ATE311206T1 - Substituierte porphyrine - Google Patents

Substituierte porphyrine

Info

Publication number
ATE311206T1
ATE311206T1 AT99919995T AT99919995T ATE311206T1 AT E311206 T1 ATE311206 T1 AT E311206T1 AT 99919995 T AT99919995 T AT 99919995T AT 99919995 T AT99919995 T AT 99919995T AT E311206 T1 ATE311206 T1 AT E311206T1
Authority
AT
Austria
Prior art keywords
substituted porphyrins
oxidants
compounds
relates
processes
Prior art date
Application number
AT99919995T
Other languages
English (en)
Inventor
James D Crapo
Brian Day
Polivina Jolicia F Gauuan
Anthony D Pechulis Jr
Michael P Trova
Original Assignee
Univ Duke
Aeolus Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke, Aeolus Sciences Inc filed Critical Univ Duke
Application granted granted Critical
Publication of ATE311206T1 publication Critical patent/ATE311206T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT99919995T 1998-04-24 1999-04-23 Substituierte porphyrine ATE311206T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8288198P 1998-04-24 1998-04-24
PCT/US1999/008905 WO1999055388A1 (en) 1998-04-24 1999-04-23 Substituted porphyrins

Publications (1)

Publication Number Publication Date
ATE311206T1 true ATE311206T1 (de) 2005-12-15

Family

ID=22174053

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99919995T ATE311206T1 (de) 1998-04-24 1999-04-23 Substituierte porphyrine

Country Status (10)

Country Link
US (1) US6479477B1 (de)
EP (1) EP1071474B1 (de)
JP (1) JP4648542B2 (de)
AT (1) ATE311206T1 (de)
AU (1) AU771259B2 (de)
CA (1) CA2329751C (de)
DE (1) DE69928655T2 (de)
DK (1) DK1071474T3 (de)
ES (1) ES2257858T3 (de)
WO (1) WO1999055388A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
WO1999023097A1 (en) 1997-11-03 1999-05-14 Duke University Substituted porphyrins
ES2257858T3 (es) 1998-04-24 2006-08-01 Duke University Porfirinas sustituidas.
US6632808B1 (en) 1998-08-11 2003-10-14 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of amyloid formation
ATE312103T1 (de) * 1999-01-25 2005-12-15 Nat Jewish Med & Res Center Substituierte porphyrine und deren therapeutische verwendungen
US6403788B1 (en) 2000-07-11 2002-06-11 Eukarion, Inc. Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species
EP1439842A4 (de) * 2001-06-01 2009-09-02 Nat Jewish Med & Res Center Oxidantienfänger zur behandlung von diabetes oder zur verwendung bei der transplantation oder induktion von immuntoleranz
JP2003012547A (ja) * 2001-06-27 2003-01-15 Meiji Seika Kaisha Ltd インスリン依存性糖尿病の診断剤および治療剤
US20040132706A1 (en) * 2001-10-05 2004-07-08 Daniela Salvemini Composition comprising a catalyst for the dismutation of superoxide and use of the composition for preventing and treating hypotension
US7485721B2 (en) 2002-06-07 2009-02-03 Duke University Substituted porphyrins
WO2004007496A1 (en) * 2002-07-15 2004-01-22 Scinopharm Taiwan, Ltd. Process for the preparation of imidazo(1,2-a)pyridine-3-acetamides
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
CA2528347A1 (en) * 2003-06-06 2005-01-06 Eukarion, Inc. Orally bioavailable low molecular weight metalloporphyrins as antioxidants
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
US7807825B2 (en) * 2004-02-09 2010-10-05 Duke University Substituted porphyrins
US7699964B2 (en) 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
US8165651B2 (en) 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
BRPI0509359A (pt) * 2004-03-29 2007-09-04 Inotek Pharmaceuticals Corp compostos de porfirina substituìda por piridila e métodos de empregos destes
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US20080289053A1 (en) * 2007-05-15 2008-11-20 The Regents Of The University Of California Methods and systems for identifying modulators of longevity
ATE556708T1 (de) * 2008-01-31 2012-05-15 Technion Res & Dev Foundation Corrole für neuroprotektion und neuro-rescue
CN102105146A (zh) 2008-05-23 2011-06-22 国立犹太保健医院 用于治疗与暴露于烷化物质有关的损伤的方法
WO2012048164A2 (en) * 2010-10-06 2012-04-12 Aeolus Sciences, Inc. Porphyrin treatment of neurodegenerative diseases
EP2785339A4 (de) 2011-12-02 2015-11-25 Univ Colorado Regents Neurologische behandlungen mit metalloporphyrin
US10646595B2 (en) * 2013-02-12 2020-05-12 The Governing Council Of The University Of Toronto Porphyrin compounds and their use as MRI contrast agents
WO2015034778A1 (en) 2013-09-03 2015-03-12 Biomimetix J.V., Llc Methods of treating erectile dysfunction
AU2014374361B9 (en) 2013-12-31 2019-07-04 Abbott Diabetes Care Inc. Self-powered analyte sensor and devices using the same
WO2015112588A1 (en) 2014-01-22 2015-07-30 Biomimetix Jv, Llc Methods of treating skin disorders
US10080759B2 (en) 2014-01-22 2018-09-25 Duke University Methods of treating pruritus
KR101894575B1 (ko) * 2017-01-03 2018-09-04 주식회사 인트론바이오테크놀로지 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 화학적 방법
WO2022074014A1 (en) * 2020-10-05 2022-04-14 Biolitec Unternehmensbeteiligungs Ii Ag Tetrapyrrole-based compounds and their formulations for anti-microbial therapy

