ATE313526T1 - Zwischenstufe für die synthese von amlodipin, herstellungsverfahren und entsprechende anwendung - Google Patents

Zwischenstufe für die synthese von amlodipin, herstellungsverfahren und entsprechende anwendung

Info

Publication number: ATE313526T1
Authority: AT; Austria
Prior art keywords: amlodipine; synthesis; production process; corresponding application; intermediate stage
Prior art date: 1998-10-26

Application number

AT99952654T

Other languages

English (en)

Inventor

Laura Coppi

Guillen Yolanda Gasanz

Pardo Julio Campon

Original Assignee

Esteve Quimica Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-26

Filing date

1999-10-18

Publication date

2006-01-15

1999-10-18 Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa

2006-01-15 Application granted granted Critical

2006-01-15 Publication of ATE313526T1 publication Critical patent/ATE313526T1/de

Links

HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title abstract 2
229960000528 amlodipine Drugs 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 3
238000002360 preparation method Methods 0.000 abstract 3
USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 abstract 1
239000005695 Ammonium acetate Substances 0.000 abstract 1
WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 abstract 1
229940043376 ammonium acetate Drugs 0.000 abstract 1
235000019257 ammonium acetate Nutrition 0.000 abstract 1
125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
OEBFVKDPQVFAPH-LUAWRHEFSA-N ethyl (z)-3-amino-4-[2-(1,3-dioxoisoindol-2-yl)ethoxy]but-2-enoate Chemical group C1=CC=C2C(=O)N(CCOCC(/N)=C/C(=O)OCC)C(=O)C2=C1 OEBFVKDPQVFAPH-LUAWRHEFSA-N 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
General Health & Medical Sciences (AREA)
Vascular Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Urology & Nephrology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Electric Double-Layer Capacitors Or The Like (AREA)

AT99952654T 1998-10-26 1999-10-18 Zwischenstufe für die synthese von amlodipin, herstellungsverfahren und entsprechende anwendung ATE313526T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009802240A ES2151850B1 (es)	1998-10-26	1998-10-26	Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
PCT/ES1999/000333 WO2000024714A1 (es)	1998-10-26	1999-10-18	Intermedio para la sintesis de amlodipino, procedimiento para su obtencion y utilizacion correspondiente

Publications (1)

Publication Number	Publication Date
ATE313526T1 true ATE313526T1 (de)	2006-01-15

Family

ID=8305582

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99952654T ATE313526T1 (de)	1998-10-26	1999-10-18	Zwischenstufe für die synthese von amlodipin, herstellungsverfahren und entsprechende anwendung

Country Status (12)

Country	Link
US (1)	US6603006B2 (de)
EP (1)	EP1125924B1 (de)
JP (1)	JP2002528436A (de)
KR (1)	KR100576166B1 (de)
AT (1)	ATE313526T1 (de)
AU (1)	AU752042B2 (de)
CA (1)	CA2349013C (de)
DE (1)	DE69929079T2 (de)
DK (1)	DK1125924T3 (de)
ES (2)	ES2151850B1 (de)
SI (1)	SI1125924T1 (de)
WO (1)	WO2000024714A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1346214A2 (de)	2000-12-29	2003-09-24	Pfizer Limited	Referenzstandards und verfahren zur bestimmung der reinheit oder stabilität von amlodipin-maleat
GB2372036B (en)	2000-12-29	2004-05-19	Bioorg Bv	Aspartate derivative of amlodipine
EP1309554A1 (de)	2000-12-29	2003-05-14	Synthon Licensing, Ltd.	Amid-derivat von amlodipin
ES2254495T4 (es)	2000-12-29	2007-06-16	Pfizer Limited	Hemimaleato de amlodipina.
US6653481B2 (en)	2000-12-29	2003-11-25	Synthon Bv	Process for making amlodipine
SI1309555T1 (sl)	2000-12-29	2005-12-31	Pfizer Ltd	Postopek izdelave amlodipin-maleata
MXPA03005882A (es)	2000-12-29	2005-04-19	Pfizer Ltd	Derivado amida de amlodipina.
US7335380B2 (en)	2000-12-29	2008-02-26	Synthon Ip Inc.	Amlodipine free base
AT5874U1 (de)	2000-12-29	2003-01-27	Bioorg Bv	Pharmazeutische zubereitungen enthaltend amlodipinmaleat
CA2433181C (en)	2000-12-29	2005-11-22	Pfizer Limited	Amlodipine hemifumarate
US6680334B2 (en)	2001-08-28	2004-01-20	Pfizer Inc	Crystalline material
US6784297B2 (en)	2002-09-04	2004-08-31	Kopran Limited	Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
US20040072879A1 (en) *	2002-10-10	2004-04-15	Dr. Reddy's Laboratories Limited	Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
ES2211317B1 (es) *	2002-11-18	2005-10-16	Finaf 92, S.A.	Compuestos intermedios para la obtencion de principios activos antihipertensivos y procedimientos correspondientes.
ES2318275T3 (es) *	2003-03-07	2009-05-01	Syngenta Participations Ag	Procedimiento para la produccion de esteres del acido niocotinico sustituidos.
KR100807336B1 (ko)	2006-10-23	2008-02-28	명문제약주식회사	암로디핀의 제조를 위한 신규한 중간체 화합물, 이의 제조방법 및 이를 이용한 암로디핀의 제조 방법
JP2010100562A (ja) *	2008-10-23	2010-05-06	Daito Kk	アムロジピン製造中間体の精製方法
EP3334485B1 (de)	2015-08-14	2024-03-06	ResMed Pty Ltd	Überwachung der atemdrucktherapie

