ATE315026T1 - Amlodipin-hemimaleat - Google Patents

Amlodipin-hemimaleat

Info

Publication number
ATE315026T1
ATE315026T1 AT01974984T AT01974984T ATE315026T1 AT E315026 T1 ATE315026 T1 AT E315026T1 AT 01974984 T AT01974984 T AT 01974984T AT 01974984 T AT01974984 T AT 01974984T AT E315026 T1 ATE315026 T1 AT E315026T1
Authority
AT
Austria
Prior art keywords
amlodipine hemimaleate
hemimaleate
amlodipine
new
crystalline
Prior art date
Application number
AT01974984T
Other languages
English (en)
Inventor
Gerrit Jan Bouke Ettema
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Application granted granted Critical
Publication of ATE315026T1 publication Critical patent/ATE315026T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
AT01974984T 2000-12-29 2001-08-15 Amlodipin-hemimaleat ATE315026T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25860300P 2000-12-29 2000-12-29
US80935601A 2001-03-16 2001-03-16
BE2001/0711A BE1014454A6 (nl) 2000-12-29 2001-11-05 Amlodipinehemimaleaat.

Publications (1)

Publication Number Publication Date
ATE315026T1 true ATE315026T1 (de) 2006-02-15

Family

ID=29740327

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01974984T ATE315026T1 (de) 2000-12-29 2001-08-15 Amlodipin-hemimaleat

Country Status (10)

Country Link
US (1) US6538012B2 (de)
EP (1) EP1309557B9 (de)
AT (1) ATE315026T1 (de)
BE (1) BE1014454A6 (de)
BR (1) BR0116552A (de)
CA (1) CA2433190C (de)
DE (1) DE60116514T2 (de)
ES (1) ES2254495T4 (de)
MX (1) MXPA03005884A (de)
WO (1) WO2002053539A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03005882A (es) * 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
RS53403A (sr) * 2000-12-29 2006-10-27 Pfizer Limited Postupak za dobijanje amlodipin maleata
WO2002053541A1 (en) * 2000-12-29 2002-07-11 Pfizer Limited Amide derivative of amlodipine
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
JP2007528349A (ja) * 2003-01-27 2007-10-11 ハンミ ファーム． シーオー．， エルティーディー． 高い安定性を有する無定形アムロジピンカムシレート、その製造方法及びこれを含む経口投与用組成物
EP3960158B1 (de) 2016-10-07 2025-05-21 Silvergate Pharmaceuticals, Inc. Amlodipinformulierungen
CN112334134A (zh) 2018-04-11 2021-02-05 希沃盖特制药公司 氨氯地平制剂
CN116332832A (zh) * 2023-03-29 2023-06-27 安徽美致诚药业有限公司 一种马来酸左旋氨氯地平无定型晶型及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
US4983740A (en) 1986-08-04 1991-01-08 Adir Et Compagnie Process for 1,4-dihydropyridine compounds
FR2602231B1 (fr) * 1986-08-04 1988-10-28 Adir Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
GB8710493D0 (en) 1987-05-02 1987-06-03 Pfizer Ltd Dihydropyridines
US5155120A (en) 1991-01-14 1992-10-13 Pfizer Inc Method for treating congestive heart failure
WO1993006082A1 (en) 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
US5389654A (en) 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
HU221810B1 (hu) 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
ZA9810320B (en) 1997-11-14 2000-05-11 Gea Farmaceutisk Fabrik As Process for the preparation of 1,4-dihydropyridines and novel compounds of use for such purpose.
PL189666B1 (pl) 1998-04-09 2005-09-30 Adamed Sp Z Oo Sposób otrzymywania benzenosulfonianu amlodypiny
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
ES2151850B1 (es) 1998-10-26 2001-08-16 Esteve Quimica Sa Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
GB9827387D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel process
GB9827431D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel compound

Also Published As

Publication number Publication date
US20020128297A1 (en) 2002-09-12
WO2002053539A1 (en) 2002-07-11
CA2433190A1 (en) 2002-07-11
US6538012B2 (en) 2003-03-25
MXPA03005884A (es) 2005-04-08
DE60116514T2 (de) 2006-08-17
CA2433190C (en) 2005-11-15
ES2254495T3 (es) 2006-06-16
EP1309557B9 (de) 2006-11-15
ES2254495T4 (es) 2007-06-16
DE60116514D1 (de) 2006-03-30
BE1014454A6 (nl) 2003-10-07
BR0116552A (pt) 2004-02-03
EP1309557A1 (de) 2003-05-14
EP1309557B1 (de) 2006-01-04

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Legal Events

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