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US465902A (en) * 1891-12-29 Cultivator
US2951799A (en) 1957-11-13 1960-09-06 Monsanto Chemicals Photoxidation processes using heterocyclic photosensitizers
DE3464252D1 (en) 1983-06-03 1987-07-23 Hoffmann La Roche Labelled molecules for fluorescence immunoassays and processes and intermediates for their preparation
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
GB8429845D0 (en) 1984-11-26 1985-01-03 Efamol Ltd Porphyrins & cancer treatment
US4758422A (en) 1985-01-04 1988-07-19 Salutar Inc. Ferrioxamine paramagnetic contrast agents for MR imaging
JPS63500175A (ja) 1985-05-22 1988-01-21 リポソ−ム テクノロジ−,インコ−ポレイテツド リポソ−ム吸入法および吸入システム
DK402785D0 (da) 1985-09-03 1985-09-03 Syn Tek Ab Fremgangsmaade til fremstilling af et enzym
US5248603A (en) 1985-09-03 1993-09-28 Symbicom Aktiebolag Superoxide dismutase
US4746735A (en) 1986-11-21 1988-05-24 The Dow Chemical Company Regiospecific aryl nitration of meso-substituted tetraarylporphyrins
DE3854872D1 (de) 1987-03-14 1996-02-22 Boehringer Ingelheim Int Humane Mangan-Superoxiddismutase (hMn-SOD)
US5223538A (en) 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
US5227405A (en) 1987-03-31 1993-07-13 Duke University Superoxide dismutase mimic
US4892941A (en) 1987-04-17 1990-01-09 Dolphin David H Porphyrins
US4851403A (en) 1987-04-21 1989-07-25 Johnson Matthey, Inc. Radiation sensitizers
US4885114A (en) 1987-04-22 1989-12-05 Barnes Engineering Co. Metallized tetra((meso)-5-methyl-2-thiophene)porphines, platinum (5-bromo octaethylporphine) and optical filters containing same
US5051337A (en) 1987-06-10 1991-09-24 Director-General Of Agency Of Industrial Science And Technology Optical recording material
GB8805849D0 (en) 1988-03-11 1988-04-13 Efamol Holdings Porphyrins & cancer treatment
US5162519A (en) 1988-03-11 1992-11-10 Efamol Holdings Plc Porphyrins and cancer treatment
US5284647A (en) 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
DE3809671A1 (de) 1988-03-18 1989-09-28 Schering Ag Porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5109016A (en) 1988-05-23 1992-04-28 Georgia State University Foundation, Inc. Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions
FR2632187B1 (fr) 1988-06-02 1990-09-14 Centre Nat Rech Scient Derives de metalloporphyrines, leur preparation, leur application en therapeutique et leur utilisation pour la preparation de molecules hybrides
US5171680A (en) 1988-06-14 1992-12-15 Chiron Corporation Superoxide dismutase analogs having novel binding properties
DE69027383T2 (de) 1989-03-06 1996-11-14 Masayasu Inoue Neue superoxyd-dismutase
DK455789D0 (da) 1989-09-15 1989-09-15 Symbicom Ab Polypeptid
EP0424033A3 (en) 1989-10-19 1991-07-31 Pola Chemical Industries Inc External skin preparation
US5236915A (en) 1990-05-31 1993-08-17 Health Research, Inc. Meso poly(4-sulfonatophenyl) porphines as MRI image enhancing agents
EP0462836A3 (en) 1990-06-20 1992-08-26 Mitsui Toatsu Chemicals, Inc. Recombinant vector plasmid capable of expressing human manganese superoxide dismutase, and process of producing this enzyme
US5202317A (en) 1990-09-13 1993-04-13 The Regents Of The University Of California Synthetic drug molecules that mimic metalloenzymes
US5217966A (en) 1990-09-13 1993-06-08 The Regents Of The University Of California Synthetic drug molecules that mimic metalloenzymes
AU8947791A (en) 1990-11-01 1992-05-26 Scripps Research Institute, The Glycosaminoglycan-targeted fusion proteins, their design, construction and compositions
US5192757A (en) * 1990-12-20 1993-03-09 Glaxo Inc. Cobalt porphyrins
GB9103991D0 (en) 1991-02-26 1991-04-10 Nat Res Dev Molecular electronic devices
FR2676738B1 (fr) 1991-05-22 1995-05-05 Ir2M Nouveau derive organique de metal de transition a structure porphyrinique, composition therapeutique le contenant, en particulier a activite hypoglycemiante.
EP0598753B1 (de) 1991-07-19 1998-03-18 Monsanto Company Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren.
CA2072934C (en) 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5262532A (en) 1991-07-22 1993-11-16 E.R. Squibb & Sons, Inc. Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
US5212300A (en) 1991-09-12 1993-05-18 Sun Company, Inc. (R&M) Cyano- and polycyanometallo-porphyrins as catalysts for alkane oxidation
US5493017A (en) 1992-08-14 1996-02-20 The Trustees Of The University Of Pennsylvania Ring-metalated porphyrins
US5371199B1 (en) 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5599924A (en) * 1992-08-14 1997-02-04 Trustees Of The University Of Pennsylvania Electron-deficient porphyrins and processes and intermediates for preparing same
EP0658109B1 (de) * 1992-09-03 2001-05-30 The Regents Of The University Of California Metallporphyrinzusammensetzungen
US5696109A (en) 1992-12-07 1997-12-09 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
DE4305523A1 (de) * 1993-02-17 1994-08-18 Diagnostikforschung Inst Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5994339A (en) 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
CN1222286C (zh) 1994-05-13 2005-10-12 孟山都公司 过亚硝酸盐分解催化剂的应用方法及其药物组合物
WO1996009053A1 (en) 1994-09-20 1996-03-28 Duke University Oxidoreductase activity of manganic porphyrins
CA2132690A1 (en) 1994-09-22 1996-03-23 Dean Willis Control and modulation of inflammatory response in humans in need of such control and modulation
AU725602B2 (en) 1995-06-07 2000-10-12 Duke University Oxidant scavengers
EP0988037A1 (de) 1997-02-05 2000-03-29 Board Of Regents, The University Of Texas System Porphyrinverbindungen als telomerase inhibitoren
WO1999023097A1 (en) 1997-11-03 1999-05-14 Duke University Substituted porphyrins
ES2257858T3 (es) 1998-04-24 2006-08-01 Duke University Porfirinas sustituidas.
ATE312103T1 (de) 1999-01-25 2005-12-15 Nat Jewish Med & Res Center Substituierte porphyrine und deren therapeutische verwendungen
AU1087401A (en) 1999-10-13 2001-04-23 Uab Research Foundation Metalloporphyrin treatment of neurologic disease
AU2001268366A1 (en) 2000-06-14 2001-12-24 Duke University Tetrapyrroles