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CS228917B2 (en) *	1981-03-14	1984-05-14	Pfizer	Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) *	1982-03-11	1991-12-09	Pfizer	Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
PL140069B1 (en) *	1982-12-21	1987-03-31	Pfizer	Method of obtaining new derivatives of dihydropiridine
GB8422139D0 (en) *	1984-09-01	1984-10-03	Fisons Plc	Biologically active nitrogen heterocyclics
WO1988001266A1 (fr) *	1986-08-14	1988-02-25	Byk Gulden Lomberg Chemische Fabrik Gmbh	Piperidines nouvelles
GB9119983D0 (en) *	1991-09-19	1991-11-06	Erba Carlo Spa	Dihydropyridine derivatives useful in antitumor therapy

1998
- 1998-10-26 ES ES009802240A patent/ES2151850B1/es not_active Expired - Fee Related
1999
- 1999-10-18 WO PCT/ES1999/000333 patent/WO2000024714A1/es not_active Ceased
- 1999-10-18 EP EP99952654A patent/EP1125924B1/de not_active Expired - Lifetime
- 1999-10-18 DK DK99952654T patent/DK1125924T3/da active
- 1999-10-18 KR KR1020017005232A patent/KR100576166B1/ko not_active Expired - Fee Related
- 1999-10-18 DE DE69929079T patent/DE69929079T2/de not_active Expired - Lifetime
- 1999-10-18 AT AT99952654T patent/ATE313526T1/de not_active IP Right Cessation
- 1999-10-18 JP JP2000578284A patent/JP2002528436A/ja active Pending
- 1999-10-18 ES ES99952654T patent/ES2251843T3/es not_active Expired - Lifetime
- 1999-10-18 AU AU64772/99A patent/AU752042B2/en not_active Ceased
- 1999-10-18 SI SI9930870T patent/SI1125924T1/sl unknown
- 1999-10-18 CA CA002349013A patent/CA2349013C/en not_active Expired - Fee Related
2002
- 2002-01-10 US US10/041,475 patent/US6603006B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1125924B1 (de)	2005-12-21
KR20010093781A (ko)	2001-10-29
CA2349013A1 (en)	2000-05-04
JP2002528436A (ja)	2002-09-03
US20020068831A1 (en)	2002-06-06
ES2151850A1 (es)	2001-01-01
CA2349013C (en)	2007-10-02
DK1125924T3 (da)	2006-05-08
ES2251843T3 (es)	2006-05-01
US6603006B2 (en)	2003-08-05
WO2000024714A1 (es)	2000-05-04
AU6477299A (en)	2000-05-15
KR100576166B1 (ko)	2006-05-03
SI1125924T1 (sl)	2006-04-30
AU752042B2 (en)	2002-09-05
DE69929079T2 (de)	2006-06-22
DE69929079D1 (de)	2006-01-26
ES2151850B1 (es)	2001-08-16
EP1125924A1 (de)	2001-08-22

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2006-08-15

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