ATE314853T1 - 5-n-heterocyclyl-1-(4-sulfonyl-phenyl)-1h-pyraz l derivate mit cyclooxygenase 2 (cox-2) hemmender wirkung zur behandlung von entzündlichen erkrankungen - Google Patents

5-n-heterocyclyl-1-(4-sulfonyl-phenyl)-1h-pyraz l derivate mit cyclooxygenase 2 (cox-2) hemmender wirkung zur behandlung von entzündlichen erkrankungen

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Publication number
ATE314853T1
ATE314853T1 AT02257241T AT02257241T ATE314853T1 AT E314853 T1 ATE314853 T1 AT E314853T1 AT 02257241 T AT02257241 T AT 02257241T AT 02257241 T AT02257241 T AT 02257241T AT E314853 T1 ATE314853 T1 AT E314853T1
Authority
AT
Austria
Prior art keywords
treatment
inhibitant
pyraz
cyclooxygenase
cox
Prior art date
Application number
AT02257241T
Other languages
English (en)
Inventor
Martha Lou Minich
Subas Man Sakya
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE314853T1 publication Critical patent/ATE314853T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
AT02257241T 2001-11-02 2002-10-18 5-n-heterocyclyl-1-(4-sulfonyl-phenyl)-1h-pyraz l derivate mit cyclooxygenase 2 (cox-2) hemmender wirkung zur behandlung von entzündlichen erkrankungen ATE314853T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33630601P 2001-11-02 2001-11-02

Publications (1)

Publication Number Publication Date
ATE314853T1 true ATE314853T1 (de) 2006-02-15

Family

ID=23315492

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02257241T ATE314853T1 (de) 2001-11-02 2002-10-18 5-n-heterocyclyl-1-(4-sulfonyl-phenyl)-1h-pyraz l derivate mit cyclooxygenase 2 (cox-2) hemmender wirkung zur behandlung von entzündlichen erkrankungen

Country Status (10)

Country Link
US (1) US6627626B2 (de)
EP (1) EP1308161B1 (de)
JP (1) JP2003183259A (de)
AT (1) ATE314853T1 (de)
BR (1) BR0204551A (de)
CA (1) CA2410364A1 (de)
DE (1) DE60208509T2 (de)
ES (1) ES2252398T3 (de)
MX (1) MXPA02010781A (de)
WO (1) WO2003037352A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0611587D0 (en) * 2006-06-12 2006-07-19 Glaxo Group Ltd Novel compounds
WO2016196385A1 (en) 2015-05-29 2016-12-08 Portola Pharmaceuticals, Inc. Cerdulatinib for the treatment of b-cell malignancies
US10851087B2 (en) * 2018-05-04 2020-12-01 Portola Pharmaceuticals, Inc. Synthesis of cerdulatinib
WO2019213606A2 (en) 2018-05-04 2019-11-07 Portola Pharmaceuticals, Inc. Solid forms of cerdulatinib

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3575130D1 (de) * 1984-05-12 1990-02-08 Fisons Plc Antiinflammatorische 1,n-diarylpyrazol-3-amine, deren zusammensetzungen und verfahren zu deren herstellung.
DE3545036A1 (de) * 1985-12-19 1987-09-10 Bayer Ag 5-heterocyclyl-1-aryl-pyrazole
DE3707686A1 (de) * 1987-03-11 1988-09-22 Bayer Ag 4-cyano-1-aryl-pyrazole
DK1104760T3 (da) * 1999-12-03 2003-06-30 Pfizer Prod Inc Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
DE60018792T2 (de) * 1999-12-03 2006-01-26 Pfizer Products Inc., Groton Heterocyclo-alkylsulfonylpyrazolderivate zur verwendung als anti-imflammatorische oder analgetische verbindungen
WO2001064669A1 (en) * 2000-03-03 2001-09-07 Pfizer Products Inc. Pyrazole ether derivatives as anti-inflammatory/analgesic agents

Also Published As

Publication number Publication date
EP1308161A1 (de) 2003-05-07
EP1308161B1 (de) 2006-01-04
BR0204551A (pt) 2004-06-08
WO2003037352A1 (en) 2003-05-08
US20030144279A1 (en) 2003-07-31
ES2252398T3 (es) 2006-05-16
US6627626B2 (en) 2003-09-30
DE60208509D1 (de) 2006-03-30
JP2003183259A (ja) 2003-07-03
DE60208509T2 (de) 2006-08-10
CA2410364A1 (en) 2003-05-02
MXPA02010781A (es) 2003-05-07

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