Also Published As

Publication number Publication date
US6479477B1 (en) 2002-11-12
DE69928655T2 (de) 2006-08-24
EP1071474B1 (de) 2005-11-30
EP1071474A1 (de) 2001-01-31
WO1999055388A9 (en) 2000-01-27
DE69928655D1 (de) 2006-01-05
AU771259B2 (en) 2004-03-18
WO1999055388A1 (en) 1999-11-04
CA2329751C (en) 2010-10-12
CA2329751A1 (en) 1999-11-04
JP2002512989A (ja) 2002-05-08
ES2257858T3 (es) 2006-08-01
AU3758899A (en) 1999-11-16
JP4648542B2 (ja) 2011-03-09
DK1071474T3 (da) 2006-04-10
EP1071474A4 (de) 2002-10-24

Similar Documents

Publication Publication Date Title
ATE311206T1 (de) Substituierte porphyrine
ATE238307T1 (de) Substituierte porphyrinen
BR0007720A (pt) Porfirinas substituìdas
PT1140944E (pt) Derivados de epotilona e sua utilizacao como agentes antitumorais
EP1432714A4 (de) Chemische verbindungen
EP1126849A4 (de) Heterozyklische kalium-kanal inhibitoren
AU5624699A (en) Use of 5ht-6 antagonists
ATE296826T1 (de) Pyrazolo(1,5)pyridinderivate
TR199900856T2 (xx) Bron�la ilgili terapi maddeleri olarak benzonaftiridinler
ATE274348T1 (de) Überbrückte indenopyrrolocarbazole
AP2001002188A0 (en) 5HT1 antagonists for antidepressant therapy.
EA200000522A1 (ru) 5-htагонисты
DE60131968D1 (de) PYRANOÄ2,3-cÜIMIDAZOÄ1,2-aÜPYRIDIN-DERIVATE ZUR BEHANDLUNG VON GASTROINTESTINALEN ERKRANKUNGEN
WO2000043375A3 (de) Substituierte arylheterocyclen
EP1436279A4 (de) Chemische verbindungen
ATE213236T1 (de) Substituierte benzyloxyimino-verbindungen
ATE281455T1 (de) Oxindolderivate
TR200100475T2 (tr) N-İkameli azabisikloheptan türevlerinin üretimleri ve kullanımları.
DE59911958D1 (de) Fluorierte 3,4-dihydrochinolin-derivative als nos-inhibitoren
MY127539A (en) Bridged indenopyrrolocarbazoles

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties