylaten zur behandlung von krebs ATE311189T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US20035800P	2000-04-28	2000-04-28
CA002307278A CA2307278A1 (en)	2000-04-28	2000-04-28	Use of n-heterocyclic substituted salicylic acids for inhibition of cellular uptake of cystine
PCT/CA2001/000570 WO2001082907A2 (en)	2000-04-28	2001-04-27	Use of n-heterocyclic substituted salicylates for inhibition of cellular uptake of cystine

Publications (1)

Publication Number	Publication Date
ATE311189T1 true ATE311189T1 (de)	2005-12-15

Family

ID=25681769

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01927530T ATE311189T1 (de)	2000-04-28	2001-04-27	N-heterosubstituierten salicylaten zur behandlung von krebs

Country Status (5)

Country	Link
EP (1)	EP1278521B1 (de)
AT (1)	ATE311189T1 (de)
AU (1)	AU2001254559A1 (de)
DE (1)	DE60115414D1 (de)
WO (1)	WO2001082907A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5910560A (en) *	1996-11-29	1999-06-08	Sumitomo Chemical Company, Ltd.	Thermoplastic resin composition and molded article

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2396145A (en) *	1940-12-14	1946-03-05	Pharmscia Ab	Heterocyclic sulphonamido azo compounds
CS142691A3 (en) *	1991-05-15	1992-11-18	Vyzk Ustav Farm Biochem Sp	Process for preparing 5-//4-/(4',6'-dimethyl-2-pyrimidinyl)sulfamoyl/phenyl/azo/-acetylsalicylic acid
SE9103397D0 (sv) *	1991-11-18	1991-11-18	Kabi Pharmacia Ab	Nya substituerade salicylsyror

2001
- 2001-04-27 EP EP01927530A patent/EP1278521B1/de not_active Expired - Lifetime
- 2001-04-27 WO PCT/CA2001/000570 patent/WO2001082907A2/en not_active Ceased
- 2001-04-27 AT AT01927530T patent/ATE311189T1/de not_active IP Right Cessation
- 2001-04-27 DE DE60115414T patent/DE60115414D1/de not_active Expired - Lifetime
- 2001-04-27 AU AU2001254559A patent/AU2001254559A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1278521A2 (de)	2003-01-29
EP1278521B1 (de)	2005-11-30
DE60115414D1 (de)	2006-01-05
AU2001254559A1 (en)	2001-11-12
WO2001082907A2 (en)	2001-11-08
WO2001082907A3 (en)	2002-08-08

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Legal Events

Date	Code	Title	Description
2006-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties