ATE311877T1 - Lp(a)-mindernde mittel und inhibitoren der apoprotein (a) produktion - Google Patents
Lp(a)-mindernde mittel und inhibitoren der apoprotein (a) produktionInfo
- Publication number
- ATE311877T1 ATE311877T1 AT99905282T AT99905282T ATE311877T1 AT E311877 T1 ATE311877 T1 AT E311877T1 AT 99905282 T AT99905282 T AT 99905282T AT 99905282 T AT99905282 T AT 99905282T AT E311877 T1 ATE311877 T1 AT E311877T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- apoprotein
- inhibitors
- reducing agents
- lower alkylene
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108010012927 Apoprotein(a) Proteins 0.000 title 1
- 239000003638 chemical reducing agent Substances 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 102100040214 Apolipoprotein(a) Human genes 0.000 abstract 2
- 101710115418 Apolipoprotein(a) Proteins 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005529 alkyleneoxy group Chemical group 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical class OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4200498 | 1998-02-24 | ||
| PCT/JP1999/000798 WO1999043318A1 (en) | 1998-02-24 | 1999-02-23 | Lp(a)-LOWERING AGENTS AND APOPROTEIN (a) PRODUCTION INHIBTORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE311877T1 true ATE311877T1 (de) | 2005-12-15 |
Family
ID=12624057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99905282T ATE311877T1 (de) | 1998-02-24 | 1999-02-23 | Lp(a)-mindernde mittel und inhibitoren der apoprotein (a) produktion |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6166036A (de) |
| EP (1) | EP1000620B1 (de) |
| JP (1) | JP3412829B2 (de) |
| AT (1) | ATE311877T1 (de) |
| DE (1) | DE69928749T2 (de) |
| ES (1) | ES2255245T3 (de) |
| WO (1) | WO1999043318A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101943676B1 (ko) | 2011-06-28 | 2019-01-29 | 메르크 파텐트 게엠베하 | 금속 착물 |
| US9515266B2 (en) | 2011-10-20 | 2016-12-06 | Merck Patent Gmbh | Materials for organic electroluminescent devices |
| JPWO2015186747A1 (ja) * | 2014-06-04 | 2017-07-13 | 元夫 通 | ４−置換安息香酸誘導体の固体分散体、その製造方法およびそれを含む医薬組成物 |
| US20180318279A1 (en) * | 2015-10-23 | 2018-11-08 | Rush University Medical Center | Topical compositions providing pain relief and methods of use thereof |
| CN120035578A (zh) * | 2023-05-19 | 2025-05-23 | 深圳信立泰药业股份有限公司 | 一种磺酰胺类化合物及其制备方法和医药用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231184A (en) * | 1987-11-23 | 1993-07-27 | Janssen Pharmaceutica N.V. | Pridazinamine derivatives |
| EP0393607B1 (de) * | 1989-04-19 | 1996-02-21 | Otsuka Pharmaceutical Co., Ltd. | Phenylcarbonsäurederivate mit einem Heterocyclus |
| JPH04112868A (ja) * | 1990-09-03 | 1992-04-14 | Otsuka Pharmaceut Co Ltd | 置換ヘテロ環を有するフェニルカルボン酸誘導体 |
| HU215598B (hu) * | 1992-09-11 | 1999-01-28 | Taiho Pharmaceutical Co. Ltd. | Eljárás optikailag aktív 1-fenil-pirrolidon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
-
1999
- 1999-02-23 US US09/403,495 patent/US6166036A/en not_active Expired - Fee Related
- 1999-02-23 WO PCT/JP1999/000798 patent/WO1999043318A1/ja not_active Ceased
- 1999-02-23 AT AT99905282T patent/ATE311877T1/de not_active IP Right Cessation
- 1999-02-23 EP EP99905282A patent/EP1000620B1/de not_active Expired - Lifetime
- 1999-02-23 DE DE69928749T patent/DE69928749T2/de not_active Expired - Fee Related
- 1999-02-23 ES ES99905282T patent/ES2255245T3/es not_active Expired - Lifetime
- 1999-02-23 JP JP54339299A patent/JP3412829B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6166036A (en) | 2000-12-26 |
| JP3412829B2 (ja) | 2003-06-03 |
| EP1000620A1 (de) | 2000-05-17 |
| EP1000620B1 (de) | 2005-12-07 |
| DE69928749T2 (de) | 2006-06-29 |
| EP1000620A4 (de) | 2004-03-17 |
| WO1999043318A1 (en) | 1999-09-02 |
| ES2255245T3 (es) | 2006-06-16 |
| DE69928749D1 (de) | 2006-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |