ATE314465T1 - Verfahren zum screening von hochaktiven proteasen und hemmstoffen - Google Patents
Verfahren zum screening von hochaktiven proteasen und hemmstoffenInfo
- Publication number
- ATE314465T1 ATE314465T1 AT01960178T AT01960178T ATE314465T1 AT E314465 T1 ATE314465 T1 AT E314465T1 AT 01960178 T AT01960178 T AT 01960178T AT 01960178 T AT01960178 T AT 01960178T AT E314465 T1 ATE314465 T1 AT E314465T1
- Authority
- AT
- Austria
- Prior art keywords
- protease
- gene
- inhibitors
- highly active
- active proteases
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 6
- 239000004365 Protease Substances 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000012216 screening Methods 0.000 title abstract 2
- 102000035195 Peptidases Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 3
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
- C12N9/6408—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001273 | 2000-08-29 | ||
| PCT/DK2001/000503 WO2002018588A1 (en) | 2000-08-29 | 2001-07-17 | Method for screening highly active proteases and inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE314465T1 true ATE314465T1 (de) | 2006-01-15 |
Family
ID=8159678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01960178T ATE314465T1 (de) | 2000-08-29 | 2001-07-17 | Verfahren zum screening von hochaktiven proteasen und hemmstoffen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040038375A1 (de) |
| EP (1) | EP1315806B1 (de) |
| AT (1) | ATE314465T1 (de) |
| AU (1) | AU2001281734A1 (de) |
| CA (1) | CA2419860A1 (de) |
| DE (1) | DE60116337D1 (de) |
| WO (1) | WO2002018588A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080090745A1 (en) * | 2006-10-13 | 2008-04-17 | Fox Bryan P | Expression of Streptomyces subtilism inhibitor (SSI) proteins in Bacillus and Streptomyces sp. |
| US9403897B2 (en) | 2011-10-12 | 2016-08-02 | Sanyo Chemical Industries, Ltd. | Proteinaceous protease inhibitor and protein solution and detergent composition containing it |
| JP6591998B2 (ja) * | 2014-03-28 | 2019-10-16 | ノボザイムス アクティーゼルスカブ | 低pHでのタンパク質結晶の再可溶化 |
| US12019066B2 (en) * | 2016-05-16 | 2024-06-25 | Biomadison, Inc. | Assay with synaptobrevin based moiety |
| WO2017201079A1 (en) | 2016-05-16 | 2017-11-23 | Biomadison, Inc. | Improved assay with synaptobrevin based moiety |
| WO2020074517A1 (en) * | 2018-10-10 | 2020-04-16 | Novozymes A/S | Chymotrypsin inhibitor variants and the use thereof |
| CA3257053A1 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | COMPOSITIONS AND METHODS FOR THE PREVENTION, TREATMENT, SUPPRESSION AND/OR ELIMINATION OF PHYTOPATHOGENIC INFESTATIONS AND INFECTIONS |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2377392A (en) * | 1991-07-09 | 1993-02-11 | Robert Balint | A method for the identification of protease inhibitors |
| US6159688A (en) * | 1997-03-18 | 2000-12-12 | Novo Nordisk A/S | Methods of producing polynucleotide variants |
| CA2360022A1 (en) * | 1999-01-08 | 2000-07-13 | Bristol-Myers Squibb Company | Prokaryotic system designed to monitor protease activity |
-
2001
- 2001-07-17 WO PCT/DK2001/000503 patent/WO2002018588A1/en not_active Ceased
- 2001-07-17 US US10/363,332 patent/US20040038375A1/en not_active Abandoned
- 2001-07-17 DE DE60116337T patent/DE60116337D1/de not_active Expired - Lifetime
- 2001-07-17 AT AT01960178T patent/ATE314465T1/de not_active IP Right Cessation
- 2001-07-17 EP EP01960178A patent/EP1315806B1/de not_active Expired - Lifetime
- 2001-07-17 CA CA002419860A patent/CA2419860A1/en not_active Abandoned
- 2001-07-17 AU AU2001281734A patent/AU2001281734A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002018588A1 (en) | 2002-03-07 |
| CA2419860A1 (en) | 2002-03-07 |
| EP1315806A1 (de) | 2003-06-04 |
| EP1315806B1 (de) | 2005-12-28 |
| AU2001281734A1 (en) | 2002-03-13 |
| DE60116337D1 (de) | 2006-02-02 |
| US20040038375A1 (en) | 2004-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |