ATE311448T1 - Menschliche neuronale acetylcholin-rezeptor verbindungen und methoden zu deren anwendung - Google Patents

Menschliche neuronale acetylcholin-rezeptor verbindungen und methoden zu deren anwendung

Info

Publication number
ATE311448T1
ATE311448T1 AT96921440T AT96921440T ATE311448T1 AT E311448 T1 ATE311448 T1 AT E311448T1 AT 96921440 T AT96921440 T AT 96921440T AT 96921440 T AT96921440 T AT 96921440T AT E311448 T1 ATE311448 T1 AT E311448T1
Authority
AT
Austria
Prior art keywords
alpha
subunits
beta
human neuronal
methods
Prior art date
Application number
AT96921440T
Other languages
English (en)
Inventor
Kathryn J Elliott
Michael M Harpold
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE311448T1 publication Critical patent/ATE311448T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AT96921440T 1995-06-07 1996-06-07 Menschliche neuronale acetylcholin-rezeptor verbindungen und methoden zu deren anwendung ATE311448T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/484,722 US6485967B1 (en) 1995-06-07 1995-06-07 Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
PCT/US1996/009775 WO1996041876A1 (en) 1995-06-07 1996-06-07 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Publications (1)

Publication Number Publication Date
ATE311448T1 true ATE311448T1 (de) 2005-12-15

Family

ID=23925332

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96921440T ATE311448T1 (de) 1995-06-07 1996-06-07 Menschliche neuronale acetylcholin-rezeptor verbindungen und methoden zu deren anwendung

Country Status (9)

Country Link
US (5) US6485967B1 (de)
EP (2) EP1295945A1 (de)
JP (2) JPH11509726A (de)
AT (1) ATE311448T1 (de)
AU (1) AU704927B2 (de)
CA (1) CA2221311A1 (de)
DE (1) DE69635517T2 (de)
ES (1) ES2250993T3 (de)
WO (1) WO1996041876A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
DE19819829A1 (de) 1998-05-04 1999-11-11 Bayer Ag Nukleinsäuren, die für Acetylcholinrezeptor-Untereinheiten von Insekten kodieren
GB9913248D0 (en) * 1999-06-09 1999-08-04 Babraham Inst Recombinant nematode nicotinic receptor and uses
EP1090991A1 (de) * 1999-09-29 2001-04-11 Sanofi-Synthelabo Nikotin-acetylcholin-Rezeptor, dessen Isolierung und Verwendung
DE19959582A1 (de) * 1999-12-10 2001-06-13 Bayer Ag Nukleinsäuren, die für neue Acetylcholinrezeptor-beta-Untereinheiten von Insekten kodieren
CA2393538A1 (en) * 1999-12-14 2001-06-21 Pharmacia & Upjohn Company Human ion channels
AU2001249650A1 (en) * 2000-04-03 2001-10-15 Anne Chew Haplotypes of the chrnb3 gene
FR2813499B1 (fr) * 2000-09-04 2004-11-26 Pasteur Institut Mammifere non-humain mutant pour l'expression de la sous- unite alpha6 du recepteur nicotinique de l'acetylcholine et utilisation pour le criblage de substances susceptibles d'interagir avec ce recepteur
US7700749B2 (en) 2001-08-31 2010-04-20 Agensys, Inc. Nucleic acid and corresponding protein entitled 205P1B5 useful in treatment and detection of cancer
WO2005030145A2 (en) * 2003-09-24 2005-04-07 Targacept, Inc. Composition and pharmacology of novel alpha-6-containing nicotinic acetylcholine receptors
US20070184656A1 (en) * 2004-11-08 2007-08-09 Tel Epion Inc. GCIB Cluster Tool Apparatus and Method of Operation
US7799683B2 (en) * 2004-11-08 2010-09-21 Tel Epion, Inc. Copper interconnect wiring and method and apparatus for forming thereof
WO2006091672A2 (en) * 2005-02-23 2006-08-31 Dow Agrosciences Llc Novel assays utilizing nicotinic acetylcholine receptor subunits
US7879913B2 (en) * 2005-06-28 2011-02-01 Catholic Healthcare West Iptakalim hydrochloride for decreasing nicotine use
US9005981B2 (en) * 2008-12-30 2015-04-14 Dow Agrosciences Llc Assays utilizing nicotinic acetylcholine receptor subunits

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
US4855231A (en) 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US4837148A (en) 1984-10-30 1989-06-06 Phillips Petroleum Company Autonomous replication sequences for yeast strains of the genus pichia
US4882279A (en) 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5024939A (en) 1987-07-09 1991-06-18 Genentech, Inc. Transient expression system for producing recombinant protein
US4929555A (en) 1987-10-19 1990-05-29 Phillips Petroleum Company Pichia transformation
US4981784A (en) 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5449606A (en) 1988-03-18 1995-09-12 The Salk Institute For Biological Studies DNA encoding neuronal nicotinic acetylcholine receptor compositions containing the beta 4 subunit
CA1341554C (en) 1988-03-18 2007-10-09 The Salk Institute For Biological Studies Neuronal nicotinic acetylcholine receptor compositions and assay
US5386025A (en) 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
EP0424397B1 (de) 1988-04-04 1996-06-19 The Salk Institute Biotechnology Industrial Associates, Inc. Calciumkanal-zusammensetzungen und verfahren
DK0463064T3 (da) 1989-03-14 1999-11-29 Salk Inst For Biological Studi Neuronale nicotinacethylcholinreceptorsammensætninger indeholdende beta-4-underenheden
EP0497894A4 (en) 1989-10-25 1993-03-31 The Salk Institute For Biological Studies Receptor infection assay
US5091518A (en) 1989-11-16 1992-02-25 The Salk Institute For Biological Studies Beta retinoic acid response elements compositions and assays
US5369028A (en) 1990-04-03 1994-11-29 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
DE69434067T2 (de) 1993-03-08 2006-03-02 Merck & Co., Inc. Menschliche neuronale nikotin-acetylcholin-rezeptor-verbindungen und methoden ihres einsatzes
WO1995013299A1 (en) 1993-11-08 1995-05-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Also Published As

Publication number Publication date
EP1295945A1 (de) 2003-03-26
US6524789B1 (en) 2003-02-25
AU704927B2 (en) 1999-05-06
WO1996041876A1 (en) 1996-12-27
US7169895B2 (en) 2007-01-30
ES2250993T3 (es) 2006-04-16
DE69635517T2 (de) 2006-08-10
AU6266496A (en) 1997-01-09
US20070185313A1 (en) 2007-08-09
US7119067B2 (en) 2006-10-10
CA2221311A1 (en) 1996-12-27
EP0832230B1 (de) 2005-11-30
EP0832230A1 (de) 1998-04-01
US20040002122A1 (en) 2004-01-01
US20030138911A1 (en) 2003-07-24
DE69635517D1 (de) 2006-01-05
US6485967B1 (en) 2002-11-26
JP2009050270A (ja) 2009-03-12
JPH11509726A (ja) 1999-08-31

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